Gauge symmetries play a central role, both in the mathematical foundations as well as the conceptual construction of modern (particle) physics theories. However, it is yet unclear whether they form a necessary component of theories, or whether they can be eliminated. It is also unclear whether they are merely an auxiliary tool to simplify (and possibly localize) calculations or whether they contain independent information. Therefore their status, both in physics and philosophy of physics, remains to be fully clarified. In this (...) overview we review the current state of affairs on both the philosophy and the physics side. In particular, we focus on the circumstances in which the restriction of gauge theories to gauge invariant information on an observable level is warranted, using the Brout-Englert-Higgs theory as an example of particular current importance. Finally, we determine a set of yet to be answered questions to clarify the status of gauge symmetries. (shrink)

The participation of vulnerable patients in clinical research poses apparent ethical dilemmas. Depending on the nature of the vulnerability, their participation may challenge the ethical principles of autonomy, non-maleficence, or justice. On the other hand, non-participation may preclude the building of a knowledge base that is a prerequisite for defining the optimal clinical management of vulnerable patients. Such clinical uncertainty may also incur substantial economic costs. We present the participation of pre-menopausal women with atrial fibrillation in trials of novel oral (...) anticoagulant drugs as a case study. Due to their non-participation in pivotal trials, it is uncertain whether for them, the risks that are associated with these drugs are outweighed by the advantages compared with conventional treatment. We addressed the question whether research of this new class of drugs in this subgroup would be appropriate from both, an ethical as well an economic perspective. We used the method of specifying norms as a wider framework to resolve the apparent ethical dilemma, while incorporating the question whether research of oral anticoagulants in premenopausal women with atrial fibrillation can be justified on economic grounds. For the latter, the results of a value-of-information analysis were used. Further clinical research on NOACs in premenopausal women with atrial fibrillation can be justified on both, ethical and economic grounds. Addressing apparent ethical dilemmas by invoking a method such as specifying norms can improve the quality of public practical reasoning. As such, the method should also prove valuable to committees that have formally been granted the authority to review trial protocols and proposals for scientific research. (shrink)

Background The European Union aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase multicenter research efficiency. We investigated IRB procedures in a large prospective European multicenter study on traumatic brain injury, aiming to inform and stimulate initiatives to improve efficiency. Methods We reviewed relevant documents regarding IRB submission and IRB approval from European neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury. (...) Documents included detailed information on IRB procedures and the duration from IRB submission until approval. They were translated and analyzed to determine the level of harmonization of IRB procedures within Europe. Results From 18 countries, 66 centers provided the requested documents. The primary IRB review was conducted centrally or locally and primary IRB approval was obtained after one, two or three review rounds with a median duration of respectively 50 and 98 days until primary IRB approval. Additional IRB approval was required in 55% of countries and could increase duration to 535 days. Total duration from submission until required IRB approval was obtained was 114 days and appeared to be shorter after submission to local IRBs compared to central IRBs. Conclusion We found variation in IRB procedures between and within European countries. There were differences in submission and approval requirements, number of review rounds and total duration. Research collaborations could benefit from the implementation of more uniform legislation and regulation while acknowledging local cultural habits and moral values between countries. (shrink)

Coping with recent heritage is troublesome for history of science museums, since modern scientific artefacts often suffer from a lack of esthetic and artistic qualities and expressiveness. The traditional object-oriented approach, in which museums collect and present objects as individual showpieces is inadequate to bring recent heritage to life. This paper argues that recent artefacts should be regarded as “key pieces.” In this approach the object derives its meaning not from its intrinsic qualities but from its place in an important (...) historical event or development. The “key pieces” approach involves a more organic way of collecting and displaying, focussing less on the individual object and more on the context in which it functioned and its place in the storyline. Finally, I argue that the “key pieces” approach should not be limited to recent heritage. Using this method as a general guiding principle could be a way for history of science museums to appeal to today’s audiences. (shrink)