A tree‐like hierarchical branching structure is present in many biological systems, such as the kidney, lung, mammary gland, and blood vessels. Most of these organs form through branching morphogenesis, where outward growth results in smaller and smaller branches. However, the blood vasculature is unique in that it exists as two trees (arterial and venous) connected at their tips. Obtaining this organization might therefore require unique developmental mechanisms. As reviewed here, recent data indicate that arterial trees often form in reverse order. (...) Accordingly, initial arterial endothelial cell differentiation occurs outside of arterial vessels. These pre‐artery cells then build trees by following a migratory path from smaller into larger arteries, a process guided by the forces imparted by blood flow. Thus, in comparison to other branched organs, arteries can obtain their structure through inward growth and coalescence. Here, new information on the underlying mechanisms is discussed, and how defects can lead to pathologies, such as hypoplastic arteries and arteriovenous malformations. -/- . (shrink)

The COVID-19 pandemic has witnessed an increase and amplification of anti-Asian racism and violence across the globe. Stop AAPI Hate1 in the United States and the COVID-19 Racism Incident Report2 i...

The establishment of distinct cellular identities was pivotal during the evolution of Metazoa, enabling the emergence of an array of specialized tissues with different functions. In most animals including vertebrates, cell specialization occurs in response to a combination of intrinsic (e.g., cellular ontogeny) and extrinsic (e.g., local environment) factors that drive the acquisition of unique characteristics at the single‐cell level. The first functional organ system to form in vertebrates is the cardiovascular system, which is lined by a network of endothelial (...) cells whose organ‐specific characteristics have long been recognized. Recent genetic analyses at the single‐cell level have revealed that heterogeneity exists not only at the organ level but also between neighboring endothelial cells. Thus, how endothelial heterogeneity is established has become a key question in vascular biology. Drawing upon evidence from multiple organ systems, here we will discuss the role that lineage history may play in establishing endothelial heterogeneity. (shrink)

The purpose of this paper is to use the Social Cognitive Theory and its moral disengagement framework to emphasize the need for stock-type horse associations to minimize potential and actual threats to their legitimacy in an effort to maintain and strengthen self-regulating governance, specifically relating to the occurrence of inhumane treatment to horses. Despite having stated rules within their handbooks, the actions of leading stock-type associations in response to reports of inhumane treatment provide evidence of their ability to self-regulate. (...) The authors recommend the following actions: develop a commonly understood and accepted definition of inhumane treatment; publicly communicate with stakeholders violation enforcement efforts of inhumane treatment rules; increase efforts to educate stakeholders on the reasons why certain training techniques or methods are inhumane and harmful to the horse; ensure all actions taken are proactively focused on shaping future behaviors, and critically review more cases of inhumane treatment and the industry’s response. (shrink)

Lynch et al., in an article in this issue, argue that an entire microbiome is rarely, if ever, the right target of analysis for causal explanations in microbiome research. They argue, using interventionist criteria of proportionality, specificity and stability, for restricting causal claims to the smallest subset of microbes—a causal core—that generate the effect of interest. A further question remains: what kind of interactions generate a consortium of microbes that can operate as causal agents in this manner? Here I introduce (...) two possible kinds of such consortia: ‘trojan horses’ and ‘syntrophic’ individuals. (shrink)

Though animal ethics in sport obviously applies most urgently to cases of animals at mortal risk (e.g., hunting and bullfighting) or vulnerable to various types of abuse (e.g., doping and harmful training practices), less obvious domains bear scrutiny as well. Here I examine whether we can strictly take not just riders but horses to be players in equine sports. There is an apparent tension in the concept of equestrian prowess, a peculiar blend of skills and attitudes, between regarding (...) class='Hi'>horses as subjects of persuasion or collaboration and treating them as objects of control. As our understanding of animal cognition and behaviour continues to improve, it becomes increasingly clear that animal intelligence and agential capacities are far greater than we formerly presumed. In this light, using Suits’s theory of games, I argue that horses are game players that sometimes consent (or assent) and sometimes refuse to play equine sports. Drawing on recent accounts of horse-rider partnership and on my own equestrian background, I conclude by sketching a utopian vision of what equine sports could be. (shrink)

(1992). Horse race: John William Dawson, Charles Lyell, and the competition over the Edinburgh natural history chair in 1854–1855. Annals of Science: Vol. 49, No. 5, pp. 461-477.

