Hoerl & McCormack argue that children are incapable of reasoning about time until age 5. However, their dual timing perspective does not address non-symbolic timing, or timing in the absence of symbols/language. Given substantial evidence that infants and children are capable of non-symbolic timing, I argue that infants and children are well-tuned timers prior to age 5.

Timers and sensors are common devices that make our daily life safer, more convenient, and more efficient. In a cellular context, they arguably play an even more crucial role as they ensure the survival of cells in the presence of various extrinsic and intrinsic stresses. Biological timers and sensors generate distinct signaling profiles, enabling them to produce different types of cellular responses. Recent data suggest that they can work together to guarantee correct timing and responsiveness. By exploring examples of cellular (...) stress signaling from mitosis, DNA damage, and hypoxia, the authors discuss the common architecture of timer‐sensor integration, and how its added features contribute to the generation of desired signaling profiles when dealing with stresses of variable duration and strength. The authors propose timer‐sensor integration as a widespread mechanism with profound biological implications and therapeutic potential. -/- . (shrink)

This article argues that autistic people occasionally experience greater comfort from imposed routines than from a yielding form of love and understanding, which I will call naive humanism. Collins's theory of action, with its attention toward the achievements residing in a reductionist approach, can help to point out the flaws of a naive humanistic stance. It would, however, be a mistake to stop at this point and remain satisfied with the problem-solving capacity of such a reductionist stance. In a ward (...) for autistic youths, the risk of cruelty resides in a purely mechanistic stance as much as in a naive humanistic approach. Thus, the social context of care of autistic people urges us to question the scope of a traditional scheme of thought, which cherishes a deep distinction between humans and machines. (shrink)

Multicellular organisms develop on a predictable schedule that depends on both cell‐intrinsic timers and sequential cell‐cell interactions mediated by extracellular signals. The interplay between intracellular timers and extracellular signals is well illustrated by the development of oligodendrocytes, the cells that make the myelin in the vertebrate central nervous system. An intrinsic timing mechanism operates in each oligodendrocyte precursor cell to limit the length of time the cell divides before terminally differentiating. This mechanism consists of two components, a timing component, which (...) depends on the mitogen platelet‐derived growth factor (PDGF) and measures elapsed time, and an effector component, which depends on thyroid hormone and stops cell division and initiates differentiation at the appropriate time. The cell‐cycle inhibitor p27/Kip1 accumulates in the precursor cells as they proliferate and is part of both components of the timer. It seems likely that similar timing mechanisms operate in other cell lineages. BioEssays 22:64–71, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

The marine ecosystem is governed by a multitude of environmental cycles, all of which are linked to the periodical recurrence of the sun or the moon. In accordance with these cycles, marine species exhibit a variety of biological rhythms, ranging from circadian and circatidal rhythms to circalunar and seasonal rhythms. However, our current molecular understanding of biological rhythms and clocks is largely restricted to solar‐controlled circadian and seasonal rhythms in land model species. Here, we discuss the first molecular data emerging (...) for circalunar and circatidal rhythms and present selected species suitable for further molecular analyses. We argue that a re‐focus on marine species will be crucial to understand the principles, interactions and evolution of rhythms that govern a broad range of eukaryotes, including ourselves. (shrink)

Domestic eco-efficient technologies, such as recycling bins and compact florescent light bulbs, are integral to the eco-modernisation project. To date, however, little research has examined their role in the production of 'sustainable citizens'. In response, this paper explores the productivities of commonplace domestic objects. It draws on qualitative research into a Sydney-based sustainable living programme called 'GreenHome', to examine how participants' environmental ethics became articulated through objects' use. This forges a form of embodied 'techno-ethics' that permeates socio-material relations beyond the (...) immediate. Therefore, this examination of the quotidian deployment of eco-efficient technologies, whilst not denying the problematic nature of technologically-dependant futures, suggests some positive outcomes from individuals' enrolment in domestic eco-modernisation. (shrink)

AbstractmiRNA‐mediated gene repression and ubiquitin‐dependent processes are among the oldest and most versatile mechanisms that control multiple molecular pathways, rather than just protein turnover. These systems were discovered decades ago and have become among the most studied. All systems within cells are interconnected, and these two are no exception: the plethora of studies have demonstrated that the activity of the miRNAs system depends on players of the ubiquitin‐centered universe of processes, and vice versa. This review focuses on recent progress that (...) highlights that very similar mechanisms of regulation of miRNAs by ubiquitin‐related processes are likely to be found in distantly related species, including animals, plants, and viruses. Most of them occur through the ubiquitination of Argonaute proteins, but some of the other miRNA system factors are also regulated. This suggests that their regulatory relationships are either ancient evolutionary acquisitions or have arisen independently in different kingdoms. (shrink)

