Several recently discovered small proteins of less than 100 amino acids control important, but sometimes surprising, steps in the metabolism of cyanobacteria. There is mounting evidence that a large number of small protein genes have also been overlooked in the genome annotation of many other microorganisms. Although too short for enzymatic activity, their functional characterization has frequently revealed the involvement in processes such as signaling and sensing, interspecies communication, stress responses, metabolism, regulation of transcription and translation, and in the formation (...) of multisubunit protein complexes. Cyanobacteria are the only prokaryotes that perform oxygenic photosynthesis. They thrive under a wide variety of conditions as long as there is light and must cope with dynamic changes in the environment. To acclimate to these fluctuations, frequently small regulatory proteins become expressed that target key enzymes and metabolic processes. The consequences of their actions are profound and can even impact the surrounding microbiome. This review highlights the diverse functions of recently discovered small proteins that control cyanobacterial metabolism. It also addresses why many of these proteins have been overlooked so far and explores the potential for implementing metabolic engineering strategies to improve the use of cyanobacteria in biotechnological applications. (shrink)

At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multi-national data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from (...) social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar was found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-negligible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic. (shrink)

Alexander Pruss has recently argued on probabilistic grounds that Christian philosophers should reject Open Futurism—roughly, the thesis that there are no true future contingents—on account of this view’s alleged inability to handle certain statements about infinite futures in a mathematically or religiously adequate manner. We argue that, once the distinction between being true and becoming true is applied to such statements, it is evident that they pose no problem for Open Futurists.

In her article, Pascale Hess raises the issue of whether her proposed model may be extrapolated and applied to clinical research fields other than stem cell-based interventions in the brain (SCBI-B) (Hess 2012). Broadly summarized, Hess’s model suggests prioritizing efficacy over safety in phase 1 trials involving irreversible interventions in the brain, when clinical criteria meet the appropriate population suffering from “degenerative brain diseases” (Hess 2012). Although there is a need to reconsider the traditional phase 1 model, especially with respect (...) to first-in-human clinical trials involving novel technologies, the question arises as to whether it is appropriate to advocate for a new model that prioritizes efficacy over safety across all phase 1 clinical research trials involving irreversible interventions in the brain. -/- . (shrink)

This dissertation is about prejudice. In particular, it examines the theoretical and ethical questions raised by research on implicit social biases. Social biases are termed "implicit" when they are not reported, though they lie just beneath the surface of consciousness. Such biases are easy to adopt but very difficult to introspect and control. Despite this difficulty, I argue that we are personally responsible for our biases and obligated to overcome them if they can bring harm to ourselves or to others. (...) My dissertation addresses the terms of their removal. It is grounded in a comprehensive examination of empirical research and, as such, is a contribution to social psychology. Although implicit social biases significantly influence our judgment and action, they are not reducible to beliefs or desires. Rather, they constitute a class of their own. Understanding their particular character is vital to determining how to replace them with more preferable habits of mind. I argue for a model of interpersonal fluency, a kind of ethical expertise that requires transforming our underlying dispositions of thought, feeling, and action. (shrink)

In this book, Michael Arbib, a researcher in artificial intelligence and brain theory, joins forces with Mary Hesse, a philosopher of science, to present an integrated account of how humans 'construct' reality through interaction with the social and physical world around them. The book is a major expansion of the Gifford Lectures delivered by the authors at the University of Edinburgh in the autumn of 1983. The authors reconcile a theory of the individual's construction of reality as a network (...) of schemas 'in the head' with an account of the social construction of language, science, ideology and religion to provide an integrated schema-theoretic view of human knowledge. The authors still find scope for lively debate, particularly in their discussion of free will and of the reality of God. The book integrates an accessible exposition of background information with a cumulative marshalling of evidence to address fundamental questions concerning human action in the world and the nature of ultimate reality. (shrink)

It is commonly claimed that the universality of critical phenomena is explained through particular applications of the renormalization group. This article has three aims: to clarify the structure of the explanation of universality, to discuss the physics of such RG explanations, and to examine the extent to which universality is thus explained. The derivation of critical exponents proceeds via a real-space or a field-theoretic approach to the RG. Building on work by Mainwood, this article argues that these approaches ought to (...) be distinguished: while the field-theoretic approach explains universality, the real-space approach fails to provide an adequate explanation. (shrink)

