This chapter considers two types of fine‐tuning, those dealing with the initial conditions of the universe and those based on fixed parameters. Three approaches have been taken to argue that fine‐tuning does not need any special explanation. The first is an appeal to coincidence. The second is that the data are biased by our own observations. The third has to do with the nature of probability itself. The chapter assesses each of these objections in detail. Many (...) naturalistic explanations have been offered for fine‐tuning. The chapter considers the three most important ones. The first is that future discoveries might show that fine‐tuning was not improbable after all. The second is that other life‐permitting ranges for the fine‐tuned constants (FTCs) might exist, allowing for exotic forms of life unlike ours. The third is that we might live in a multiverse of many different universes all with different values of FTCs. (shrink)

This paper defends the view that discovering that our universe is fine-tuned should make us more confident that other universes exist. My defense exploits a distinction between ideal and non-ideal evidential support. I use that distinction in concert with a simple model to disarm the most influential objection—the this-universe objection—to the view that fine-tuning supports the existence of other universes. However, the simple model fails to capture some important features of our epistemic situation with respect to (...) class='Hi'>fine-tuning. To capture these features, I introduce a more sophisticated model. I then use the more sophisticated model to show that, even once those complicating factors are taken into account, fine-tuning should boost our confidence in the existence of other universes. (shrink)

Fine-tuning arguments are a frequent find in the literature on quantum field theory. They are based on naturalness—an aesthetic criterion that was given a precise definition in the debates on the Higgs mechanism. We follow the history of such definitions and of their application at the scale of electroweak symmetry breaking. They give rise to a special interpretation of probability, which we call Gedankenfrequency. Finally, we show that the argument from naturalness has been extended to comparing different models (...) of the physics beyond the Standard Model and that naturalness in this case can at best be understood a socio-historic heuristic. (shrink)

According to the Fine-Tuning Argument, the existence of life in our universe confirms the Multiverse Hypothesis. A standard objection to FTA is that it violates the Requirement of Total Evidence. I argue that RTE should be rejected in favor of the Predesignation Requirement, according to which, in assessing the outcome of a probabilistic process, we should only use evidence characterizable in a manner available before observing the outcome. This produces the right verdicts in some simple cases in which (...) RTE leads us astray, and, when applied to FTA, it shows that our evidence does confirm HM. (shrink)

I argue that the standard way of formalizing the fine-tuning argument for design is flawed, and I present an alternative formalization. On the alternative formalization, the existence of life is not treated as the evidence that confirms design; instead it is treated as part of the background knowledge, while the fact that fine tuning is required for life serves as the evidence. I argue that the alternative better captures the informal line of thought that gives the (...) fine-tuning argument its intuitive plausibility, and I show that the alternative formalization avoids all of the most prominent objections to the fine-tuning argument, including the objection from observation selection effects, the problem of old evidence, the problem of non-normalizable probability measures and a further objection due to Monton. I conclude that the alternative formalization is the one that attention should be focused on. (shrink)

Abstract: Proponents of the this-universe objection to fine-tuning arguments for a multiverse claim that while the multiverse hypothesis raises the probability that some universe is fine-tuned for life, it fails to raise the probability that this one is. Because that is so, they further argue, those who take the fine-tuning of this universe as evidence for the multiverse hypothesis are guilty of a probabilistic fallacy. I argue that a proper evaluation of the this-universe objection requires (...) the development of a general, formal framework for reasoning probabilistically with evidence statements expressed using indexical terms (such as the statement This universe is fine-tuned). I proceed to develop such a framework and then to apply it to the this-universe objection. While my primary aim is to defend the this-universe objection from recent rebuttals, a secondary aim is to exhibit the utility of the framework itself, which has the potential for wider application. (shrink)

