Prior knowledge structures (or schemas) confer multiple behavioral benefits. First, when we encounter information that fits with prior knowledge structures, this information is generally better learned and remembered. Second, prior knowledge can support prospective planning. In humans, memory enhancements related to prior knowledge have been suggested to be supported, in part, by computations in prefrontal and medial temporal lobe cortex. Moreover, animal studies further implicate a role for the hippocampus in schema-based facilitation and in the emergence of prospective planning signals (...) following new learning. To date, convergence across the schema-enhanced learning and memory literature may be constrained by the predominant use of hippocampally dependent spatial navigation paradigms in rodents, and non-spatial list-based learning paradigms in humans. Here, we targeted this missing link by examining the effects of prior knowledge on human navigational learning in a hippocampally dependent virtual navigation paradigm that closely relates to foundational studies in rodents. Outside the scanner, participants overlearned Old Paired Associates (OPA – item-location associations) in multiple spatial environments, and they subsequently learned New Paired Associates (NPA – new item-location associations) in the environments while undergoing fMRI. We hypothesized that greater OPA knowledge precision would positively affect NPA learning, and that the hippocampus would be instrumental in translating this new learning into prospective planning of navigational paths to NPA locations. Behavioral results revealed that OPA knowledge predicted one-shot learning of NPA locations, and neural results indicated that one-shot learning was predicted by the rapid emergence of performance-predictive prospective planning signals in hippocampus. Prospective memory relationships were not significant in parahippocampal cortex and were marginally dissociable from the primary hippocampal effect. Collectively, these results extend understanding of how schemas impact learning and performance, showing that the precision of prior spatial knowledge is important for future learning in humans, and that the hippocampus is involved in translating this knowledge into new goal-directed behaviors. (shrink)

Researchers and practitioners are increasingly using machine-generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data is often understood (...) to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

Hardman and Hutchinson claim that ethics is ‘grounded in particular, everyday concerns’. According to them, an implication of this is that ethics courses for (future) clinicians should de-emphasise teaching the theories and principles of philosophical ethics and focus instead on pedagogical activities more closely related to everyday concerns, for example, exposure to real patient accounts. I respond that, even if ethics is an ‘everyday’ phenomenon, learning philosophical ethics may be of significant practical benefit to clinicians. I argue that the theories (...) of philosophical ethics can reasonably be interpreted as partial, simplified descriptions—or models—of moral phenomena, and that they can be effectively deployed in tandem by clinicians as complementary decision-making tools for help in navigating ethically complex situations in the clinic. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

THIS PAPER PROVIDES A READING OF DESCARTES' COGITO WHICH RESOLVES THE PROBLEMS ENCOUNTERED BY THE OTHER PREVALENT ANALYSES OF HIS THOUGHT. I FIRST INDICATE THE WAYS IN WHICH THE INFERENTIAL AND PERFORMATIVE VIEWS FAIL TO ADEQUATELY EXPLICATE DESCARTES' OWN STATEMENTS REGARDING THE COGITO. I THEN SET OUT MY "GENERATIVE VIEW" AND SHOW THAT IT PROVIDES A FULLY CONSISTENT READING OF THESE SAME STATEMENTS. I CONCLUDE THAT THE GENERATIVE VIEW MORE ADEQUATELY REPRESENTS DESCARTES' INTENTIONS.

Descartes' Meditations is one of the most thoroughly analyzed of all philosophical texts. Nevertheless, central issues in Descartes' thought remain unresolved, particularly the problem of the Cartesian Circle. Most attempts to deal with that problem have weakened the force of Descartes' own doubts or weakened the goals he was seeking. In this book, Stephen I. Wagner gives Descartes' doubts their strongest force and shows how he overcomes those doubts, establishing with metaphysical certainty the existence of a non-deceiving God and (...) the truth of his clear and distinct perceptions. Wagner's innovative and thorough reading of the text clarifies a wide range of other issues that have been left unclear by previous commentaries, including the nature of the cogito discovery and the relationship between Descartes' proofs of God's existence. His book will be of great interest to scholars and upper-level students of Descartes, early modern philosophy and theology. (shrink)

Descartes' procedure in "Meditation II" must be brought into line with his claim that "we must never ask about the existence of anything until we first understand its essence." And Descartes' "Meditation III" claim that he is aware of his mind's power to cause ideas must be grounded in a prior discovery of this power. Both demands are met by reading "Meditation II" as a progressive clarification of the nature of mind, with the investigation of the wax providing the discovery (...) of the mind's generative power. This process of discovery also provides the meanings of "thinking" and "existing" -- as "causing ideas" and "exercising causal power", respectively. Thus the discovery of the mind's nature also grounds the cogito. I provide a close reading of the wax investigation which supports this view. (shrink)

Matthew Lipman befriended me at an APA meeting in 1974. Through more than twenty years of phone calls, I got to chat with, consult with, and learn from Matt the details and challenges of developing philosophy for children. He acknowledged that I convinced him that the program needed “branding,” lest anyone present similar-sounding programs—some of which might be good and others not. He got a snippet of a video of my teaching troubled sixth-graders with his book Harry Stottlemeier’s Discovery on (...) the Today Show with Bryant Gumbel. That did much to shape my future, as did branding for sustaining Matt’s program. Lipman and I spoke by phone several times every year from 1976 until the mid-1990s. (shrink)

This chapter discusses a re-emerging topic in Cartesian scholarship—mind and body interaction. A number of thinkers, from his contemporaries onward, have maintained that Descartes' account of his two substances rules out the possibility of the interaction that he attempted to defend. Often, however, the ground for asserting this impossibility has been left less than explicit. Recent discussion has attempted to clarify the issue by asking whether there can be specified grounds within Descartes' philosophy which are sufficient to rule out mind–body (...) interaction. There are three elements of Descartes' thinking which might seem to create problems for mind–body interaction—his insistence that mind and body are absolutely distinct substances, his own restrictions on possible causal relations, and his views on the freedom of the will. Recent work has focused on the first two of these issues. The chapter's goal is to suggest that an essential element of Descartes' worldview has been overlooked in this recent discussion, and to show that once it is taken into account many of the apparent difficulties about Cartesian interaction can be resolved. (shrink)