Understanding how scientific activities use naming stories to achieve disciplinary status is important not only for insight into the past, but for evaluating current claims that new disciplines are emerging. In order to gain a historical understanding of how new disciplines develop in relation to these baptismal narratives, we compare two recently formed disciplines, systems biology and genomics, with two earlier related life sciences, genetics and molecular biology. These four disciplines span the twentieth century, a period in which the processes (...) of disciplinary demarcation fundamentally changed from those characteristic of the nineteenth century. We outline how the establishment of each discipline relies upon an interplay of factors that include paradigmatic achievements, technological innovation, and social formations. Our focus, however, is the baptism stories that give the new discipline a founding narrative and articulate core problems, general approaches and constitutive methods. The highly plastic process of achieving disciplinary identity is further marked by the openness of disciplinary definition, tension between technological possibilities and the ways in which scientific issues are conceived and approached, synthesis of reductive and integrative strategies, and complex social interactions. The importance – albeit highly variable – of naming stories in these four cases indicates the scope for future studies that focus on failed disciplines or competing names. Further attention to disciplinary histories could, we suggest, give us richer insight into scientific development. (shrink)

Darwin in Russian Thought represents the first comprehensive and systematic study of Charles Darwin's influence on Russian thought from the early 1860s to the October Revolution. While concentrating on the role of Darwin's theory in the development of Russian science and philosophy, Vucinich also explores the dominant ideological and sociological interpretations of evolutionary thought, providing a deft analysis of the views held by the leaders of Russian nihilism, populism, anarchism, and marxism. Darwin's thinking profoundly influenced intellectual discourse in Russia: it (...) effected the emergence of "theoretical theology," a modern effort to provide theological responses to the revolutionary changes in the natural sciences, contributed to the evolution of a modern scientific community, and spurred the rapidly growing concern with the epistemological and ethical foundations of science in general. Scholarly battles were waged among the critics of Darwin--Karl von Baer, Nikolai Iakovlevich Danilevskii and Sergei Ivanovich Korzhinskii, and others--and the defenders of the faith. Vucinich is able to delineate the distinctive national characteristics of Russian Darwinism: the strong influence of Lamarckian thought, the delayed recognition of the contributions of genetics, the near-universal rejection of Social Darwinism, the early anticipation of the triumph of "evolutionary synthesis," and the heavy concentration on the social and moral aspects of evolutionary thought. Vividly argued and rich in detail, Darwin in Russian Thought provides a unique glimpse into the Russian psyche. Darwin in Russian Thought represents the first comprehensive and systematic study of Charles Darwin's influence on Russian thought from the early 1860s to the October Revolution. While concentrating on the role of Darwin's theory in the development of Russian science and philosophy, Vucinich also explores the dominant ideological and sociological interpretations of evolutionary thought, providing a deft analysis of the views held by the leaders of Russian nihilism, populism, anarchism, and marxism. Darwin's thinking profoundly influenced intellectual discourse in Russia: it effected the emergence of "theoretical theology," a modern effort to provide theological responses to the revolutionary changes in the natural sciences, contributed to the evolution of a modern scientific community, and spurred the rapidly growing concern with the epistemological and ethical foundations of science in general. Scholarly battles were waged among the critics of Darwin--Karl von Baer, Nikolai Iakovlevich Danilevskii and Sergei Ivanovich Korzhinskii, and others--and the defenders of the faith. Vucinich is able to delineate the distinctive national characteristics of Russian Darwinism: the strong influence of Lamarckian thought, the delayed recognition of the contributions of genetics, the near-universal rejection of Social Darwinism, the early anticipation of the triumph of "evolutionary synthesis," and the heavy concentration on the social and moral aspects of evolutionary thought. Vividly argued and rich in detail, Darwin in Russian Thought provides a unique glimpse into the Russian psyche. (shrink)

Those who hold that all fundamental sparse properties have dispositional essences face a problem with structural (e.g. geometrical) properties. In this paper I consider a further route for the dispositional monist that is enabled by the requirement that physical theories should be background-free. If this requirement is respected then we can see how spatial displacement can be a causally active relation and hence may be understood dispositionally.

