Seit Beginn der frühen Neuzeit ist das naturwissenschaftliche Verfahren maßgeblich durch ein neues Konzept geprägt: das Konzept des experimentellen, gestalterischen Eingriffs in die Natur. Es geht nun nicht mehr darum, eine Geschichte der "freien und ungebundenen Natur" (Bacon) zu erzählen, die in ihrem eigenen Lauf belassen und als vollkommene Bildung betrachtet wird. Es geht vielmehr darum, der "gebundenen und bezwungenen Natur" (Bacon) vermittels der experimentellen Tätigkeit des Menschen die Geheimnisse zu entreißen. Diese technisch-praktische Konzeption grenzt sich explizit von den klassischen (...) kontemplativen Wissenschaftsvorstellungen der Antike ab. Wie es Kant paradigmatisch in Bezug auf Bacon formuliert hat, ist diese "Revolution der Denkart" maßgeblich durch ein gewandeltes Verständnis des Verhältnisses des Menschen zur Natur geprägt. Der Mensch als Experimentator hat für Kant nicht mehr die "Qualität eines Schülers", der sich passiv von der Natur belehren läßt und an ihrem "Leitbande" (Kant) gegängelt wird. Seine neu gewonnene Autorität verleiht ihm vielmehr den Status eines Richters, der nun die Natur nötigen kann, auf gestellte Fragen zu antworten. Die Laborforschung der modernen Naturwissenschaft ist von den Formen der alten Naturwissenschaft so weit entfernt, daß sie den Vorwurf auf sich zog, sie untersuche Artefkakte, aber nicht Natur. Die grundlegenden Theorien über Natur können in der Regel nur unter den künstlichen Bedingungen des Labors aufgestellt werden. Daraus darf aber nicht geschlossen werden, die anhand von Laborphänomenen aufgestellten und getesteten Theorien handelten nicht von der Natur außerhalb der Labore. Aber ihrer exakten und detaillierten Anwendung auf Prozesse außerhalb der Labore stehen eine Fülle von Schwierigkeiten entgegen. Insofern markiert das Labor sehr wohl eine Grenze exakter Naturforschung, die für den Umgang der wissenschaftlich-technischen Zivilisation mit der Natur wichtige Konsequenzen hat. (shrink)

Seit Beginn der frühen Neuzeit ist das naturwissenschaftliche Verfahren maßgeblich durch ein neues Konzept geprägt: das Konzept des experimentellen, gestalterischen Eingriffs in die Natur. Es geht nun nicht mehr darum, eine Geschichte der "freien und ungebundenen Natur" (Bacon) zu erzählen, die in ihrem eigenen Lauf belassen und als vollkommene Bildung betrachtet wird. Es geht vielmehr darum, der "gebundenen und bezwungenen Natur" (Bacon) vermittels der experimentellen Tätigkeit des Menschen die Geheimnisse zu entreißen. Diese technisch-praktische Konzeption grenzt sich explizit von den klassischen (...) kontemplativen Wissenschaftsvorstellungen der Antike ab. Wie es Kant paradigmatisch in Bezug auf Bacon formuliert hat, ist diese "Revolution der Denkart" maßgeblich durch ein gewandeltes Verständnis des Verhältnisses des Menschen zur Natur geprägt. Der Mensch als Experimentator hat für Kant nicht mehr die "Qualität eines Schülers", der sich passiv von der Natur belehren läßt und an ihrem "Leitbande" (Kant) gegängelt wird. Seine neu gewonnene Autorität verleiht ihm vielmehr den Status eines Richters, der nun die Natur nötigen kann, auf gestellte Fragen zu antworten. Die Laborforschung der modernen Naturwissenschaft ist von den Formen der alten Naturwissenschaft so weit entfernt, daß sie den Vorwurf auf sich zog, sie untersuche Artekakte, aber nicht Natur. Die grundlegenden Theorien über Natur können in der Regel nur unter den künstlichen Bedingungen des Labors aufgestellt werden. Daraus darf aber nicht geschlossen werden, die anhand von Laborphänomenen aufgestellten und getesteten Theorien handelten nicht von der Natur außerhalb der Labore. Aber ihrer exakten und detaillierten Anwendung auf Prozesse außerhalb der Labore stehen eine Fülle von Schwierigkeiten entgegen. Insofern markiert das Labor sehr wohl eine Grenze exakter Naturforschung, die für den Umgang der wissenschaftlich-technischen Zivilisation mit der Natur wichtige Konsequenzen hat. Inhalt: Kristian Köchy / Gregor Schiemann: Natur im Labor Lothar Schäfer: Die Erscheinung der Natur unter Laborbedingungen Holm Tetens: Das Labor als Grenze der exakten Naturforschung Christoph Rehmann-Sutter: Genes in Labs - Concepts of Development and the Standard Environment Kristian Köchy: Lebewesen im Labor. Das Experiment in der Biologie Jutta Weber: Mannigfaltige Techno-Naturen. Von epistemischen Modellsystemen und situierten Maschinen Thomas Sören Hoffmann: Gezeigte versus sich zeigende Natur. Eine Skizze im Blick auf das Verhältnis von Labor und Natur Klaus Michael Meyer-Abich: Laborforschung im Erkenntnishandeln der Experimentiergesellschaft. Eine holistisch-pragmatische Perspektive für die Wissenschaftstheorie. (shrink)

