As life extended into eukaryota, a great host of strategies emerged in the pursuit of cellular life. Some cells have been successful in solitude, some moved into cooperatives (i.e., multicellular organisms), but one additional strategy emerged. Throughout eukaryotes, many of the diverse multicellular cooperatives took life in partnership one step further. These cells came together and lost their singularity in the expanse of syncytial life. Recently in our search for this elusive “how”, we discovered the intriguing peculiarity of a nuclear, (...) RNA‐binding protein living a second life as a fusion manager at the surface of developing osteoclasts, ushering them into syncytia 1. It is from here that we will develop several thoughts about the advantages of multinucleated cells and discuss how these fusing cells pass through several hallmarks of cell death. We will propose that cell fusion shares much with cell death because cell fusion is a death of sorts for the cells that undergo it – a death of the life that was and the beginning of new life in a community without borders. (shrink)

A brain model based on glial-neuronal interactions is proposed. Glial-neuronal synaptic units are interpreted as elementary reflection mechanisms, called proemial synapses. In glial networks (syncytia), cyclic intentional programs are generated, interpreted as auto-reflective intentional programming. Both types of reflection mechanisms are formally described and may be implementable in a robot brain. Based on the logic of acceptance and rejection, the robot is capable of rejecting irrelevant environmental information, showing at least a "touch" of subjective behavior. Since reflective intentional programming (...) generates both relevant and irrelevant structures already within the brain, ontological gaps arise which must be integrated. In the human brain, the act of self-reference may exert a holistic function enabling self-consciousness. However, since the act of self-reference is a mysterious function not experimentally testable in brain research, it cannot be implemented in a robot brain. Therefore, the creation of self-conscious robots may never be possible. Finally, some philosophical implications are discussed. (shrink)