Proponents of the this-universe objection to fine-tuning arguments for a multiverse claim that while the multiverse hypothesis raises the probability that some universe is fine-tuned for life, it fails to raise the probability that this one is. Because that is so, they further argue, those who take the fine-tuning of this universe as evidence for the multiverse hypothesis are guilty of a probabilistic fallacy. I argue that a proper evaluation of the this-universe objection requires the (...) development of a general, formal framework for reasoning probabilistically with evidence statements expressed using indexical terms (such as the statement [This universe is fine-tuned]). I proceed to develop such a framework and then to apply it to the this-universe objection. While my primary aim is to defend the this-universe objection from recent rebuttals, a secondary aim is to exhibit the utility of the framework itself, which has the potential for wider application. (shrink)

In this paper, I propose that, in addition to the multiverse hypothesis, which is commonly taken to be an alternative explanation for fine-tuning, other than the design hypothesis, the simulation hypothesis is another explanation for fine-tuning. I then argue that the simulation hypothesis undercuts the alleged evidential connection between ‘designer’ and ‘supernatural designer of immense power and knowledge’ in much the same way that the multiverse hypothesis undercuts the alleged evidential connection between ‘fine-tuning’ and (...) ‘fine-tuner’ (or ‘designer’). If this is correct, then the fine-tuning argument is a weak argument for the existence of God. (shrink)

Many physics parameters need to be precisely set in order for life to exist in our universe. Or so says the fine-tuning argument. That the actual values are just right for life, the argument concludes, is a fact in need of deep physical or metaphysical explanation. Perhaps, the story goes, the parameter values settings are a matter of divine design. Or perhaps they result from a selection effect given our place in the “multiverse”. However, a very different approach (...) to the problem is possible. One may argue that the fine-tuning is an artefact of theorizing: it is explicable as the precise balancing act necessary for compact, systematic representation in science. Given such an explanation and drawing on earlier work from a number of sources, this essay shows how fine-tuning is best understood as evidence for a non-governing conception of laws rather than for design or multiverse. (shrink)

The Fine-Tuning Argument (FTA) is a variant of the Design Argument for the existence of God. In this paper the evidence of fine-tuning is explained and the Fine-Tuning Design Argument for God is presented. Then two objections are covered. The first objection is that fine-tuning can be explained in terms of the existence of multiple universes (the 'multiverse') plus the operation of the anthropic principle. The second objection is the 'normalizability problem'– the (...) objection that the Fine-Tuning Argument fails because fine-tuning is not actually improbable. (shrink)

Let us consider that version of the Argument from Design which appeals to the so called "fine tuning" of the physical constants of the universe. Call it "the Fine tuning Argument." It has many advocates, both on the Internet and in print. For some of the Internet articles, see the following web site: http://www.reasons.org/resources/papers/>. One of the argument's "print" advocates is George Schlesinger, who says the following: In the last few decades a tantalizingly great number of (...) exceedingly rare coincidences, vital for the existence of a minimally stable universe and without which no form of life could exist anywhere, have been discovered. . . . [G]iven any one of infinitely many universes, some conjunction or other of physical magnitudes will have to obtain. However, the prevailing conjunction is not merely one of indefinitely many; it is also an instance of a virtually infinitesimally rare kind of universe: the kind capable of sustaining life. The hypothesis that it was produced by a Being interested in sentient organic systems adequately explains this otherwise inexplicably astonishing fact. NEW PERSPECTIVES ON OLD TIME RELIGION, Oxford U.P., 1988, pp. 130,133] A more precise formulation of the argument is the following, with premises indicated by "P" and conclusions indicated by "C": (P1) The combination of physical constants that we observe in our universe is the only one capable of sustaining life as we know it. (P2) Other combinations of physical constants are conceivable. (shrink)

Jan Greben criticized fine-tuning by taking seriously the idea that “nature is quantum mechanical”. I argue that this quantum view is limited, and that fine-tuning is real, in the sense that our current physical models require fine-tuning. Second, I examine and clarify many difficult and fundamental issues raised by Rüdiger Vaas’ comments on Cosmological Artificial Selection.