In the videogame Trojan Horse, players are given the task of defending the ancient city of Troy from invading Achaeans, who attack the city both at ground level and by scaling the walls by means of their massive wooden horse. The frontal assault depicted in the game thus bears only passing resemblance to the traditional tale, in which wily Odysseus and a select band of warriors enter and ultimately capture the city by secreting themselves inside the horse. Much work has (...) been done in the genre of what might be called vegan apologetics, the explicit defence of veganism against the attacks of its opponents. This essay, however, considers an alternative, complementary tactic, which eschews confrontation in favour of a less direct stratagem. (shrink)

The horse was essential to past human societies but became a recreational animal during the twentieth century as the world became increasingly mechanized. As the author reviews here, recent studies of ancient genomes have revisited the understanding of horse domestication, from the very early stages to the most modern developments. They have uncovered several extinct lineages roaming the far ends of Eurasia some 4000 years ago. They have shown that the domestic horse has been significantly reshaped during the last millennium (...) and experienced a sharp decline in genetic diversity within the last two centuries. At a time when no truly wild horses exist any longer, this calls for enhanced conservation in all endangered populations. These include the Przewalski's horse native to Mongolia, and the many local breeds side‐lined by the modern agenda, but yet representing the living heritage of over five millennia of horse breeding. (shrink)

Language skirts the somatic fringes of the moment, particularly in practices where the powers of human speech and writing seem nullified. Horse training is one such practice. We tell stories of horse training that sensitize us and bring us close to creatures whose movements, resonating with our own, connect us to a prelinguistic, animate world. In so doing, we bridge the gap between the reflective detachment of our customary, wordy practices and the wordlessness of pre-reflective animality. Yet a phenomenological discursiveness (...) shows us how vital moments of “becoming animal” can be consciously and linguistically sustained. “Becoming horse in the duration of the moment” addresses the corporeally-charged consciousness of being with horses on the ground and in the saddle. This paper describes a relationality and temporality that, though mostly wordless in strictly human terms, speaks a sophisticated language of moment resonance. In so doing, it contests the dualisms of verbal and non-verbal discourses, the separation of humans and other animals, and the divisions that keep somaticity on the fringes of consciousness. It responds to the ecological challenge to get beyond the linguistic appropriation of the other, human speciesism and anthropomorphic projections, in order to discern the kinesthetic and energetic expressivities of connecting with other beings and with the elements of animate existence. Horse training provides a case for “living” in the somatic fullness of the moment. (shrink)

As one example of how modern Western societies are increasingly obliged to reconcile questions of civility and justice against common, indeed revered, practices that compromise nonhuman animals, this paper examines the recent history of public debate regarding the use of animals for public entertainment in the Canadian West. Using media-based public dialogue regarding the annual Calgary Stampede as a case study and couching the high-risk use of horses in the sociological language of “sports-related violence,” the paper explores the various (...) arguments for and against the continued use of horses at the self-proclaimed “Greatest Outdoor Show on Earth” despite unambiguous evidence of the harm that regularly, and sometimes graphically, occurs. (shrink)

Horse racing has begun to enter an economic decline in many countries, notably represented by a decline in revenues in betting volumes. A number of reasons may be attributed to this: the success of...

This article examines and assesses Bernard Hodgson’s critique of the Neoclassical concept of rationality and its place in the literature. It is argued that Hodgson’s Trojan horse critique is superior to the others because it addresses the role of empiricist epistemology in reducing reason to instrumental rationality and consequent disappearance of the human subject of political economy. The second phase of the empiricist level of analysis reintroduces the capacities for ethical deliberation, self-determination, and the socio-historical conditions and institutional setting of (...) the economic agent. Because Hodgson’s solutions presuppose empiricist terrain, they are arbitrary. This occurs because the fundamental problem of Neoclassical rationality is its ontology. Yet by introducing the human subject into economic theory, Hodgson’s solutions move onto an ontological terrain adequate for economic analysis of human subjects. (shrink)

In this paper I argue that Frege’s concept horse paradox is not easily avoided. I do so without appealing to Wright’s Reference Principle. I then use this result to show that Hale and Wright’s recent attempts to avoid this paradox by rejecting or otherwise defanging the Reference Principle are unsuccessful.