Aging of the organism is associated with highly reproducible DNA methylation (DNAm) changes, which facilitate estimation of donor age. Cancer is also associated with DNAm changes, which may contribute to disease development. Here, we speculate that age‐associated DNAm changes may increase the risk of tumor initiation. Notably, when using epigenetic signatures for age‐estimations tumor cells are often predicted to be much older than the chronological age of the patient. We demonstrate that aberrant hypermethylation within the gene DNA methyltransferase 3A (DNMT3A) (...) – which may contribute to initiation of acute myeloid leukemia (AML) – is particularly observed in AML samples that reveal significantly more age‐associated DNAm changes. The functional relevance of age‐associated DNAm changes remains to be elucidated, but they occur genome wide, in a highly reproducible manner, and most likely influence chromatin organization – and hence may favor acquisition of aberrant DNAm patterns contributing to cancer in the elderly. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:White Power and American Neoliberal Culture by Patricia Ventura and Edward K. ChanJennifer A. Wagner-LawlorPatricia Ventura and Edward K. Chan. White Power and American Neoliberal Culture. Oakland: University of California Press, 2023. 168 pp., hardcover, $22.95. ISBN 9780520392793.White Power and American Neoliberal Culture, by utopian studies scholars Patricia Ventura and Edward K. Chan, feels like a tour de force. I say "feels" for a reason: if you (...) live in America, what you read in this book feels entirely familiar, sketching out U.S. racialized socio-political dynamics. But I also experienced a feeling of uncanniness, as Ventura and Chan expose the underbelly of a white supremacist United States—in which I happen to live. I have not read so clear and so well historicized an account of the kinds of events that prompt me to say, almost nightly, "This country is insane." The book does not change that opinion—but it does do something else: it makes sense of the insanity. It is a diagnosis of the social and ethical dis-ease, the etiology of which the authors locate in the country's very earliest days (indeed before). I do not usually point at book jacket blurbs in reviews, but I found the comments on this text's back cover absolutely accurate, with words like "urgent," "striking," "gripping," "timely," and "chilling" precisely describing my own experience of reading White Power and American Neoliberal Culture. Part of that affective impact, for a well-educated white citizen of this country, comes from the book's frank assessments not only of white supremacists' ongoing threat to democracy but also of the complicity of the "intellectual class" in this country, which often finds itself frankly baffled by such phenomena as a twice-impeached, four-times-(so-far)-indicted, overtly racist and sexist ex-president to be the unchallenged frontrunner for the Republican Party's nomination for the 2024 presidential election. The authors of White Power do not hesitate to describe events such as the Charlottesville white supremacy march and the January 6 insurrection as anything but a "horror"; that said, the point of their analysis is not to demonize "Trump voters" as "far white" supremacists and "cultists" [End Page 251] (CNN's most frequent nomination recently) but to distinguish carefully the factors at play that pull together "normal Republicans" and fringe racist and nationalist groups under one banner. The "red thread" from the founding of the colonies to this moment is always, and still, they argue, race. It is actually "chilling" to read Ventura's and Chan's explanation of how the white nationalist movement, which seems (and is) so radically anti-democratic, makes a certain kind of sense, and why a populist attraction to authoritarianism will continue to threaten what "we" (the identity of which is, of course, the central question) have (mis)understood "democracy in America" to be.Many readers will know that Ventura and Chan have collaborated for some years—and to see a co-authored book emerge from that work is a testament to how that collaboration has thrived, by "building on our previous separate scholarship that analyzes white power utopias (Chan) and American neoliberal culture (Ventura)" (4). In the overlap of their work, they have illuminated a troubling gap in the literature of neoliberalism and utopia alike: race. The intersection of critical race studies and utopian studies was only starting to appear in the 1990s and early 2000s; the collaboration of Ventura and Chan in mining the historical and narratological resources of thinking utopia through race, and race through utopia, has proven itself more than the sum of its parts, as they say: their work has been generative in several fields.Moreover, their mutual accountability as authors has a direct impact on the quality of the book's prose. Both are admirably clear writers in their own right. In White Power, the rigor of this collaborative process, which ultimately depends on trust and on an intellectual consensus about what they put down on paper, informs the confidence and concision of the prose; the careful historicizing of literary/aesthetic, political, and economic contexts heightens the urgency of the book's conclusions. There is... (shrink)

Israel Scheffler's ground-breaking essay, On Human Potential, deserves to be more widely known among educational policy analysts, especially in light of the popularity in educationist circles of W.E. Deming's organizational philosophy known as Total Quality Management . In what follows,I argue that the heuristical value of Deming's perscriptions are entailed in Scheffler's On Human Potential. More importantly, I argue, where Deming's work falls short, especially in being naive about the human condition, Scheffler's analysis provides a foundation for management theory in (...) education that insures the flourishing of an optimal number of contributing participants. In fashioning these ideas, Scheffler brings pioneering thinking to the emerging fields of management studies generally and educational policy specifically. (shrink)

This paper spells out the implications, for Descartes's theory of ideas, of my earlier paper, "Descartes's Wax: Discovering the Nature of Mind." I show that my reading of the wax investigation provides a number of clarifications of Descartes's Meditation III discussion of ideas. My reading of Meditation III provides a ground, internal to the Meditations for Descartes's claims about objective reality, the causal laws, material falsity and the idea of God. I show that Descartes's claims and conclusions regarding these issues (...) is strengthened by the perspective I have provided. (shrink)

