Relying on interviews and fieldwork observations, the article investigates the choice of signs made by guide dogs and their visually impaired handlers while the team is on the move. It also explores the dependence of the choice of signs on specific functions of communication and examines the changes and development of sign usage throughout the team’s work. A significant part of the team’s communication appears to be related to retaining the communicative situation itself: to the establishment of intrateam contact; to (...) keeping the other prone to receive messages and to establish adequate sign relations; to giving and receiving feedback. The signs used for the purpose of retaining contact are analyzed in the article mainly with the handler in the role of the addresser. Signs also vary according to the character and aim of the team’s referential communication. Searching for objects and places, orientation and avoidance of obstacles can be discerned as three major functional frames that determine the choice of signs. As the team’s cooperation evolves, so also do the means of communication. The analysis shows that intrateam communication becomes less segmented and the signs used in referential communication shift from symbolic to symptomatic signs and become harder to detect for an outside observer. (shrink)

Chromosomes are not only carriers of the genetic material, but also actively regulate the assembly of complex intracellular architectures. During mitosis, chromosome‐induced microtubule polymerisation ensures spindle assembly in cells without centrosomes and plays a supportive role in centrosome‐containing cells. Chromosomal signals also mediate post‐mitotic nuclear envelope (NE) re‐formation. Recent studies using novel approaches to manipulate histones in oocytes, where functions can be analysed in the absence of transcription, have established that nucleosomes, but not DNA alone, mediate the chromosomal regulation of (...) spindle assembly and NE formation. Both processes require the generation of RanGTP by RCC1 recruited to nucleosomes but nucleosomes also acquire cell cycle stage specific regulators, Aurora B in mitosis and ELYS, the initiator of nuclear pore complex assembly, at mitotic exit. Here, we review the mechanisms by which nucleosomes control assembly and functions of the spindle and the NE, and discuss their implications for genome maintenance. (shrink)

The mitotic spindle contains the machinery responsible for sister chromatid segregation. It is composed of a complex and dynamic array of microtubules, which are nucleated from the spindle poles. Studies of yeast spindle functions by molecular genetic analysis and by in vitro functional analysis have identified proteins that are mitosis‐specific and present at very low concentrations in the cell, and have revealed the molecular bases of several processes required for the formation and functioning of the mitotic spindle. Here I (...) review the current knowledge of the processes that are common to most eukaryotes: microtubule nucleation at the spindle poles, bipolar spindle assembly, maintenance of the spindle structure, chromosome attachment to the spindle and chromosome separation on the spindle. (shrink)

This article devoted to study of the issues of formation and functioning of national political elites in the context of globalization processes. According to the author, processes of globalization, socio-political, public-legal, and financial-economic development in national societies and States led to the formation of the national political elites in a single global governing elite in the face of the global Manager class, which, in turn, forms the main approaches, requirements and principles that underlie the formation and functioning of national political (...) elites. However, all this leads to the fact that global and national management of the elite are unable on the one hand, to quickly solve global problems facing humanity, and on the other hand, to ensure the progressive development of humanity as a whole, resulting in the creation and development of a revolutionary situation in the national and international scale. The only alternative to the existing trends of the formation and development of national political elites in anti-state and anti-social manner, which inevitably can lead humankind to destruction or self-destruction, is the growing activity of civil society to the state of leveling of power and influence of the global ruling elite in the face of the global Manager class. In the present work, a number of scientific methods of research were used, in particular: comparison; hermeneutic analysis; socio-phenomenological approach. (shrink)