Frege’s rejection of singular reference to concepts is centrally implicated in his notorious paradox of the concept horse. I distinguish a number of claims in which that rejection might consist and detail the dialectical difficulties confronting the defense of several such claims. Arguably the least problematic such claim—that it is simply nonsense to say that a concept can be referred to with a singular term—has recently received a novel defense due to Robert Trueman. I set out Trueman’s argument for this (...) claim, identifying and remedying some omissions and errors of formulation therein. I then develop a response to the argument by showing, pace Trueman, that it is possible—and how it is possible—to express identities between objects and concepts. (shrink)

Abstract Kung?sun Lung's thesis on ?White Horse [is] not Horse? has been solved by A. C. Graham on the basis of a part/whole logic and by Chad Hansen on that and a ?mass?noun? hypothesis. We present it as a case of reducing White Horse to its two most telling marks and then, on the basis of the good Sense (instead of Reference) in a Negative Logic?the pragmatics of locating X as the remainder left over when all non?X's have been removed?show (...) how a stable hand, receiving an order for White Horse would scan first for Horse by removing all non?horse shapes and then for White by removing all colours except White. This way we can prove how indeed ?A request for White Horse cannot be satisfied by Black and Brown that fills an order for Horse... (because) to exclude some colour [in the second scan] is not the same as to exclude yet no colour [in the first scan].? No part/whole or mass?sum is presumed. The whole discussion is set in the context of shifting criteria for judging name from Confucius to Hsun?tzu. (shrink)

This paper provides a new solution to the concept horse paradox. Frege argued no name co-refers with a predicate because no name can be inter-substituted with a predicate. This led Frege to embrace the paradox of the concept horse. But Frege got it wrong because predicates are impurely referring expressions and we shouldn’t expect impurely referring expressions to be intersubstitutable even if they co-refer, because the contexts in which they occur are sensitive to the extra information they carry about their (...) referents. (shrink)

In this article I argue against Chad Hansen’s version of the “White Horse Dialogue” (Baimalun) of Gongsun Longzi as intelligible through writings of the later Moists. Hansen regards the Baimalun as an attempt to demonstrate how the compound baima, “white horse,” is correctly analyzed in one of the Moist ways of analyzing compound term semantics but not the other. I present an alternative reading in which the Baimalun arguments point out, via reductio, the failure of either Moist analysis; in particular (...) they point out how neither analysis accounts for ordinary, acceptable inferences like “There is a white horse; therefore there is a horse.” At issue for Gongsun Longzi is a fundamental problem with atomic terms: none of them seems capable of referring to a particular, “stand-alone” individual. (shrink)

This is a study of the development of student agency from a gender perspective in a Finnish classroom. The data originates from an ethnographic research project in an elementary school classroom engaging in a play pedagogy project called a “playworld.” The article has two purposes. The first is to examine the potential of imagination and improvised fantasy play in the development of agency. The second is to investigate the role of gender as a social category in shaping the students’ possibilities (...) for agency in the play pedagogical setting. The creative use of imagination is at the center of the playworld pedagogy. However, it has rarely been studied in relation to the potentially uneven or stereotypic consequences of cultural tools, symbols, and categories. The analytical focus is on the gender-related categorization of a ‘horse girl’ and the role it played in the development of the agency of two seven-year-old girls as they participated in the playworld. I have used a multidisciplinary analytical framework to sensitize myself to the data. In the article I combine Vygotsky’s ideas of double stimulation, Sacks’ categorization analysis and, Holzkamp’s concept of action potence . The results show that the playworld pedagogy that explicitly aimed at developing children’s agency and collaboration was strongly gender categorized and thus was constraining for the girls in this study. On the other hand, the girls’ unplanned fantasy play, which took place on the sidelines of the classroom activity, contained important agentive elements. It gave the girls a sense of agency crucial to their enactment of agency in the wider playworld setting. It is argued that the girls were able to become agentive players in the activity through questioning the gendered categories openly in the classroom. (shrink)