Could God have created a better universe? Well, the fundamental scientific laws and parameters of the universe have to be within a certain miniscule range, for a life-sustaining universe to develop: the universe must be ‘Fine Tuned’. Therefore the ‘embryonic universe’ that came into existence with the ‘big bang’ had to be either exactly as it was or within a certain tiny range, for there to develop a life-sustaining universe. If it is better that there exist a life-sustaining universe (...) than not, then it was better that the embryonic universe was one of this small set of very similar embryonic universes than that it was not. Furthermore, there are no firm grounds for claiming that of this small set of very similar embryonic universes, there is one which would have developed into a universe better than ours. Therefore there are no firm grounds for claiming that God could have created a better universe than ours. (shrink)

The Myopic Anthropic Principle: an attempt to show that the popular anthropic reasoning of our time — often taken to show that laws of nature are fine-tuned by a god for us — should be seen merely as an indication of fine-tuning by us. This preference for short-sightedness in this case is shown (shown?) to support the best-system account of scientific law.

The multiverse hypothesis is the leading alternative to the competing fine-tuning hypothesis. The multiverse dispels many aspects of the fine-tuning argument by suggesting that there are different initial conditions in each universe, varying constants of physics, and the laws of nature lose their known arbitrary values; thus, making the previous single-universe argument from fine- tuning incredibly weak. The position that will be advocated will be that a form of multiverse could exist and that any (...) level of Tegmark's multiverse does not circumvent the fine-tuning argument for the existence of a fine-tuner. An argument will be presented suggesting that the multiverse could strengthen the fine-tuning argument by narrowing down the parameters of the data to a more fundamental description needed for the multiverse to function as it does since it may be the case that some physical descriptions are not the same in every universe. That is, the task of explaining how the multiverse mechanism functions cannot be accounted for by the multiverse itself. Fine-tuning by a mind serves as a sufficient and best explanation for the data. (shrink)

This paper seeks to explicate and analyze an alternative response to fine-tuning arguments from those that are typically given—namely, design or brute contingency. The response I explore is based on necessity, the necessitarian response. After showing how necessity blocks the argument, I explicate the reply I claim necessitarians can give and suggest how its three requirements can be met: firstly, that laws are metaphysically necessary; secondly, that constants are metaphysically necessary; and thirdly, that the fundamental properties that determine (...) the laws and constants are necessary. After discussing each in turn, I end the paper by assessing how the response fares when running the fine-tuning argument in two ways, as an inference to best explanation and as a Bayesian argument. (shrink)

Fine-tuning in physics and cosmology is often used as evidence that a theory is incomplete. For example, the parameters of the standard model of particle physics are “unnaturally” small, which has driven much of the search for physics beyond the standard model. Of particular interest is the fine-tuning of the universe for life, which suggests that our universe’s ability to create physical life forms is improbable and in need of explanation, perhaps by a multiverse. This claim (...) has been challenged on the grounds that the relevant probability measure cannot be justified because it cannot be normalized, and so small probabilities cannot be inferred. We show how fine-tuning can be formulated within the context of Bayesian theory testing in the physical sciences. The normalizability problem is seen to be a general problem for testing any theory with free parameters, and not a unique problem for fine-tuning. Physical theories in fact avoid such problems in one of two ways. Dimensional parameters are bounded by the Planck scale, avoiding troublesome infinities, and we are not compelled to assume that dimensionless parameters are distributed uniformly, which avoids non-normalizability. (shrink)

The Fine-tuning argument takes the existence of life as evidence that an agent had a hand in making the universe. The argument is thought to hinge on the claim that ‘fine-tuning’ of various parameters is required for life to evolve. Jonathan Weisberg argues that even granting that life can provide evidence for design, further data about the fine-tuning required add nothing to the case. Weisberg charges the argument rests on unsupported assumptions about a designer’s (...) preference for a fine-tuned universe (over and above favouring life). I argue that he is mistaken. The assumptions that Weisberg grants (for the sake of argument) are sufficient to make fine-tuning relevant to design. (shrink)

