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Why the missing heritability might not be in the DNA
Bioessays 39 (7):1700067 (2017)
Abstract
Graphical AbstractThere are four major hypotheses (H1, H2, H3, and H4) as to the source of missing heritability. We propose that estimates obtained from GWAS underestimate heritability by not taking into account non-DNA (epigenetic) sources of heritability. Taking those factors into account (H4) should result in increased heritability estimates.Author Profiles
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Citations of this work
Causation and Single Nucleotide Polymorphism Heritability.Pierrick Bourrat - 2020 - Philosophy of Science 87 (5):1073-1083.
Dissolving the Missing Heritability Problem.Pierrick Bourrat & Qiaoying Lu - 2017 - Philosophy of Science 84 (5):1055-1067.
Across the great divide: pluralism and the hunt for missing heritability.Lucas J. Matthews & Eric Turkheimer - 2019 - Synthese 198 (3):2297-2311.
Half a century later and we're back where we started: How the problem of locality turned in to the problem of portability.Lucas J. Matthews - 2022 - Studies in History and Philosophy of Science Part A 91 (C):1-9.
Unifying heritability in evolutionary theory.Pierrick Bourrat - 2022 - Studies in History and Philosophy of Science Part A 91 (C):201-210.
References found in this work
The Evolutionary Gene and the Extended Evolutionary Synthesis.Qiaoying Lu & Pierrick Bourrat - 2017 - British Journal for the Philosophy of Science 69 (3):775-800.
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