Helmholtz's public reflection about the nature of the experiment and its role in the sciences is a historically important description, which also helps to analyze his own works. It is a part of his conception of science and nature, which can be seen as an ideal type of science and its goals. But its historical reach seems to be limited in an important respect. Helmholtz's understanding of experiments is based on the idea that their planning, realization and evaluation lies in (...) the hands of a person or group acting according to decisions of free will. In my opinion this idea is characteristic for the foundation of the experimental method in early modern times, not however for several forms of its present structures. Above all, the increasing technization of producing knowledge reduces the roIe of the subject in conducting experiments. My lecture consists of three parts. In its first part I would like to present a summary of Helmholtz's own theory of experiment and the change of his conception of science and nature. In the second part I would like to discuss three examples of his experimental practice, which were taken in chronological order from three different periods of his work; in the third part I would like to compare the examples with the change of his conception of science and nature. (shrink)

We seem to talk about repeatable artworks, like symphonies, films, and novels, all the time. We say things like, "The Moonlight Sonata has three movements" and "Duck Soup makes me laugh". How are these sentences to be understood? We argue against the simple subject/predicate view, on which the subjects of the sentences refer to individuals and the sentences are true iff the referents of the subjects have the properties picked out by the predicates. We then consider two alternative responses that (...) involve reading these sentences as generics, similar to "The polar bear has four paws". The first response takes these sentences to be about kinds, and the second takes the relevant noun-phrases to act as predicates. We reject these accounts, but offer a third alternative which is informed by both, and which enables us to deny the existence of repeatable artworks while endorsing the truth of sentences seemingly about them. (shrink)

In a series of recent papers, Ben Bramble defends a version of hedonism which holds that purely repetitious pleasures add no value to one’s life (i.e. Non-Repeatable Hedonism). In this paper, we pose a dilemma for Non-Repeatable Hedonism. We argue that it is either committed both to a deeply implausible asymmetry between how pleasures and pains affect a person’s well-being and to deeply implausible claims about how to maximize well-being, or is committed to the claim that a life of eternal (...) pleasure for a person can be just as good for them as a life of eternal suffering. The only way out of this dilemma is for Bramble to reject the Non-Repetition Requirement. Yet, rejecting this requirement both forces Bramble to reject the wholly unique, core component, of his view and undermines his view’s ability to handle one of the most powerful objections to hedonism, viz., that a life with a larger quantity of so-called “base” (or lower) pleasures is better for a person than a life with a slightly smaller quantity of so-called higher pleasures. We conclude that Non-Repeatable Hedonism must be rejected in favor of standard forms of hedonism or some non-hedonic view of well-being. (shrink)

It is commonly believed that when a finite value is received in a game that has an infinite expected value, it is in one’s interest to redo the game. We have argued against this belief, at least in the repeated St Petersburg two-envelope case. We also show a case where repeatedly opting for a higher expected value leads to a worse outcome.

Background: Magnetic resonance spectroscopic imaging is a neuroimaging technique that may be useful for non-invasive mapping of brain temperature over a large brain volume. To date, intra-subject reproducibility of MRSI-based brain temperature has not been investigated. The objective of this repeated measures MRSI-t study was to establish intra-subject reproducibility and repeatability of brain temperature, as well as typical brain temperature range.Methods: Healthy participants aged 23–46 years were scanned at two time points ~12-weeks apart. Volumetric MRSI data were processed by (...) reconstructing metabolite and water images using parametric spectral analysis. Brain temperature was derived using the frequency difference between water and creatine for 47 regions of interest delineated by the modified Automated Anatomical Labeling atlas. Reproducibility was measured using the coefficient of variation for repeated measures, and repeatability was determined using the standard error of measurement. For each region, the upper and lower bounds of Minimal Detectable Change were established to characterize the typical range of TCRE values.Results: The mean global brain temperature over all subjects was 37.2°C with spatial variations across ROIs. There was a significant main effect for time [F = 37.0, p < 0.0001] and for brain region [F = 2.66, p < 0.0001]. The time*brain region interaction was not significant [F = 0.80, p = 0.83]. Participants' TCRE was stable for each ROI across both time points, with ROIs' COVrep ranging from 0.81 to 3.08% ; majority of ROIs had a COVrep <2.0%.Conclusions: Brain temperature measurements were highly consistent between both time points, indicating high reproducibility and repeatability of MRSI-t. MRSI-t may be a promising diagnostic, prognostic, and therapeutic tool for non-invasively monitoring brain temperature changes in health and disease. However, further studies of healthy participants with larger sample size and numerous repeated acquisitions are imperative for establishing a reference range of typical brain TCRE, as well as the threshold above which TCRE is likely pathological. (shrink)

