Abstract

The development of genetically modified model organisms for the study of human diseases may be beneficial in the research of causes and possible treatments, but there are serious concerns about animal welfare and safety issues that must be addressed. Guidelines and regulations for the use and care of genetically modified organisms are needed to improve their welfare. The appropriateness of genetically modified organisms suitable for modeling human disease should be evaluated, as well as an analysis of benefits versus harms. In establishing biotechnology using animal models for the study of human disease is important to listen to the public concerns of civilians so that research is subjected to public scrutiny.