Many authors have turned their attention to the notion of constitution to determine whether the hypothesis of extended cognition (EC) is true. One common strategy is to make sense of constitution in terms of the new mechanists’ mutual manipulability account (MM). In this paper I will show that MM is insufficient. The Challenge of Trivial Extendedness arises due to the fact that mechanisms for cognitive behaviors are extended in a way that should not count as verifying EC. This challenge (...) can be met by adding a necessary condition: cognitive constituents satisfy MM and they are what I call behavior unspecific. (shrink)

This critical study of Sanford Goldberg's Relying on Others focuses on the book's central claim, the extendedness hypothesis, according to which the processes relevant for assessing the reliability of a hearer's testimonial belief include the cognitive processes involved in the production of the testimony.Send article to KindleTo send this article to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your (...) Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service.CRITICAL STUDY OF GOLDBERG'S RELYING ON OTHERSVolume 9, Issue 1Mikkel GerkenDOI: https://doi.org/10.1017/epi.2011.6Your Kindle email address Please provide your Kindle [email protected]@kindle.com Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Dropbox To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox. CRITICAL STUDY OF GOLDBERG'S RELYING ON OTHERSVolume 9, Issue 1Mikkel GerkenDOI: https://doi.org/10.1017/epi.2011.6Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Google Drive To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive. CRITICAL STUDY OF GOLDBERG'S RELYING ON OTHERSVolume 9, Issue 1Mikkel GerkenDOI: https://doi.org/10.1017/epi.2011.6Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Export citation Request permission. (shrink)

Mainstream analytic epistemology regards knowledge as the property of individuals, rather ‎than groups. Drawing on insights from the reality of knowledge production and dissemination ‎in the sciences, I argue, from within the analytic framework, that this view is wrong. I defend ‎the thesis of ‘knowledge-level justification communalism’, which states that at least some ‎knowledge, typically knowledge obtained from expert testimony, is the property of a ‎community and possibly none of its individual members, in that only the community or some ‎members (...) of it collectively possesses knowledge-level justification for its individual members’ ‎beliefs. I address several objections that individuals, qua individuals, have or are able to ‎acquire knowledge-level justification for all the beliefs they obtain from expert testimony. I ‎argue that the problem I identify with individualism is invariant under any specific account of ‎justification, internalist or externalist. ‎. (shrink)

Our main hypothesis is that an extended moral agent cannot fulfill their expectation of “extendedness” without a dynamical and evolutionary ecosystem where the agent develops and behave properly. It is important to establish a bridge between extended moral agents and ecosystems for two reasons: first, because there is not an enough direct theoretical reflection about this link. The scholars focus has been independently in improving the “extended agent theory”, the concepts of “ecosystem” or “ecosystem of innovation”. Second, if we (...) want to understand the wide scope of the decentered ethics in design of mobile robots and AI these two theoretical frames cannot be seen separately but in join interdependency. (shrink)

In Relying on others [Goldberg, S. 2010a. Relying on others: An essay in epistemology. Oxford: Oxford University Press], I argued that, from the perspective of an interest in epistemic assessment, the testimonial belief-forming process should be regarded as interpersonally extended. At the same time, I explicitly rejected the extendedness model for beliefs formed through reliance on a mere mechanism, such as a clock. In this paper, I try to bolster my defense of this asymmetric treatment. I argue that a (...) crucial assumption lying behind the argument I used to establish interpersonal extendedness in testimony cases does not apply to beliefs formed through reliance on instruments. In this respect, at least, there appears to be something epistemically distinctive about relying on another epistemic agent. (shrink)