In Hurrian, timer/timar ‘dark’ appears exclusively in the phrase timerre eženi “the dark earth”. It has been suggested that this phrase and its reflexes in Hittite and Greek derive from the common religious trope of “the devouring earth” originating in northern Mesopotamia, with Hurrian providing the first attestation. However, the atypical morphology of the adjective, which cannot be derived from a noun and does not have the normal VC root pattern of Hurrian, and the semantic field, with Hurrian having (...) borrowed many words for colors, make a native Hurrian origin for timer/timar unlikely. It is suggested instead that the adjective, as well as its counterpart timiraš ‘a dark/black color ’ in the Kassite language, was borrowed from Indo-Aryan *tam-[e]r, probably as a result of a shared Indo-Aryan cultural superstratrum. While no alternatives are offered, such an etymology calls into question a Hurrian origin for the religious concept of “devouring earth.”. (shrink)

Many prepared actions have to be withheld for a certain amount of time in order to have the most beneficial outcome. Therefore, keeping track of time accurately is vital to using temporal regularities in our environment. Traditional theories assume that time is tracked by means of a clock and an “attentional gate” (AG) that modulates subjective time if not enough attentional resources are directed toward the temporal process. According to the AG theory, the moment of distraction does not have an (...) influence on the subjective modulation. Here, we show, based on an analysis of 28,354 datasets, that highly motivated players of the online multiplayer real‐time strategy game StarCraft2 indeed respond later to timed events when they are distracted by other tasks during the interval. However, transient periods of distraction during the interval influence the response time to a lesser degree than distraction just before the required response. We extend the work of Taatgen, van Rijn, and Anderson (2007) and propose an alternative active check theory that postulates that distracted attention prevents people from checking their internal clock; we demonstrate that this account better predicts variance observed in response time. By analyzing StarCraft2 data, we assessed the role of attention in a naturalistic setting that more directly generalizes to real‐world settings than typical laboratory studies. (shrink)

Many prepared actions have to be withheld for a certain amount of time in order to have the most beneficial outcome. Therefore, keeping track of time accurately is vital to using temporal regularities in our environment. Traditional theories assume that time is tracked by means of a clock and an “attentional gate” (AG) that modulates subjective time if not enough attentional resources are directed toward the temporal process. According to the AG theory, the moment of distraction does not have an (...) influence on the subjective modulation. Here, we show, based on an analysis of 28,354 datasets, that highly motivated players of the online multiplayer real‐time strategy game StarCraft2 indeed respond later to timed events when they are distracted by other tasks during the interval. However, transient periods of distraction during the interval influence the response time to a lesser degree than distraction just before the required response. We extend the work of Taatgen, van Rijn, and Anderson (2007) and propose an alternative active check theory that postulates that distracted attention prevents people from checking their internal clock; we demonstrate that this account better predicts variance observed in response time. By analyzing StarCraft2 data, we assessed the role of attention in a naturalistic setting that more directly generalizes to real‐world settings than typical laboratory studies. (shrink)

Social preservation is a bundle of ethics and practices rooted in the desire of some people to live near old-timers, whom they associate with “authentic” community. To preserve authentic community, social preservationists, who tend to be highly educated and residentially mobile, work to limit old-timers’ displacement by gentrification. However, they do not consider all original residents authentic. They work to preserve those they believe embody three claims to authentic community: independence, tradition, and a close relationship to place. Underlining their attraction (...) to these characteristics are resistance to the evolution of neighborhoods and towns, and the notion that certain groups have a greater claim to authentic community than others. These beliefs, and, secondarily, local institutions and boosters, influence their preservation of certain groups. While the quest for the authentic is typically viewed as affirming the authenticity of its seekers, social preservationists measure the authenticity of others’ communities against their own in authenticity. That is, they are committed to virtuous marginality, which exists when people associate authenticity with, and highly value, characteristics they do not share, and consequently, out of a desire to preserve the authentic, come to regard their distance from it – their marginality – as virtuous. This article reveals the consequences of definitions of authenticity, and more generally of ideology, by demonstrating how they shape preservationists’ lives, particularly their experience of community. (shrink)

The literature on time perception is discussed. This is done with reference both to the ''cognitive-timer'' model for time estimation and to the subjective experience of apparent duration. Three assumptions underlying the model are scrutinized. I stress the strong interplay among attention, arousal, and time perception, which is at the base of the cognitive-timer model. It is suggested that a multiplicative function of two key components (the number of subjective time units and their size) should predict apparent duration. (...) Implications for other cognitive domains are drawn, and in particular an analogy is suggested between apparent duration and apparent movement. (shrink)