Upon the release of Brokeback Mountain, the conservative film critic, Michael Medved, in a television interview, predicted that a gay western – or maybe he called it a gay cowboy movie – would not attract an audience, presumably on grounds that the intersection of the audience for gay movies and the audience for westerns would yield, as the logicians say, the null set. Medved was proven wrong, as Brokeback, which cost $14 million to produce, went on to earn $83 million (...) on first release in the United States (plus $95 million abroad). But Medved was also wrong in his initial description. Although rodeos, horses, and cattle percolate through the film, Brokeback does not fit the classic American Western movie storyline. From the films of William S. Hart and Tom Mix down through Gary Cooper in The Virginian and High Noon, John Wayne in Stagecoach, Alan Ladd in Shane, and Clint Eastwood in The Unforgiven, the Western hero wears a cowboy hat, rides a horse, and carries a gun. His ultimate goal is to save the good folks from the bad guys, and he always succeeds. Brokeback, of course, is not like these films at all. Jack Twist and Ennis Del Mar are not engaged in the Westerner’s project of vanquishing evil. In fact, Ang Lee’s film more closely resembles the stories of such star-crossed lovers as Abelard and Heloise, Tristan and Isolde, and Romeo and Juliet. More interestingly, it fits a narrative pattern common in the nineteenth-century operas of Bellini, Donizetti, Verdi, and Wagner. In.. (shrink)

There is a burgeoning corner of the philosophical literature on germline gene editing (GGE) about whether GGE is “person-affecting” or “identify-affecting.” The distinction between actions that aff...

Berkeley’s immaterialism depends on a correct answer to the question whether, in experiencing what is described as hearing a coach in the street, a perceiving subject really only immediately perceives certain sounds, auditory sensible ideas that are partly constitutive of the carriage as a sensible thing, or in immediately experiencing the associated sounds immediately perceives the carriage itself. Much hangs on how the word ‘perceive’ is thought to be propery used, and how wide and deeply penetrating its intentionality is conceived (...) to be, whether we can perceive sensible things like carriages or only carriagey sensible ideas. There are problems with answers on both sides of the inevitable opposition, and hence a number of related dilemmas running through and sometimes across one another in this part of Berkeley’s philosophy. The coach and horse argument in Berkeley’s Three Dialogues affirms radical phenomenalism as the strictly philosophically correct thesis that all perceiving is immediately perceiving sensible ideas, to the exclusion of sensible things as total congeries of sensible ideas. Relevant passages in Berkeley’s text set in an interpretative framework and proper context of philosophical exchange between Berkeley’s dialogue partners reveals the carriage argument as more subtle in structure and more powerfully supportive of a radical idealist phenomenalism in Berkeley’s empiricist epistemology than is exemplified elsewhere in Three Dialogues. (shrink)

This paper explores how horses are represented in the discourses of "natural horsemanship" , an approach to training and handling horses that advocates see as better than traditional methods. In speaking about their horses, NH enthusiasts move between two registers: On one hand, they use a quasi-scientific narrative, relying on terms and ideas drawn from ethology, to explain the instinctive behavior of horses. Within this mode of narrative, the horse is "other" and must be understood through (...) the human learning to communicate and through appropriate training. On the other hand, NH enthusiasts—like many horse owners—seek to emphasize partnership. In this type of discourse, people portray their horses as almost human. The tensions between these two ways of talking about horses reflect contradictory ideas about control versus freedom in relating to horses, especially as related to emotions expressed by caregivers about their relationships with horses. (shrink)

This paper discusses some remarks Kaplan made in ‘Bob and Carol and Ted and Alice’ concerning empty names. I show how his objections to a particular view involving descriptions derived from Ramsification can be avoided by a nearby alternative framed in terms of discourse reference. I offer a treatment of empty names as variables carrying presuppositions concerning unique occupants of roles, or sets of properties, determined by the originating discourse.

Our long-standing hypothesis has been that feedforward information flow is sufficient for speech perception, reading, and sentence (syntactic and semantic) processing more generally. We are encouraged by the target article's argument for the same hypothesis, but caution that more precise quantitative predictions will be necessary to advance the field.