In recent years, the idea has been gaining ground that our traditional conceptions of knowledge and cognition are unduly limiting, in that they privilege what goes on inside the ‘skin and skull’ of an individual reasoner. Instead, it has been argued, knowledge and cognition need to be understood as embodied, situated, and extended. Whether these various interrelations and dependencies are ‘merely’ causal, or are in a more fundamental sense constitutive of knowledge and cognition, is as much a matter of controversy (...) as the degree to which they pose a challenge to ‘traditional’ conceptions of cognition, knowledge and the mind. In this paper we argue that when the idea of ‘extendedness’ is applied to a core concept in epistemology and the philosophy of science—namely, scientific evidence—things appear to be on a much surer footing. The evidential status of data gathered through extended processes—including its utility as justification or warrant—do not seem to be weakened by virtue of being extended, but instead are often strengthened because of it. Indeed, it is often precisely by virtue of this extendedness that scientific evidence grounds knowledge claims, which individuals may subsequently ascribe to themselves. The functional equivalence between machine-based gathering, filtering, and processing of data and human interpretation and assessment is the crucial factor in deciding whether evidence has been gathered, rather than the distinction between intra- and extracranial processes or individual and social processes. To prioritize biological processes here, and to assert the superiority of human cognitive capacities seems both arbitrary and unwarranted with respect to gathering evidence, and ultimately would lead to an unattractive skepticism about many of the methods used in science to gather evidence. In other words, conceiving of scientific evidence as ‘impersonal’ not only better captures the character of evidence-gathering in practice, but also makes sense of a large amount of evidence-gathering that ‘personal’ accounts fail to either acknowledge or accurately describe. Whilst we suggest it is likely that all internally-distributed evidence-gathering processes are merely contingently internal processes, a significant number of externally-distributed evidence-gathering processes are necessarily externally-distributed. Some evidence can only be gathered by extended epistemic agents. (shrink)

The visual attention (VA) span is defined as the amount of distinct visual elements which can be processed in parallel in a multi-element array. Both recent empirical data and theoretical accounts suggest that a VA span deficit might contribute to developmental dyslexia, independently of a phonological disorder. In this study, this hypothesis was assessed in two large samples of French and British dyslexic children whose performance was compared to that of chronological-age matched control children. Results of the French study show (...) that the VA span capacities account for a substantial amount of unique variance in reading, as do phonological skills. The British study replicates this finding and further reveals that the contribution of the VA span to reading performance remains even after controlling IQ, verbal fluency, vocabulary and single letter identification skills, in addition to phoneme awareness. In both studies, most dyslexic children exhibit a selective phonological or VA span disorder. Overall, these findings support a multi-factorial view of developmental dyslexia. In many cases, developmental reading disorders do not seem to be due to phonological disorders. We propose that a VA span deficit is a likely alternative underlying cognitive deficit in dyslexia. (shrink)

Can concepts be acquired by testing hypotheses about these concepts? Fodor famously argued that this is not possible. Testing the correct hypothesis would require already possessing the concept. I argue that this does not generally hold for mathematical concepts. I discuss specific, empirically motivated, hypotheses for number concepts that can be tested without needing to possess the relevant number concepts. I also argue that one can test hypotheses about the identity conditions of other mathematical concepts, and then fix the application (...) conditions based on those hypotheses—under the assumption that the neo‐logicist view on abstraction principles is correct. (shrink)

Mathematical models can be profitably used to establish whether our perception of the external world is accurate. Donald Hoffman and his collaborators have developed a promising mathematical framework within which this question can be addressed and which is based on an exhaustive taxonomy of the different possible relations between perceptual representations and the external world. After reformulating their framework by means of an improved formal system, we discuss their application of evolutionary game theory, which appears to show that an essentially (...) anti-realistic perceptual strategy would in the long run biologically outcompete its rivals. We argue that their model does not take the crucial biological significance of environmental changes into due consideration and propose alternative models which do. We conclude that a partially realistic representation would be favoured in our models. (shrink)

Extender-based Prikry–Magidor forcing for overlapping extenders is introduced. As an application, models with strong forms of negations of the Shelah Weak Hypothesis for various cofinalities are constructed.