ABSTRACTI present a new objection to Bundle Theory. The objection rests on the repeatability of universals, and targets every version of Bundle Theory that assumes that concrete particulars constituted by the same universals are numerically identical. The only way that bundle theorists can elude this objection is to admit the possibility of distinct bundles constituted by the same universals. If even this view is untenable, then Bundle Theory as such is hopeless. Finally, I show how the present inquiry reshapes (...) the dialectical relationship between Bundle Theory and the principle of Identity of Indiscernibles. (shrink)

Fisher criticised the Neyman-Pearson approach to hypothesis testing by arguing that it relies on the assumption of “repeated sampling from the same population.” The present article considers the responses to this criticism provided by Pearson and Neyman. Pearson interpreted alpha levels in relation to imaginary replications of the original test. This interpretation is appropriate when test users are sure that their replications will be equivalent to one another. However, by definition, scientific researchers do not possess sufficient knowledge about the relevant (...) and irrelevant aspects of their tests and populations to be sure that their replications will be equivalent to one another. Pearson also interpreted the alpha level as a personal rule that guides researchers’ behavior during hypothesis testing. However, this interpretation fails to acknowledge that the same researcher may use different alpha levels in different testing situations. Addressing this problem, Neyman proposed that the average alpha level adopted by a particular researcher can be viewed as an indicator of that researcher’s typical Type I error rate. Researchers’ average alpha levels may be informative from a metascientific perspective. However, they are not useful from a scientific perspective. Scientists are more concerned with the error rates of specific tests of specific hypotheses, rather than the error rates of their colleagues. It is concluded that neither Neyman nor Pearson adequately rebutted Fisher’s “repeated sampling” criticism. Fisher’s significance testing approach is briefly considered as an alternative to the Neyman-Pearson approach. (shrink)

Linguistic repetitions in children are conceptualized as negative in children with autism – echolalia, without communicative purpose – and positive in typically developing (TD) children – linguistic alignment involved in shared engagement, common ground and language acquisition. To investigate this apparent contradiction we analyzed spontaneous speech in 67 parent–child dyads from a longitudinal corpus (30 minutes of play activities at 6 visits over 2 years). We included 32 children with autism and 35 linguistically matched TD children (mean age at recruitment (...) 32.76 and 20.27 months). We found a small number of exact repetitions in both groups (roughly 1% of utterances across visits), which increased over time in children with autism and decreased in the TD group. Partial repetitions were much more frequent: children reused caregivers' words at high rates regardless of diagnostic group (24% of utterances at first visit), and this increased in frequency (but not level) over time, faster for TD children (at final visit: 33% for autism, 40% for TD). The same happened for partial repetition of syntax and semantic alignment. However, chance alignment (as measured by surrogate pairs) also increased and findings for developmental changes were reliable only for syntactic and semantic alignment. Children with richer linguistic abilities also displayed a higher tendency to partially re–use their caregivers' language (alignment rates and semantic alignment). This highlights that all children commonly re–used the words, syntax, and topics of their caregivers, albeit with some quantitative differences, and that most repetition was at least potentially productive, with repeated language being re–contextualized and integrated with non–repeated language. The salience of echolalia in ASD might be partially explained by slight differences in frequency, amplified by lower semantic alignment, persistence over time, and expectations of echolalia. More in–depth qualitative and quantitative analyses of how repetitions are used and received in context are needed. (shrink)

This paper examines whether having school students repeat a year improves their performance, focusing on learning English as a foreign language. It takes students’ English examination results from five years from a Chinese‐medium school, together with data on their learning styles and learning strategies. Drawing on local cultural and pedagogic factors, the study finds that repeating a year, far from improving scores, homogenizes the results of males and females, and, while finding a small but statistically insignificant rise in the scores (...) of females, is detrimental to the performance of males. Repeating a year either makes no difference or a negative difference to results. It is suggested that repeating a year reproduces, sharpens and potentiates gender differences in learning and performing in English as a foreign language, and that repeating a year is the medium and outcome of gender inequality. Implications are drawn for practice. (shrink)

Head injuries are an inherent risk of participating in the major collision sports played in Australia. Protocols introduced by the governing bodies of these sports are ostensibly designed to improve player safety but do not prevent players suffering from repeated concussions. There is evidence that repeated traumatic brain injuries increase the risk of developing a number of long term problems but scientific and popular debates have largely focused on whether there is a causal link between concussion and chronic traumatic encephalopathy. (...) We argue that the governing bodies of collision sports played in Australia have used uncertainty about CTE to justify a “wait and see” approach instead of attempting to prevent repeated head injuries. This stance is difficult to defend when these governing bodies claim to give a high priority to protecting player welfare. (shrink)

Across her diverse body of work, the Canadian-born poet Anne Carson repeatedly returns to the objects of her preoccupation. From Lazarus—“a person who had to die twice” (Nox)—to Herakles and countless other figures, themes, and images, Carson repeatedly reworks old ground, particularly around the unknowable divide separating the living and the dead. This essay adopts a repetitive approach to explore how H of H and The Trojan Women can be understood as in reiterative conversation with the poet’s source texts, her (...) own work, and wider thinking on the utility of repeating ourselves. (shrink)

