Abstract
This chapter presents and defends key ethical principles for the use of animals in the scientific study of human disease. The discussion focuses on the roles that general ethical principles, and sets or collections of such principles, play in this research. Because of the importance and wide applicability of general principles in ethical assessment of human health-related animal research, the chapter is able to provide a useful overview of ethical issues raised by this research. The chapter discusses the roles that sets of general principles play in providing ethical guidance to those involved in this research, and in expressing their central obligations and ideals. The chapter identifies the ethical core of human health-related animal research: the basic general ethical principles that govern its use and care of animals.