The objective of this paper is analyzing to which extent the multiverse hypothesis provides a real explanation of the peculiarities of the laws and constants in our universe. First we argue in favor of the thesis that all multiverses except Tegmark’s “mathematical multiverse” are too small to explain the fine tuning, so that they merely shift the problem up one level. But the “mathematical multiverse" is surely too large. To prove this assessment, we have performed a number of (...) experiments with cellular automata of complex behavior, which can be considered as universes in the mathematical multiverse. The analogy between what happens in some automata (in particular Conway’s “Game of Life") and the real world is very strong. But if the results of our experiments can be extrapolated to our universe, we should expect to inhabit—in the context of the multiverse—a world in which at least some of the laws and constants of nature should show a certain time dependence. Actually, the probability of our existence in a world such as ours would be mathematically equal to zero. In consequence, the results presented in this paper can be considered as an inkling that the hypothesis of the multiverse, whatever its type, does not offer an adequate explanation for the peculiarities of the physical laws in our world. (shrink)

It is commonly argued that the fact that our universe is fine-tuned for life favors both a design hypothesis as well as a non-teleological multiverse hypothesis. The claim that the fine-tuning of this universe supports a non-teleological multiverse hypothesis has been forcefully challenged however by Ian Hacking and Roger White. In this paper we take this challenge even further by arguing that if it succeeds, then not only does the fine-tuning of this universe fail to (...) support a multiverse hypothesis, but it tends to favor a single-universe hypothesis instead. (shrink)

If the physical constants, initial conditions, or laws of nature in our universe had been even slightly different, then the evolution of life would have been impossible. This observation has led many philosophers and scientists to ask the natural next question: why is our universe so "fine-tuned" for life? The debates around this question are wide-ranging, multi-disciplinary, complicated, technical, and heated. This study is a comprehensive investigation of these debates and the many metaphysical and epistemological questions raised by cosmological (...) fine-tuning. Waller's study reaches two significant and controversial conclusions. First, he concludes that the criticisms directed at the "multiverse hypothesis" by theists and at the "theistic hypothesis" by naturalists are largely unsuccessful. Neither of these options can plausibly be excluded. Choosing between them seems to turn on primitive metaphysical intuitions. Second, in order to break the philosophical deadlock, Waller moves the debate from the level of universes to the level of possible worlds. Arguing that possible worlds are also "fine-tuned" in an important and interesting sense, Waller concludes that the only plausible explanation for the fine-tuning of the actual world is to posit the existence of some kind of "God-like-thing.". (shrink)

My purpose, in this paper, is to defend the claim that the fine-tuning argument suffers from the poor design worry. Simply put, the worry is this: if God created the universe, specifically with the purpose of bringing about moral agents, we would antecedently predict that the universe and the laws of nature, taken as a whole, would be well-equipped to do just that. However, in light of how rare a life-permitting universe is, compared to all the ways the (...) universe might be have been life-prohibiting given the laws of physics, strongly suggests that the universe was poorly designed for that purpose. This casts doubt on the claim that God has much to do with designing the universe. First, I introduce the fine-tuning argument, and second, I explain and defend the poor design worry against objections that, while apparently compelling, I argue are misleading. (shrink)

The universe appears fine-tuned for life. Bayesian confirmation theory is utilized to examine two competing explanations for this fine-tuning, namely design (theism) and the existence of many universes, in comparison with the ’null’ hypothesis that just one universe exists as a brute fact. Some authors have invoked the so-called ’inverse gambler’s fallacy’ to argue that the many-universes hypothesis does not explain the fine-tuning of ’this’ universe, but flaws in this argument are exposed. Nevertheless, the hypothesis (...) of design, being simpler, is arguably of higher prior probability and, therefore, to be preferred. The hypothesis of the single brute-fact universe is disconfirmed. (shrink)

