Results for 'ubiquitinome'

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    How ubiquitination regulates the TGF‐β signalling pathway: New insights and new players.Surinder M. Soond & Andrew Chantry - 2011 - Bioessays 33 (10):749-758.
    Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases. One pathway that has received much attention in this context is transforming growth factor‐beta (TGF‐β) signalling, particularly during the regulation of epithelial‐mesenchymal transition (EMT) and tumour progression. While E3‐ubiquitin ligases offer themselves as potential therapeutic targets, much remains to be unveiled regarding mechanisms that culminate in their (...)
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