Nostalgia as one of the complex emotions has been challenged over the past few decades due to its psychological and physiological functions. The present experiment investigates the effect of recalling nostalgic memories on amelioration of homeostatic and health state of people with cardiovascular disease. Method: The participants were 30 patients who were hospitalized for angiography procedure. The research was based on an experimental design with randomized and post-test groups. The instruments used included a thermometer with ° C, a checkout manipulation (...) test, a blood pressure monitor, an ice container and a manual timer, a pain intensity perception scale and Batcho’s nostalgia questionnaire. Results: The results showed that there was a significant difference between the two groups in perceived temperature, the resilience in the face of pain, and the perceived pain. The experimental group perceived higher temperature and showed greater resilience in the face of pain and also lower pain intensity was reported. There was no significant difference in blood pressure between the two groups. Conclusion: The results of this study provide significant evidence for the embodiment emotions hypothesis and positive role of Nostalgia in psychological and physiological homeostatic. Further practical implications of results and suggestions for future research were considered. (shrink)

In this article, we explore the learning of newcomers in a religious community through a micro-sociological approach, making use of Jean Lave and Etienne Wenger’s (1991) notion of “legitimate peripheral participation” to conceptualize initial stages of inclusion and involvement in social practice. Our case study concerns Orthodox Christianity and is based on material gathered through fieldwork in a course targeting potential new members organized by a Finnish Orthodox parish. In the analysis, we inquire into how beginners learn skilful participation in (...) Orthodox liturgical life, and specifically embodied ritual conduct. This learning takes place primarily through participation in real-life divine services. The article highlights challenges faced by beginners in acquiring the embodied repertoire of Orthodox ritual, including adapting to the artistic use of ritual gestures, and negotiating the meanings produced through them. Furthermore, it also illustrates how nuanced dynamics between newcomers and old-timers influence the learning process. (shrink)

Enzyme engineering allows to explore sequence diversity in search for new properties. The scientific literature is populated with methods to create enzyme libraries for engineering purposes, however, choosing a suitable method for the creation of mutant libraries can be daunting, in particular for the novices. Here, we address both novices and experts: how can one enter the arena of enzyme library design and what guidelines can advanced users apply to select strategies best suited to their purpose? Section I is dedicated (...) to the novices and presents an overview of established and standard methods for library creation, as well as available commercial solutions. The expert will discover an up‐to‐date tool to freshen up their repertoire (Section I) and learn of the newest methods that are likely to become a mainstay (Section II). We focus primarily on in vitro methods, presenting the advantages of each method. Our ultimate aim is to offer a selection of methods/strategies that we believe to be most useful to the enzyme engineer, whether a first‐timer or a seasoned user. (shrink)

I met Hans Albert twice, in Vienna in 2002 at the Popper Centennial Congress, and, a few months later, in Alpbach, where he was an old timer who had seen the institution develop over half a century and took pride in belonging in its history. I found Albert charming, jolly and generous, very different from my image of the German mandarin. As a Popper scholar, I had, of course, heard of him before.