Introduces the applications of repeated measures design processes with the popular IBM® SPSS® software Repeated Measures Design for Empirical Researchers presents comprehensive coverage of the formation of research questions and the analysis of repeated measures using IBM SPSS and also includes the solutions necessary for understanding situations where the designs can be used. In addition to explaining the computation involved in each design, the book presents a unique discussion on how to conceptualize research problems as well as identify appropriate repeated (...) measures designs for research purposes. Featuring practical examples from a multitude of domains including psychology, the social sciences, management, and sports science, the book helps readers better understand the associated theories and methodologies of repeated measures design processes. The book covers various fundamental concepts involved in the design of experiments, basic statistical designs, computational details, differentiating independent and repeated measures designs, and testing assumptions. Along with an introduction to IBM SPSS software, Repeated Measures Design for Empirical Researchers includes: A discussion of the popular repeated measures designs frequently used by researchers, such as one-way repeated measures ANOVA, two-way repeated measures design, two-way mixed design, and mixed design with two-way MANOVA Coverage of sample size determination for the successful implementation of designing and analyzing a repeated measures study A step-by-step guide to analyzing the data obtained with real-world examples throughout to illustrate the underlying advantages and assumptions A companion website with supplementary IBM SPSS data sets and programming solutions as well as additional case studies Repeated Measures Design for Empirical Researchers is a useful textbook for graduate- and PhD-level students majoring in biostatistics, the social sciences, psychology, medicine, management, sports, physical education, and health. The book is also an excellent reference for professionals interested in experimental designs and statistical sciences as well as statistical consultants and practitioners from other fields including biological, medical, agricultural, and horticultural sciences. J. P. Verma, PhD, is Professor of Statistics and Director of the Center for Advanced Studies at Lakshmibai National Institute of Physical Education, India. Professor Verma is an active researcher in sports modeling and data analysis and has conducted many workshops on research methodology, research designs, multivariate analysis, statistical modeling, and data analysis for students of management, physical education, social science, and economics. He is the author of Statistics for Exercise Science and Health with Microsoft® Office Excel®, also published by Wiley. (shrink)

Over 20 unstable microsatellite repeats have been identified as the cause of neurological disease in humans. The repeat nucleotide sequences, their location within the genes, the ranges of normal and disease‐causing repeat length and the clinical outcomes differ. Unstable repeats can be located in the coding or the non‐coding region of a gene. Different pathogenic mechanisms that are hypothesised to underlie the diseases are discussed. Evidence is given both from studies in simple model systems and from studies on human material (...) and in animal models. Since somatic instability might affect the clinical outcome, this is briefly touched on. Available data and theories on the timing and mechanisms of the repeat instability itself are discussed, along with factors that have been observed to affect instability. Finally, the question of why the often harmful unstable repeats have been maintained throughout evolution is addressed. (shrink)

Expressivists traditionally explain normative supervenience by saying it is a conceptual truth. I argue against this tradition in two steps. First, I show the modal claim that stands in need of explanation has been stated imprecisely. Classic arguments in metaethics for normative supervenience and those that rely on it as a premise presuppose a constraint on the supervenience base that is rarely (if ever) made explicit: the repeatability of the non-normative properties on which the normative supervenes. Non-normative properties are (...) repeatable when it is possible for numerically distinct individuals to share them. Second, I show if the modal truth that stands in need of explanation entails that there are individuals exactly alike in repeatable non-normative respects that cannot normatively differ, then standard expressivist accounts of normative supervenience as a conceptual truth are unsuccessful. Expressivist metasemantics for normative terms, together with constitutive facts about the non-cognitive attitudes essentially involved in normative thought, strongly suggest that repeatable supervenience could not be a conceptual truth. I argue, finally, that although repeatable supervenience bears the marks of a conceptual truth, expressivists should be content to treat it as an ordinary normative truth, and to explain it the same way they explain other normative truths. (shrink)

This study examined students' reasoning about simple repeated choices. Each choice involved ''betting'' on two events, differing in probability. We asked subjects to generate or evaluate alternative strategies such as betting on the most likely event on every trial, betting on it on almost every trial, or employing a ''probability matching'' strategy. Almost half of the college students did not generate or rank strategies according to their expected value, but few subjects preferred a strategy of strict probability matching. High-school students (...) showed greater deviations from expected value than college students. Similar misunderstandings were observed in a choice task involving real (not hypothetical) repeated trials. Large gender differences in prediction strategies and in related computational skills were observed. Subjects who understand the optimal strategy usually do so in terms of independence of successive trials rather than calculation. Some subjects understand the concept of independence but fail to bring it to bear, thinking it can be overridden by intuition or local balancing (representativeness). (shrink)