그간의 아도르노의 매체론에 대한 연구는 『계몽의 변증법』과 『미니마 모랄리아』에 집중되었다. 그러나 해당하는 저작들은 아도르노의 본격적인 매체론에 대한 서술보다는 아도르노의 미학에 천착하는 것이며 또한 그마저도 파편적으로 서술되어 있다는 점에서 대부분 그의 견해를 간접적으로 드러내는 것에 그쳤다. 이에 몇몇의 연구들에서는 그의 보다 후기 저작들인 『영화를 위한 작곡』과 논문 「영화투명성」에 관한 탐구를 통해 그의 매체론에 대한 직접적인 해명을 시도하였다. 그러나 국내에서는 아직 「영화투명성」 논문 자체에 대한 분석보다는 그의 전반적인 매체론을 규명하기 위해서 해당 논문이 참조되는 형식을 취하는 연구가 대부분이었다. 이에 본고에서는 「영화투명성」에 등장하는 테제들을 (...) 밝히고 그러한 테제들이 아도르노의 매체론 안에서 어떠한 의의를 갖는지에 대해 규명해보고자 한다. (shrink)

The Kristeva–Lacan relationship has been a difficult one, with commentators tending to either collapse the former into the latter or insist on an absolute division wherein Kristeva emphasizes the m...

Even the simplest cell exhibits a high degree of functional differentiation (FD) realized through several mechanisms and devices contributing differently to its maintenance. Searching for the origin of FD, we briefly argue that the emergence of the respective organizational complexity cannot be the result of either natural selection (NS) or solely of the dynamics of simple self-maintaining (SM) systems. Accordingly, a highly gradual and cumulative process should have been necessary for the transition from either simple self-assembled or self-maintaining systems (...) of functionless structural components to systems with FD. We follow results of recent in vitro experiments with respect to competition among protocells, where a primitive type of selection begins to operate among them accompanied by a parallel evolution of their functional domain. We argue that minimal forms of FD should be established within the evolution of SM processes in protocells as they undergo a simpler selection process for stability and persistence in a prebiotic environment. We then suggest the concept of closure of constraints (CoC) as a way to identify and describe minimal FD in a far-from-equilibrium SM organization. We show in detail how the concept of CoC together with the conditions for its fulfillment can be applied in the case of a simple protocellular system that begins to couple internal chemical reactions with the formation of its membrane components. Finally, we discuss how such SM systems can evolve towards significantly higher levels of FD, suggesting this is mainly the result of functional recombination (formation of mechanisms) in the context of a modular SM organization. (shrink)

Empirical research has increasingly turned its attention to distributed cognition. Acts of remembering are embedded in a social, interactional context; cognitive labor is divided between a rememberer and external sources. The present article examines the benefits and costs associated with distributed, collaborative, conversational remembering. Further, we examine the consequences of joint acts of remembering on subsequent individual acts of remembering. Here, we focus on influences on memory through social contagion and socially shared retrieval-induced forgetting. Extending beyond a single social interaction, (...) we consider work that tracks the propagation of socially shared retrieval-induced forgetting throughout larger networks made up of several agents. Although much work has focused on how distributing cognition can augment memory, this is not the primary lesson we draw from the conversational remembering literature. Rather, mnemonic convergence between communicators is a boon to sociality. It allows the formation and maintenance of mnemonic communities, rather than expanding capacity or accuracy of memory per se. (shrink)

The article examines the process of formation and evolution of political elites, as well as changes in their functioning under the conditions of globalization and technological transformations. The aim of the work is to analyze historical approaches to the study of political elites and their evolution in the context of contemporary changes. The research is based on a comparative method that allows identifying the key trends characterizing the functioning of elites in various political systems and social contexts. The relevance of (...) the study is determined by the need to reassess classical approaches to elites, particularly in the context of the influence of global factors such as international organizations, transnational corporations, and the development of information technologies. The problem of democratic legitimacy of political elites in the conditions of postmodernism, especially in post-Soviet countries, where political elites are influenced by both internal and external factors, is highlighted. The main results of the research include the identification of key stages in the development of political elites, as well as new approaches to studying them in the context of technological and social changes. Specifically, the role of information technologies in changing political communication and the influence of new social groups on the formation of political elites are analyzed. New approaches to ensuring the democratic legitimacy of elites through feedback mechanisms between elites and voters are also considered. The practical significance of the work lies in revealing modern trends in the evolution of political elites, allowing for a deeper understanding of their role in democratic processes and political changes. It also opens new perspectives for research in political theory, particularly in the context of globalization, the influence of international institutions, and the impact of new technologies on political structures. The conclusions of the article highlight the importance of reassessing traditional approaches to the study of political elites in the context of contemporary challenges such as globalization, digitalization, and changes in the social structure of society. (shrink)