The fundamental constants that are involved in the laws of physics which describe our universe are finely-tuned for life, in the sense that if some of the constants had slightly different values life could not exist. Some people hold that this provides evidence for the existence of God. I will present a probabilistic version of this fine-tuning argument which is stronger than all other versions in the literature. Nevertheless, I will show that one can have reasonable opinions such (...) that the fine-tuning argument doesn’t lead to an increase in one’s probability for the existence of God. (shrink)

The multiverse hypothesis is one of the leading proposed explanations of cosmic fine-tuning for life. One common objection to the multiverse hypothesis is that, even if it were true, it would not explain why this universe, our universe, is fine-tuned for life. To think it would so explain is allegedly to commit “the inverse gambler's fallacy.” This paper presents what the inverse gambler's fallacy is supposed to be, then surveys the discussion of it in the philosophical literature (...) of the last 35 years. (shrink)

It is commonly argued that an undesirable feature of a theoretical or phenomenological model is that salient observables are sensitive to values of parameters in the model. But in what sense is it undesirable to have such ‘fine-tuning’ of observables? In this paper, we argue that the fine-tuning can be interpreted as a shortcoming of the explanatory capacity of the model: in particular it signals a lack of a particular type of explanatory depth. The aspect of (...) depth that we probe relates most closely to a lack of sensitivity to changes in parameters associated with such models. In support of this argument, we develop a schema—for models that arise broadly in physical settings—that quantitatively relates fine-tuning of observables to a lack of depth of explanations based on these models. We apply our schema in two different settings in which, within each setting, we compare the depth of two competing explanations. The first setting involves explanations for the Euclidean nature of spatial slices of the universe today: in particular, we compare an explanation provided by the big-bang model of the early 1970s with an explanation provided by a general model of cosmic inflation. The second setting has a more phenomenological character, where the goal is to infer from a limited sequence of data points, using maximum entropy techniques, the underlying probability distribution from which these data are drawn. In both of these settings we find that our analysis favors the model that intuitively provides the deeper explanation of the observable of interest. We thus provide an account that relates two ‘theoretical virtues’ of models used broadly in physical settings—namely, a lack of fine-tuning and explanatory depth—and argue that finely tuned models sacrifice explanatory depth. (shrink)

I present a novel objection to fine-tuning arguments for God's existence. On any values of the physical constants, the psychophysical laws could be set to permit intelligent and happy beings, so the specific values of the physical constants in our world provide little evidence for God's existence. For example, even if the physical constants didn't allow carbon or any atoms larger than hydrogen, the psychophysical laws could be set so that charge is sufficient to realize romantic desire. Then (...) every hydrogen atom would be a proton and electron in love. (shrink)

Cell membranes are now emerging as finely tuned molecular systems, signifying that re‐evaluation of our understanding of their structure is essential. Although the idea that cell membrane lipid bilayers do little more than give shape and form to cells and limit diffusion between cells and their environment is totally passé, the structural, compositional, and functional complexity of lipid bilayers often catches cell and molecular biologists by surprise. Models of lipid bilayer structure have developed considerably since the heyday of the fluid (...) mosaic model, principally by the discovery of the restricted diffusion of membrane proteins and lipids within the plane of the bilayer. In reviewing this field, we now suggest that further refinement of current models is necessary and propose that describing lipid bilayers as “finely‐tuned molecular assemblies” best portrays their complexity and function. Also see the video abstract here: https://www.youtube.com/watch?v=ddkP-QRZTl8. (shrink)

Force strengths, particle masses, etcetera, appear "fine tuned" for intelligent life. There may be many very diverse universes, observational selection explaining why we see a life-permitting one. The alternative is divine selection. The God hypothesis can explain how one and the same force strength or particle mass satisfies life’s many different requirements, and why there are life-encouraging laws of relativity and of quantum theory. It could also answer why any universe exists. God’s existence could be accounted for Platonically, by (...) its ethical requiredness. The most plausible world-view would then be Spinozistic, on lines explored in my recent book "Infinite Minds". (shrink)