In this paper we review the factors alleged to be responsible for the creation of inaccurate reports among preschool-aged children, focusing on so-called "source misattribution errors." We present the first round of results from an ongoing program of research that suggests that source misattributions could be a powerful mechanism underlying children′s false beliefs about having experienced fictitious events. Preliminary findings from this program of research indicate that all children of all ages are equally susceptible to making source misattributions. Data from (...) a follow-up wave of data indicate that very young children may be disproportionately vulnerable to these kinds of errors when the procedure is changed slightly to create mental images more easily. This vulnerability leads younger preschoolers, on occasion, to claim that they actually experienced events that they only thought about. These preliminary findings are discussed in the context of the ongoing debate over the veracity and durability of delayed reports of early memories, repressed memories, dissociative states, and the validity risks posed by therapeutic techniques that entail repeated visually guided imagery inductions. (shrink)

We previously showed that the illusory sense of ownership and agency over a moving body in immersive virtual reality can trigger subjective and physiological reactions on the real subject’s body and, therefore, an acute improvement of cognitive functions after a single session of high-intensity intermittent exercise performed exclusively by one’s own virtual body, similar to what happens when we actually do physical activity. As well as confirming previous results, here, we aimed at finding in the elderly an increased improvement after (...) a longer virtual training with similar characteristics. Forty-two healthy older subjects completed a parallel-group randomized controlled trial including an adapted version of the virtual training previously used: while sitting, participants observed the virtual body in a first-person perspective or a third-person perspective performing 20 min of virtual high-intensity intermittent exercise. This was repeated twice a week for 6 weeks. During the vHIE, we measured the heart rate and administered questionnaires to evaluate illusory body ownership and agency. Before the beginning of the intervention, immediately after the first session of vHIE, and at the end of the entire intervention, we evaluated the cognitive performance at the Stroop task with online recording of the hemodynamic activity over the left dorsolateral prefrontal cortex. While we confirm previous results regarding the virtual illusion and its physiological effects, we did not find significant cognitive or neural improvement immediately after the first vHIE session. As a novelty, in the 1PP group only, we detected a significant decrease in the response time of the Stroop task in the post-intervention assessment compared to its baseline; coherently, we found an increased activation on left dorsolateral prefrontal cortex after the entire intervention. While the current results strengthen the impact of the virtual full-body illusion and its physiological consequences on the elderly as well, they might have stronger and more established body representations. Perhaps, a longer and increased exposure to those illusions is necessary to initiate the cascade of events that culminates to an improved cognitive performance. (shrink)

I sketch here an intuitive picture of repeatable artworks as created types, which are individuated in part by historical paths (re)production. Although attractive, this view has been rejected by a number of authors on the basis of general claims about abstract objects. On consideration, however, these general claims are overgeneralizations, which whilst true of some abstracta, are not true of all abstract objects, and in particular, are not true of created types. The intuitive picture of repeatable artworks as created types (...) is, then, left in place. (shrink)

_Repeating Žižek_ offers a serious engagement with the ideas and propositions of philosopher Slavoj Žižek. Often subjecting Žižek's work to a Žižekian analysis, this volume's contributors consider the possibility of formalizing Žižek's ideas into an identifiable philosophical system. They examine his interpretations of Hegel, Plato, and Lacan, outline his debates with Badiou, and evaluate the implications of his analysis of politics and capitalism upon Marxist thought. Other essays focus on Žižek's approach to Christianity and Islam, his "sloppy" method of reading (...) texts, his relation to current developments in neurobiology, and his theorization of animals. The book ends with an afterword by Žižek in which he analyzes Shakespeare's and Beckett's plays in relation to the subject. The contributors do not reach a consensus on defining a Žižekian school of philosophy—perhaps his idiosyncratic and often heterogeneous ideas simply resist synthesis—but even in their repetition of Žižek, they create something new and vital. Contributors. Henrik Jøker Bjerre, Bruno Bosteels, Agon Hamza, Brian Benjamin Hansen, Adrian Johnston, Katja Kolšek, Adam Kotsko, Catherine Malabou, Benjamin Noys, Geoff Pfeifer, Frank Ruda, Oxana Timofeeva, Samo Tomšic, Gabriel Tupinambá, Fabio Vighi, Gavin Walker, Sead Zimeri, Slavoj Žižek. (shrink)

The rapid generation of new shapes observed in the living world is the result of genetic variation, especially in “morphological” developmental genes. Many of these genes contain coding tandem repeats. Fondon and Garner have shown that expansions and contractions of these repeats are associated with the great diversity of morphologies observed in the domestic dog, Canis familiaris.1 In particular, they found that the repeat variations in two genes were significantly associated with changes in limb and skull morphology. These results open (...) the possibility that such a mechanism contributes to the diversity of life. BioEssays 27:581–587, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

SOME PHILOSOPHERS (NOTABLY RICHARD SWINBURNE AND NINIAN SMART) HAVE ARGUED THAT WHILE THERE IS A LOGICAL POSSIBILITY OF A MIRACLE OCCURRING, THERE COULD NOT BE A REPEATABLE MIRACLE. I DISCUSS VARIOUS INTERPRETATIONS OF THIS CLAIM AND ARGUE THAT THERE IS NO INTERESTING SENSE IN WHICH IT IS TRUE.