Several current theories have essences as primary drivers of inductive potential: e.g., people infer dogs share properties because they share essences. We investigated the possibility that people take occupational roles as having robust inductive potential because of a different source: their position in stable social institutions. In Studies 1–4, participants learned a novel property about a target, and then decided whether two new individuals had the property (one with the same occupation, one without). Participants used occupational roles to robustly generalize (...) rights and obligations, functional behaviors, personality traits, and skills. In Studies 5–6, we contrasted occupational roles (via label) with race/gender (via visual face cues). Participants reliably favored occupational roles over race/gender for generalizing rights and obligations, functional behaviors, personality traits, and skills (they favored race/gender for inferring leisure behaviors and physiological properties). Occupational roles supported inferences to the same extent as animal categories (Studies 4 and 6). In Study 7, we examined why members of occupational roles share properties. Participants did not attribute the inductive potential of occupational roles to essences, they attributed it to social institutions. In combination, these seven studies demonstrate that any theory of inductive potential must pluralistically allow for both essences and social institutions to form the basis of inductive potential. (shrink)

This paper explores the prospects for using the notion of a primitive normative attitude in responding to the sceptical argument about meaning developed in chapter 2 of Saul Kripke’s Wittgenstein on Rules and Private Language. It takes as its stalking-horse the response to Kripke’s Wittgenstein developed in a recent series of important works by Hannah Ginsborg. The paper concludes that Ginsborg’s attempted solution fails for a number of reasons: it depends on an inadequate response to Kripke’s Wittgenstein’s ‘finitude’ objection to (...) reductive dispositionalism; it erroneously rejects the idea that a speaker’s understanding of an expression guides her use; it threatens to collapse into either full-blown non-reductionism or reductive dispositionalism; and there is no motive for accepting it over forms of non-reductionism such as those developed by Barry Stroud and John McDowell. (shrink)

Volume 20, Issue 6, June 2020, Page 30-32.

According to proponents of the continuity hypothesis, metaphors represent one end of a spectrum of linguistic phenomena, which includes various forms of loosening/broadening, such as category extensions and approximations, as well as hyperbolic interpretations. The continuity hypothesis is used to establish that the inferences derived from the set of linguistic expressions mentioned above result from the same or nearly similar pragmatic processes. In this paper, we want to challenge that particular aspect of the continuity hypothesis. We do so based on (...) considerations and analysis of an understudied linguistic phenomenon that we call the metaphorical uses of proper names (MPNs). We first explain how MPNs represent a unique linguistic class distinguishable from, for example, nicknames. In addition, we offer some remarks on how MPNs can be understood against the background of current debates between referentialists and predicativists about names. Our discussion leads us to conclude that MPNs are categorically different from literal interpretations of proper names. We spell out the consequences that the results of our analysis have for the continuity hypothesis. (shrink)

In this paper, we investigate the trust-based mechanisms underlying the relationship between ethical leadership and followers’ organisational citizenship behaviours (OCBs). Based on three-wave survey data obtained from 184 employees and their supervisors, we find that ethical leadership leads to higher levels of both affective and cognitive trust. In addition, we find support for a three-path mediational model, where cognitive trust and affective trust, in turn, mediate the relationship between ethical leadership and follower OCBs. That is to say, we found that (...) ethical leadership leads to the development of cognitive trust, which subsequently influences the development of affective trust. Affective trust, in turn, induces followers to exhibit OCBs as a means of reciprocating the leader’s favourable behaviour. Our findings suggest that both affective and cognitive trust plays an important role in the social exchange processes that underlie the relationship between ethical leadership and the discretionary behaviour of followers. (shrink)

Hempel's qualitative criteria of converse consequence and special consequence for confirmation are examined, and the resulting paradoxes traced to the general intransitivity of confirmation. Adopting a probabilistic measure of confirmation, a limiting form of transitivity of confirmation from evidence to predictions is derived, and it is shown to what extent its application depends on prior probability judgments. In arguments involving this kind of transitivity therefore there is no necessary "convergence of opinion" in the sense claimed by some personalists. The conditions (...) of application of the limiting transitivity theorem are most perspicuously described in terms of De Finetti's notion of exchangeability, which leads to a suggested revaluation of the function of theories in relation to confirmation and explanation. (shrink)

The first complete posthumous reflection on the work of Richard Rorty, one of the most important and influential American philosophers of recent times.

