The neurobiology and development of human morality in light of evolution -- More than genes : human inheritances and the moral sense -- The dynamic self : emotions and development -- Moral heritage 1 : engagement of the heart -- Moral heritage 2 : communal imagination -- Undercare and the stress response : early life gone wrong -- The morality that stress promotes : self protective ethics -- Shifting moral mindsets -- Culture and imagination: cooperation or competition? -- Paths (...) to moral wisdom -- Common-self wisdom: fostering a good life for self and others -- The road to human excellence and flourishing. (shrink)

Organoids and specifically human cerebral organoids (HCOs) are one of the most relevant novelties in the field of biomedical research. Grown either from embryonic or induced pluripotent stem cells, HCOs can be used as in vitro three-dimensional models, mimicking the developmental process and organization of the developing human brain. Based on that, and despite their current limitations, it cannot be assumed that they will never at any stage of development manifest some rudimentary form of consciousness. In the absence of behavioral (...) indicators of consciousness, the theoretical neurobiology of consciousness being applied to unresponsive brain-injured patients can be considered with respect to HCOs. In clinical neurology, it is difficult to discern a capacity for consciousness in unresponsive brain-injured patients who provide no behavioral indicators of consciousness. In such scenarios, a validated neurobiological theory of consciousness, which tells us what the neural mechanisms of consciousness are, could be used to identify a capacity for consciousness. Like the unresponsive patients that provide a diagnostic difficulty for neurologists, HCOs provide no behavioral indicators of consciousness. Therefore, this article discusses how three prominent neurobiological theories of consciousness apply to human cerebral organoids. From the perspective of the Temporal Circuit Hypothesis, the Global Neuronal Workspace Theory, and the Integrated Information Theory, we discuss what neuronal structures and functions might indicate that cerebral organoids have a neurobiological capacity to be conscious. (shrink)

The neurobiological mechanisms associated with affiliation, that Depue & Collins argue are a central component of extraversion are not specified in their model. In addition, only the involvement of the prefrontal cortex in extraversion is discussed, although recent evidence suggests that activity associated with additional cortical regions may be related to this trait. Finally, the assumption that neurobiological mechanisms underlie or play a causal, and therefore, more fundamental role than psychological constructs in the trait is challenged.

With a focus on receptive language, we examine the neurobiological evidence for the interdependence of receptive and expressive language processes. While we agree that there is compelling evidence for such interdependence, we suggest that Pickering & Garrod's (P&G's) account would be enhanced by considering more-specific situations in which their model does, and does not, apply.

A cartoon description of the goals of cognitive science and neuroscience might read respectively “How the mind works” and “How the brain works.” In this caricature, there would seem to be little overlap in the vocabularies employed by each domain. The cartoon cognitive scientist could speak at length about decision making and short‐term memory in a relatively self‐consistent manner, without any need to make reference to the language of neuroscience. Likewise, the cartoon neuroscientist could provide an immense body of physical (...) detail about the function of neurons, synapses, and their component parts. She could even build models about how collections of neurons work together, or even how they might have developed. (shrink)

During the postpartum period, the paternal brain suffers extensive and complex neurobiological alterations, through the experience of father–infant interactions. Although the impact of such experience in the mother has been increasingly studied over the past years, less is known about the neurobiological correlates of fatherhood—that is, the alterations in the brain and other physiological systems associated with the experience of fatherhood. With the present study, we aimed to perform a scoping review of the available literature on the genetic, neuroendocrine, and (...) brain correlates of fatherhood and identify the main gaps in the current knowledge. PubMed, Scopus, and Web of Science electronic databases were searched for eligible studies on paternal neuroplasticity during the postpartum period, over the past 15 years. Reference lists of relevant key studies and reviews were also hand-searched. The research team independently screened the identified studies based on the established inclusion criteria. Extracted data were analyzed using tables and descriptive synthesis. Among the 29 studies that met our inclusion criteria, the vast majority pertained to neuroendocrine correlates of fatherhood, followed by brain activity or connectivity, association studies of candidate genes, and brain structure correlates. Collectively, studies published during the past 15 years suggest the existence of significant endocrine and neurofunctional alterations as a result of fatherhood, as well as preliminary evidence of genetic variability accounting for individual differences during the postpartum period in fathers. No studies were so far published evaluating epigenetic mechanisms associated with the paternal brain, something that was also the focus of the current review. We highlight the need for further research that examines neuroplasticity during the experience of fatherhood and that considers both the interplay between hormones and simultaneous assessment of the different biomarkers ; data collection protocols and assessment times should also be refined. (shrink)

Aggression, violence, and cruelty are symptoms of psychiatric illness. They reflect abnormalities in the regulation of the stress and emotion circuitries. The functioning of these circuitries depends upon the interaction between genetics and environment. Abuse and neglect during infancy, as well as maternal stress and poor quality of maternal care, are some of the causes that produce these types of abnormal behavior. Research on the neurobiological bases of emotion regulation will allow the detection of the population at risk.