This contribution is about semiology and art history. More specifically, it argues against the frequent claims that art history ought to take much more notice of semiology than it has tended to do so far. The argument against these claims is simple and basic: art history deals largely with images, and semiology does not — it has, in fact, little to say about them.Semiology has recently been presented as a “supra-disciplinary” theory” that, although in practice most often applied to written (...) texts, could equally well be applied to the art of painting. It has been considered merely a “historical accident” that semiotics was developed primarily “in conjunction with literary texts”. I do not think this is so. Semiology (or semiotics) not only has a strong anti-iconical bias, this bias was in fact one of its principles from the very beginning.Furthermore, the so-called “supra-disciplinary theory” of semiotics (in the form advocated for the humanities) is based upon specific views of language, signification and meaning, and these are not as evident as they are often made out to be — not even with regard to language itself. In particular the overriding importance attached to the role of “arbitrariness” within sign systems is questionable.In any case images are indeed in a class of their own, and without the acknowledgement of what is typical about them, it is hard to make much sense of either their use or construction — let alone of the history of art. (shrink)

Distributive justice is the paradigmatic philosophical position regarding matters of contemporary justice. Distributive justice often focuses on issues of resource allocation and/or welfare allocation. In this essay I argue that this paradigm has ‘the cart before the horse’ because issues of productive justice—logically and normatively—are of antecedent concern. The way in which people work, and the nature of the productive workplace, conditions the conceptual and concrete possibilities of obtaining distributive justice, thus productive justice is of antecedent concern for realizing justice (...) overall. Contra Rawls, it is productive justice which in the ‘first instance’ ought to provide ‘a conception of social justice’. But even if this claim is hasty, it remains the case that distributive justice theorists have not allowed productive justice into their considered judgments and thus are operating with something short of serious reflective equilibrium. Productive justice therefore deserves unprecedented analysis and philosophical consideration. (shrink)

The object of the study is the image of an emaciated horse in Chinese culture. It represents a real artistic phenomenon, serving as a reflection of the self-perception of authors who are faced with a sense of alienation and injustice, isolation from society, and the inability to get help. The subject is the image of thin horses in the painting by the Italian Catholic artist Giuseppe Castiglione, who arrived in China for missionary work. His stay in China coincided with (...) a period of strong rejection of Catholicism in the country. The article pays special attention to the use of the image of a skinny horse as a metaphor, a veiled way to convey the subjective perception of the situation at the Qing court. The emaciated animal is considered by the author both as a visual phenomenon enriching the variety of characters in the paintings, and as a reflection of philosophical reasoning about the relationship between man and society. Formal-stylistic and structural-semantic types of analysis became the leading research methods. With their help, the author studied the compositional structure, coloristic features and semantic aspects of the fragments of the painting analyzed in the article by Giuseppe Castiglione. The scientific novelty of the research is due to the small number of thematic publications in Russian art history. One can find scientific works on Chinese culture devoted either to the image of horses in general, or taking into account exclusively the work of Giuseppe Castiglione. Combining the analysis of the image of an exhausted horse as such and the analysis of the painting "A Hundred Horses", the author closed the gap in a highly specialized art criticism problem, arguing the theses put forward with biographical data about the artist and historical references. New information deepens knowledge about the cultural characteristics of the Chinese people and can serve as an aid for further research by art historians. The author comes to several conclusions. First, he discovers the specific philosophical significance of the image of an emaciated horse. Secondly, it notes its stability in various creative figures. Thirdly, he reveals the peculiarities of the fate of Giuseppe Castiglione using the example of "Hundreds of Horses". (shrink)

The Asvaraja story relates the adventures of a caravan of merchants shipwrecked on an island of demonesses and rescued by a flying horse, the asvaraja, ‘king of horses’. The Simhala story continues this narrative to include the chief merchant, Simhala, being followed home by a demoness, who tries to get him back before seducing and eating the king. Simhala is crowned king and invades the island. Each story has many versions, both Mahayana and non-Mahayana. This paper examines five key (...) versions: birth story with ‘ocean of samsara’ metaphor; political and quasi-historical narrative of the invasion of Sri Lanka by the Sinhalese; warning that ‘all women are demonesses’; glorifi cation of the bodhisattva Avalokitesvara; and Newar warning of the dangers of travelling to Tibet. Each version reveals some of the issues that its community is preoccupied with. (shrink)