Books Reviewed in this Article: Transforming Bible Study. By Walter Wink. Pp.175, London, SCM Press, 1981, £3.50. Isaiah 1–39. By R.E. Clements. Pp.xvi. 301, London, Marshall, Morgan and Scott, 1980, £3.95. Isaiah 40–66. By R.N. Whybray. Pp.301, London, Marshall, Morgan and Scott, 1975, Reprinted 1981, £3.95. Die Gestalt Jesu in den synoptischen Evangelien. By Heinrich Kahlefeld. Pp.264, Frankfurt, Verlag Josef Knecht, 1981, no price given. Following Jesus: Discipleship in the Gospel of Mark. By Ernest Best. Pp.283, Sheffield, JSOT Press, 1981, (...) £15.00, £5.95. The Origin of Paul's Gospel. By Seyoon Kim. Pp.xii, 391, Tübingen, J.C.B. Mohr, 1981, 78 DM. An die Römer. By Ernst Käsemann. Pp.xvi, 411, Tübingen, J.C.B. Mohr, 1980, 48 DM. Les Récits de Resurrection des Morts dans le Nouveau Testament. By Gerard Rochais. Pp.xv, 252, Cambridge, Cambridge University Press, 1981, £15.00. Prêtres Anciens, Prétre Nouveau selon le Nouveau Testament. By Albert Vanhoye. Pp.366, Paris Editions du Seuil, 1980, no price given. Woman in the World of Jesus. By Evelyn and Frank Stagg. Pp.292, Edinburgh, The St Andrew Press, 1981, no price given. Jesus, Man and the Church. By Karl Rahner. Pp.260, London, Darton Longman & Todd, 1981, £14.50. Jesus Lord and Savior: A Theopathic Christology and Soteriology. By William M. Thompson. Pp.ix, 287, Leominster, Fowler Wright, 1981, £7.45. God and World in Schleiermacher's ‘Dialektik’ and ‘Glaubenslehre’. Criticism and the Methodology of Dogmatics. By John E. Thiel. Pp.xiv, 239, Bern, Frankfurt and Las Vegas, Peter Lang, 1981, SF 49.50. Ministry: A Case for Change. By Edward Schillebeeckx. Pp.ix, 165, London, SCM Press, 1981, £4.95. The Sacraments: Readings in Contemporary Sacramental Theology. Edited by Michael J. Taylor. Pp.274, New York, Alba House, 1981, $7.95. Believing in the Church: The Corporate Nature of Faith. A Report by the Doctrine Commission of the Church of England. Pp.ix, 310, London, SPCK, 1981, £8.50. Confessing the Faith in the Church of England Today. By R.T. Beckwith. Pp.36, Oxford, La timer House, 1981, £1.00. A Kind of Noah's Ark? The Anglican Commitment to Comprehensiveness. By J.I. Packer. Pp.39, Oxford, Latimer House, 1981, £1.00. Reasonable Belief: A Survey of the Christian Faith. By Anthony Hanson and Richard Hanson. Pp.xii, 283, Oxford University Press, 1981, £8.50. Doctrine in the Church of England. The 1938 Report with a new introduction by G.W.H. Lampe. Pp.lx, 242, London, SPCK, 1982, £8.50. The Divine Right of the Papacy in Recent Ecumenical Theology. By J. Michael Miller. Pp.xvi, 322, Rome, Università Gregoriana Editrice, 1980, 18,000 Lire. Der heilige Geist in der Theologie von Heribert Mühlen: Versucheiner Darstellung und Würdigung. By John B. Banawiratma. Pp.ix, 310, Frankfurt and Bern: Peter D. Lang, 1981, SFr. 60.00. Standing Before God: Studies on Prayer in Scriptures and Tradition with Essays in Honor of John M. Oesterreicher. Edited by Asher Frinkel and Lawrence Frizzell. Pp.410, New York, Ktav Publishing House, 1981, $29.50. Judaism and Healing. By J. David Bleich. Pp.xiii, 199, New York, Ktav, 1981, $15.00. The Diversity of Moral Thinking. By Neil Cooper. Pp.x, 303, Oxford, Clarendon Press: Oxford University Press, 1981, £15.00. L'Homme: Sujet ou Objet? By Jacques Croteau. Pp.260, Montreal, Bellarmin: Tournai, Desclée et Cie, 1981, $15.00. The Texture of Knowledge: An Essay on Religion and Science. By James W. Jones. Pp.97, Washington, University Press of America, 1981, no price given. Cosmos and Creator. By Stanley L. Jaki. Pp.xii, 168, Edinburgh, Scottish Academic Press, 1980, £6.75. Dante, Philomythes and Philosopher: Man in the Cosmos. By Patrick Boyde. Pp.vii, 408, Cambridge, Cambridge University Press, 1981, £30.00. Dissidence et Philosophie au Mayen Âge. By E.L. Fortin. Pp.201, Montreal, Bellarmin, 1981, $12.00. The Philosophy of John Norris of Bemerton. By Richard Acworth. Pp.x, 388, Hildesheim, Georg Olms, 1979, 74 DM. Philosophy and Ideology in Hume's Political Thought. By David Miller. Pp.xii, 218, Oxford, Clarendon Press, 1981, £15.00. Hegelianism. By John Edward Toews. Pp.x, 450, Cambridge, Cambridge University Press, 1980, £25.00. One Hundred Years of Thomism. Edited by V.B. Brezik. Pp.210, Houston, Centre for Thomistic Studies, 1981, no price given. Gramsci's Political Thought: Hegemony, Consciousness and the Revolutionary Process. By J.V. Femia. Pp.xiii, 303, Oxford, Clarendon Press, 1981, £17.50. Greek and Roman Slavery. By Thomas Wiedemann. Pp.xvi, 284, London, Croom Helm, 1981, £10.95, £5.95. Prophecy and Millenarianism. Essays in Honour of Marjorie Reeves. Edited by Ann Williams. Pp.x, 355, London, Longman, 1980, £25.00. Of Prelates and Princes: A Study of the Economic and Social Position of the Tudor Episcopate. By Felicity Heal. Pp.xv, 353, Cambridge, Cambridge University Press, 1980, £17.50. Radical Religious Movements in Early Modern Europe. By Michael Mullett. Pp.xxiv, 193, London, George Allen & Unwin, 1980, £10.50. The Jesuits. By J.C.H. Aveling. Pp.390, London, Blond and Briggs, 1981, £16.95. The Beginnings of Ideology. By Donald R. Kelley. Pp.xv, 351, Cambridge, Cambridge University Press, 1981, £24.00. Utopia and the Ideal Society: A Study of English Utopian Writing 1516–1700. By J.C. Davis. Pp.x, 427, Cambridge, Cambridge University Press, 1981, £25.00. Eastern Politics of the Vatican 1917–1979. By Hansjakob Stehle. Pp.466, Athens, Ohio University Press, 1981, £16.20, £8.10. Structuralism or Criticism? By Geoffrey Strickland. Pp.viii, 209, Cambridge, Cambridge University Press, 1981, £17.50. The Call of God: The Theme of Vocation in the Poetry of Donne and Herbert. By Robert B. Shaw. Pp.xiii, 123, Cambridge, Mass., Cowley Publications, 1981, $5.00. John and Charles Wesley: Selected Prayers, Hymns, Journal Notes, Sermons, Letters and Treatises. Edited by Frank Whaling. Pp.xx, 412, London, SPCK, 1981, £8.95. The Trickster in West Africa: A Study of Mythic Irony and Sacred Delight. By Robert D. Pelton. Pp.312, Berkeley, University of California Press, 1980, £15.00. (shrink)

