Many philosophers and psychologists have attempted to elucidate the nature of mental representation by appealing to notions like isomorphism or abstract structural resemblance. The ‘structural representations’ that these theorists champion are said to count as representations by virtue of functioning as internal models of distal systems. In his 2007 book, Representation Reconsidered, William Ramsey endorses the structural conception of mental representation, but uses it to develop a novel argument against representationalism, the widespread view that cognition essentially involves the manipulation of (...) mental representations. Ramsey argues that although theories within the ‘classical’ tradition of cognitive science once posited structural representations, these theories are being superseded by newer theories, within the tradition of connectionism and cognitive neuroscience, which rarely if ever appeal to structural representations. Instead, these theories seem to be explaining cognition by invoking so-called ‘receptor representations’, which, Ramsey claims, aren’t genuine representations at all—despite being called representations, these mechanisms function more as triggers or causal relays than as genuine stand-ins for distal systems. I argue that when the notions of structural and receptor representation are properly explicated, there turns out to be no distinction between them. There only appears to be a distinction between receptor and structural representations because the latter are tacitly conflated with the ‘mental models’ ostensibly involved in offline cognitive processes such as episodic memory and mental imagery. While structural representations might count as genuine representations, they aren’t distinctively mental representations, for they can be found in all sorts of non-intentional systems such as plants. Thus to explain the kinds of offline cognitive capacities that have motivated talk of mental models, we must develop richer conceptions of mental representation than those provided by the notions of structural and receptor representation. (shrink)

We situate the debate on intentionality within the rise of cognitive neuroscience and argue that cognitive neuroscience can explain intentionality. We discuss the explanatory significance of ascribing intentionality to representations. At first, we focus on views that attempt to render such ascriptions naturalistic by construing them in a deflationary or merely pragmatic way. We then contrast these views with staunchly realist views that attempt to naturalize intentionality by developing theories of content for representations in terms of information and biological function. (...) We echo several other philosophers by arguing that these theories over-generalize unless they are constrained by a theory of the functional role of representational vehicles. This leads to a discussion of the functional roles of representations, and how representations might be realized in the brain. We argue that there’s work to be done to identify a distinctively mental kind of representation. We close by sketching a way forward for the project of naturalizing intentionality. This will not be achieved simply by ascribing the content of mental states to generic neural representations, but by identifying specific neural representations that explain the puzzling intentional properties of mental states. (shrink)

It is widely held in contemporary philosophy of mind that states with underived representational content are ipso facto psychological states. This view—the Content View—underlies a number of interesting philosophical projects, such as the attempt to pick out a psychological level of explanation, to demarcate genuinely psychological from non-psychological states, and to limn the class of states with phenomenal character. The most detailed and influential theories of underived representation in philosophy are the tracking theories developed by Fodor, Dretske, Millikan and others. (...) Tracking theorists initially hoped to ‘naturalize’ underived representation by showing that although it is distinctively psychological it is not irreducibly so, yet they ended up developing theories of representation that by their own lights don’t pick out a distinctively psychological phenomenon at all. Burge sets out to develop a theory of underived representation that does pick out a distinctively psychological phenomenon. His theory promises to vindicate the Content View and the various philosophical projects that depend on it. In this paper I argue that Burge’s theory dementalizes representation for the same reason tracking theories do: These theories hold that representations are states with underived accuracy conditions, yet such states are found in all sorts of mindless systems, like plants. (shrink)

In this paper I survey a range of trolling behaviors and analyze a particular species that stands out. After a brief discussion of some of the inherent challenges in studying internet speech, I describe a few examples of behaviors commonly described as ‘trolling’ in order to identify what they have in common. I argue that most of these behaviors already have well-researched offline counterparts. In contrast, in the second half of the paper I argue that so-called ‘subcultural trolling’ calls out (...) for further analysis: it cannot be fully explained using standard tools like insincerity or bullshit, or even using new tools like dogwhistling. Instead, I propose a new species of speech act force. I conclude by highlighting some implications for broader issues in pragmatics and ethics. (shrink)

Intuitively, a speaker who uses slurs to refer to people is doing something morally objectionable even if no one is measurably affected by their speech. Perhaps they are only talking to themselves, or they are speaking with bigots who are already as vicious as they can be. This paper distinguishes between slurring as an expressive act and slurring as the act of causing a psychological effect. It then develops an expression-focused ethical account in order to explain the intuition that slurring (...) involves an effect-independent moral wrong. The core idea is that the act of expressing a morally defective attitude is itselfpro tantomorally objectionable. Unlike theories that focus only on problematic effects, this view is able to shift the moral burden of proof away from victims of slurring acts and onto speakers. It also offers moral guidance with respect to metalinguistic and pedagogical utterances of slurs. (shrink)