In Houston several projects in philosophy for children are in process or are about to be initiated. To begin with, I am continuing the work in philosophy for children which I began at the Laboratory School of the University of Missouri in 1976. My earlier work in Missouri focused primarily on the effect of philosophy for children as adjunct in developing children's syntactic skills and their understanding of science. Since arriving here in Houston, I have operated philosophy for children classes (...) for gifted students in the Clear Creek Independent School District of Houston. My interest in philosophy as an adjunct to science education continues and is now accompanied by an additional concern: the use of philosophy to increase student appreciation and understanding of mathematics. (shrink)

In this review of Mark Weinstein’s Logic, Truth, and Inquiry, a book in which Weinstein explains his conception of the Method of Emerging Truth (MET), the reviewer, Paul Wagner, appreciates Weinstein’s assertion that “The MET attempts to characterize the process of truth emerging as evidence of the epistemic adequacy of the warrants that support theoretical explanations and govern theory driven inferences.” While he finds several things to question in Weinstein’s explanation of this conception, the reviewer, nonetheless, concludes that “This (...) is a book I heartily recommend to every reader especially those interested in critical thinking but whose academic preparation and home is outside philosophy or logic.”. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Last Man by Mary ShelleyJennifer A. Wagner-LawlorMary Shelley. The Last Man. 1826. Edited by Chris Washington. Norton Critical Editions. New York: W. W. Norton, 2023. xxiv + 571 pp. Paperback, ISBN 9780393887822.New critical editions of well-known literary works serve several important functions, and those designed specifically for students serve two of the most important: to introduce readers to texts that were overlooked during and since the (...) author’s time, but that might find greater favor today; and to re-introduce to a new generation of students classic texts that have lost critical favor or been neglected. Mary Shelley’s The Last Man (1826) is a novel long overshadowed by brilliance and resilient legacy of her first novel, Frankenstein (1818), written at a mere eighteen years of age. As so often happened to nineteenth-century women who published under their own names, both Frankenstein and The Last Man were hammered critically by male reviewers (and often by the few female ones) unable to believe any woman, and certainly no “good” woman, could compose these stories. And by 1826, Mary Shelley had already gained notoriety thanks to her association with the radical politics and “free-loving” Shelley-Byron circle). No wonder then that contemporaneous reviewers—even as they brought themselves to compliment the narratological and formal accomplishment the novel represents—could not countenance either its content or its author, as the novel “violated” certain forms of literary and gender propriety: indeed, the novel was deemed the product of a “diseased imagination” (The Monthly Review).Modern assessments of the novel are far more admiring of Shelley’s sophisticated examination of national and cultural mythic structuralizations, and receptive to the boldness of Shelley’s profoundly ironical assessments of them. In this new Norton Critical Edition of The Last Man, Chris Washington comes to the text with a refreshingly undeferential approach to Shelley’s Romantic forebears and immediate companions. Not because they [End Page 582] deserve being knocked off their pedestals, but because—granting all that—Shelley’s text has a lot more to give to us. This is the first time the Norton Critical Edition series has produced an annotated critical edition of The Last Man (Broadview’s appeared in 1996), and it is therefore both welcome and well overdue. For this reader, The Last Man is in some ways arguably superior to Frankenstein, certainly better written and developed. Frankenstein packs the greater punch, but The Last Man picks up and reweaves, on a much larger loom, the same thematic threads: justice and judgment; hospitality and generosity; family love and ethical obligation to community and nation; “civilized” and “wild” spaces. These themes are figured not only in terms of landscape but also in terms of geopolitical organization (i.e., the West vs. “the East,” presumed source of the virus); the bounded- vs. unbound-ness of the creative imagination (also tied to cultural notions of civilization and wilderness); solitude and loneliness; alienness and otherness; alienation and self-alienation and/as dehumanization; the human and the posthuman. While part of Frankenstein’s greatness is its narrative concision and stylistic spareness, the greatness of The Last Man, written by the more mature writer, intellectually and technically (and without the interference of Percy Shelley), is how fully Shelley “fleshes out” those entanglements in this later novel.Setting aside therefore the inclusion of “the usual suspects” (xx) of earlier editions, Washington gives space to critical approaches that are not focused so intensely on the influences of Shelley’s biography. In an excellent introduction Washington emphasizes the various ways in which this novel opens up to (still) intractable political and human rights issues: slavery, imperialism, nonheteronormative genders and sexualities, and precarious lives.Washington addresses particularly what Shelley’s text has to offer—and does offer—to today’s students. He shares his own experience of teaching this novel during COVID times, finding the students, used to speed of communication and multimedia delivery, resistant initially to the narrative’s pacing, and reintroducing them to the pleasures of the slow build-up of plot and setting, as well as the excruciating tension of watching a slow-burn approach to seemingly unavoidable catastrophe. But Washington rejects... (shrink)

León and Zahavi (2023) have made a compelling case for the necessity of philosophy — and not only neuroscience — for investigating consciousness. In particular, they argue that any theory of consciousness cannot avoid philosophical enquiry and thus only can choose between good or bad philosophy. Also, the topics of self-consciousness and selfhood are highlighted as problems of consciousness sui generis next to the mind–body problem. I will try to elucidate a bit more the specific approaches to consciousness that philosophy (...) and neuroscience take and thus elaborate why the philosophy and the neuroscience of consciousness are complimentary rather than mutually exclusive. (shrink)

David Chalmers has distinguished the “hard” and the “easy” problem of consciousness, arguing that progress on the “easy problem”—on pinpointing the physical/neural correlates of consciousness—will not necessarily involve progress on the hard problem—on explaining why consciousness, in the first place, emerges from physical processing. Chalmers, however, was hopeful that refined theorizing would eventually yield philosophical progress. In particular, he argued that panpsychism might be a candidate account to solve the hard problem. Here, I provide a concise stock-take on both the (...) empirical-neuroscientific and philosophical-conceptual progress on consciousness. It turns out that, whereas empirical progress is indisputable, philosophical progress is much less pronounced. While Chalmers was right, I argue, in distinguishing distinctive types of problems of consciousness, his prediction of progress on the hard problem was overly optimistic. Empirical progress and philosophical progress are essentially uncoupled; a more skeptical perspective on progress in philosophy in general is appropriate. (shrink)