The present article proposes a new take on the realist interpretation of the _Gōngsūn Lóngzǐ,_ which theorizes the existence of a theory of universals in the text. Building on the “two-level ontology” hypothesis, it argues that the _Gōngsūn Lóngz_ǐ elaborates a complex category theory that should rather be interpreted in terms of concrete rather than abstract universals. Through the analysis of some of the most famous arguments debated in the text, such as the “white horse” and the “hard and white (...) stone,” among others, the article delineates a distinction between what seems to be two different types of categories, “incidental qualities” and “structural qualities.” Through this analysis, the article aims to show how this interpretation can help disambiguate the meaning of certain obscure passages, and to identify an underlying line of reasoning that runs like a thread through the text, despite its complex textual history. (shrink)

Because Plains Indians, as well as some other groups of Native Americans, generally perceived people and animals as closely related, medical therapies and preventive regimes in human and veterinary medical practice often overlapped. The sense of partnership that mounted people shared with their horses dictated that it was appropriate for certain equine remedies to be similar to those used for themselves. Horses, as well as people, could possess useful knowledge in the realm of curing. Reciprocity between humankind and (...) nature was expressed by the interactive healing powers of people and horses as well as by recorded examples of the connection that existed between human and equine health maintenance measures and medical procedures. (shrink)

The ethics of using genetic engineering to enhance athletic performance has been a recurring topic in the sport philosophy and bioethics literature. In this article, we analyze the ethics of cloning horses for polo competition. In doing so, we critically examine the arguments most commonly advanced to justify this practice. In the process, we raise concerns about cloning horses for polo competition, centering on normative aspects pertaining to sport ethics usually neglected by defenders of cloning. In particular, we (...) focus on how this practice could have a detrimental impact on the central skills of polo, and how it unjustly creates an uneven playing field. We suggest that the polo community would benefit from critically considering the ethical quandaries posed by the practice of cloning horses for polo competition. (shrink)

I offer an analysis of the sentence "the concept horse is a concept". It will be argued that the grammatical subject of this sentence, "the concept horse", indeed refers to a concept, and not to an object, as Frege once held. The argument is based on a criterion of proper-namehood according to which an expression is a proper name if it is so rendered in Frege's ideography. The predicate "is a concept", on the other hand, should not be thought of (...) as referring to a function. It will be argued that the analysis of sentences of the form "C is a concept" requires the introduction of a new form of statement. Such statements are not to be thought of as having function--argument form, but rather the structure subject--copula--predicate. (shrink)

Inspiring and empowering, this journey behind the scenes of humanity's greatest creations reveals the surprising way we make something new. What do Thomas Jefferson's ice cream recipe, Coca Cola, and Chanel No. 5 have in common? They all depended on a nineteenth-century African boy who, with a single pinch, solved one of nature's great riddles and gave birth to the multimillion-dollar vanilla industry. Kevin Ashton opens his book with the fascinating story of the young slave who launched a flavor revolution (...) to show that invention and creation come in unexpected shapes and sizes. From the crystallographer's laboratory where the secrets of DNA were first revealed by a long-forgotten woman, to the electromagnetic chamber where the stealth bomber was born on a 25-cent bet, Ashton weaves tales of humanity's greatest creations to unpack the surprising true process of discovery. Drawing on the Amish and the iPhone, Kandinsky and cans of Coke, Lockheed, South Park, and the Wright brothers--who set out to "fly a horse"--he showcases the seemingly unremarkable individuals, gradual steps, multiple failures, and countless ordinary--and usually uncredited--acts that led to our most astounding breakthroughs. Creators, he shows, apply everyday, ordinary thinking that we are all capable of in particular ways, taking thousands of small steps, working in an endless loop of problem and solution. He explores why innovators meet resistance and how they overcome it, why most organizations stifle creative people, and how the most creative organizations work. In a passionate and profound narrative that amazes and inspires, Ashton's book sheds new light on how "new" comes to be. (shrink)