The gaze cueing effect is characterized by faster attentional orienting to a gazed-at than a non-gazed-at target. This effect is often enhanced when the gazing face bears an emotional expression, though this finding is modulated by a number of factors. Here, we tested whether the type of task performed might be one such modulating factor. Target localization and target discrimination tasks are the two most commonly used gaze cueing tasks, and they arguably differ in cognitive resources, which could impact how (...) emotional expression and gaze cues are integrated to orient attention. In a within-subjects design, participants performed both target localization and discrimination gaze cueing tasks with neutral, happy, and fearful faces. The gaze cueing effect for neutral faces was greatly reduced in the discrimination task relative to the localization task, and the emotional enhancement of the gaze cueing effect was only present in the localization task and only when this task was performed first. These results suggest that cognitive resources are needed for gaze cueing and for the integration of emotional expressions and gaze cues. We propose that a shift toward local processing may be the mechanism by which the discrimination task interferes with the emotional modulation of gaze cueing. The results support the idea that gaze cueing can be greatly modulated by top-down influences and cognitive resources and thus taps into endogenous attention. Results are discussed within the context of the recently proposed EyeTune model of social attention. (shrink)

Intrauterine insemination is one of many treatments provided to infertility patients. Many factors such as, but not limited to, quality of semen, the age of a woman, and reproductive hormone levels contribute to infertility. Therefore, the aim of our study is to establish a statistical probability concerning the prediction of which groups of patients have a very good or poor prognosis for pregnancy after IUI insemination. For that purpose, we compare the results of two analyses: Cluster Analysis and Kohonen Neural (...) Networks. The k-means algorithm from the clustering methods was the best to use for selecting patients with a good prognosis but the Kohonen Neural Networks was better for selecting groups of patients with the lowest chances for pregnancy. (shrink)

In this essay, I propose a novel hybrid metanormative theory. According to this theory, speakers making normative claims express both cognitive and motivational attitudes in virtue of the constitutive norms of the particular speech acts they perform. This view has four principal virtues: it is consistent with traditional semantic theories, it supports a form of motivational judgment internalism that does justice to externalist intuitions, it illuminates the connection between normative language and normative thought, and it explains how speakers can express (...) different conative states when speaking in different normative domains. In the first section, I discuss the theories of Stephen Finlay and David Copp. I show that they each come very close to having it both ways but ultimately fail. Understanding the shortcomings of these views is instrumental to a clear presentation of my own Hybrid Speech Act theory in section two. In the final section, I demonstrate how my view achieves its four advantages. (shrink)

Neuroclassicism is the view that cognition is explained by “classical” computing mechanisms in the nervous system that exhibit a clear demarcation between processing machinery and read–write memory. The psychologist C. R. Gallistel has mounted a sophisticated defense of neuroclassicism by drawing from ethology and computability theory to argue that animal brains necessarily contain read–write memory mechanisms. This argument threatens to undermine the “connectionist” orthodoxy in contemporary neuroscience, which does not seem to recognize any such mechanisms. In this paper I argue (...) that the neuroclassicist critique rests on a misunderstanding of how computability theory constrains theorizing about natural computing mechanisms. (shrink)

Philosophers have traditionally held that propositions mark the domain of rational thought and inference. Many philosophers have held that only conceptually sophisticated creatures like us could have propositional attitudes. But in recent decades, philosophers have adopted increasingly liberal views of propositional attitudes that encompass the mental states of various non-human animals. These views now sit alongside more traditional views within the philosophical mainstream. In this paper I argue that liberalized views of propositional attitudes are so liberal that they encompass states (...) of all sorts of apparently mindless systems like circadian clocks in plants. I begin by arguing that on the most well-developed and widely endorsed theories of underived representation in philosophy, circadian clocks qualify as representations. I then argue that standard reasons for thinking that perceptual states and pictures have propositional content carry over to circadian clocks. Finally, I argue that circadian representations in plants play the kind of functional role that is widely taken to be partly constitutive of belief-like attitudes. So according to mainstream theories of representation, propositions, and attitudes, plants have propositional attitudes. Yet on other more traditional views, this conclusion would seem absurd. So, contrary to appearances, there is no shared, stable understanding of what propositional attitudes are in contemporary philosophy. (shrink)