The theorizing of utopia is a persistent theme throughout several generations of the French continental tradition, and alongside the process theory of Alfred North Whitehead to a large degree recuperates the concept of utopia from its supposed dismissal by Marx and his intellectual descendants. Most recently, attention to the notion of plasticity, popularized by Catherine Malabou, extends speculation on utopian possibility. Compelled to answer to Marx’s denigration of utopia as fantasy, the tendency was to compensate for the absence of a (...) programmatic politics by stressing what is “useful” about utopian dreaming, and therefore where or how exactly a utopian text reveals or creates political drive, or motivates political action. In this essay, I argue that theorists have overlooked the use of utopia as not only the reproduction of difference, or what Malabou calls positive plasticity, but also as, therefore, a disruption; Malabou might prefer the term accident here. Tracing the concept of plasticity from Roland Barthes to Malabou, with a nod at Miguel Abensour, this essay teases out the links between a contemporary notion of plasticity to argue, simply put, that utopia is plastic. This plasticity of the concept ensures its political force. These links, obscured in the essay “Plastic,” Barthes makes only later in his writing. But for Malabou, plasticity underlies a principle of futurity and/as generativity, such that new forms, new meanings, new concepts emerge through difference. Utopia’s horizons of potentiality depend on difference, and on non-achievement. Finally, I argue that the persistence of utopia as a form of thinking is the most important, and political, effect of utopian plasticity. (shrink)

C. I. Lewis’s distinction between the given and the concept is often exposed as the key element of his treatment of the problem of intentionality in that the given and the concept would be necessary and sufficient conditions for objective purport. Such an account nonetheless offers a truncated picture of Lewis’s treatment of the problem of intentionality. The best way to appreciate this verdict is to state the predicament this account is confronted with: If the distinction between the given and (...) the concept apparently leads to a version of the same problem it was designed to address, how could it be the key element contributing to answering the problem of intentionality? Indeed, according to Lewis, the given and the concept are mutually independent so that prima facie nothing guarantees that concepts are applicable to the given. The difficulty is what Lewis calls “the problem of the a priori”: how to guarantee that our concepts can be imposed upon a content of experience which is independent and not yet given? This is a version of the problem that Kant’s Transcendental Deduction addresses: How can categories, as subjective conditions of experience, be objectively valid? A natural question is then: How does Lewis address the problem of the a priori? The main purpose of this essay is then to investigate how C. I. Lewis’s addresses the problem of the a priori and to contribute to restoring an appropriate understanding of Lewis’s conceptual pragmatism. (shrink)

David Chalmers has distinguished the “hard” and the “easy” problem of consciousness, arguing that progress on the “easy problem”—on pinpointing the physical/neural correlates of consciousness—will not necessarily involve progress on the hard problem—on explaining why consciousness, in the first place, emerges from physical processing. Chalmers, however, was hopeful that refined theorizing would eventually yield philosophical progress. In particular, he argued that panpsychism might be a candidate account to solve the hard problem. Here, I provide a concise stock-take on both the (...) empirical-neuroscientific and philosophical-conceptual progress on consciousness. It turns out that, whereas empirical progress is indisputable, philosophical progress is much less pronounced. While Chalmers was right, I argue, in distinguishing distinctive types of problems of consciousness, his prediction of progress on the hard problem was overly optimistic. Empirical progress and philosophical progress are essentially uncoupled; a more skeptical perspective on progress in philosophy in general is appropriate. (shrink)

While the words “utopia” and “anticipation” frequently appear together in discussions of the concepts of utopia and dystopia, little attention to the relationship of Anticipation Studies to utopian studies exists. Moreover, the relevance of literature and the arts to Anticipation Studies seems almost invisible. This essay focuses on the structuring of the original utopian narrative, Sir Thomas More’s Utopia, in order to understand how this seminal text conceptualizes utopia’s relation to past, present, and future. This analysis focuses on the complex (...) framing devices characteristic of utopian narrative, as well as its open-endedness. The embedding of narratives sets up the dynamic movement between past, present, and future – the various forms of temporality – that allows us to clarify the nature of utopian anticipation.Throughout the chapter, I attempt to connect utopian textual and conceptual theory to specific concepts in the emerging field of Anticipation Studies, with which Utopian Studies, a long-established interdisciplinary field, have not yet engaged. Of particular interest is the notion, promoted by Miguel Abensour, that utopia is always a disruption and thus not an anticipation in any “natural” or logical sense: “what matters is the orientation toward what is different, the wish for the advent of a radical alterity here and now” : 407, 2008). From this premise, we can reintroduce a neglected literary term from science fiction theorist, Darko Suvin: the novum. The eruption of a future from a point of radical alterity – an ontological accident – opens up radical implication for the nature of utopian anticipation and futurity.Finally the essay suggests that Robert Poli’s and Robert Rosen’s description of an anticipatory system as comprising “the predictive model of itself” within the genre’s formal characteristics is in fact present in the structure of the utopian narratives: that is, that the persistence of utopia – as a literary genre and as a political concept – inheres in the narratological structuring of the possibility of another story and another listener. Utopian narrative thus ultimately anticipates not only temporal relationality, but an ethical relation between the outside narrator, the utopian traveler/narrator, and the reader. It anticipates another story. (shrink)