This paper investigates the complexity hypothesis in microbial evolutionary genetics from a philosophical vantage. This hypothesis, in its current version, states that genes with high connectivity are likely to be resistant to being horizontally transferred. We defend four claims. There is an important distinction between two different ways in which a gene family can persist: vertically and horizontally. There is a trade-off between these two modes of persistence, such that a gene better at achieving one will be worse at achieving (...) the other. At least some genes are likely to experience selection favoring increased transferability. One consequence of this can be encapsulated as the “simplicity hypothesis”: horizontally persisting genes will experience selection favoring reduced connectivity. In order to make sense of the simplicity hypothesis, we need to consider evolutionary populations that transcend species boundaries. Vertical and horizontal persistence are therefore not two competing ways of succeeding at the same game, but involve playing two different games altogether. The complexity hypothesis can be understood in terms of two related notions: entrenchment and Cuvierian functionalism. This framing reveals previously unrecognized and philosophically interesting connections between reasoning about deep conservation and horizontal transfer. (shrink)

Retrotransposon-derived elements (RDEs) can disrupt gene expression, but are nevertheless widespread in metazoan genomes. This review presents a hypothesis that repressive RNA-binding proteins (RBPs) facilitate the large-scale accumulation of RDEs. Many RBPs bind RDEs in pre-mRNAs to repress the effects of RDEs on RNA processing, or the formation of inverted repeat RNA structures. RDE-binding RBPs often assemble on extended, multivalent binding sites across the RDE, which ensures repression of cryptic splice or polyA sites. RBPs thereby minimize the effects of RDEs (...) on gene expression, which likely reduces the negative selection against RDEs. While mutations that change splice sites in RDEs act as an off-on switch in exon formation, mutations that decrease the multivalency of RBP binding sites resemble a rheostat that enables a more gradual evolution of new RDE-derived exons. RBPs might also repress aberrant processing of active retrotransposons, thus increasing the chance that full-length copies are made. Taken together, in this review, it is proposed that RBPs facilitate the widespread accumulation of intronic RDEs by repressing RNA processing while chaperoning their potential to gradually evolve into new exons. (shrink)

Mechanisms occurring at the atomic level are now known to drive processes essential for life, as revealed by quantum effects on biochemical reactions. Some macroscopic characteristics of organisms may thus show an atomic imprint, which may be transferred across organisms and affect their evolution. This possibility is considered here for the first time, with the aim of elucidating the appearance of an animal innovation with an unclear evolutionary origin: migratory behaviour. This trait may be mediated by a radical pair (RP) (...) mechanism in the retinal flavoprotein cryptochrome, providing essential magnetic orientation for migration. Isotopes may affect the performance of quantum processes through their nuclear spin. Here, we consider a simple model and then apply the standard open quantum system approach to the spin dynamics of cryptochrome RP. We changed the spin quantum number (I) and g‐factor of hydrogen and nitrogen isotopes to investigate their effect on RP's yield and magnetic sensitivity. Strong differences arose between isotopes with I = 1 and I = 1/2 in their contribution to cryptochrome magnetic sensitivity, particularly regarding Earth's magnetic field strengths (25–65 µT). In most cases, isotopic substitution improved RP's magnetic sensitivity. Migratory behaviour may thus have been favoured in animals with certain isotopic compositions of cryptochrome. (shrink)

The disease construction of schizophrenia is no longer tenable. That construction originated during a period of rapid growth of biological science based on mechanistic principles. Crude diagnostis measures failed to differentiate absurd, unwanted conduct due to biological conditions from atypical conduct directed to solving existential or identity problems. The construction was communicated - in the absence of solid evidence - by medical practitioners by means of symbolic, rhetorical, and organizational acts. The patient came to be regarded as an object without (...) agency or goals. In spite of enormous research funding, no biological or psychological marker has been discovered that would differentiate diagnosed schizophrenics from normals without creating unacceptable proportions of false positives and false negatives. Employing a moral category, "unwanted conduct," as a criterion, and tacitly transforming moral judgments to the medical category, schizophrenia, leads to the use of schizophrenia/nonschizophrenia as the independent variable in research designs. The failure of eight decades of research to produce a reliable marker leads to the conclusion that schizophrenia is an obsolescent hypothesis and should be abandoned. (shrink)