Contemporary philosophy’s three main naturalisms are methodological, ontological and epistemological. Methodological naturalism states that the only authoritative standards are those of science. Ontological and epistemological naturalism respectively state that all entities and all valid methods of inquiry are in some sense natural. In philosophy of mathematics of the past few decades methodological naturalism has received the lion’s share of the attention, so we concentrate on this. Ontological and epistemological naturalism in the philosophy of mathematics are discussed more briefly in section (...) 6. (shrink)

The standard, foundationalist reading of Our Knowledge of the External World requires Russell to have a view of perceptual acquaintance that he demonstrably does not have. Russell’s actual purpose in “constructing” physical bodies out of sense-data is instead to show that psychology and physics are consistent. But how seriously engaged was Russell with actual psychology? I show that OKEW makes some non-trivial assumptions about the character of visual space, and I argue that he drew those assumptions from William James’s Principles. (...) This point helps us take a fresh look at the complex relationship between the two men. In light of this surprising background of agreement, I highlight ways their more general approaches to perception finally diverged in ways that put the two at epistemological odds. (shrink)

Questions about the structure and justification of theories, the interpretation of data, and the problem of realism have been in the forefront of debate in recent philosophy of science, and the topic of models and analogies is increasingly recognized as integral to this debate. Models of physical matter and motion ‐ for example, models of atoms and planetary systems ‐ were already familiar in Greek science, but serious analysis of “model” as a concept entered philosophy of science only in the (...) nineteenth century. This was largely the result of proliferation in classical physics of theoretical entities such as “atom,” “electro‐magnetic wave,” and “electron,” for which there appeared to be no directly observable evidence (see theoretical terms). (shrink)

Relational egalitarians argue that democratic institutions are justified by appeal to relational equality. According to the skeptical challenge, equality of political power is not required for relational equality, and the relational egalitarian case for democracy fails. I defend the relational egalitarian justification of democracy. I develop an analysis of social status and show that inequalities of power will not entail inequalities of status. I then show that inequalities of power will robustly cause inequalities of status and argue that this vindicates (...) the relational egalitarian case for democracy, because such theories have a much more pragmatic standard of success for the justification of democracy than conceptual necessity. I consider the objection that if inequalities of power robustly cause inequalities of status, then relational egalitarians should also oppose democratic institutions, because officials such as legislators or judges will have more power than citizens. In reply, I argue that relational egalitarians are only opposed to inequalities of status that mark a failure of recognition respect, and that inequalities of status that follow from democratically licensed inequalities of power will not mark such a failure. I conclude that the skeptical challenge is unsuccessful, and that the relational egalitarian justification of democracy is sound. (shrink)

What is W. V. O. Quine’s relationship to classical pragmatism? Although he resists the comparison to William James in particular, commentators have seen an affinity between his “web of belief” model of theory confirmation and James’s claim that our beliefs form a “stock” that faces new experience as a corporate body. I argue that the similarity is only superficial. James thinks our web of beliefs should be responsive not just to perceptual but also to emotional experiences in some cases; Quine (...) denies this. I motivate James’s controversial view by appealing to an episode in the history of medicine when a researcher self-experimented by swallowing a vial of bacteria that at the time had not been studied in much detail. The researcher’s commitment to his own as-yet untested hypothesis was based in part on emotional considerations. Finally, I argue that Quine’s insistence that emotions can never be relevant to adjusting our web of belief reflects a tacit holdover of one of logical positivism’s crucially anti-pragmatist commitments—that philosophy of science should focus exclusively on the context of justification, not the context of discovery. James’s emphasis on discovery as a (perhaps the) crucial locus for epistemological inquiry is characteristic of pragmatism in general. Since Quinean epistemology is always an epistemology of justification, he is not happily viewed as a member of the pragmatist tradition. (shrink)

The clinical clerkships in medical school are the first formal opportunity for trainees to apply bioethics concepts to clinical encounters. These clerkships are also typically trainees’ first sustained exposure to the “reality” of working in clinical teams and the full force of the challenges and ethical tensions of clinical care. We have developed a specialized, embedded ethics curriculum for Vanderbilt University medical students during their second year to address the unique experience of trainees’ first exposure to clinical care. Our embedded (...) curriculum is centered around core “ethics competencies” specific to the clerkship: for Medicine, advanced planning and end-of-life discussions; for Surgery, informed consent; for Pediatrics, the patient-family-provider triad; for Obstetrics and Gynecology, women’s autonomy, unborn child’s interests, and partner’s rights; and for Neurology/Psychiatry, decision-making capacity. In this paper, we present the rationale for these competencies, how we integrated them into the clerkships, and how we assessed these competencies. We also review the additional ethical issues that have been identified by rotating students in each clerkship and discuss our strategies for continued evolution of our ethics curriculum. (shrink)