The transient cellular organelles known as migrasomes, which form during cell migration along retraction fibers, have emerged as a crutial factor in various fundamental cellular processes and pathologies. These membrane vesicles originate from local membrane swellings, encapsulate specific cytoplasmic content, and are eventually released to the extracellular environment or taken up by recipient cells. Migrasome biogenesis entails a sequential membrane remodeling process involving a complex interplay between various molecular factors such as tetraspanin proteins, and mechanical properties like membrane tension and (...) bending rigidity. In this review, we summarize recent studies exploring the mechanism of migrasome formation. We emphasize how physical forces, together with molecular factors, shape migrasome biogenesis, and detail the involvement of migrasomes in various cellular processes and pathologies. A comprehensive understanding of the exact mechanism underlying migrasome formation and the identification of key molecules involved hold promise for advancing their therapeutic and diagnostic applications. (shrink)

Pozdně středověký filosof Walter Burley (cca 1275–1344) chápal myšlení jako určitý druh změny, konkrétně jako trpnost, přičemž každý tzv. akt myšlení má podle něho tři hlavní složky: myslící intelekt, pojem a myšlenou věc. Tato studie si dává za cíl prozkoumat, jak Burley pohlížel ve vztahu k myšlení zejména na poslední dvě z těchto složek. První část se pokusí odpovědět na otázku, jakým způsobem dochází ke vzniku pojmů. Druhá část se zaměří na problematiku intencionality našeho myšlení, tj. na otázku, jakým způsobem (...) je podle Burleyho možné říci, že je naše myšlení o nějaké věci. (shrink)

A decade ago I postulated that ROS formation in mitochondria was influenced by different FADH2/NADH (F/N) ratios of catabolic substrates. Thus, fatty acid oxidation (FAO) would give higher ROS formation than glucose oxidation. Both the emergence of peroxisomes and neurons not using FAO, could be explained thus. ROS formation in NADH:ubiquinone oxidoreductase (Complex I) comes about by reverse electron transport (RET) due to high QH2 levels, and scarcity of its electron‐acceptor (Q) during FAO. The then new, unexpected, finding of an (...) FAO enzyme, ACAD9, being involved in complex I biogenesis, hinted at connections in line with the hypothesis. Recent findings about ACAD9's role in regulation of respiration fit with predictions the model makes: cementing connections between ROS production and F/N ratios. I describe how ACAD9 might be central to reversing the oxidative damage in complex I resulting from FAO. This seems to involve two distinct, but intimately connected, ACAD9 characteristics: (i) its upregulation of complex I biogenesis, and (ii) releasing FADH2, with possible conversion into FMN, the crucial prosthetic group of complex I. Also see the video abstract here: https://youtu.be/N7AT_HBNumg. (shrink)