Infertility is recognized as a major problem of modern society. Assisted Reproductive Technology is the one of many available treatment options to cure infertility. However, the efficiency of the ART treatment is still inadequate. Therefore, the procedure’s quality is constantly improving and there is a need to determine statistical predictors as well as contributing factors to the successful treatment. There is a concern over the application of adequate statistical analysis to clinical data: should classic statistical methods be used or would (...) it be more appropriate to apply advanced data mining technologies? By comparing two statistical models, Multivariable Logistic Regression analysis and Artificial Neural Network it has been demonstrated that Multivariable Logistic Regression analysis is more suitable for theoretical interest but the Artificial Neural Network method is more useful in clinical prediction. (shrink)

In this article, I argue that the recent emphasis on compassion in healthcare practice lacks conceptual richness and clarity. In particular, I argue that it would be helpful to focus on a larger concept of empathy rather than compassion alone and that compassion should be thought of as a component of this larger concept of empathy. The first part of the article outlines a critique of the current discourse of compassion on three grounds. This discourse naturalizes, individualizes, and reifies compassion (...) leading to a decontextualized and simplified understanding of failures in healthcare practice. The second part uses resources from phenomenology and contemporary moral philosophy to construct a “hybrid” concept of empathy that includes both pre‐reflective/intuitive and cognitive/imaginative components. This “hybrid” concept of empathy leads to a more complex understanding of the multiple responses to others' distress. I conclude that there are no straightforward normative naturalistic responses to others' distress. Rather than conceptualizing compassion as a naturalistic impulse or a character‐based trait, we need to consider the complexity of our empathic recognition of vulnerable others. (shrink)

Most of us think that we can obtain knowledge about the aesthetic properties of objects via testimony – at least sometimes. We can learn that a painting is beautiful by reading a book, or learn that a film is awful by talking to a friend (as long as our sources are reliable). At the same time, if we go on to share this knowledge we have to carefully qualify it as second-hand in order to avoid misleading our audience. Simply stating (...) that a painting is beautiful or that a film is awful is liable to give off the impression that we have experienced it ourselves. In this paper I draw on my other work in the pragmatics of normative language to explain why aesthetic discourse has these distinctive features. Because our aesthetic practices have developed as a way for us to share both our beliefs and our affective states, traditional theories of assertion and testimony fail to capture the full richness of what we are up to in our aesthetic conversations. (shrink)

Here, a moral case is presented as to why sign languages such as Auslan should be made compulsory in general school curricula. Firstly, there are significant benefits that accrue to individuals from learning sign language. Secondly, sign language education is a matter of justice; the normalisation of sign language education and use would particularly benefit marginalised groups, such as those living with a communication disability. Finally, the integration of sign languages into the curricula would enable the flourishing of Deaf culture (...) and go some way to resolving the tensions that have arisen from the promotion of oralist education facilitated by technologies such as cochlear implants. There are important reasons to further pursue policy proposals regarding the prioritisation of sign language in school curricula. (shrink)

In this article I offer an account of normative thought inspired by Plato's proposal in the Theaetetus that judgement is ‘speech spoken … silently.’ After arguing that force conventionalism is the speech act theory best suited for modeling dialogic inner speech, I close the article by sketching the picture of normative thought that results. Though I defend a particular theory of normative speech elsewhere, the core insights of this article can be used by other theorists as well. The arguments offered (...) here also serve as an important step forward for the more general program of using social speech to better understand thought. (shrink)

In this paper, we describe how critical data designers have created projects that ‘push back’ against the eclipse of environmental problems by dominant orders: the pioneering pollution database Scorecard, released by the US NGO Environmental Defense Fund in 1997; the US Environmental Protection Agency’s EnviroAtlas that brings together numerous data sets and provides tools for valuing ecosystem services; and the Houston Clean Air Network’s maps of real-time ozone levels in Houston. Drawing on ethnographic observations and interviews, we analyse how critical (...) data designers turn scientific data and findings into claims and visualisations that are meaningful in contemporary political terms. The skills of critical data designers cross scales and domains; they must identify problems calling for public consideration, and then locate, access, link, and create visualisations of data relevant to the problem. We conclude by describing hazards ahead in work to leverage Big Data to understand and address environmental problems. Critical data designers need to understand what counts as a societal problem in a particular context, what doesn’t, what is seen as connected and not, what is seen as ethically charged, and what is exonerated and discounted. Such recognition is produced through interpretive, ‘close reading’ of the historical moment in which they operate. (shrink)