The article starts from delineating the precise coordinates of the concept of action as it can be found in the work of Slavoj Žižek and Alain Badiou. It argues in detail why to properly grasp its reach and with it what is at stake in the two philosophical enterprises can best be comprehended when it is read as an attempt of re-actualizing Marx. But, as the article demonstrates, actualization does not come down to being a mere gesture of repetition. It (...) rather involves a complex linkage of different elements that can be best captured by the psychoanalytic slogan of remembering, repeating and working through. It implies remembering Marx gesture, repeating his involvement with Hegel and a working through of the concept of negation. All this gives rise to a new form of ideology critique and a new form of materialist dialectics. The article systematically reconstructs the different articulations which the actualization of Marx finds in Žižek and Badiou and ends by marking a crucial difference with regard to their renewed dialectics. (shrink)

Transcranial magnetic stimulation (TMS) of the visual cortex can induce phosphenes as can non-diagnostic ultrasound, the latter while participants have closed their eyes during Stimulation. Here we sought to study potential alteration of a visual target (a white crosshair) due to application of diagnostic ultrasound to the visual cortex. We applied a randomized series of actual or sham diagnostic ultrasound to the visual cortex of healthy participants while they stared at a visual target, with the ultrasound device placed where TMS (...) elicited phosphenes. These participants observed percepts 7 out of 10 times, consisting of extra or extensions of lines relative to the original crosshair, and additional colors. Observation of a percept occurred an average of 53.7 +/- 2.6% of the time over the course of the experiment for these participants. In contrast, 7 out of 10 participants exposed to sham-only diagnostic ultrasound observed comparable percepts an average of 36.3 +/ 1.9% of the time, a statistically significant difference (p < 0.00001). Moreover, on average, participants exposed to a combination of sham and actual ultrasound reported a net increase of 47.9 percentage points in the likelihood that they would report a visual effect by the end of the experiment. Our experiment demonstrated that a random combination of sham-only and actual diagnostic ultrasound applied to the visual cortex of participants increased the likelihood that they would observe visual effects, but not the type of effects, with that likelihood increasing over the course of the experiment. From this we conclude that repeated exposures by diagnostic ultrasound made the visual cortex more responsive to stimulation of their visual cortex by the visual target. These observations, consistent with other’s observation of effects of diagnostic ultrasound stimulation of human motor cortex and amygdala, as well as the FDA approved nature of diagnostic ultrasound, may lead to increased study of diagnostic ultrasound applied to human brain. (shrink)

In this paper Ludwig Wittgenstein is interpreted as a philosopher of language and technology. Due to current developments, a special focus is on lifeworld practice and technoscientific research. In particular, image-interpretation is used as a concrete methodical example. Whereas in most science- or technology-related Wittgenstein interpretations the focus is on the Tractatus, the Investigations or On Certainty, in this paper the primary source is his very late triune fragment Bemerkungen über die Farben. It is argued that Wittgenstein’s approach can supplement (...) Don Ihde’s concept of material hermeneutics, and that Wittgenstein’s constructivist and pragmatist claims relate to current authors in the philosophy of technology like Peter Janich, Carl Mitcham or Jürgen Mittelstraß. Ludwig Wittgenstein enables a philosophical approach of transcendental grammars, techno-linguistic forms of life and technoscientific language games. In detail, several methodological aspects regarding relations between language and technology are summarized. Here concretely repeatability and methodical actions play major roles in uncertain situations of language and technology practice. It is shown that Wittgenstein is still underestimated in the philosophy of technology—although his thoughtful conceptualizations of language, social practice and technology bear important methodical insights for current technosciences like synthetic biology, robotics and many others. (shrink)

Repeatable artworks, such as novels and musical works, have often been construed as universals whose instances are particular printings or performances. In Art and Art-Attempts, Christy Mag Uidhir offers a nominalist account of repeatable artworks, eschewing talk of universals. Mag Uidhir argues that all artworks are concrete, and artworks that we regard as repeatable are simply unified by a relevant similarity relation: we use the name Beloved to refer to two concrete printed novels because they are relevantly similar to each (...) other and to certain other printings that are the product of Toni Morrison’s art-attempt. I discuss two potential difficulties for Mag Uidhir’s notion of relevant similarity: a difficulty related to appropriation, and a difficulty related to the fact that musical performances are often the product of distinct art-attempts by the composer and by the performer. I suggest that both difficulties could be addressed by enriching the notion of relevant similarity by appeal to the artist’s specification of which similarities are essential for two works to count as relevantly similar. (shrink)

This paper empirically investigates the interaction between repeated transactions and endogenous contractual incompleteness. We design an indefinitely repeated games experiment between identifiable players. In this experiment, the probability of continuation and the level of shared information vary over the treatments. The level of contractual completeness is decided by participants at each period. Our results show that past interactions are a stronger determinant of the level of investment in contractual completeness than the perspective of future business.