Let κ be a regular cardinal and P a partial ordering preserving the regularity of κ. If P is (κ-Baire and) of density κ, then there is a mad family on κ killed in all generic extensions (if and) only if below each p∈P there exists a κ-sized antichain. In this case a mad family on κ is killed (if and) only if there exists an injection from κ onto a dense subset of Ult(P) mapping the elements of onto nowhere (...) dense sets. If 2< κ =κ, then in each generic extension of V, in which κ is the minimal cardinal obtaining new subsets, some mad family on κ is killed or an independent subset of κ appears. Also, the κ-Suslin Hypothesis holds iff there exists a mad family on κ which is killed in each generic extension containing new subsets of κ and preserving P(λ) for λ<κ. (shrink)

ABSTRACT16p11.2 deletion syndrome is a severe genetic disorder associated with the deletion of 27 genes from a Copy Number Variant region on human chromosome 16. Symptoms associated include cognitive impairment, language and motor delay, epilepsy or seizures, psychiatric disorders, autism spectrum disorder (ASD), changes in head size and body weight, and dysmorphic features, with a crucial need to define genes and mechanisms responsible for symptomatology. In this review, we analyze the clinical associations and biological pathways of 16p11.2 locus genes and (...) identify that a majority of 16p11.2 genes relate to metabolic processes. We present a hypothesis in which changes in the dosage of 16p11.2 metabolic genes contribute to pathology through direct or indirect alterations in pathways that include amino acids or proteins, DNA, RNA, catabolism, lipid, energy (carbohydrate). This hypothesis suggests that research into the specific roles of each metabolic gene will help identify useful therapeutic targets. (shrink)

This paper concerns local yet systematic problems of contrastive underdetermination of model choice in cognitive neuroscience debates about the so-called two visual systems hypothesis. The underdetermination problem is systematically generated by the way certain assumptions about the representationalist nature of computation are translated into experimental practice. The problem is that behavioural data underdetermine the choice between competing representational models. In this paper, I diagnose how these assumptions generate underdetermination problems in the choice between competing functional models of perception–action. Using the (...) tools of philosophy of science, I describe the type of underdetermination and sketch a possible cure. (shrink)

Preregistration has been proposed as a useful method for making a publicly verifiable distinction between confirmatory hypothesis tests, which involve planned tests of ante hoc hypotheses, and exploratory hypothesis tests, which involve unplanned tests of post hoc hypotheses. This distinction is thought to be important because it has been proposed that confirmatory hypothesis tests provide more compelling results (less uncertain, less tentative, less open to bias) than exploratory hypothesis tests. In this article, we challenge this proposition and argue that there (...) are several advantages of exploratory hypothesis tests that can make their results more compelling than those of confirmatory hypothesis tests. We also consider some potential disadvantages of exploratory hypothesis tests and conclude that their advantages can outweigh the disadvantages. We conclude that exploratory hypothesis tests avoid researcher commitment and researcher prophecy biases, reduce the probability of data fraud, are more appropriate in the context of unplanned deviations, facilitate inference to the best explanation, and allow peer reviewers to make additional contributions at the data analysis stage. In contrast, confirmatory hypothesis tests may lead to an inappropriate level of confidence in research conclusions, less appropriate analyses in the context of unplanned deviations, and greater bias and errors in theoretical inferences. (shrink)

It is generally accepted among philosophers of science that hypothesis testing is a key methodological feature of science. As far as philosophical theories of confirmation are con...

Although many researchers may perceive empirical hypothesis testing using inferential statistics to be a value free process, I argue that any conclusion based on inferential statistics contains an important and intractable value judgment. Consequently, I conclude that researchers should use the same rationale for examining the ethical ramifications of committing errors in statistical inference that they use to examine the ethical parameters of a proposed research design.