Clock time involves two motions, one of which can be easily counted, such as the movement of one of the hands around the face of a watch or the movement of sand from one part of a timer to another. The repetition and regularity of such motions make them easy to number. They can be made to keep on repeating themselves, each can easily be taken as the same as any other, and we can easily tell that there have (...) been "three" or "eight" of them. At one time the primary instance of clocking motions were the movements of the sun, moon, and stars, but the precision of our clocks has made these celestial motions recede into the background in our handling of time. Six A.M. or seven P.M., 600 hours or 1900 hours, are more prominent for us than sunrise and sunset; we say that the sun rises at 600 hours and sets at 1900, as though the rising and setting were placed against a process more fundamental than these solar events. But of course our clocks still run against the pattern of the sun, moon, and stars, and many of the standard sums we reckon with in clock time are defined by the less accurate but larger wholes, the days, months, and years, that the movements of the heavens provide. (shrink)

Stimulates thoughts and expands awareness of the philosophical dimensions of yoga in its many forms and practices Yoga — Philosophy for Everyone presents a wide array of perspectives by people whose lives have been touched by yoga. Addressing myriad aspects of yoga's divergent paths, topics include body image for men and women; the religious and spiritual aspects of yoga; and issues relating to ethics, personal growth, and the teaching of yoga. Written by philosophers and non-philosophers alike, with contributions from professional (...) yoga instructors, lifelong practitioners, and first-timers, Yoga — Philosophy for Everyone offers a wealth of material for both enjoyment and deep reflection. (shrink)

At least seven orphan members of the nuclear receptor superfamily are transcriptionally regulated by the steroid hormone ecdysone and expressed during the onset of Drosophila metamorphosis. A recent paper provides functions for two of these receptors, E75B and DHR3, through trans‐regulation and heterodimerization(1). DHR3 appears to function as a switch that defines the transition from a late larva to a prepupa, and E75B functions as a timer that modulates this transition. This study provides a biological function for orphan receptor (...) interactions during development. (shrink)

We highlight a recent study exploring the hand‐off of UV damage to several key nucleotide excision repair (NER) proteins in the cascade: UV‐DDB, XPC and TFIIH. The delicate dance of DNA repair proteins is choreographed by the dynamic hand‐off of DNA damage from one recognition complex to another damage verification protein or set of proteins. These DNA transactions on chromatin are strictly chaperoned by post‐translational modifications (PTM). This new study examines the role that ubiquitylation and subsequent DDB2 degradation has during (...) this process. In total, this study suggests an intricate cellular timer mechanism that under normal conditions DDB2 helps recruit and ubiquitylate XPC, stabilizing XPC at damaged sites. If DDB2 persists at damaged sites too long, it is turned over by auto‐ubiquitylation and removed from DNA by the action of VCP/p97 for degradation in the 26S proteosome. (shrink)