Social theory between progress and apocalypse -- Autonomy and domination: Weber's cage -- Barbarism and modernity: Eisenstadt's regret -- Integration and justice: Parsons' utopia -- Despising others: Simmel's stranger -- Meaning evil -- De-civilizing the civil sphere -- Psychotherapy as central institution -- The frictions of modernity and their possible repair.

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.2 (2003) 1-18 [Access article in PDF] Aesthetic Inquiry in Education:Community,Transcendence, and the Meaning of Pedagogy Hanan A. Alexander What does it mean to understand education as an art, to conceive inquiry in education aesthetically, or to assess pedagogy artistically? Answers to these queries are often grounded in Deweyan instrumentalism, neo-Marxist critical theory, or postmodern skepticism that tend to fall prey to the (...) paradoxes of radical relativism and extreme subjectivism. 1 This essay offers an alternative, communitarian account of education as an art and a neo-Kantian approach to aesthetic inquiry in education that avoids these difficulties.I begin by examining the emergence of aesthetic inquiry in education in the context of the larger qualitative revolution in educational research. The struggle to justify the qualitative turn in educational thought was initially framed in terms of two influential doctrines: that cognition and affect on the one hand, and truth, beauty, and goodness on the other, can be clearly distinguished from one another. Qualitative methods were conceived as an alternative research paradigm — a new epistemology — in keeping with Thomas Kuhn's influential book The Structure of Scientific Revolutions. 2 Qualitative research, on this account, is a cognitive endeavor aimed at discovering a form of knowledge no less valid and reliable than that produced by quantitative methodologies. This way of framing the discussion led to the dichotomizing of positivist and postpositivist epistemologies, one embracing absolutism, objectivism, and rationalism, the other relativism, subjectivism, and romanticism. 3 This approach succeeded in pointing to some serious flaws in the prevailing positivist account of social research, yet it left qualitative inquiry dependent on versions of epistemological relativism and subjectivism that philosophers of knowledge have shown to be self-contradictory and incoherent. 4 [End Page 1]Conceiving of pedagogy in aesthetic terms challenges the prevailing positivist epistemology on a deeper level because it questions the accepted distinctions between thinking and feeling, and between truth, beauty, and goodness. If art can be conceived as a form of cognitive inquiry in addition to affective expression, then the appreciation and assessment of education as art requires not merely a new research paradigm or an alternative epistemology. Rather, it entails a reshuffling of our very conception of the relations between science, art, and ethics.These concepts can be reconceived to avoid the paradoxes of radical relativism and extreme subjectivism if we recognize with Iris Murdoch that sovereignty belongs to communal conceptions of a transcendent good. Educational arts empower people to express, appreciate, and critique collective conceptions of goodness, and artistic criticism of pedagogy celebrates a sacred dimension in educational thought and practice. 5 This approach occasions a fresh look not only at the practice, appreciation, and assessment of pedagogy, but also at the very meaning of the concept of education and the sorts of inquiry that can fruitfully inform its practice. Two Dogmas of Educational Research Two dogmas have dominated educational research for most of this century: the idea that there exists a clear disjunction between the cognitive and affective domains; and the supposed radical independence from one another of truth, beauty, and goodness. 6 According to a popular view rooted in these doctrines, the search for truth is a cognitive affair governed by science, while ethics and the arts are tied to the emotions and the humanities. Inquiry into the former is objective — reliability depends on method not researcher — and into the latter, subjective — results can vary according to interpreter. In this attitude, the cognitive domain dominates the public arena through the influence and prestige of science and measurement. 7Until the middle 1970s, behavioral and social research in education expressed these dichotomies in the distinction made between quantitative and qualitative research. The former was thought to be scientific and objective, the latter, humanistic and subjective. As qualitative inquiry came into its own in the 1980s, its proponents sought justification and legitimization in accord with cognitive dominance. 8 First, they argued that qualitative research methods had checks against error as rigorous as its quantitative counterparts. 9 Later, the cognitive domain... (shrink)