Chronic pain is a common disorder with enormous sociomedical importance. A major part of primary and secondary costs of illness is caused by the various pain syndromes. Nociception – the sensory perception of a painful stimulus – is a complex process relying on an intricate system of anatomical, neurophysiological and biochemical networks. This applies even more so to pain – the state of experiencing a nociceptive event, of interpreting it in terms of meaning for the affected individual and of suffering (...) a range of emotions it elicits. This intricacy renders it obvious, that the empirical medical sciences alone cannot explain all aspects of pain. Hence, it has also become a focus of phenomenological research. One aspect of these investigations is the interaction of pain and the perception of the lived body’s spatiality. The focus of this article will build on these concepts to develop a construct of the alteration of temporality caused by chronic pain and the effects this spells out for the affected subject. To this end, I will primarily draw on Merleau-Ponty’s ideas of the lived body as well as on theories of enactivism and embodiment. I will also point out parallels to neuroscientific data, thereby demonstrating the proximity of phenomenology and neuroscience. A possible partial solution to the pain dilemma may be derived from psychology: techniques relying on cognitive behavioural intervention, awareness training, and existential analysis may provide alleviation to patients suffering from chronic pain. (shrink)

Nous traduisons, pour la première fois en langue française, l’essai célèbre de Clarence Irving Lewis (1883-1964), « A pragmatic conception of the a priori » (1923). Cette traduction est précédée d’une introduction revenant sur les deux moments argumentatifs clés de la refonte par Lewis des notions d’a priori et de catégorie : (1) la critique des conceptions traditionnelles de l’a priori et de la manière dont elles comprennent les deux éléments constitutifs du concept d’a priori, à savoir la nécessité et (...) l’indépendance à l’égard de l’expérience ; (2) l’alternative que C. I. Lewis élabore en lieu et place de ces conceptions et qui peut être entendue comme une conception tout à la fois pratique et pragmatique de l’a priori et des catégories. C’est la pièce angulaire du pragmatisme conceptuel élaboré dans le maître ouvrage de C. I. Lewis, Mind and the World Order (1929) qui se trouve ainsi élucidée. (shrink)

ABSTRACT This paper proposes a vision of rhetoric as metaphysical enactment. This position contrasts with traditionally accepted views of rhetoric as phenomenological practice, evidenced prominently in contemporary rhetorical theory. I advance a framework that employs metaphorical accommodation and indicates a way that rhetoric can be situated as a perpetually productive force. The analytic tradition affords a method and vocabulary that when placed in conversation with rhetorical studies offers an alternative for viewing rhetoric as metaphysical enactment. I determine that rhetorical theory (...) should engage with rhetoric as a measure of action, activity, and vitality that raises our awareness and connects us. (shrink)

THE NIETZSCHE-WAGNER CORRESPONDENCE CHAPTER I. FIRST MEETING. MY brother writes in "Ecce Homo": "From the moment a piano edition of 'Tristan and Isolde* appeared (my compliments, ...

Some habits are vital to who we are in that they shape both our self-perception and how we are seen by others. This is so, I argue, because there is a constitutive link between what I shall call ‘identity-shaping habits’ and narrative agency. Identity-shaping habits are paradigmatically acquired and performed by persons. The ontology of personhood involves both synchronic and diachronic dimensions which are structurally analogous to the synchronic acquisition and the diachronic performance of habits, and makes persons distinctly suitable (...) to being shaped by habits. Since habits differ vastly in their scope, I develop a conceptualization that carves out defining features of identity-shaping habits. Such habits, I venture, fundamentally alter a person’s embodiment such that the alterations to their psychological and physiological make-up vitally inform their persistence—if not metaphysically, then at least practically by crucially shaping one’s narrative agency. (shrink)

In this article we present a new experimental paradigm: comparative visual search. Each half of a display contains simple geometrical objects of three different colors and forms. The two display halves are identical except for one object mismatched in either color or form. The subject's task is to find this mismatch. We illustrate the potential of this paradigm for investigating the underlying complex processes of perception and cognition by means of an eye‐tracking study. Three possible search strategies are outlined, discussed, (...) and reexamined on the basis of experimental results. Each strategy is characterized by the way it partitions the field of objects into “chunks.” These strategies are: (i) Stimulus‐wise scanning with minimization of total scan path length (a “traveling salesman” strategy), (ii) scanning of the objects in fixed‐size areas (a “searchlight” strategy), and (iii) scanning of object sets based on variably sized clusters defined by object density and heterogeneity (a “clustering” strategy). To elucidate the processes underlying comparative visual search, we introduce besides object density a new entropy‐based measure for object heterogeneity. The effects of local density and entropy on several basic and derived eye‐movement variables clearly rule out the traveling salesman strategy, but are most compatible with the clustering strategy. (shrink)

I am very grateful to Simon Beck for his thoughtful response to my paper “Transplanting Brains?” (2016). Needless to say, he raises more issues than I can hope to answer in a brief response. While Beck seemingly feels that the deck has been stacked against him, I think that the majority of his criticisms result from misconceptions and misunderstandings that I intend to straighten out in what follows. Before proceeding, I would like to draw attention to a worry that is (...) lurking in the shadows. Perhaps Beck and I talk at cross purposes. While Beck is concerned with a metaphysical theory of personal identity that supposedly holds across all possible worlds—and as such places heavy importance on counterfactuals and intuitions—I am concerned only with the natural world with the aim of generating empirically substantiated hypotheses about how things really are when it comes to persons persisting through time. Now, here is a disclaimer: If the natural world does not exhaust reality, then my discussion is only partial. It goes without saying that most contemporary philosophers given a choice between going with science and going with intuitions, go with science. (shrink)