In recent years, many researchers engaged in diverse areas and approaches of “cultural-historical activity theory” (CHAT) realized an increasing international interest in Lev S. Vygotsky’s, A. N. Leont’ev’s, and A. Luria’s work and its continuations. Not so long ago, Yrjö Engeström noted that the activity approach was still “the best-held secret of academia” (p. 64) and highlighted the “impressive dimension of theorizing behind” it. Certainly, this remark reflects a time when CHAT was off the beaten tracks. But if this situation (...) begins to change today, in which direction will CHAT be heading? Will it continue to be one of those projects “unique for its practical, political, and civic engagement” committed “to ideals of social justice, equality, and social change” as it was in the beginning (Stetsenko & Arievitch, 2004, p. 58)? Although a positive future of CHAT seems to lie ahead, we consider in this article some of the problematics that may challenge all those who want to pass the “impressive dimensions of theorizing” from “insider” circles to a larger audience and from one generation to another as well as encourage newcomers to become part of this tradition through critical engagement in its theory and practice. A key to these engagements, we suggest, is not only the comprehensive empirical and philosophical basis, but also the role of dialectics as both topic and method. Therefore, the challenge for newcomers (as well as for “old-timers”) to take on the tradition of CHAT is not a small one indeed. We assume that a major reason for the increasing interest in CHAT lies in its potential to provide a non-reductionist approach to human development, which is due to its affinity to dialectics; however, the close interrelation to a tradition that reaches back to the theories of Georg W.F. Hegel and Karl Marx, among others, is not the easiest to master. In consideration of these difficulties, the purpose of this article is to investigate how contemporary approaches within CHAT can continue to provide a dialectical framework to preserve and renew the critical intention of this tradition, and how we run the risk of losing this sting. Thereby, we sensitize researchers to the problem of developing a cultural-historical approach within a historical situation that confronts us with new, unanswered questions. In this light, we also problematize the use of scientific language, for it may lead us to speak and argue un-dialectically when in fact we intend or ought to think dialectically. This article seeks to convey insights and arguments of how we can relate our theoretical approaches to a tradition of dialectical thinking and in what ways this is paramount for a critical engagement in theory and practice. In the first part, we therefore discuss not only some major theorems in Hegel’s and Marx’s work but also, and above all, Vygotsky’s way of developing the cultural-historical approach of psychology. Second, we argue that the contemporary, widely known version of CHAT, related to Yrjö Engeström’s theoretical and empirical work, neglects different aspects of dialectical thinking and consequently narrows its potential to a socio-critical approach to societal practice and human development. A crucial question of this scrutiny will be the notion of contradictions and how development is supposed to be achieved. In general, our intention is not only to clarify the role of dialectics as a method for activity theory but also to problematize the role of the subjects of research in CHAT and to confront ourselves with the problems of practicing and developing a critical science in face of a complex and challenging societal world. (shrink)

This paper presents and discusses a recent Israeli proposal to legislate on the rights of the dying patient. A gap exists between elitist biases of the committee proposing the law, and popular values and sentiments. The proposed law divides the dying patients into two groups: “those who wish to go on living” and “those who wish to die”. The former will have a right to life prolonging extraordinary care. It is not clear who would foot the bill for this care. (...) Also it is hard to see how this munificence could fail to discriminate against all other patients. Both the secular ethicists and the rabbis involved in drawing up the proposal accepted the assumption that it is good for some terminal patients to die. The rabbis objected, however, to direct and active interventions that shorten life. The solution arrived at was to install timers in the ventilators so as to allow them to expire automatically unless the patient wishes for their resetting. (shrink)

_Stimulates thoughts and expands awareness of the philosophical dimensions of yoga in its many forms and practices_ _Yoga — Philosophy for Everyone_ presents a wide array of perspectives by people whose lives have been touched by yoga. Addressing myriad aspects of yoga's divergent paths, topics include body image for men and women; the religious and spiritual aspects of yoga; and issues relating to ethics, personal growth, and the teaching of yoga. Written by philosophers and non-philosophers alike, with contributions from professional (...) yoga instructors, lifelong practitioners, and first-timers, _Yoga — Philosophy for Everyone_ offers a wealth of material for both enjoyment and deep reflection. (shrink)