In The Second Sex, Simone de Beauvoir diagnoses “woman” as the “lost sex,” torn between her individual autonomy and her “feminine destiny.” Becoming a “real woman” in patriarchal societies demands that women lose their authentic, autonomous selves to become the “inessential Other” for Man. To better understand this diagnosis and how women might refind themselves, I rehabilitate the influence of Søren Kierkegaard and his concept of repetition as what must be lost to be found again in Beauvoir’s account of freedom (...) and, specifically, the liberation of women. Beauvoir offers a dual account of repetition, that of mundane repetition and sacrificial repetition, bringing them to bear both on her diagnosis of women’s oppression and her theorization of our liberation. Sacrificial repetition becomes a temporality for freedom—one must be able to repeat or retake their autonomy continuously toward an open future. For this to happen concretely, Beauvoir insists that we must sacrifice the (racist, classist) patriarchal ideals of the “real woman” and “real man” as we retake our autonomy and reconfigure the meaning of sex difference anew. (shrink)

Trinucleotide repeat expansions are now a well‐established mutational mechanism in human genetic disease. An unstable CAG repeat is known to be responsible for three neurodegenerative disorders: Huntington's disease, spinal and bulbar musclar atrophy and spinocerebellar ataxia type 1. Similarities in the genetics of these diseases, the size of the repeat expansions and the position of the unstable repeat within the gene (when known) suggest a common basis to the observed phenotypes. The cloning of two regions at which chromosome breakage can (...) be induced (FRAXA and FRAXE) has in each case uncovered an unstable CG‐rich triplet repeat which becomes methylated when fully expanded. In addition to these two classes of mutation, the presence of an expanded CTG repeat in the 3′ untranslated region of a protein kinase causes myotonic dystrophy. The size of the respective expansions, repeat stability, mutational origins and possible mechanisms of action are discussed. (shrink)

Risky decision-making is highly influenced by emotions and can lead to fatal consequences. Attempts to reduce risk-taking include the use of mindfulness-based interventions, which have shown promising results for both emotion regulation and risk-taking. However, it is still unclear whether improved emotion regulation is the mechanism responsible for reduced risk-taking. In the present study, we explore the effect of a 5-week MBI on risky driving in a group of repeat traffic offenders by comparing them with non-repeat offenders and repeat offenders (...) without training. We evaluated the driving behavior of the participants through a driving simulation, and self-reported emotion regulation, both before and after the intervention. At baseline, poor emotion regulation was related to a more unstable driving behavior, and speeding. The group that received mindfulness training showed improved performance during risky driving situations and had fewer accidents, although their overall driving behavior remained largely unchanged. The observed trend toward improved emotion regulation was not significant. We discuss whether other effects of MBI – such as self-regulation of attention – could underlie the observed reduction in risky driving in the initial stages. Nonetheless, our findings still confirm the close relationship between emotion regulation skills and risky driving. (shrink)

Adaptation can optimize information processing by allowing the visual system to always adjust to the environment. However, only a few studies have investigated how the visual system makes adjustments to repeatedly occurring changes in the input, still less about the related neural mechanism. Our previous study found that contrast adaptation attenuated after multiple daily sessions of repeated adaptation, which was explained by the habituation of either the adapter’s effective strength or the adaptation mechanisms. To examine the former hypothesis, in the (...) present study we used the frequency tagging technique to measure the adapter-elicited steady-state visual evoked potential amplitudes. Participants repeatedly adapted to the same contrast adapter in a top-up manner for six continuous days, which was called training of adaptation. The behavioral adaptation effect and SSVEP response to the trained adapter and an untrained control adapter were measured before and after training. The psychophysical results showed that the effect of adaptation in the trained condition significantly reduced after training, replicating our previous finding. Contradicting the prediction of the hypothesis that repeated adaptation attenuated the effective strength of the adapter, the SSVEP amplitude was unchanged after training, which was further confirmed by an equivalence test. Taken together, the results challenge the account of habituation of adapter in repeated adaptation, while leaving the account of habituation of adaptation mechanism to be tested. (shrink)

Repeating history? Public and community health nursing in AustraliaDespite the long history in Australia of public and community health nursing, it has never been regarded as important as hospital‐based nursing. Notwithstanding the establishment of nursing organisations in the very early years of the 20th century and subsequent efforts to develop the nursing workforce, public and community health nursing has been neglected in terms of policy, research into public health nursing practice and workforce development. Even in the present day, public and (...) community health nurses are marginalised from mainstream nursing interests and there is a lack of conceptualisation about the value of nursing’s contribution to the primary health sector. This sector is experiencing a new wave of reforms driven by a combination of managerialism and systems change for improved responses to address health inequalities. Because there is not a strong institutionalised professional policy and support base for public and community health nurses, they are vulnerable in these reforms to increased domination and appropriation of their practice by stronger professional interests. There is an urgent need for professionally organised support from mainstream nursing to ensure that public and community health nurses are positioned as a unified force in efforts to advance the health of the community. (shrink)

