The origin of marine invertebrate larvae has been an area of controversy in developmental evolution for over a century. Here, we address the question of whether a pelagic “larval” or benthic “adult” morphology originated first in metazoan lineages by testing the hypothesis that particular gene co-option patterns will be associated with the origin of feeding, indirect developing larval forms. Empirical evidence bearing on this hypothesis is derivable from gene expression studies of the sea urchin larval gut of two closely related (...) but differently developing congenerics, Heliocidaris tuberculata (feeding indirect-developing larva) and H. erythrogramma (nonfeeding direct developer), given two subsidiary hypotheses. (1) If larval gut gene expression in H. tuberculata was co-opted from an ancestral adult expression pattern, then the gut expression pattern will remain in adult H. erythrogramma despite its direct development. (2) Genes expressed in the larval gut of H. tuberculata will not have a coordinated expression pattern in H. erythrogramma larvae due to loss of a functional gut. Five structural genes expressed in the invaginating archenteron of H. tuberculata during gastrulation exhibit substantially different expression patterns in H. erythrogramma with only one remaining endoderm specific. Expression of these genes in the adult of H. erythrogramma and larval gut of H. tuberculata, but not in H. erythrogramma larval endoderm, supports the hypothesis that they first played roles in the formation of adult structures and were subsequently recruited into larval ontogeny during the origin and evolution of feeding planktotrophic deuterostome larvae. (shrink)

A provocative Target Article in this issue of AJOB proposes a new approach to decision-making for babies born in the “gray-zone” at the margins of viability. Titled “Postponed Withholding: balanced...

Erasmus was one of the most widely read and controversial authors of the early modern period, inspiring a broad range of reader reactions. The present volume addresses various aspects of Erasmus's reception, including how the author's name was sometimes used to bolster decidedly "un-Erasmian" ideals.

ch. 1. Ocherki teorii intelligent︠s︡ii -- ch. 2. Ocherki istorii russkoĭ intelligent︠s︡ii.

The numerous historical episodes of free banking have invariably ended in the establishment of central banking. Was the failure of free banking due to ?theory,? ?seignorage??the attempt by governments to use central banks for revenue purposes?or to ?crises?? Would a free banking system be stable, free of crises? This is the crux of the theoretical and historical debate.

Shoemaker's book can be divided into two main sections; the first five chapters, which consist of somewhat tedious criticisms of some classical and semi-classical positions, and Chapter Six, "How is Self-Knowledge Possible?" Of particular interest in the latter are his claims that we have non-criterial knowledge of personal identity and that "sincere and confident perceptual and memory statements" are necessarily generally true. The book is an outgrowth of Shoemaker's doctoral dissertation and retains a dissertorial style. The influence of Malcolm is (...) evident throughout.—A. E. J. (shrink)

This is a clear assessment of Hume's theories of the self and personal identity, including his famous Treatise on Human Nature . Pitson provides a critical exploration of his thinking, also examining the continuing relevance of Hume's theories for contemporary philosophy and relating it to his broader reflections on human nature itself. Divided into two parts, Pitson's study follows Hume's important distinction between two aspects of personal identity: the "mental" and the "agency". The first part discusses Hume's conception of the (...) mind as a "bundle" or "system" of perceptions and explores Hume's position on the traditional mind/body problem. In the second part Pitson examines a range of topics including Hume's treatment of character, the relationship between human and animal nature, and the nature of agency. (shrink)

AT the conclusion of his recently published paper on Corinna1 Professor Page leaves open the question whether the poetess was a contemporary of Pindar or of Moschus-whether she belongs to the middle of the fifth century or the end of the third. He gives excellent reasons for believing that these two dates exhaust the possibilities: they are far more probable than a date either outside or between them; but there seems to be no sure criterion by which we can decide (...) between the two, and Professor Page has to end his researches with a suspension of judgement. (shrink)

Many years ago Wilamowitz desiderated a systematic collection of the texts which relate to the different types of poetry composed by the great lyric poets of Greece. He hoped that if we could only crystallize our admittedly scanty information about the characteristics of, say, the Paean or the Dirge, we might be able to reach a slightly better understanding than we have now of the formal structure and artistic design of the poems and fragments which have come down to us (...) under these titles. Indeed, this kind of knowledge is very important. (shrink)

Both the author and the date of this five-volume poem, the first Western document to link the houses of the zodiac with the course of human affairs, are uncertain. The author's name may be Marcus Manilius, or Manlius, or Mallius, and the latest datable event mentioned in the books themselves is the disastrous defeat of Varus' Roman legions by the German tribes in 9 CE. The writing shows knowledge of the work of Lucretius, but the work is not referred to (...) by any subsequent writer, suggesting that it was never widely disseminated. A manuscript was rediscovered by Poggio Bracciolini in 1416 or 1417, and editions were produced by Scaliger and Bentley, but this immensely erudite edition of 1903–1930 by the scholar and poet A. E. Housman is regarded as authoritative. Volume 3 describes the working out of horoscopes. (shrink)

OBJECTIVES: To report the outcome of applications to 43 research ethics committees. SETTING: Four regional health authorities in England. FINDINGS: The research ethics committees varied considerably in their practices. The time lapse until notification of the outcome of the approval ranged from just under one week to 23 weeks with a mean of 8.6 weeks. Four research ethics committees failed to notify the research team of an outcome of their request for approval. CONCLUSION: A national research ethics committee is needed (...) to review national and multi-location research studies in the light of the fragmented and variable practice of local research ethics committees. (shrink)