‘Plant neurobiology’ has emerged in recent years as a multidisciplinary endeavor carried out mainly by steady collaboration within the plant sciences. The field proposes a particular approach to the study of plant intelligence by putting forward an integrated view of plant signaling and adaptive behavior. Its objective is to account for the way plants perceive and act in a purposeful manner. But it is not only the plant sciences that constitute plant neurobiology. Resources from philosophy and cognitive science (...) are central to such an interdisciplinary project, if plant neurobiology is to maintain its target well-focused. This manifesto outlines a road map for the establishment and development of a new subject—the Philosophy of Plant Neurobiology—, a new field of research emerging at the intersection of the philosophy of cognitive science and plant neurobiology. The discipline is herewith presented, introducing challenges and novel lines of engagement with the empirical investigation, and providing an explanatory framework and guiding principles that will hopefully ease the integration of research on the quest for plant intelligence. (shrink)

Gold & Stoljar pose a dilemma for linguistics should neurobiology win out as the science of mind. The dilemma can be avoided by reestablishing linguistics as an autonomous discipline, rather than a branch of the science of mind. Independent considerations for doing this are presented.

With the aid of some Scotistic conceptual distinctions, I develop a way of meeting the apparent deterministic sway of neurobiology. I make a careful distinction between formal and material freedom. Formal freedom, the ability to will or not to will a certain state of affairs regardless of whether it can be effectuated, remains, even if our material freedom to effectuate it is hampered by neurobiological mechanisms. These conceptual findings are linked with contemporary empirical research on obsessive-compulsive disorder and the (...) possibility of volitional modulation of cerebral function. (shrink)

The rise of neuroplasticity has led to new fields of study about the relation between social inequalities and neurobiology, including investigations into the “neuroscience of poverty.” The neural phenotype of poverty proposed in recent neuroscientific research emerges out of classed, gendered, and racialized inequalities that not only affect bodies in material ways but also shape scientific understandings of difference. An intersectional, sociomaterial approach is needed to grasp the implications of neuroscientific research that aims to both produce and repair neurobiological (...) difference. Following Benjamin’s critique of the “carceral imagination” of technoscience, this article considers how such research may fix in terms of helping, or in contrast, fix by classifying and reifying, vulnerable subjects. I address the potential for biosocial determinism in linking neural phenotypes and social problems. I use an intersectional approach to consider the presence and absence of race in this body of research and explore how some methodological and conceptual framings of the “brain on poverty” mark poor and minority children for intervention in concert with neoliberal approaches to poverty. (shrink)

While parents have long received guidance on how to raise children, a relatively new element of this involves explicit references to infant brain development, drawing on brain scans and neuroscientific knowledge. Sometimes called ‘brain-based parenting’, this has been criticised from within sociological and policy circles alike. However, the engagement of parents themselves with neuroscientific concepts is far less researched. Drawing on 22 interviews with parents/carers of children (mostly aged 0–7) living in Scotland, this article examines how they account for their (...) (non-)use of concepts and understandings relating to neuroscience. Three normative tropes were salient: information about children’s processing speed, evidence about deprived Romanian orphans in the 1990s, and ideas relating to whether or not children should ‘self-settle’ when falling asleep. We interrogate how parents reflexively weigh and judge such understandings and ideas. In some cases, neuroscientific knowledge was enrolled by parents in ways that supported biologically reductionist models of childhood agency. This reductionism commonly had generative effects, enjoining new care practices and producing particular parent and infant subjectivities. Notably, parents do not uncritically adopt or accept (sometimes reductionist) neurobiological and/or psychological knowledge; rather, they reflect on whether and when it is applicable to and relevant for raising their children. Thus, our respondents draw on everyday epistemologies of parenting to negotiate brain-based understandings of infant development and behaviour, and invest meaning in these in ways that cannot be fully anticipated (or appreciated) within straightforward celebrations or critiques of the content of parenting programmes drawing on neuropsychological ideas. (shrink)