One of the distinguishing features of mathematics is the exceptional level of consensus among mathematicians. However, an analysis of what mathematicians agree on, how they achieve this agreement, and the relevant historical conditions is lacking. This paper is a programmatic intervention providing a preliminary analysis and outlining a research program in this direction.First, I review the process of ‘negotiation’ that yields agreement about the validity of proofs. This process most often does generate consensus, however, it may give rise to another (...) kind of disagreement: whether the original and new proof are effectively the same, leading to potential disagreement about the validity of the original proof.Second, I historicize the phenomenon of consensus. I show that in earlier European mathematics and other mathematical cultures, consensus about the validity of arguments was substantially weaker or conceived differently than it is today. This means that contemporary consensus about the validity of mathematical proofs should be explained by historical changes in mathematical practice.Finally, I conjecture what brought about the contemporary form of mathematical consensus. Since a sharp rise in consensus occurs around the turn of the 20th century, it makes sense to explain this consensus by the concurrent formalization of mathematics. However, this explanation has a major flaw: it explains a really existing phenomenon (consensus) by something that hardly ever happens (writing proofs in formal languages). I will therefore explain the ways in which formalization does enter mathematical practice so as to account for contemporary forms of mathematical consensus. (shrink)

The Adam Smith problem refers to a claimed inconsistency between the Theory of Moral Sentiments and the Wealth of Nations, regarding the portrayal of human nature in these two books. Previous research predominantly resolved the claimed inconsistency by uncovering virtuous, less selfish character traits in the Wealth of Nations. This article voices caution. I acknowledge – on methodological grounds – fundamental differences regarding the portrayal of human nature in Smith’s behavioral ethics, i.e. the Theory of Moral Sentiments, as compared with (...) Smith’s economic research. The key argument is that Smith’s two books address different research problems and hence do not, need not and cannot adopt the same view of human nature – for methodological reasons, so my argument. Adam Smith scholarship overlooked that Smith himself in considerable degrees understood “economic man” as a heuristic abstraction. I connect to the philosophies of science of Imre Lakatos and Karl Popper. (shrink)

Compatibilist methods borrowed from the free will debate are often used to establish doxastic freedom and epistemic responsibility. Certain analogies between the formation of intention and belief make this approach especially promising. Despite being a compatibilist myself in the practical debate, I will argue that compatibilist methods fail to establish doxastic freedom. My rejection is not based on an argument against the analogy of free will and free belief. Rather, I aim at showing that compatibilist free will and free belief (...) are equally misguided because freedom is a concept that only applies to an agent’s actions and not to her mental attitudes. Compatibilist strategies that seek to define control by reason-responsiveness merely weaken the conditions for freedom such that arbitrary forms of control can be defined. I will demonstrate that these methods also commit to freedom of fear, freedom of hope and freedom of anger. However, I accept the compatibilist challenge to account for the addict’s and the paranoid’s unfreedom. I will sketch a unified approach to compatibilist free agency that does justice to these phenomena without the help of free will or free belief. (shrink)

This edited collection explores the philosophy of Clarence Irving Lewis through two major concepts that are integral to his conceptual pragmatism: the a priori and the given. The relation between these two elements of knowledge form the core of Lewis’s masterpiece _Mind and the World-Order_. While Lewis’s conceptual pragmatism is directed against any conception of the _a priori_ as constraining the mind and experience, it also emphasizes the inalterability and the unavoidability of the given that remains the same through any (...) interpretation of it by the mind. The essays in this volume probe Lewis’s new account of the relation between the a priori and the given in dialogue with other notable figures in 20 th -century philosophy, including Carnap, Friedman, Goodman, Putnam, Quine, Russell, Sellars, and Sheffer. _C.I. Lewis’s Conceptual Pragmatism_ __represents a focused treatment of a long-neglected figure in 20 th -century American philosophy. (shrink)

Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type (...) critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity‐based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre‐existing characters. (shrink)

The Book I of Euclid’s Elements begins with three propositiones that ask for the solution of three problems. Unlike other propositiones, these do not assert properties or relationships between geometric objects. In them, some of these objects are assumed as given, and actions are demanded in order to obtain other objects. The solution to this type of problem is a construction, and its foundations can be found in the definitions and postulates of the Geometry of Euclid. Furthermore, each construction is (...) normally accompanied by the resolution of a second problem. This consists in demonstrating that the previously offered solution is correct, i.e., that the presented construction indeed produces what was demanded in the formulation of the initial problem. The first theorem of the Elements is exactly the fourth proposition. We will consider, in a propaedeutic manner, the implications of adopting an approach to geometry where all propositions are interpreted as problems and the solution to any specific construction problem consists in offering a procedure such that, globally, the execution of this procedure on a workspace by a geometer will be simulated by an Euclid machine—which is the central object of analysis of the present article. From this perspective, the Geometry of Euclid would admit an interpretation in which it would be, in addition to a foundational milestone in the history of mathematics, also a foundational milestone in the development of the notion of effective procedure that would only fully come to light in the twentieth century. (shrink)

Many persons find it intuitive that being friends with someone with immoral beliefs is wrong as such. I contest this claim, instead I argue that there is nothing necessarily wrong with such friendships. In coming to this conclusion I examine a number of arguments, including two of the most notable contributions put forward by Mason (2021) and Isserow (2018), that attempt to elucidate the wrongness involved in such friendships and find they do not successfully do so. I conclude by offering (...) some arguments as to why such friendships are not necessarily wrong. (shrink)

Suspension of judgment or belief is often described as the neutral doxastic position or stance, alongside belief and disbelief. However, in this contribution, I will demonstrate that there is more than one way of being neutral. I will introduce paradigmatic cases involving cognitive neutrality and highlight significant differences in their nature, such as their relation to inquiry. I will argue that judgment suspension is an act of committing to indecision, leading to a qualified neutral state of mind. However, subjects can (...) commit to indecision in different ways: depending on their epistemic situation and goals, they can suspend agnostically, precautionarily, or hypothetically. These three resulting states of committed indecision must be distinguished from uncommitted indecision, which is the basic state of doxastic neutrality. (shrink)

This text considers several case studies of subaltern silence as micro political resistance. Around these examples I thread a theoretical model (using ideas of such thinkers as Spivak, Bataille, Foucault and Baudrillard) to explain how performing silences could resist oppression without assuming an underlying well-articulated subjectivity. The article deals with the force of silence, its conditions of possibility, and its position with respect to representation.