Simone de Beauvoir held that human experience is intrinsically ambiguous and that there are no values extrinsic to experience, but she also designated some actions as absolute evil. This essay explains how Beauvoir utilized an intrinsic absolute value to ground an action-guiding principle of freedom that justifies her notion of evil. Morgan's analysis counters Robin May Schott's objections that Beauvoir failed to systematically justify her notion of absolute evil and that Beauvoir shifted from a “logic of action” to a “logic (...) of history” when she utilized the concept. (shrink)

Institutional Review Boards have expressed concern that research into sensitive topics such as mental disorder will cause participants undue distress. This study investigated the emotional responses of 5,220 Australians to a survey on mental-health-related discrimination. Participants were interviewed about their mental health and experiences of discrimination across 10 life domains and then the emotional impacts of the survey. Results suggested that a minority experienced a negative reaction in contrast to 88% reporting positive experiences. A mental health problem was associated with (...) both negative and positive reactions. (shrink)

Abstract:In this paper, I offer a philosophical critique of the Power Threat Meaning Framework (PTMF). This framework was launched in the UK in January 2018 as a non-pathologizing way of understanding mental distress. It argues that those experiences diagnosed as mental illnesses are better understood as meaning-based threat responses to the negative operation of power. My critique consists of three parts. First, the PTMF argues that it is opposed to a concept of mental distress as illness. However, the PTMF unfolds (...) an account of mental distress that is very similar to other accounts of mental illness in the philosophical literature. The PTMF does not reflect upon, recognize or give an account of its own grounds for judging mental distress as distress. If it were to do so, I argue that it would produce an account of mental distress that is very similar to many other accounts of psychiatric illness or disorder. Second, I criticize the account given of meaning in the PTMF. I argue that this account is ultimately a reductive, behavioral account of adaptation that downplays important existential aspects of experience. Furthermore, the account of interpretive sense-making in the PTMF is conceptually confused. Finally, I outline a critique of the way that the concept of power, the great strength of the PTMF approach, is reduced to a concept of threat. I argue that this tends toward a linear view of causality that is reductive in its search for the meaning of mental distress. (shrink)

This paper analyses three concepts of life in Adorno's philosophy and considers the relationship between these concepts and the idea of a speculative materialism. The paper is concerned with Adorno's late concept of metaphysical experience and articulates a response to two key problems for the interpretation of this concept. First, given Adorno's emphasis on a purely negative philosophy, how does transcendence arise? Second, how can we give an experiential content to this idea of transcendence? A response to these two questions (...) is configured through an analysis of three concepts of life; mere life, damaged life and ephemeral life. (shrink)