I present and defend an “indexical” version of the Fine-Tuning Argument. I begin by outlining the dialectic between the Fine-Tuning Argument, the Multiverse Objection, and the This-Universe Reply. Next, I sketch an indexical fine-tuning argument and defend it from two new objections. Then, I show that such an argument is immune to the Multiverse Objection. I explain how a further augmentation to the argument allows it to avoid an objection I call the “Indifference Objection.” (...) I conclude that my indexical version of the Fine-Tuning Argument is no less cogent than the standard version, and yet it is immune to the Multiverse Objection. (shrink)

After briefly outlining the fine-tuning argument (FTA), I explain how it relies crucially on the claim that it is not improbable that God would design a fine-tuned universe. Against this premise stands the divine psychology objection: the contention that the probability that God would design a fine-tuned universe is inscrutable. I explore three strategies for meeting this objection: (i) denying that the FTA requires any claims about divine psychology in the first place, (ii) defining the motivation (...) and intention to design a fine-tuned universe into the theistic hypothesis, and (iii) providing arguments that the relevant probability is not terribly low. While I reject the first two, I conclude, in line with the third, that considerations about life's objective value establish that it is not absurdly improbable that God would design a fine-tuned universe, whether one regards the FTA as an inference merely to a cosmic designer, or to theism proper. Accordingly, the divine psychology objection fails. (shrink)

When it is suggested that the fine‐tuning of the universe for life provides evidence for a cosmic designer, the multiple‐universe hypothesis is often presented as an alternative. Some philosophers object that the multiple‐universe hypothesis fails to explain why this universe is fine‐tuned for life. We suggest the “This Universe” objection is no better than the “This Planet” objection. We also fault proponents of the “This Universe” objection for presupposing that we could not have existed in any other (...) universe and that the values of the free parameters of the Universe could have been different. Lastly, we reflect on why fine‐tuning for life needs explaining. (shrink)

I assess various proposals for the source of the intuition that there is something problematic about contextuality, ultimately concluding that contextuality is best thought of in terms of fine-tuning. I then argue that as with other fine-tuning problems in quantum mechanics, this behaviour can be understood as a manifestation of teleological features of physics. Finally I discuss several formal mathematical frameworks that have been used to analyse contextuality and consider how their results should be interpreted by (...) scientific realists. In the course of this discussion I obtain several new mathematical results—I demonstrate that preparation contextuality is a form of fine-tuning, I show that measurement contextuality can be explained by appeal to a global constraint forbidding closed causal loops, and I demonstrate how negative probabilities can arise from a classical ontological model together with an epistemic restriction. (shrink)

This paper defends a novel sceptical response to the fine-tuning argument for the existence of God (FTA). According to this response, even if FTA can establish, what I call, the confirmation proposition: ‘fine-tuning confirms the God hypothesis’, there is no reason to think that a strengthening of FTA can establish the evidence-favouring proposition: ‘fine-tuning favours the God hypothesis over its competitors’. My argument is that, any criteria for the explanation of fine-tuning that (...) permit us to take the God hypothesis seriously ought to make us sceptical that fine-tuning favours the God hypothesis over its competitors. As taking the God hypothesis seriously requires us to give a fair hearing to all sorts of non-theistic explanations, including the so-called weird sorts of atheism. (shrink)