Gyenis and Rédei (G&R) have shown that any prior _p_ on a finite algebra _A_, however chosen, significantly restricts the set of posteriors derivable from _p_ by Jeffrey conditioning (JC) on a nontrivial measurable partition (i.e., a partition consisting of members of _A_, at least one of which is not an atom of _A_). They support this claim by proving that the set of potential posteriors _not derivable_ from _p_ in this way, which they call the _Bayes blind spot of (...) p_, is large, having cardinality _c_ and normalized Lebesgue measure 1, as well as being of second Baire category for a natural metrizable topology. In the present paper, we establish results analogous to those of G&R for probability measures on any infinite sigma algebra of subsets of a countably infinite set (which requires distinctly different treatments of the topological and measure-theoretic cases). We also show, in both the finite and infinite cases, that all of the limitative results for a single prior _p_ continue to hold for the intersection of the Bayes blind spots of countably many priors. This leads us to reject the claim of G&R that the large size of blind spots in the single prior case is attributable to the limitations imposed by priors. We argue instead that it is the so-called _rigidity property_ of JC that accounts for the large size of Bayes blind spots. G&R also prove that _any_ potential posterior _q_ can be derived from a prior _p_ by at most two applications of JC on nontrivial partitions. But they remark that their particular two-stage derivation of an \(r \in BS(p)\) from _p_ is barely distinguishable from a single, complete reassessment on a trivial partition. We show, however, that there are two-stage derivations of _r_ from _p_ that require no direct assessment of the probability of any atom at either stage. Finally, in order to situate the aforementioned limitative results in the proper context, we demonstrate that a probability revision that would amount to complete reassessment within a Jeffrey evidentiary framework may arise, in a different evidentiary framework, in a way that involves no direct assessment of the probability of any atom, as, for example, in a generalization of Jeffrey’s solution to the problem of old evidence and new explanation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Platonopolis: Platonic Political Philosophy in Late AntiquityMichael F. WagnerDominic J. O'Meara. Platonopolis: Platonic Political Philosophy in Late Antiquity. Oxford: Clarendon Press, 2003. Pp. xi + 249. Cloth, $55.00.Porphyry tells of Plotinus's failed petition to emperor Gallienus to (re)establish a "city of philosophers" conformed to Plato's laws, named Platonopolis (Vit. Plo.12). O'Meara here articulates primary themes and developments in philosophical political thought in the classical Neoplatonic period, from Plotinus's (...) day in the mid-third century into the sixth century. Concurrently, he addresses head on "the conventional view that the Platonist philosophers of Late Antiquity had no political philosophy" (3). This view exemplifies the more general perspective that the Neoplatonists were simply disinterested in this-worldly affairs in lieu of "an immaterial world... our true 'homeland,' where we can at last attain the good we desire" (3). Consequently, O'Meara provides both a unique study of an important [End Page 205] topic and a compelling case for a more complete, balanced understanding of Neoplatonic other-worldly-ness. O'Meara's study covers key figures from four main groups of (neo)Platonists: Plotinus and his students; the schools in Syria and Asia Minor inspired by Iamblichus; the Athenian school (Plutarch, Proclus, Damascius et al.); and the Alexandrian school (Hyapatia, Philoponus, Olympiodorus et al.). He organizes his investigation (chapters) into three Parts.The pivotal concept in O'Meara's two-pronged endeavor is divinization - "assimilation and unification, as far as possible, to god" (31, Proclus) - a concept whose meaning for classical Neoplatonists ranges from "becoming a god" to "imitating some form of divine life, in one way or another" (31). Part I focuses on the Neoplatonists' shared association of a human soul's divinization with virtue-osity [my jargon], beginning with Plotinus's distinction between political virtue(s) and purification—or purificatory virtue(s). O'Meara emphasizes the relevance of the resulting "scale of virtues" to a life of continued activity—for example explicating Plotinus's denial that a "purified" soul is somehow exempt from the rightness-of-acting expected of the politically virtuous soul: rather, "reaching higher principles and different measures he will act [directly, immediately] according to these" (43, En. I,2,7).Another organizing theme as O'Meara's investigations proceed beyond Plotinus is the significance of the increasing complexities of particular Neoplatonic metaphysical systems, and so also of their moral systems - e.g. their "scales of virtue." Part I also articulates related attempts (beginning with Porphyry and Iamblichus) to articulate programs of moral and philosophical study - i.e. a related "scale of sciences." Of special note here are proposals by some Neoplatonists to divide the "practical sciences" associated on this scale with political virtuousness into legislative science(s) and judicial science (56). Implicit in the Neoplatonic scale(s) of virtue(s) was the thesis that as one progresses towards divinization "lower" virtue-osity is not transcended in the sense of lost or dismissed but rather it is included or incorporated into a higher form. Arguably, "lower" sciences are likewise not merely aids or stepping-stones towards something "higher," but genuine topoi of study and knowledge in their own right.Part II is the true heart of O'Meara's outstanding scholarly and philosophical inquiry. Here is where he fulfills his intent to discern a substantive tradition of political philosophy and to articulate its key themes and concepts. Though he associates this part of his investigation with Plato's conceit of the philosopher's return to the cave, he immediately parses this "descent" as a "divinization of political life through philosophy" (71). He articulates various Neoplatonists' approaches to questions inspired by Plato's cave allegory—e.g. Is the philosopher socially obligated to "return"? Could s/he then still be happy? (His investigation here does seem to overlook Neoplatonic conceptions of choice, volition, or will as these might pertain to such questions.) O'Meara recognizes, however, that the more fundamental link between Neoplatonic metaphysics and Neoplatonic ethical-political thought derives from Plotinus's conception "of fecundity, of an [overflowing] abundance" (74) in his highest One, and so in a soul assimilated to It. In Proclus's formulation: "that which... (shrink)