In his attempt at a renewal of the concept of reification, Axel Honneth has referred to reification as a kind of forgetting. He uses an epigraph from Adorno and Horkheimer’s work to introduce this theme. This article considers the different accounts that are given by Honneth, on the one hand, and Adorno and Horkheimer, on the other, as to the way that reification is a forgetting of core experiential capacities of intersubjective human relations. It argues that Honneth’s account relies too (...) much on a foundational and undifferentiated notion of ‘empathetic engagement’, and that in order to articulate the damage done by reification, we need to contend with the more radical notion of forgetting that is outlined in Adorno and Horkheimer’s work. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Remnants of SenseAlastair Morgan, PhD (bio)In an interview outlining her approach to understanding mental distress, Lucy Johnstone states that when faced with ostensibly bizarre, irrational or distressing experiences:[T]he guiding principle of "At some level it all makes sense" applies. In fact, I can't immediately think of anyone I've worked with for whom it did not, in the end, turn out to be true.1The two commentaries on my paper (...) point to two levels where this sense-making might operate; a structural and an individual level.Havi Carel (2023) draws attention to the important concept of power in the Power Threat Meaning Framework and suggests a widening of the concept of threat to a concept of vulnerabilization that refers to the multiple factors that expose people to institutional neglect and violence that is interlaced with a range of forms of discrimination, neglect and disadvantage. Whilst the main strength of the PTMF approach is to draw attention to the structural importance of power in contributing to forms of psychic distress, the emphasis on a concept of threat tends towards a reactive and reductive concept of power. Carel (2023) helpfully points to a wider concept of power that can be utilised for further work in understanding the impact of societal violence on forms of mental distress.Such a widening of the concept of power does not only rest on a critique of institutions but also an understanding of the ways in which people can be abandoned and neglected by state support of one kind or another. Power operates through a dual logic of exposure and abandonment. Some people are particularly exposed to forms of institutional power from an early age and vulnerabilized by such exposure, but there is also a logic of abandonment within such exposure; the ever present possibility of neglect. Such an operation of power is not univocal (or embedded in one profession) but dispersed and differentially applied. As Didier Fassin (2018, p. 43) writes: "All lives are precarious but certain lives much more so than others—and above all, quite differently."Psychiatric power is one important focus when trying to understand this process of the exposure and abandonment of power, however, as Carel (2023, p. 75) notes, "the medical realm is not its own kingdom." Psychiatry is inserted into a network of dispersed power that has multiple and differential effects, both positive and negative. The focus on the question of psychiatric diagnosis as the apotheosis of societal power neglects the multiple effects of diagnosis or the lack of diagnosis on people who are particularly vulnerable to the operations of power. In situations where institutional care is crumbling and under-resourced the focus on psychiatric care alone as a problem of power risks just compounding such an institutional neglect. [End Page 77] Veena Das (2020) asks the question of what happens before the arrival of the psychiatrist on the scene of care and after her disappearance. Das (2020, p. 174) is interested in the multiple ways that power flows across and between both formal and informal institutions to produce a "milieu of madness." Such flows of power will also apply to increasingly hegemonic psychological formulations of signs of distress as problems in living, as problems in adaptive reactions to adversity. Such formulations are themselves inserted into a nexus of power relations and processes of vulnerabilization and are not somehow free of the taint of other forms of understanding. Indeed, as Carel notes, the process of demedicalization and de-professionalisation can very easily be inserted into the dual logic of exposure and abandonment that I discussed earlier. People can be exposed to power in a wider range of settings as psychic distress is demedicalized but also subjected to abandonment and neglect as mental distress is no longer thought of as an illness but just one of many wider and non-medical problems in living that does not require state support.The structural account of the determinants of mental distress offers an important corrective to individualised and medicalised approaches to meaning, but doesn't completely erase the problem of understanding and interpreting mental distress. Mohammed Abouelleil Rashed's commentary raises important issues with the... (shrink)

Recently, we reported that melanoma risk in redheads is linked not only to pale skin, but also to the synthesis of the pigment – called pheomelanin – that gives red hair its color. We demonstrated that pheomelanin synthesis is associated with increased oxidative stress in the skin, yet we have not uncovered the chemical pathway between the molecule pheomelanin and the DNA damage that drives melanoma formation. Here, we hypothesize two possible pathways. On one hand, pheomelanin might generate reactive oxygen (...) species (ROS) that directly or indirectly cause oxidative DNA damage. On the other hand, pheomelanin synthesis might consume cellular antioxidant stores and make the cell nucleus more vulnerable to other endogenous ROS. Uncovering the mechanistic pathway between pheomelanin and oxidative DNA damage will be an important step in developing strategies to lower melanoma risk in redheads. (shrink)

PurposeSocial exclusion as a result of gender, race, and class inequality is perhaps one of the most pressing challenges associated with the development of a diverse information technology workforce. Women remain under represented in the IT workforce and college majors that prepare students for IT careers. Research on the under representation of women in IT typically assumes women to be homogeneous in nature, something that blinds the research to variation that exists among women. This paper aims to address these issues.Design/methodology/approachThe (...) paper challenges the assumption of heterogeneity by investigating how the intersection of gender, race, and class identities shape the experiences of Black female IT workers and learners in the USA.FindingsThe results of this meta‐analysis offer new ways of theorizing that provide nuanced understanding of social exclusion and varied emancipatory practices in reaction to shared group exposure to oppression.Originality/valueThis study on the under‐representation of women as IT workers and learners in the USA considers race and class as equally important factors for understanding variation among women. In addition, this paper provides rich insights into the experiences of Black women, a group that is largely absent from the research on gender and IT. (shrink)

Log-linear analysis is a practical tool for examining relationships, successfully applied in many fields of science. This paper discusses the topic of estimation of the chance of getting pregnant in couples that underwent ART insemination. The authors focus on finding significant interactions between variables, on the basis of which statistical models are built. With the use of results of log-linear analysis, a model predicting the chances of achieving a clinical pregnancy that contained interactions was successfully built. Moreover, it was more (...) complete than the model obtained with the use of logistic regression alone. (shrink)

Contents.--The pursuit of values.--Science and values.--Biological viewpoints.--Mental attitudes.--Ethics.--Religion.--The management of life.--The social mind social progress.--Government.--International relations.--Education.--Proportion in education.--The American college.--Objective experience.