Cells fine‐tune their DNA repair, selecting some regions of the genome in preference to others. In the paradigm case, excision of UV‐induced pyrimidine dimers in mammalian cells, repair is concentrated in transcribed genes, especially in the transcribed strand. This is due both to chromatin structure being looser in transcribing domains, allowing more rapid repair, and to repair enzymes being coupled to RNA polymerases stalled at damage sites; possibly other factors are also involved. Some repair‐defective diseases may involve repair‐transcription coupling: (...) three candidate genes have been suggested.However, preferential excision of pyrimidine dimers is not uniformly linked to transcription. In mammals it varies with species, and with cell differentiation. In Drosophila embryo cells it is absent, and in yeast, the determining factor is nucleosome stability rather than transcription.Repair of other damage departs further from the paradigm, even in some UV‐mimetic lesions. No selectivity is known for repair of the very frequent minor forms of base damage. And the most interesting consequence of selective repair, selective mutagenesis, normally occurs for UV‐induced, but not for spontaneous mutations. The temptation to extrapolate from mammalian UV repair should be resisted. (shrink)

This study examines the sequential and situated organization associated with framing locational formulations by dislocated parties to mobile phone calls for the joint accomplishment of location-related social action. The data come from 22 mundane Farsi mobile phone calls involving location inquiring and/or reporting. The analysis of the data, informed by conversational analysis and Levinson’s conceptual framework of perspective-taking, adds frame of reference to Schegloff’s location, membership, and topic or activity analyses operative in the selection of locational formulations. The trajectory plotted (...) for location-related action indicates the contingent roles which material, linguistic and semiotic resources play in the selection of locational formulations deployed for co-presence purposes. The findings suggest consequentiality of the-relevant-next action for the framing of locational descriptions and provide insight into how conversationalists interact with their physical environment in a wider social context. (shrink)

In recent years, several prominent authors have criticized fine-tuning arguments for failing to show that the universe’s purported fine-tuning for intelligent life calls for explanation. In this paper, I provide a systematic categorization and a detailed evaluation of the proffered critiques. I argue that these critiques cast doubt on various instances of fine-tuning reasoning, but fail to undermine fine-tuning arguments’ conclusion that the universe’s purported fine-tuning for intelligent life can be (...) justifiably taken to call for explanation. I then explicate the implications of this result for the ongoing philosophical debate concerning the merits of fine-tuning arguments and the conditions under which specific events or states of affairs are justifiably taken to call for explanation. (shrink)

Interview of Tim Mawson by Luke Muehlhauser.

Does the fine-tuning of the universe for life continue in the afterlife? Aquinas would answer yes. In his view, the cosmic conditions post-apocalypse are set to support the resurrected body and the sensible knowledge of God’s majesty as reflected in the renewed material creature. The renewed universe is, thus, fine-tuned for immortal human life. In the first part, I present Aquinas’ version of fine-tuning, referring to earthly life and the afterlife. I distinguish between two modes (...) of fine-tuning: organic and cognitive. In the second part, I analyze the characteristics of the universe post-apocalypse in connection with the resurrected body in general and the qualities of the blessed body in particular. (shrink)

Included in the acute response of lowlanders exposed to reduced oxygen availability is an elevated red blood cell count due to increased erythropoietin (Epo) synthesis. According to current thinking, hypoxia is “sensed” by hydroxylases that permit Hypoxia Inducible Factor 1α (HIF‐1α) to complex with HIF‐1β to form a transcriptional activator (HIF‐1) that drives expression of hypoxia‐sensitive genes (such as EPO) under hypoxic conditions. In altitude‐adapted Andean natives, the Epo hypoxic response may be blunted; however, our data indicate that the DNA (...) sequences of the genes encoding Epo (including the 3′ regulatory region) and HIF‐1α appear to be conserved. Hence, adaptive changes in the Andean hypoxic response are not a consequence of changes in the primary sequence of these proteins or of known transcriptional regulatory domains of EPO. These results suggest that the altered erthropoietic response in Andean natives reflects adaptations in hypoxia sensing, rather than hypoxia response, mechanisms. BioEssays 25:515–519, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Autophagy functions in both selective and non‐selective ways to maintain cellular homeostasis. Endoplasmic reticulum autophagy (ER‐phagy) is a subclass of autophagy responsible for the degradation of the endoplasmic reticulum through selective encapsulation into autophagosomes. ER‐phagy occurs both under physiological conditions and in response to stress cues, and plays a crucial role in maintaining the homeostatic control of the organelle. Although specific receptors that target parts of the ER membrane, as well as, internal proteins for lysosomal degradation have been identified, the (...) molecular regulation of ER‐phagy has been elusive. Recent work has uncovered novel regulators of ER‐phagy that involve post‐translational modifications of ER‐resident proteins and functional cross‐talk with other cellular processes. Herein, we discuss how morphology affects the function of the peripheral ER, and how ER‐phagy modulates the turnover of this organelle. We also address how ER‐phagy is regulated at the molecular level, considering implications relevant to human diseases. (shrink)