Realism about the external, natural world is an overarching empirical hypothesis. The method of hypothetical realism rejects as an excessive concession to the skeptic these two assumptions of constructivist intuitionism: first, that everything real must be exhaustively inspectable; and second, that our beliefs are to be justified to the point of certainty. We prefer to say that nothing is ever known directly; that all of our contact with the world is mediated by thoughts, words, and percepts construed as signs having (...) referents distinct from themselves. We organize these signs into meaningful and possibly true hypotheses as we speculate--in practice, science and metaphysics--about a world we have not made. (shrink)

There are scenarios in which letting one’s own views on the question whether p direct one’s inquiry into that question brings about individual and collective epistemic benefits. However, these scenarios are also such that one’s evidence doesn’t support believing one’s own views. So, how to vindicate the epistemic benefits of directing one’s inquiry in such an asymmetric way, without asking one to hold a seemingly irrational doxastic attitude? To answer this question, the paper understands asymmetric inquiry direction in terms of (...) having one’s inquiry be guided by a doxastic attitude, which I call hypothesis, that’s governed by the following norm: One’s hypothesis that p is rational just in case it is a manifestation of the best feasible way to form a doxastic attitude regarding p that promotes the best feasible ways to advance towards settling the question of p’s (or of any other suitably related proposition’s) truth-value. (shrink)

There is probably only one information system in living nature — the macromolecular system including DNA, RNA and protein. Its unity for the genetic and nervous activity can be followed in the storage of information (heredity, memory) and in its processing (recombination and selection of both genetic and mental information). According to the hypothesis of the code of nerve impulses, nucleotide triplets of the nucleus, or more likely amino acids of the surface protein of the impulse generating area of a (...) neuron, generate a limited variety of interspike intervals so that each amino acid corresponds to a certain interspike interval and this particular interval initiates by means of a specific neurotransmitter, the synthesis of the same amino acid (or nucleotide triplet) in the postsynaptic neuron. Thus, a series of impulses produces in the postsynaptic neuron a sequence of amino acids in a form of a polypeptide identical to the polypeptide of the presynaptic neuron. (shrink)

The singularity hypothesis is a radical hypothesis about the future of artificial intelligence on which self-improving artificial agents will quickly become orders of magnitude more intelligent than the average human. Despite the ambitiousness of its claims, the singularity hypothesis has been defended at length by leading philosophers and artificial intelligence researchers. In this paper, I argue that the singularity hypothesis rests on scientifically implausible growth assumptions. I show how leading philosophical defenses of the singularity hypothesis (Chalmers 2010, Bostrom 2014) fail (...) to overcome the case for skepticism. I conclude by drawing out philosophical implications of this discussion for our understanding of consciousness, personal identity, digital minds, existential risk, and ethical longtermism. GPI Working Paper No . 19-2022. (shrink)

This hypothesis is that anorexia nervosa is a biologically driven disorder, and mammalian hibernation may offer clues to its pathogenesis. Using this approach, this hypothesis offers suggestions for employing heart rate variability as an early diagnostic test for anorexia nervosa; employing the ketogenic diet for refeeding patients, attending to omega 3:6 ratio of polyunsaturated fatty acids in the refeeding diet; and exploring clinical trials of the endocannabinoid-like agent, palmitoylethanolamde for patients with anorexia nervosa. This hypothesis also explores the role of (...) lipids and autoimmune phenomena in anorexia nervosa, and suggest a lipodomics study to search for antibodies in the serum on patients with anorexia nervosa. (shrink)

What follows for the ability hypothesis reply to the knowledge argument if knowledge-how is just a form of knowledge-that? The obvious answer is that the ability hypothesis is false. For the ability hypothesis says that, when Mary sees red for the first time, Frank Jackson’s super-scientist gains only knowledge-how and not knowledge-that. In this paper I argue that this obvious answer is wrong: a version of the ability hypothesis might be true even if knowledge-how is a form of knowledge-that. To (...) establish this conclusion I utilize Jason Stanley and Timothy Williamson’s well-known account of knowledge-how as “simply a species of propositional knowledge” . I demonstrate that we can restate the core claims of the ability hypothesis – that Mary only gains new knowledge-how and not knowledge-that – within their account of knowledge-how as a species of knowledge-that. I examine the implications of this result for both critics and proponents of the ability hypothesis. (shrink)