European integration needs to be analyzed in terms that address the normative self-understanding of the emerging polity or, in other words, the self-understanding of European modernity. While it is often argued that such European self-understanding is either entirely indistinct from the general self-understanding of the West, i.e. a commitment to human rights and liberal democracy, or highly problematic, because it makes overly ‘thick’ presuppositions, which are untenable against the background of European cultural diversity and risk to revive non-liberal European political (...) traditions, the attempt here to reconstruct European political modernity suggests that the general, universalist commitment to liberal democracy is insufficient to understand Western polities, and it aims to propose this argument by elaborating a more complex concept of political modernity than can usually be found in political theory. The struggles about European political modernity across history are interpreted with a view to understanding how the self-understanding of a modern polity evolved and changed. (shrink)

Freezing of gait can cause reduced independence and quality of life for many with Parkinson’s disease. Episodes frequently occur at points of transition such as navigating a doorway. Therapeutic interventions, i.e., drugs and exercise, do not always successfully mitigate episodes. There are several different, but not exclusive causes for freezing of gait. People with freezing of gait are able to navigate dynamic situations like stairways by utilizing a different attentional strategy to over-ground walking, but may freeze when passing through a (...) doorway. The question is, is it possible to employ a special attentional strategy to prevent freezing at this point? Motor imagery allows for learning motor skills in absolute safety and has been widely employed in a variety of populations, including other neuro-compromised groups. Motor imagery is not studied in a homologous manner in people with Parkinson’s Disease, leading to conflicting results, but may have the potential to establish a different attentional strategy which allows a subject to mitigate freezing of gait episodes. This paper will identify and discuss the questions that still need to be answered in order to consider this approach i.e., can this population access motor imagery, can motor imagery alter the attentional strategy employed when moving through doorways, what is the best motor imagery approach for people with Parkinson’s Disease and freezing of gait, and what dosage is most effective, while briefly outlining future research considerations. (shrink)

In this paper, I spell out a descriptive account of agnosticism that captures the intuitive view that a subject enters the mental state of agnosticism via an act or event called suspension. I will argue that agnosticism is a complex mental state, and that the formation of an attitude is the relevant act or event by which a subject commits to indecision regarding some matter. I will suggest a ‘two-component analysis’ that addresses two aspects that jointly account for the settled (...) state of agnosticism: the subject’s de facto indecision and the subject’s commitment to her indecision. Unlike meta-cognitivist or sui generis accounts, I do not take the agnostic’s commitment to indecision as constitutive for her indecision but rather as an evaluation or qualification of the indecision that she already exhibits. Agnosticism, thus, is a settled form of indecision that marks the end of inquiry. (shrink)

Why do humans menstruate while most mammals do not? Here, we present our answer to this long‐debated question, arguing that (i) menstruation occurs as a mechanistic consequence of hormone‐induced differentiation of the endometrium (referred to as spontaneous decidualization, or SD); (ii) SD evolved because of maternal–fetal conflict; and (iii) SD evolved by genetic assimilation of the decidualization reaction, which is induced by the fetus in non‐menstruating species. The idea that menstruation occurs as a consequence of SD has been proposed in (...) the past, but here we present a novel hypothesis on how SD evolved. We argue that decidualization became genetically stabilized in menstruating lineages, allowing females to prepare for pregnancy without any signal from the fetus. We present three models for the evolution of SD by genetic assimilation, based on recent advances in our understanding of the mechanisms of endometrial differentiation and implantation. Testing these models will ultimately shed light on the evolutionary significance of menstruation, as well as on the etiology of human reproductive disorders like endometriosis and recurrent pregnancy loss. (shrink)

There is a striking similarity between the philosophy of Martin Heidegger and Harry G. Frankfurt: they both argue that the temporal nature of human existence and agency is due to the fact that humans care about things. Even though Heidegger’s concept of care and Frankfurt’s concept of caring are very different, they are worth comparing because they play a similar role and have similar significance in their thinking. This comparison also offers an opportunity for a desired dialog between philosophers working (...) in those two different traditions. I argue that the two views can complement each other: Though Frankfurt provides a detailed psychological description of caring, his concept of caring is too mentalistic and leads to solipsism. Thus, his theory can be enriched with the help of Heidegger’s view based on the concept of Being-in-the-world. (shrink)

I begin with a discussion of the value of privacy and what we lose without it. I then turn to the difficulties of preserving privacy for genetic information and other medical records in the face of advanced information technology. I suggest three alternative public policy approaches to the problem of protecting individual privacy and also preserving databases for genetic research:(1) governmental guidelines and centralized databases, (2) corporate self-regulation, and (3) my hybrid approach. None of these are unproblematic; I discuss strengths (...) and drawbacks of each, emphasizing the importance of protecting the privacy of sensitive medical and genetic information as well as letting information technology flourish to aid patient care, public health and scientific research. (shrink)

Common wisdom holds that communication is impossible when messages are costless and communicators have totally opposed interests. This article demonstrates that such wisdom is false. Non-convergent dynamics can sustain partial information transfer even in a zero-sum signalling game. In particular, I investigate a signalling game in which messages are free, the state-act payoffs resemble rock–paper–scissors, and senders and receivers adjust their strategies according to the replicator dynamic. This system exhibits Hamiltonian chaos and trajectories do not converge to equilibria. This persistent (...) out-of-equilibrium behaviour results in messages that do not perfectly reveal the sender's private information, but do transfer information as quantified by the Kullback–Leibler divergence. This finding shows that adaptive dynamics can enable information transmission even though messages at equilibria are meaningless. This suggests a new explanation for the evolution or spontaneous emergence of meaning: non-convergent adaptive dynamics. (shrink)