This article explores children’s narrative identity formation and the impact of adult–child relationships on shaping a child’s narrative. The formation of identity in all children is vulnerable to a culture of ‘adultism’, wherein the authority wielded by adults can potentially subject children to abuse and neglect. Consequently, adultism has the aptitude to hinder the constructive development of a life-affirming identity in children. The primary objective of this article is to develop a childist narrative theology of praxis methodology, aimed at raising (...) consciousness and educating adults on both life-denying and life-giving ways of engaging in the process of children’s narrative identity formation.To achieve this goal, the methodology is developed by adapting Denise Ackermann’s ‘feminist theology of praxis’ to focus specifically on children. The application of feminist theory principles is deemed relevant to the social standing of children as it aligns with the broader goal of liberating oppressed groups, whether women or children. Additionally, John Wall’s work is employed to elucidate the terms ‘childist’ and ‘childism’ as interpretive frameworks. Positioned within the scientific domain of Practical Theology, this study seeks to transform conditions that impede human flourishing into opportunities for positive change.The research objectives determine that a literature review will be suitable to gather essential information for the formulation of a childist narrative theology of praxis. This review, characterised as explorative and descriptive, is conducted within the field of Practical Theology.Contribution: The significance of this study is underscored by its exploration and description of the pastoral functions of consciousness, awareness-raising, and education concerning adult–child relations. By scrutinising these pastoral functions, the emphasis is placed on the proactive, preventive, and universal aspects of pastoral care in the context of children, thereby contributing valuable insights to the discourse. (shrink)

A common misunderstanding of the selected effects theory of function is that natural selection operating over an evolutionary time scale is the only functionbestowing process in the natural world. This construal of the selected effects theory conflicts with the existence and ubiquity of neurobiological functions that are evolutionary novel, such as structures underlying reading ability. This conflict has suggested to some that, while the selected effects theory may be relevant to some areas of evolutionary biology, its relevance to neuroscience is (...) marginal. This line of reasoning, however, neglects the fact that synapses, entire neurons, and potentially groups of neurons can undergo a type of selection analogous to natural selection operating over an evolutionary time scale. In the following, I argue that neural selection should be construed, by the selected effect theorist, as a distinct type of function-bestowing process in addition to natural selection. After explicating a generalized selected effects theory of function and distinguishing it from similar attempts to extend the selected effects theory, I do four things. First, I show how it allows one to identify neural selection as a distinct function-bestowing process, in contrast to other forms of neural structure formation such as neural construction. Second, I defend the view from one major criticism, and in so doing I clarify the content of the view. Third, I examine drug addiction to show the potential relevance of neural selection to neuroscientific and psychological research. Finally, I endorse a modest pluralism of function concepts within biology. (shrink)

The inductive category formation framework, an influential set of theories of learning in psychology and artificial intelligence, is deeply flawed. In this framework a set of necessary and sufficient features is taken to define a category. Such definitions are not functionally justified, are not used by people, and are not inducible by a learning system. Inductive theories depend on having access to all and only relevant features, which is not only impossible but begs a key question in learning. The crucial (...) roles of other cognitive processes (such as explanation and credit assignment) are ignored or oversimplified. Learning necessarily involves pragmatic considerations that can only be handled by complex cognitive processes.We provide an alternative framework for learning according to which category definitions must be based on category function. The learning system invokes other cognitive processes to accomplish difficult tasks, makes inferences, analyses and decides among potential features, and specifies how and when categories are to be generated and modified. We also examine the methodological underpinnings of the two approaches and compare their motivations. (shrink)

There is a growing body of literature using the tools of syntactic models of word formation (e.g. Distributed Morphology) to provide analyses of language mixing phenomena, in particular word internal mixing. In fact, the very phenomenon of word internal mixing directly supports a syntactic approach to word formation, according to which words are structurally complex. On the basis of this view, the basic units of word formation involve roots that combine with functional elements in the syntax. The combination of (...) roots with functional elements creates words. This paper is in line with this work and investigates further the question of how word formation operates in cases of language mixing and what exactly is being mixed in mixing, i.e. words vs. roots. After reviewing literature on word internal mixing, I will discuss compound formation in language contact situations, the question being of how compounding in mixing can inform both theories of mixing and theories of word-hood. Compounding is important to answer the question of what exactly is being mixed in mixing, as language differ with respect to the units they employ for compound formation, i.e. words vs. roots and to the availability of linking elements to form compounds. Moreover, compounding is important to understand the role the two languages play in mixing, as languages differ with respect to head-ness (left or right) of their compounds. The data to be discussed will be a mixture of materials that have already been published in the literature and newly collected data and involve several mixing varieties, namely Greek-English, Greek-German, Greek-Turkish, Turkish-Norwegian, Turkish-Dutch and French-Dutch. (shrink)