The study of morality is increasingly an interdisciplinary endeavor spanning the cognitive, social, and biological sciences. This article provides an overview and synthesis of recent work fields relevant to the scientific understanding of morality, with a focus on how moral judgment and behavior are rooted in the functioning, development, and evolution of the brain. It presents themes that have emerged from studies examining the cognitive processes involved in morality. It shows studies that directly investigate the neural substrates of morality using (...) modern brain imaging techniques. A number of brain regions and systems are identified that appear to be essential for normal moral behavior. The article focuses on two clinical conditions: lesions to the prefrontal cortex and psychopathy. Furthermore, it discusses neuroendocrinology and evolutionary neurobiology—that is relevant to understanding the development of morality and concerns evolutionary history and functions of two neuropeptides, oxytocin and vasopressin, in the mammalian brain and their effects on behavior. (shrink)

Are there neurobiological reasons why we are willing to trust other people and why ‘trust’ and moral values such as ‘care’ play a quite pivotal role in our social lives and the judgements we make, including our social interactions and judgements made in the context of schooling? In pursuing this question, this paper largely agrees with claims made by Patricia Churchland in her 2011 book Braintrust. She believes that moral values are rooted in basic brain circuitry and chemistry, which have (...) been shaped over evolutionary time. However, these naturalistic claims raise important issues, including the standard philosophical objection that they fall victim to the naturalistic and/or deontic fallacies. This paper provides an overview of the neurobiology of trust and examines some of the main objections, in the belief that recognising the neurobiological substrate of care and trust can deepen our appreciation of the role these play in education. (shrink)

Life, whatsoever it is, is a temporal flux. Everything is doomed to change often apparently beyond our awareness. My body appears totally different now, so does my mind. I have gained new attitudes and new ambitions, and a substantial number of old ones have been discarded. But, I am still the same person in an ongoing manner. Besides, recent neuroscientific and psychological evidence has shown that our conscious perception happens as a series of discrete or bounded instants—it emerges in temporally (...) scattered, gappy, and discrete forms. But, if it is so, how does the brain persevere our self-continuity (or continuity of identity) in this gappy setting? How is it possible that despite moment-to-moment changes in my appearance and mind, I am still feeling that I am that person? How can we tackle with this second by second gap and resurrection in our existence which leads to a foundation of wholeness and continuity of ourself? How is continuity of self (collective set of our connected experiences in the vessel of time) that results in a feeling that one’s life has purpose and meaning preserved? To answer these questions, the problem has been comprehended from a philosophical, psychological, and neuroscientific perspective. I realize that first and foremost fact lies in the temporal nature of identity. Having equipped with these thoughts, in this article, it is hypothesized that according to two principles (the principle of reafference or corollary discharge and the principle of a time theory) self-continuity is maintained. It is supposed that there should be a precise temporal integration mechanism in the CNS with the outside world that provides us this smooth, ungappy flow of theSelf. However, we are often taken for granted the importance of self-continuity, but it can be challenged by life transitions such as entering adulthood, retirement, senility, emigration, and societal changes such as immigration, globalization, and in much unfortunate and extreme cases of mental illnesses such as schizophrenia. (shrink)

Neurobiological models of language need a level of analysis that can account for the typical range of language phenomena. Because linguistically motivated models have been successful in explaining numerous language properties, it is premature to dismiss them as biologically irrelevant. Models attempting to unify neurobiology and linguistics need to be sensitive to both sources of evidence.

Backgrounds: Transcranial direct current stimulation is a non-invasive brain stimulation technique for the treatment of several psychiatric disorders, e.g., mood disorders and schizophrenia. Therapeutic effects of tDCS are suggested to be produced by bi-directional changes in cortical activities, i.e., increased/decreased cortical excitability via anodal/cathodal stimulation. Although tDCS provides a promising approach for the treatment of psychiatric disorders, its neurobiological mechanisms remain to be explored.Objectives: To review recent findings from neurophysiological, chemical, and brain-network studies, and consider how tDCS ameliorates psychiatric conditions.Findings: (...) Enhancement of excitatory synaptic transmissions through anodal tDCS stimulation is likely to facilitate glutamate transmission and suppress gamma-aminobutyric acid transmission in the cortex. On the other hand, it positively or negatively modulates the activities of dopamine, serotonin, and acetylcholine transmissions in the central nervous system. These neural events by tDCS may change the balance between excitatory and inhibitory inputs. Specifically, multi-session tDCS is thought to promote/regulate information processing efficiency in the cerebral cortical circuit, which induces long-term potentiation by synthesizing various proteins.Conclusions: This review will help understand putative mechanisms underlying the clinical benefits of tDCS from the perspective of neurotransmitters, network dynamics, intracellular events, and related modalities of the brain function. (shrink)

Neurons repeatedly exposed to similar perceptual experiences fire together and wire together to form ‘meaning kernels’ of concepts. Pulvermueller argues that abstract concepts may be devoid of meaning kernels, because the perceptual experiences that construct abstract concepts are subject to great variation and share few common features. Abstract concept are therefore grounded in the brain through features that belong to ‘meaning halos’, rather than to ‘meaning kernels’.