Analyses of religious and cultural perspectives on the use of force continue to receive criticism for questionable motives, for insufficient holism, and for exaggerating uniqueness. Claims of recurrent problems educe consideration of interdisciplinary proposals designed to resolve related challenges. Thought together, some suggest that a transversal research program into ethical orientations toward war can facilitate fair and rigorous exploration of crosscultural similarities and differences. Tentative findings emphasizing textual precepts indicate some resonance amid diversity across eleven ethical frameworks including Western just (...) war thinking. Maximizing relevance depends upon expanding the range of orientations and practices studied. Future results might be integrated with knowledge about the influence of other variables to more completely capture the phenomenon of making judgments regarding the use of force in all its manifestations. (shrink)

Simone de Beauvoir incorporates a significantly altered form of the Hegelian master/slave dialectic into "The Ethics of Ambiguity." Her ethical theory explains and denounces extreme wrongdoing, such as the mass murder of millions of Jews at the hands of the Nazis. This essay demonstrates that, in the Beauvoirean dialectic, the Nazi value system (and Hitler) was the master, Adolf Eichmann was a slave, and Jews were denied human status. The analysis counters Robin May Schott's claims that "Beauvoir portrays the attitudes (...) of the oppressor as defined fundamentally in relation to the oppressed" and that her use of the dialectic is "inadequate to account for how human beings create extreme situations of evil, such as that of genocide.". (shrink)

Socrates teaches in the Meno that in order for a belief to be justified, an appropriate relation must ‘tie down’ the belief to its truth. Alvin Goldman’s position of externalism holds that for a belief to be justified, an appropriately reliable process must have obtained. One need not be aware of this reliable process. Conversely, Laurence BonJour’s brand of internalism holds that this relation between a belief and its truth is just what the cognizer needs to be aware of in (...) order for that belief to be justified. This work examines their debate, with particular interest paid to BonJour’s case of Norman: a clairvoyant who forms a belief via this ability but has no evidence for or against the belief or his own clairvoyance. Using this case, I propose an ‘epistemological spectrum’ wherein the insight of externalism is appreciated – what Robert Brandom deems the Founding Insight of Reliabilism – that a reliably produced belief bears some epistemic legitimacy, while retaining the insight of internalism: that objective reliability cannot offset subjective irrationality. This is done by classifying cases wherein only the obtainment of a reliable process occurs as epistemically rational, though not justified. Ultimately I reconcile the virtues of both positions, and propose that Goldman’s brand of full blooded externalism was generated by following an intuitional illusion by way of affirming the consequent. (shrink)

Recent debates concerning the abolition of the schizophrenia label in psychiatry have focused upon problems with the scientific status of the concept. In this article, I argue that rather than attacking schizophrenia for its lack of scientific validity, we should focus on the conceptual history of this label. I reconstruct a specific tradition when exploring the conceptual history of schizophrenia. This is the concern with the question of the sense of life itself, conducted through the confrontation with schizophrenia as a (...) form of life that does not live, or as Robert Jay Lifton termed it ‘lifeless life’ (1979: 222—39). I conclude by arguing that the contemporary attempt to deconstruct or abolish the schizophrenia concept involves a fundamental shift in concern. The attempt both to normalize psychotic experiences, and to conceive them purely in terms of cognitive processes that can be mapped onto brain function, results in a fundamental move away from the attempt to understand the experience of madness. (shrink)

SummaryMuch excitement surrounded the proposal that a family of endo‐lysosomal channels, the two‐pore channels (TPCs) were the long sought after targets of the Ca2+‐mobilising messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, the role of TPCs in NAADP signalling may be more complex than originally envisaged. First, NAADP may not bind directly to TPCs but via an accessory protein. Second, two papers recently challenged the notion that TPCs are NAADP‐regulated Ca2+ channels by suggesting that they are highly selective Na+ channels (...) regulated by the lipid phosphatidylinositol 3,5‐bisphosphate and by ATP. This paper aims critically to evaluate the evidence for TPCs as NAADP targets and to discuss how the new findings fit in with what we know about endo‐lysosomal Ca2+ stores. (shrink)