The idea that there might be multiple universes with different parameters of nature is often considered an attractive response to the finding that various parameters appear to be delicately fine-tuned for life. The present paper investigates whether the appeal to fine-tuning can legitimately be combined with an appeal to independent empirical evidence for other universes or whether, as suggested by Cory Juhl, combining such appeals inevitably results in illegitimate double counting of the finding that the parameters are (...) right for life. In doing so, the paper takes into account the fact that the parameters' life-friendliness is old evidence for us, which makes Bayesianism's problem of old evidence relevant to Bayesian analysis of its evidential impact. Ultimately, the verdict reached is that the warning of double counting is helpful, but that double counting can in principle be avoided. The paper highlights remaining independent challenges against the fine-tuning argument for the multiverse. (shrink)

Jonathan Weisberg (2010 ) argues that, given that life exists, the fact that the universe is fine-tuned for life does not confirm the design hypothesis. And if the fact that life exists confirms the design hypothesis, fine-tuning is irrelevant. So either way, fine-tuning has nothing to do with it. I will defend a design argument that survives Weisberg’s critique — the fact that life exists supports the design hypothesis, but it only does so given (...) class='Hi'>fine-tuning. (shrink)

It is claimed that the universe appears to be fine-tuned so as to admit the development of life. In this article Rodney Holder examines the evidence for fine-tuning and the chief rival explanation to design, namely the existence of a.

Perry Hendricks’ original impairment argument for the immorality of abortion is based on the impairment principle (TIP): if impairing an organism to some degree is immoral, then ceteris paribus, impairing it to a higher degree is also immoral. Since abortion impairs a fetus to a higher degree than fetal alcohol syndrome (FAS) and giving a fetus FAS is immoral, it follows that abortion is immoral. Critics have argued that the ceteris paribus is not met for FAS and abortion, and so (...) we proposed the Modified Impairment Principle (MIP) to avoid these difficulties. Dustin Crummett has responded, arguing that MIP is open to various counterexamples which show it to be false. He also shows that MIP can generate moral dilemmas. Here, we propose a modification to MIP that resolves the issues Crummett raises. Additionally, Alex Gillham has criticized our appropriation of Don Marquis’ ‘future like ours’ reasoning about the wrongness of impairment. We show that his objections have minimal implications for our argument. (shrink)

Does the evidence that our universe contains fine-tuned life confirm the multiverse hypothesis? The answer depends on our approach to self-locating beliefs. In a recent paper, Isaacs, Hawthorne, and Russell (2022) offer two arguments for thinking that such evidence does confirm the multiverse hypothesis. First, they argue that the three leading approaches to self-locating beliefs all entail that such evidence confirms the multiverse hypothesis. Second, they present a pair of theorems showing that any approach to self-locating beliefs that satisfies (...) certain “reasonable” constraints will entail that such evidence confirms the multiverse hypothesis. I argue that Isaacs, Hawthorne, and Russell’s two arguments are not compelling, the first because they fail to consider some natural approaches to self-locating beliefs, the second because their theorems rely on a suspect premise that we should reject. Contra Issacs, Hawthorne, and Russell, I argue that on a natural approach to self-locating beliefs the evidence that our universe contains fine-tuned life needn’t confirm the multiverse hypothesis. (shrink)