Phase separation underlies the formation of biomolecular condensates. We hypothesize the cellular processes that occur within condensates shape their structural features. We use the example of transcription to discuss structure–function relationships in condensates. Various types of transcriptional condensates have been reported across the evolutionary spectrum in the cell nucleus as well as in mitochondrial and bacterial nucleoids. In vitro and in vivo observations suggest that transcriptional activity of condensates influences their supramolecular structure, which in turn affects their function. Condensate organization (...) thus becomes driven by differences in miscibility among the DNA and proteins of the transcription machinery and the RNA transcripts they generate. These considerations are in line with the notion that cellular processes shape the structural properties of condensates, leading to a dynamic, mutual interplay between structure and function in the cell. (shrink)

The dorsal and medial pallial formations of mammals, birds, and reptiles show overall functional striking similarities. Most of these similarities have been frequently considered examples of convergent evolution. However, a considerable amount of neurobiological comparative evidence suggests the presence of a common basic pattern of vertebrate forebrain organization. This common pattern can support functional conservation.

Exploring emotions, in terms of their evolutionary origin; their basic neurobiological substratum, and their functional significance in autonomous agents, we propose a model of minimal functionality of emotions. Our aim is to provide a naturalized explanation – mostly based on an interactivist model of emergent representation and appraisal theory of emotions – concerning basic aesthetic emotions in the formation of aesthetic judgment. We suggest two processes the Cognitive Variables Subsystem (CVS) which is fundamental for the accomplishment of the function (...) of heuristic learning; and Aesthetic Appraisal Subsystem (AAS) which primarily affects the elicitation of aesthetic emotional meanings. These two subsystems (CVS and AAS) are organizationally connected and affect the action readiness of the autonomous agent. More specifically, we consider the emotional outcome of these two subsystems as a functional indication that strengthens or weakens the anticipation for the resolution of the dynamic uncertainty that emerges in the particular interaction. (shrink)

Arthrogryposis multiplex congenita (AMC) is a heterogeneous syndrome where multiple joints have reduced range of motion due to contracture formation prior to birth. A common cause of AMC is reduced embryonic movement in utero. This reduction in embryonic movement can perturb molecular mechanisms and signaling pathways involved in the formation of joints during development. The absence of mechanical stimuli can impair joint cavitation, resulting in joint fusion, and ultimately eliminate function. In turn, mechanical stimuli are critical for proper joint formation (...) during development and for mitigating AMC. Studies in experimental animal models have provided a greater understanding on the molecular pathophysiology of congenital contracture formation as a consequence of embryonic immobilization. Elucidation of how the mechanical signaling environment is transduced to initiate a biological response will be necessary to gain a deeper understanding of how mechanical stimuli are intertwined in the molecular regulation of joint development. (shrink)

Introduction. The article deals with the problem of the functional status of regions in the system of economic federalism, which is associated with the high spatial heterogeneity of Russia, and explains the need to move from the model of economic fed- eralism, which combines the presence of universal institutions and institutional exceptions, to a model that takes into account the spatial diversity of ter- ritories. The purpose of the study is to substantiate the decrease in the heterogeneity of the (...) economic federalism space when moving on to a model based on macro territories - groups of regions with the same functional status. Methods. The author uses methods of a mono- graphic review, logical and statistical analysis in the context of applying a spatial approach in studying the relations of economic federalism, as well as the concept of “smart specialization” in relation to the regions of Russia to differentiate the relationship of the federal center with the territories within the same specialization. Scientific novelty of the study. The article is the first to present a methodology for determining the functional status of regions, which is the basis for the subsequent formation of a model of relations between the federal center and macro regions. Results. The author proposes methods for deter- mining the functional status of regions and calcu- lating indicators that characterize the relations of economic federalism. The first methodology, based on economic and territorial criteria, makes it possi- ble to attribute each region of Russia to a group of macro regions according to their functional status. The second method makes it possible to substanti- ate a greater asymmetry of indicators character- izing economic federalism in the country as a whole than in the context of macro territories. Conclusions. Regarding the higher stability of indicators characterizing economic federalism by groups of macro-territories than in the country as a whole, the need for a transition to a flexible model of economic federalism based on differentiated measures and specific tools to support regions in the context of their functional specializations is substantiated. (shrink)