This essay introduces the massive redeployment hypothesis, an account of the functional organization of the brain that centrally features the fact that brain areas are typically employed to support numerous functions. The central contribution of the essay is to outline a middle course between strict localization on the one hand, and holism on the other, in such a way as to account for the supporting data on both sides of the argument. The massive redeployment hypothesis is supported by case studies (...) of redeployment, and compared and contrasted with other theories of the localization of function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Hypothesis on the Origin of TradeThe Exchange of Lives for Sacrifice and SexPablo Díaz-Morlán (bio)introductionThe primary objective of this study is to propose a hypothesis regarding the origin of trade that will help to solve the enigma of why human groups, normally each other's enemies, stopped exchanging blows in order to exchange things. The complexity of this crucial step forward in the relationships between hostile primitive groups can (...) be summarized as follows. In order for an exchange to take place, both parties must take part in it voluntarily because they see a mutual benefit in doing so. In turn, both parties should be aware that in order to obtain what interests them, which is closely guarded by the other party, in return, they must hand over what the other party is interested in. The perception of the interest of the other plays a crucial role in trade, both today and in its origins. The next step to be taken after a successful initial exchange was its consolidation, after it had been proved that it mutually benefited groups who had, until then, been enemies. Once established, this pacific exchange would have diversified considerably and its complexity would have increased significantly. An added [End Page 165] advantage, which was unexpected but real, was that its subsequent usefulness in curbing violence contributed to its growing expansion. The emergence of a comparative advantage in the groups that adopted trade would have guaranteed their future progress with respect to those that continued to systematically adopt violent conduct toward their neighbors.1Throughout this study, we will come across the old idea that the market prevents war. Without a doubt, trade and war between individuals and groups are closely connected, but the boundaries between them are fuzzy and their demarcation has proven elusive to researchers. Albert Hirschman studied the intellectual climate in the seventeenth and eighteenth centuries in favor of trade and the express declaration of Montesquieu that "peace is the natural effect of trade."2 Since then, this idea has gained ground among researchers of economics and other fields of knowledge. In L'enfer des choses and subsequent works, Jean-Pierre Dupuy and Paul Dumouchel defend that the economy (the market) is a substitute for the sacred, containing violence through violent means. The market contains violence in the two senses of the term contain: It holds it and curbs it; it is both the poison and the remedy. The consumer society makes all objects available to everyone and in this way deactivates mimetic rivalry, deferring violent conflicts. But it is only a temporary remedy. In the words of Girard, "It is always necessary to find new toys."3Following the path initiated by Dumouchel and Dupuy, with their criticism of the free market economy and their proposal for a new notion of scarcity, in his text The Empire of Value, André Orléan claims that money is at the origin of the market. My analysis alludes to a moment prior to that established by Orléan. He maintains that he does not contemplate the historical origin of money but instead uses the expression "the conceptual origin of money." In fact, when he defends the essential monetary base of the market, he refers to an already developed market system, that is, an economic system for which the operation is structured around the institution of the market.4 Mark R. Anspach also criticized the market system in his book À Charge de Revanche. This author proposes the transcending of the perverse logic of vengeance that defines both war and the market that transforms it into a positive reciprocity based on the gift. This constitutes a type of shift away from looking at the past (settling old accounts) to looking toward the future, embracing gratitude, which gives rise to the initial gesture of giving.5 This study analyzes a time prior to that examined by Orléan and Anspach. It was the moment of hominization, that is, mimicry, the subsequent violence that threatened the survival of human groups and, as we will seek to explain, the market as an institution that has accompanied humankind since its conformation as a species... (shrink)