An emerging ethical dilemma in light of the opioid crisis, repeat cardiac valve replacements for patients diagnosed with endocarditis from intravenous drug use presents specific challenges to Catholic health care organizations. While secular health care is tasked with the allocation of scarce resources, Catholic institutions must address additional considerations when balancing stewardship of scarce resources, human dignity, and patient accountability. A recent ethics consultation illustrates the issues involved in multiple valve replacements for substance-addicted patients from a Catholic ethical perspective. The (...) discussion includes policy recommendations and ethical reflections. (shrink)

Although Kuhn, Lakatos and Laudan disagree on many points, these three widely accepted accounts of scientific growth do agree on certain key features of scientific revolutions. This minimal agreement is sufficient to place stringent restraints on the historical development of science. In particular it follows from the common features of their accounts that scientific history can never repeat. Using the term 'supertheory' to denote indifferently the large scale historical entitites employed in all three accounts, it is shown that a supertheory (...) cannot succeed itself, or reappear after a number of intervening scientific revolutions. The relation of these arguments to the details of the three accounts is briefly examined. (shrink)

Cet article se propose d’appréhender le segment du point de vue de la production, en analysant les séquences identifiées lors du processus d’écriture, c’est-à-dire les unités langagières produites de manière spontanée et ininterrompue (entre deux pauses). Ces unités, que nous appelons jets textuels, ont été enregistrées grâce à l’outil de suivi de rédaction Inputlog. Nous avons tenté de caractériser les jets textuels en les mettant en regard avec divers types d’unités segmentales de langage, qu’elles soient issues de la segmentation des (...) textes finalisés, ou reconnues comme des segments préfabriqués propres à un système lexical ou syntaxique, c’est-à-dire des figements au sens large du terme. Nous nous sommes plus particulièrement penchés sur un parcours de segmentation parallèle, en production (jets textuels) et en réception (segments répétés), pour interroger quelques concepts théoriques et méthodologiques qui sous-tendent les démarches de segmentation : pré-construit, automatisme, mémorisation, figement, enracinement cognitif, fréquence, répétition. (shrink)

This paper is devoted to face recent views in the ontology of music that reject that musical works are repeatable in musical performances. It will be observed that musical works’ repeatability implies that they are audible and variable in their performances. To this extent, the aim here is to show that repeatability, audibility and variability are ontologically substantive features of musical works’ nature. The thesis that will be defended is that repeatability, audibility and variability are dispositional non-aesthetic (...) properties of musical works. The plausibility of the dispositional account of musical works’ repeatability, audibility and variability will lead us to the conclusion that they are ontologically substantive features of musical works’ nature, and consequently, any suitable explanation of the ontology of musical works must not ignore them. (shrink)

This paper explores the ontology of musical improvisation (MI). MI, as process in which creative and performing activities are one and the same generative occurrence, is contrasted with the most widespread conceptual resource used in inquiries about music ontology of the Western tradition: the type/token duality (TtD). TtD, which is used for explaining the relationship between musical works (MWs) and performances, does not fit for MI. Nonetheless MI can be ontologically related to MWs. A MW can ensue from MI and (...) MI can be required for performing a MW faithfully. As performance on a MW, MI can offer versions of a MW, manifest a MW, and, especially, use it as one of its ‘ingredients’. Recordings of MI present special challenges and an unexpected ontological revival. (shrink)

In eukaryotic cells, heterochromatin is typically composed of tandem DNA repeats and plays crucial roles in gene expression and genome stability. It has been reported that silencing at individual units within tandem heterochromatin repeats exhibits a position‐dependent variation. However, how the heterochromatin is organized at an individual repeat level remains poorly understood. Using a novel genetic approach, our recent study identified a conserved protein Rex1BD required for position‐dependent silencing within heterochromatin repeats. We further revealed that Rex1BD interacts with the 14‐3‐3 (...) protein to regulate heterochromatin silencing by linking RNAi and HDAC pathways. In this review, we discuss how Rex1BD and the 14‐3‐3 protein coordinate to modulate heterochromatin organization at the individual repeat level, and comment on the biological significance of the position‐dependent effect in heterochromatin repeats. We also identify the knowledge gaps that still need to be unveiled in the field. (shrink)

Repeat offenders receive longer sentences than first offenders in virtually every modern jurisdiction. Such prior-record enhancements are politically popular. Scholars are more divided, especially regarding severe enhancements. Retributivists have long disagreed about which enhancements, if any, are morally justifiable and on what basis. This article advances the debate, offering lessons for retributivists on all sides. I address an intuitive argument that justifies enhancements in terms of character. This argument has been caricatured and dismissed, with defenders of enhancements preferring character-independent arguments. (...) I reconstruct an argument for enhancements that assumes recidivism constitutes evidence of culpability-aggravating character traits. The argument seems at least coherent, inferentially valid, and intuitively plausible. I then raise what I see as the real threats to the argument, which are neither conceptual nor normative, but empirical. I identify some formal features that the character argument requires of culpability-aggravating traits. To support enhancements, such traits must also correlate properly with criminal records. One place to look for characterizations of such traits, and evidence of correlation, is criminology, in theories of criminogenesis and criminality. I conclude that character arguments for prior-record enhancements cannot be dismissed, although their thorough evaluation awaits answers to complex empirical questions. (shrink)