The Drosophila embryo provides a useful model system to study the mechanisms that lead to pattern and cell diversity in the central nervous system (CNS). The Drosophila CNS, which encompasses the brain and the ventral nerve cord, develops from a bilaterally symmetrical neuroectoderm, which gives rise to neural stem cells, called neuroblasts. The structure of the embryonic ventral nerve cord is relatively simple, consisting of a sequence of repeated segmental units (neuromeres), and the mechanisms controlling the formation and specification of (...) the neuroblasts that form these neuromeres are quite well understood. Owing to the much higher complexity and hidden segmental organization of the brain, our understanding of its development is still rudimentary. Recent investigations on the expression and function of proneural genes, segmentation genes, dorsoventral‐patterning genes and a number of other genes have provided new insight into the principles of neuroblast formation and patterning during embryonic development of the fly brain. Comparisons with the same processes in the trunk help us to understand what makes the brain different from the ventral nerve cord. Several parallels in early brain patterning between the fly and the vertebrate systems have become evident. BioEssays 26:739–751, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Nucleoli are the sites of ribosome biogenesis. Transcription of the ribosomal RNA genes as well as processing and initial packaging of their transcripts with ribosomal and non‐ribosomal proteins all occur within the nucleolus in an ordered manner and under defined topological conditions. Components of the nucleolus have been localized by immunocytochemistry and their functional aspects investigated by microinjection of antibodies directed against the enzyme responsible for rDNA transcription, RNA polymerase I. The role of nascent transcripts in postmitotic formation of (...) nucleoli will be discussed. (shrink)

This paper presents two formation tracking control strategies for a combined set of single and double integrator agents with an arbitrary undirected communication topology. The first approach is based on the design of distance-based potential functions with interagent collision avoidance using local information about the distance and orientation between agents and the desired trajectory. The second approach adds signed area constraints to the desired formation specification and a control strategy that uses distance as well as area terms is designed to (...) achieve tracking convergence. Numerical simulations show the performance from both control laws. (shrink)

The relevance of the research problem lies in the necessity of an axiological approach to the formation of the personality in education and the task of strengthening the ideal image of the function. The aim of this article is studying and understanding the culture of personality formation mechanisms in relation to future specialists. The leading method of research was the theoretical analysis of philosophical and cultural approaches to the cultural formation of the personality and to the content of human culture. (...) Content analysis was based on the philosophical and cultural concepts of V. S. Bibler, M. Buber, J. G. Herder, I. Kant, L. N. Kogan, D. S. Likhachev, A. Schweitzer, M. Scheler, and others. The experiment method was the experimental realization of formation stages of the future specialist as a person of culture, which allowed revealing the positive role of cultural mechanisms in this process. The result is the stages of human culture formation as well as mechanisms for their implementation. The article may be useful for specialists of the educational sphere, social philosophers, and culturologists. (shrink)

To explore whether the generation of new protein folds could be linked to metallic cofactor recruitment, we identified the oldest examples of folds for manganese, iron, zinc, and copper proteins by analyzing their fold‐domain mapping patterns. We discovered that the generation of these folds was tightly coupled to corresponding metals. We found that the emerging order for these folds, i.e., manganese and iron protein folds appeared earlier than zinc and copper counterparts, coincides with the putative bioavailability of the corresponding metals (...) in the ancient anoxic ocean. Therefore, we conclude that metallic cofactors, like organic cofactors, play an evolutionary role in the formation of new protein folds. This link could be explained by the emergence of protein structures with novel folds that could fulfill the new protein functions introduced by the metallic cofactors. These findings not only have important implications for understanding the evolutionary mechanisms of protein architectures, but also provide a further interpretation for the evolutionary story of superoxide dismutases. (shrink)