In this paper I give a detailed critical discussion of Derrida’s important 1994 book Specters of Marx. I begin by discussing the hypothesis advanced in the book and then make a number of remarks about its context. I then go on to discuss the central theme of Specters of Marx: the messianic. As a way of unpacking this theme, I address a number of subthemes in Specters of Marx: the injunction of différance, democracy to come, justice, religion and the es (...) spukt. As a consequence of this discussion, I turn to the theme of the political and address the subthemes of hegemony, the decision and the New International. I conclude the paper with a discussion of two more speculative themes that arise out of Specters of Marx: the question of the economic and the technological. (shrink)

According to the conventionalist doctrine of space elaborated by the French philosopher-scientist Henri Poincaré in the 1890s, the geometry of physical space is a matter of definition, not of fact. Poincaré's Hertz-inspired view of the role of hypothesis in science guided his interpretation of the theory of relativity (1905), which he found to be in violation of the axiom of free mobility of invariable solids. In a quixotic effort to save the Euclidean geometry that relied on this axiom, Poincaré extended (...) the purview of his doctrine of space to cover both space and time. The centerpiece of this new doctrine is what he called the "principle of physical relativity," which holds the laws of mechanics to be covariant with respect to a certain group of transformations. For Poincaré, the invariance group of classical mechanics defined physical space and time (Galilei spacetime), but he admitted that one could also define physical space and time in virtue of the invariance group of relativistic mechanics (Minkowski spacetime). Either way, physical space and time are the result of a convention. (shrink)

Several of Krueger & Funder's (K&F's) suggestions may promote more balanced social cognition research, but reconsidered null hypothesis statistical testing (NHST) is not one of them. Although NHST has primarily supported negative conclusions, this is simply because most conclusions have been negative. NHST can support positive, negative, and even balanced conclusions. Better NHST practices would benefit psychology, but would not alter the balance between positive and negative approaches.

It is widely stated that a hypothesis is necessary to the execution of a scientific investigation. However, the dogmatic acceptance of this, as of every other proposition, is to be condemned until its implications have been adequately explored.It is the writer's view that hypotheses are not prerequisite to every study which contributes to organized and systematic knowledge of the observable world. It is also concluded that the recognition of a problem requiring a solution or a question deserving an answer is (...) a step that must be taken in every sort of systematic study, and, therefore, that a problem is a more important characteristic of scientific method than a hypothesis. (shrink)

If the Past Hypothesis underlies the arrows of time, what is the status of the Past Hypothesis? In this paper, I examine the role of the Past Hypothesis in the Boltzmannian account and defend the view that the Past Hypothesis is a candidate fundamental law of nature. Such a view is known to be compatible with Humeanism about laws, but as I argue it is also supported by a minimal non-Humean "governing'' view. Some worries arise from the non-dynamical and time-dependent (...) character of the Past Hypothesis as a boundary condition, the intrinsic vagueness in its specification, and the nature of the initial probability distribution. I show that these worries do not have much force, and in any case they become less relevant in a new quantum framework for analyzing time's arrows---the Wentaculus. Hence, the view that the Past Hypothesis is a candidate fundamental law should be more widely accepted than it is now. (shrink)

The eukaryotic genome is organized into different domains by cis‐acting elements, such as boundaries/insulators and matrix attachment regions, and is packaged with different degrees of condensation. In the M phase, the chromatin becomes further highly condensed into chromosomes. The first step for transcriptional activation of a given gene, at a particular time during development, in any locus, is the opening of its chromatin domain. This locus needs to be kept in this state in each early G1 phase during every cell (...) cycle. Certain distal enhance elements, including locus control regions (LCRs) and enhancers, are believed to perform this target chromatin domain opening process and several models have been proposed to explain distal enhance action. But they did not explain precisely how a given chromatin domain is opened. Based on various studies, we propose a hypothesis for the mechanism of opening chromatin on a large scale. One important mechanism may involved breaking one or two DNA strands and reducing the linking numbers within chromatin domain. The topological changes can overpass some complexes formed on DNA strands and can be transmitted from specific localized points over a broad region, until boundary elements or insulators are reached. These may initiate downstream events such as propagation of histone acetylation and the binding of transcription factors to proximal promoters and may further augment the action mediated by distal enhancer elements. BioEssays 25:507–514, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