Wireless devices consume large amounts of energy during wireless communication. As the energy storage of battery is limited, improving energy efficiency has become an important approach to prolong the lifetime of devices. The IEEE 802.11 protocol supports the power save mode in wireless local area networks. However, the standard PSM cannot adapt to the changes of traffic load or channel conditions. Therefore, this article proposes an adaptive traffic-aware PSM mechanism that improves energy efficiency of wireless devices in a WLAN with (...) an access point. According to the current channel condition and traffic load, the AP adjusts the interval of beacons that give devices different priorities to fetch buffered packets. The devices can adaptively adjust listening intervals according to network traffic, and adopt different congestion backoff timers when channel collisions happen or the network topology changes. The APSM has been implemented and evaluated in NS-2. The simulation results have shown that devices using the APSM can improve energy efficiency by 115% at most compared with the ones using the standard PSM. The benefit of adaptive beacon interval and listening intervals is significant, while the improvement due to the adaptive backoff timer is minor. The improvement of the APSM over the PSM is more significant when the network traffic level decreases and the ratio of idle power to sleeping power increases. Additionally, the APSM increases the delay of data frames within a limited range, which does not bring any bad effect on network throughput. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hurricane Gloria LAWRENCE DUGAN A screaming northern gale flew past his wild words And slammed the sails, and pulled a wave toward heaven. —Aeneid, i.102–3 (Sarah Ruden, trans.) i. A phalanx of weather tools at the door, A shovel, an ice-pick, an umbrella, A new cane, leaning against each other, Plastic fabricated to resist storms, Reminds me of a storm I rode out years ago, The Nor’easter of 1985, (...) On the twenty-first floor of 5 Penn Center Across the street from where the Fox Theater Spread the bright wings of its marquee, folded Now forever, torn down, and then replaced With a glass-box not unlike the office I looked out of, watching the rain lashing Windows, tearing at the flags hung on poles On other buildings, solitary banners Left up as if to challenge the weather To do its worst, to refute the young storm Tearing northeast out of the Atlantic, Predicted only a few days before As a hurricane, that didn’t happen, But leaving the high-rise building nearly Deserted, with the ticker still running Across the wall; the market had opened Empty office or not, unoccupied Desks giving it that strange quietude Peculiar to such spaces, which the mind Expects to be filled, even while seeing Otherwise. arion 28.2 fall 2020 66 hurricane gloria I felt like a sailor for The only time in my life, stepping off The elevator at 21, and then Walking into the main hall and sensing The building swayed slighty, barely feeling It but knowing it distinctly, hearing It creak exactly as I had heard ships At sea in dozens of movies, and with The sound, the sway, the massive grid of pipes And beams giving and taking. jms Old timers hadn’t warned me about this Although some had ridden out several Storms as bad, real or metaphorical, Not even old Harris who remembered Moving down from Susquehanna county In ’29, to Wall Street and the Crash. ii. Future archaeologists of urban Storms will study pictures of umbrellas Taking flight, wrecked synthetic shapes blooming Against resistant hands, then abandoned, Stuffed into trash cans, twirling down alleys, Pastels, stripes or old-fashioned banker-black, The edge of the story, the windy street’s Last rebuke to those daring to stagger To lunch but caught in the nor’easterly Gale’s grey wall of wind and rain that rattled Doors and buckled windows. The building held Two dozen companies, and I still like To think one fronted for an anchorite, Some isolated individual Up on 24, alone at his desk In a skyscraper office for ten years Praying, sometimes looking down the cliff walls At the peregrine falcons sweeping home Lawrence Dugan 67 To their massive nest stuffed tight in the bronze Lap of a statue seated on City Hall, One of the allegories of Founders And Lenape chiefs placed high over Broad, The hawks diving downward athwart the storm Coming on in grey curtains wavering Over the city and the Delaware Valley. Across the river in Jersey The pines begin, in Camden the street dirt Is sand; halfway to the shore the forest Runs above the expressway, farms below, The pines flourishing in sandy barren Earth lacking nitrogen, incinerating Every dozen years, thousands of acres Blowing away in flames seen at the shore. After that rain those woods were safe for weeks. iii. Ten years and two jobs later I needed Census material and found it online On a rainy day in Center City In a high-rise office nearby, a halfDay ’s work done to my surprise in only Twenty minutes, then realizing as I Stood up from a computer that the view Was familiar. I was back on 21 In my old office; jms had moved But the grey sky cleared with a sweep of wind And the view north and south looked as before Wherever the market’s ticker-tape rolled now. The weather had surprised me again; The only full rainbow I ever saw, The ancient sign that spares the world from floods, A pure unblemished iridescent span, Appeared late in spring, in a sun shower.... (shrink)

Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error‐prone segregation is an issue, an aneuploidy‐selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC (...) generates a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge. (shrink)

Daylight is the primary cue used by circadian clocks to entrain to the day/night cycle so as to synchronize physiological processes with periodic environmental changes induced by Earth rotation.However, the temporal daylight pattern is not the same every day due to erratic weather fluctuations or regular seasonal changes. Then, how do circadian clocks operate properly in varying weather and seasons? In this paper, we discuss the strategy unveiled by recent studies of the circadian clock of Ostreococcus tauri, the smallest free‐living (...) eukaryotic organism. It combines mechanisms controlling light inputs and clock sensitivity, shaping both the dynamics of the core circadian oscillator and its forcing by light so as to ensure stable and precise synchronization in all weather and seasons.Editor's suggested further reading in BioEssays: Another place, another timer: Marine species and the rhythms of life Abstract. (shrink)

Many plants are adapted to flower at particular times of year, to ensure optimal pollination and seed maturation. In these plants flowering is controlled by environmental signals that reflect the changing seasons, particularly daylength and temperature. The response to daylength varies, so that plants isolated at higher latitudes tend to flower in response to long daylengths of spring and summer, while plants from lower latitudes avoid the extreme heat of summer by responding to short days. Such responses require a mechanism (...) for measuring time, and the circadian clock that regulates daily rhythms in behaviour also acts as the timer in the measurement of daylength. Plants from high latitudes often also show an extreme response to temperature called vernalisation in which flowering is repressed until the plant is exposed to winter temperatures for an extended time. Genetic approaches in Arabidopsis have identified a number of genes that control vernalisation and daylength responses. These genes are described and models presented for how daylength might regulate flowering by controlling their expression by the circadian clock. BioEssays 22:38–47, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