According to a widespread view the lexicon is a kind of appendix to the grammar, whose function is to list what is unpredictable and irregular about the words of a language. In more recent studies it has been acquiring a rich internal organization of its own and is becoming recognized as the site of pervasive grammatical regularities. The particular approach to the lexicon that I will assume in this paper comes out of this trend, integrating several ideas from work on (...) both morphology and phonology in the seventies. I shall begin by outlining the central assumptions and their motivation, and proceed to a series of issues raised by this framework which,have to do with the proper formulation of word—formation processes. (shrink)

Models such as the simple pendulum, isolated populations, and perfectly rational agents, play a central role in theorising. It is now widely acknowledged that a study of scientific representation should focus on the role of such imaginary entities in scientists’ reasoning. However, the question is most of the time cast as follows: How can fictional or abstract entities represent the phenomena? In this paper, I show that this question is not well posed. First, I clarify the notion of representation, and (...) I emphasise the importance of what I call the “format” of a representation for the inferences agents can draw from it. Then, I show that the very same model can be presented under different formats, which do not enable scientists to perform the same inferences. Assuming that the main function of a representation is to allow one to draw predictions and explanations of the phenomena by reasoning with it, I conclude that imaginary models in abstracto are not used as representations: scientists always reason with formatted representations. Therefore, the problem of scientific representation does not lie in the relationship of imaginary entities with real systems. One should rather focus on the variety of the formats that are used in scientific practice. (shrink)

Bioethics is not merely a theoretical discipline but a practice as well. Indeed, bioethics is a sort of moral trade. Bioethicists serve on ethics committees, give expert testimony to courts, provide guidance for healthcare policy, and receive payment for these services. The difficulty is that their role as experts able to guide clinical choice and public policy formation is brought into question by the diversity of moral understandings regarding central moral issues at the heart of the culture wars in healthcare. (...) The disconfirmation of the expert role of bioethicists by their apparent actual role as partisans of particular moral schools and perspectives could be set aside, were there an avenue to moral consensus, a door to a common moral vision to guide this new profession of moral experts. This brief article addresses the hunger for consensus in bioethics, its impossibility with respect to the controversial issues that mark the field, and the inclination nevertheless to deny this manifest diversity by appeals to a consensus that could allow bioethicists to function as ethics experts able substantively to guide clinical choices and public policy. (shrink)

Polyhedral functions provide a model for an important class of problems that includes both linear programming and applications in data analysis. General methods for minimizing such functions using the polyhedral geometry explicitly are developed. Such methods approach a minimum by moving from extreme point to extreme point along descending edges and are described generically as simplicial. The best-known member of this class is the simplex method of linear programming, but simplicial methods have found important applications in discrete approximation and statistics. (...) The general approach considered in this text, first published in 2001, has permitted the development of finite algorithms for the rank regression problem. The key ideas are those of developing a general format for specifying the polyhedral function and the application of this to derive multiplier conditions to characterize optimality. Also considered is the application of the general approach to the development of active set algorithms for polyhedral function constrained problems and associated Lagrangian forms. (shrink)

The contest between “Lockeian liberalism” and “classical republicanism” as explanatory frameworks for the intellectual history of the American Revolution, and therefore of the present-day United States, has been one of the longest running and most distinguished in recent U.S. historiography. It also has major implications for the history of political thought in the North Atlantic Anglophone world more widely. Yet this debate was merely suspended when it was held to have ended in an ill-defined compromise. Although some U.S. historians expressed (...) doubts and qualifications, attention in U.S. historiography moved on to other themes while leaving the initial problem unsolved. This article reopens the question; it suggests that a historicization of both these two categories is now both possible and necessary, and that their supersession will advance understanding of the Revolution. It seeks to help solve this problem by the same means that the debate began: that is, by re-establishing a link between U.S. and U.K. historiographies. (shrink)