We critique five points that impede the target article's far-reaching efforts toward formulating a neurobiological theory of language. Neurolinguistics amounts to no more than neurology in linguistics in this account, because it assumes “perceptual representational isomorphism,” processing autonomy and “meaning,” thereby aiming primarily at justifying modular concepts in terms of associative principles.

In this paper, we take a meta-theoretical stance and aim to compare and assess two conceptual frameworks that endeavor to explain phenomenal experience. In particular, we compare Feinberg & Mallatt’s Neurobiological Naturalism (NN) and Tononi’s and colleagues' Integrated Information Theory (IIT), given that the former pointed out some similarities between the two theories (Feinberg & Mallatt 2016c-d). To probe their similarity, we first give a general introduction to both frameworks. Next, we expound a ground plan for carrying out our analysis. (...) We move on to articulate a philosophical profile of NN and IIT, addressing their ontological commitments and epistemological foundations. Finally, we compare the two point-by-point, also discussing how they stand on the issue of artificial consciousness. (shrink)

To explore the neural mechanisms engaged by the perception of action with the intent to imitate, positron emission tomographic activation studies were performed in healthy human subjects. We discuss the results in light of the framework proposed by Byrne & Russon, especially the distinction between mechanisms subserving action-level and program-level imitation.

With the discovery of the possibility of neurobiologically and genetically interpreting the actions of a moral agent, the issue of the status of morality returned to applied ethics with renewed vigor. The biotechnological understanding of society as a whole has been a long-running trend in technoscience and can be considered as a transgression of (bio-) technologies into the sphere of ethics. The essence of the conflict between bio-conservative ethics and techno-oriented utilitarians lies in the plane of violation of the fundamental (...) value of autonomy (J. Harris) and the destruction of the principle of solidarity and equality (A. Buchanan). Supporters of techno-determined moral action as conditions for the expansion of technology into the field of morality put forward the predictability of consequences as a condition for the legitimation of technology (N. Agar), the need to prevent maximum harm (J. Savulescu, I. Persson) and the right to an autonomous choice of a biotechnological regulation of morality (V. Rakic). At the center of the discussion is the problem of the good, for the practical solution of which moral outsourcing mechanisms have already been envisaged (e.g. the service of triage officers in disaster medicine, extended informed consent for biobanks). The article compares moral action as a choice, moral action as a coercion and moral action as outsourcing, and determines the place of the neurobiological interpretation of good and moral action within the theoretical understanding of a moral act in applied ethics. In particular, the role of a cognitive act in the context of a moral act is examined, the problem of deferred risks and their regulation when making a moral decision is analyzed. It is concluded that one of the manifestations of the impact of (bio) technology on a person is the complicacy and transformation of moral decision-making models, in connection with which the universal methods that formulate a moral action (moral act as a choice) can be supplemented by new models that constitute good and moral action. (shrink)

Sunstein is right that poorly informed heuristics can influence moral judgment. His case could be strengthened by tightening neurobiologically plausible working definitions regarding what a heuristic is, considering a background moral theory that has more strength in wide reflective equilibrium than “weak consequentialism,” and systematically examining what naturalized virtue theory has to say about the role of heuristics in moral reasoning.

Recent investigations have explored how large-scale systems in the brain operate in the processes of retrieving knowledge for words and concepts. Much of the crucial evidence derives from lesion studies, because word retrieval and concept retrieval can be clearly dissociated in brain-damaged individuals. We discuss these findings from the perspective of our neurobiological framework, which is cited in Pulvermüller's target article.

The projection of conscious content is a central feature of Max Velmans' theory of consciousness, implying that conscious experiences are built within a conversation of minds and worlds in which they form a 'reflexive' unity – as stated in his reflexive monism theory. What are the neurobiological structures and functions that underpin the experience of conscious contents being located in a spatio-temporal frame outside the nervous system that instantiates them? In this paper I offer informed speculation about these neurobiological structures (...) on the basis of the concept of projection within the psychophysical 'egocentric space', having the central nervous system at the origin of coordinates and the interface with the environment as the horizon. The reasoning is based on the work of several neuroscientists on feedback signals from the motor to sensory neuron systems, building a picture of how they support the projective process. I also call attention to the integrative role of glial cells in the generation of localized sensations and other conscious contents. (shrink)