According to the Donohue-Levitt hypothesis, the legalization of abor- tion in the United States in the 1970s explains some of the decrease in crime in the 1990s. In this paper, I challenge this hypothesis. First, I argue against the intermediate mechanisms whereby abortion in the 1970s is supposed to cause a decrease in crime in the 1990s. Second, I argue against the correlations that sup- port this causal relationship.

It is still largely unclear which pathways explain the religion-health connection and how these mechanisms work. One such intervening mechanism, coherence, is the focus of this article. Based on database searches and a review of the literature retrieved, I differentiate between six meanings of coherence in religion-related research: 1) consistency; 2) credibility; 3) congruence; 4) confidence; 5) character; and 6) cohesion. In this article, this classification is utilized to analyse the conceptualizations and operationalizations of coherence within a particular strain of (...) research, namely the discourse on the so-called coherence hypothesis. In so doing, I accomplish three objectives: 1) the reconsideration of the classical coherence hypothesis launched by Idler in the mid-1980s; 2) the reconstruction of the history of the reception and modification of the hypothesis by using the example of the work of three influential scholars (Christopher G. Ellison, Linda K. George, and Sebastian Murken); and 3) the development of a new theoretical model of religion, coherence, and health. Since the review yielded that coherence was primarily used within the meaning of confidence and congruence and that personal and social factors have been widely neglected, one advantage of my model is the integration of all six conceptual varieties of coherence within a meaning-making coping framework. (shrink)

In two experiments on analogical hypothesis generation, we factorially manipulated the presence of domain and object similarities between a base situation and a target phenomenon, and assessed their effects on the transfer of the source’s explanatory structure before and after an indication to use the base analog as a source for analogical explanations. The absence of any kind of surface similarity led to very low rates of spontaneous transfer. In both experiments, however, either kind of surface similarity sufficed to enhance (...) the spontaneous transfer of the base explanation during the formulation of plausible hypotheses for the target. The transfer advantage of object and domain similarity cannot be attributed to the effect of these variables on post-access processes, since experimental conditions did not differ with regard to the ability to transfer the base explanation upon explicit request. The effect of domain similarity on spontaneous analogical explanation constitutes a relevant finding, especially given the lack of attention received by this dimension of similarity in behavioural studies and computer simulations of analogical retrieval. (shrink)

Hyperbaric oxygen (HBO) therapy still lacks proper interpretations of its many actions. This hypothesis is based on reports of temporarily elevated peripheral vascular resistance (PVR) during HBO sessions. Besides that, during HBO sessions, hyperoxygenated tissues can reduce their perfusion so much that CO2 can accumulate in them. Tissue perfusion depends on vascular innervation and on the balance between systemic constrictors and local dilators. During an HBO session, increased tissue oxygen levels suppress dilatory mechanisms. Tissue hyperoxygenation increases PVR, suggesting that the (...) HBO action on an edematous tissue may be caused by an oxygen‐induced disbalance among Starling capillary forces. The presented hypothesis is that oxygen‐caused arteriolar constriction reduces the hydrostatic pressure in downstream capillaries. Thus, more tissue fluid is absorbed in vascular capillaries, under the condition that the plasma colloid osmotic pressure remains unaltered during the HBO session. Among several known mechanisms behind the HBO actions, the vasoconstriction has been listed as a therapeutic modality for the reduction of the tissue edema, for a crush injury, for burns (in an acute phase), and for the compartment syndrome. The Bell's palsy is among often listed indications for the HBO treatment, although evidence is poor and reports of randomized trials are scarce. (shrink)