This essay explores my own situation of teaching philosophy in a more or less traditional undergraduate setting but in a way that is especially relevant to the theme of this Congress, namely, the theme of "philosophy educating humanity." In my case, I teach philosophy but from a perspective that is non-traditional and which undercuts the standard questions originating from and orienting around a "philosophia perennia." Specifically, I teach philosophy of religion from the perspective of Jewish philosophy, and even more specifically, (...) from the perspective of the French Jewish philosophy of Emmanuelle Levinas. Moreover, I teach philosophy in an educational environment that is representative of the greater global community because I teach at the University of Texas at El Paso, situated on the border that separates the United States and Latin America. Finally, my teaching situation is one that is further marginalized because of the precarious nature of my academic position, namely, trained outside the traditional borders of philosophical faculty and working at first as a part-timer and only recently as a full-time, non-tenure track teacher of philosophy and humanities. Hence, I offer my experience of doing work of successfully teaching philosophy "on the borders" in the hope that others gathered here will be challenged to think differently about their own way of educating others. (shrink)

Clearance phase at signalized crosswalks is an important parameter of pedestrians’ safety because it helps them to complete the crossing before the green signal for vehicles. However, there is the issue of pedestrian decision as to whether to cross if they arrive at the crosswalk during the clearance phase, which represents a violation in many countries. Due to the proof that pedestrian violations multiply the risk of traffic accidents, in this study, the tendency of pedestrians to commit violations during the (...) clearance time has been researched. With the aim of proposing the design of the pedestrian traffic lights, which could decrease the frequency of pedestrian violations, the comparison of pedestrians behaviour at crosswalks with and without a countdown timer during the clearance time was made, based on the data collected in the video recording. Chi square independency test showed that there is a statistically significant difference in the behaviour of pedestrians during the clearance time, depending on the existence of the timer, as well as the fact that pedestrians behave in a safer manner if there is no clearance time shown on the timer. The total delay rate on the roadway during the red signal, which was the consequence of starting the crossing during the clearance time or subsequent violations, was 1.3 times higher at the crosswalks with the countdown timer. This research was unique because for the first time, two-phase pedestrian crossings on the roadway with the median refuge island in the sense of clearance time were analysed, in spite of the previous proof that pedestrians are more likely to commit violations during the red signal in that kind of roadway. Another novelty in the research was pedestrians following till the end of crossing, due to the possibility of subsequent violations. With the means of binary logistic regression, different factors which affect pedestrians’ behaviour during the clearance time have been determined and they differ depending on the existence of the timer. At the pedestrian crosswalks with the timer, contributing factors have been determined, such as gender, the number of waiting pedestrians, distractions, arrival time, and age. If there is no timer, the contributing factors are the following: the number of crossing pedestrians, distractions, group, position of pedestrians in relation to the vehicle, the number of traffic lanes, and age. Based on the obtained results, a new design of the pedestrian traffic lights was proposed. (shrink)

In the first parts of this study on the concept of the biological clock it has been investigated how it is used in the field of biorhythmology. The analysis of the contents of the concept is preceded by a survey of the current research in this field.There are two general hypotheses with respect to the ultimate origin of rhythmic phenomena: the Endogenous Timer Hypothesis and the Exogenous Timer Hypothesis. Within the Endogenous Timer Hypothesis two contrasting viewpoints with (...) respect to the structure of the biological clock can be distinguished, which have been called: the Discrete Entity view, and the Organizational view.It has been shown that in the application of the general clock-idea upon the organism a logical distortion is present. The organism is conceived tobe a clock and tohave a clock simultaneously.In anticipation of the analysis of the explanatory value of the concept of the biological clock in part II, it has been put forward that in a number of cases time-measurement can be considered as a superfluous element in the explanation of the phenomena involved.Finally it has been demonstrated that in the case of the Exogenous Timer Hypothesis the concept of the biological clock is not relevant. The Exogenous Timer Hypothesis has been compared with the Endogenous Timer Hypothesis with respect to the criterion of the principle of parsimony, orOccam's razor. (shrink)

Inspired by recent theorization by Dreier and Lave concerning situated perspectives on learning, I illuminate learning of international graduate students in a science lab in Japan as trajectories of participation in multi-layered activities and various mutually constituted occasions, and as crossing of multiple communities of practice. By doing so, I describe trajectories of participation as unique and multiple ways characteristic of individual participants instead of as a linear process from newcomer to old-timer or from peripheral to full participation in (...) a community of practice. Identity formation is also reformulated as discovering and constituting one’s unique self through crossing multiple communities of practice rather than merely as becoming a member in a community of practice. Further, I show that identity formation may be regarded not merely as adjusting the relationship among multiple communities within individuals, but as the practice of organizing new linkages among communities and of reconstituting communities of practice. (shrink)