Evidence from Drosophila and also vertebrates predicts that two different sets of instructions may determine the development of the rostral and caudal parts of the body. This implies different cellular and inductive processes during gastrulation, whose genetic requirements remain to be understood. To date, four genes encoding transcription factors expressed in the presumptive vertebrate head during gastrulation have been studied at the functional level: Lim‐1, Otx‐2, HNF‐3β and goosecoid. We discuss here the potential functions of these genes in the (...) formation of rostral head as compared to posterior head and trunk, and in the light of recent fate map and expression analyses in mouse, chick, Xenopus and zebrafish. These data indicate that Lim‐1, Otx‐2 and HNF‐3β may be involved in the same genetic pathway controlling the formation of the prechordal mesendoderm, which is subsequently required for rostral head development. goosecoid may act in a parallel pathway, possibly in conjunction with other, yet unidentified, factors. (shrink)

Merrill, Booker and Fivush examine the social functions associated with transmitting intergenerational narratives to adolescents and emerging adults and how these family stories affect identity formation in early adulthood. Merrill et al. observed that the intergenerational stories of parents’ transgression and proud moments told by adolescents and emerging adults operate as a way to transmit life lessons, strengthen relationships with the parent and give insights into their parents and their self.

There is considerable evidence that the hippocampal system contributes both to (1) the temporary maintenance of memories and to (2) the processing of a particular type of memory representation. The findings on amnesia suggest that these two distinguishing features of hippocampal memory processing are orthogonal. Together with anatomical and physiological data, the neuropsychological findings support a model of cortico-hippocampal interactions in which the temporal and representational properties of hippocampal memory processing are mediated separately. We propose that neocortical association areas maintain (...) shortterm memories for specific items and events prior to hippocampal processing as well as providing the final repositories of long-term memory. The parahippocampal region supports intermediate-term storage of individual items, and the hippocampal formation itself mediates an organization of memories according to relevant relationships among items. Hippocampal-cortical interactions produce (i) strong and persistent memories for events, including their constituent elements and the relationships among them, and (ii) a capacity to express memories flexibly across a wide range of circumstances. (shrink)

I analyse the double function of models (representing the phenomena, and being a tool for calculating and predicting them) from a cognitive point of view. Taking the same approach as Ronald Giere, I nevertheless argue that he is to much committed to an abstract conception of theories and that one should give more attention to the particular formats in which models are expressed and grasped. By taking the example of Classical Mechanics, I show that a model, as an abstract entity, (...) doesn't represent anything if not presented in some particular format, be it linguistic, diagrammatic, or pictorial. This format is crucial to the relation between the two main functions of models. (shrink)

The relevance of the research is defined by the need to create a set of linguistic means, which would contribute to effective communication with the general public, and the need to study different functional-semantic categories, including appeals, for the competent formation of public opinion in the political context. The research aims to comprehend the functioning of linguistic means used as appeals in the example of political propaganda texts in the English media field. The methodology is based on the theoretical (...) study of the works of modern linguists, linguistic, structural, and communicative analysis of appeal linguistic units and contexts. The research considered the linguistic means that form the functional-semantic category of the appeal, examples of political contexts from the British and American media were presented, the functions of appeal were presented using specific examples, an idea of the communicative side of political propaganda texts and audience participation in this process was formed, emphasis was placed on different types of propaganda (white, black, gray), the following groups of appeals were characterized: imperatives (volitional and involuntary). The materials presented in this research can be used to form an idea of the functional-semantic category of appeal, the choice of linguistic means for the purpose of information promotion in the media or social networks, the study of communicative strategies in linguistics and their successful implementation, consideration of political propaganda texts, increasing efficiency when influencing the audience, further implementation of means of appeal in machine learning. (shrink)