Mice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated. Knockout mice provide an ideal opportunity to analyse the function of individual mammalian genes and to model a range of human inherited disorders. This powerful approach has also identified numerous examples of gene redundancy and has highlighted the need to consider metabolic (...) differences between man and mouse in disease modelling. More sophisticated gene‐targeting methods are now being used to introduce subtle gene alterations. In the future, more refined genetic analysis and genome, rather than individual gene, alterations will be achieved by incorporating site‐specific recombination into targeting strategies. Gene targeting could also make a contribution to improved protocols for gene therapy. (shrink)

Rapid developments in Artificial Intelligence are leading to an increasing human reliance on machine decision making. Even in collaborative efforts with Decision Support Systems (DSSs), where a human expert is expected to make the final decisions, it can be hard to keep the expert actively involved throughout the decision process. DSSs suggest their own solutions and thus invite passive decision making. To keep humans actively ‘on’ the decision-making loop and counter overreliance on machines, we propose a ‘reflection machine’ (RM). This (...) system asks users questions about their decision strategy and thereby prompts them to evaluate their own decisions critically. We discuss what forms RMs can take and present a proof-of-concept implementation of a RM that can produce feedback on users’ decisions in the medical and law domains. We show that the prototype requires very little domain knowledge to create reasonably intelligent critiquing questions. With this prototype, we demonstrate the technical feasibility to develop RMs and hope to pave the way for future research into their effectiveness and value. (shrink)

`Folk Psychology' - our everyday talk of beliefs, desires and mental events - has long been compared with the technical language of `Cognitive Science'. Does folk psychology provide a correct account of the mental causes of our behaviour, or must our everyday terms ultimately be replaced by a language developed from computational models and neurobiology? This broad-ranging book addresses these questions, which lie at the heart of psychology and philosophy. Providing a critical overview of the key literature in the field, (...) including the seminal work of Fodor and Churchland, the author explores the classic `Frame Problem' and assesses the future prospects of cognitive science. The scope of the frame problem, touching on connec. (shrink)

The pressures that led to the evolution of episodic memory have recently seen much discussion, but a fully satisfactory account of them is still lacking. We seek to make progress in this debate by taking a step backward, identifying four possible ways that episodic memory could evolve in relation to simulationist future planning—a similar and seemingly related ability. After distinguishing each of these possibilities, the paper critically discusses existing accounts of the evolution of episodic memory. It then presents a novel (...) argument in favor of the view that episodic memory is a by-product of the evolution of simulationist future planning. The paper ends by showing that this position allows for the maintenance of the traditional view that episodic memory operates on stored memory traces, as well as explaining a number of key features of episodic memory: its being subject to frequent and systematic errors, its neural co-location with the capacity for simulationist future planning, and the potential existence of non-human episodic memory. (shrink)

In this paper I argue that Wittgenstein is correct when he says of the Standard Metre stick that we can neither say that it is or is not a metre in length – despite what our intuitions may tell us to the contrary. Specifically, the paper deals with Kripke's criticism of Wittgenstein's claim in Naming And Necessity and with Salmon's attempt to arbitrate between the two views. I conclude that, not only is Wittgenstein correct, but that both Kripke and Salmon (...) (and possibly the majority of philosophers) simply do not understand the concept of measurement. (shrink)

Let S denote the variety of Sugihara algebras. We prove that the lattice (K) of subquasivarieties of a given quasivariety K S is finite if and only if K is generated by a finite set of finite algebras. This settles a conjecture by Tokarz [6]. We also show that the lattice (S) is not modular.

The paper begins with a defence of a new definition of privacy as the absence of undocumented personal knowledge. In the middle section, I criticise alternative accounts of privacy. Finally, I show how my definition can be worked into contemporary American Law.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Transformed Lives: Making Sense of Atonement Today by Cynthia S. W. CrysdaleVirginia W. LandgrafTransformed Lives: Making Sense of Atonement Today Cynthia S. W. Crysdale new york: seabury books, 2016. 192 pp. $16.00Cynthia Crysdale aims to show how atonement can have meaning for modern and postmodern Christians who reject the idea that God wills Jesus's violent death. She starts with stories of people who were estranged from God but (...) have been given grace to love God anew. Their subsequent lives are not perfect and involve multiple deaths of the old self and resurrections into the new. Yet there is a reconciliation not present beforehand: not a change in God, who has always loved us, but a change in us. Crysdale seeks to navigate between two undesirable positions: a penal substitutionary doctrine of the atonement, which she thinks posits a violent God, or a rejection of the idea of atonement altogether. She sees atonement as not only moral influence showing an example but a relationship that involves our whole being.Crysdale then presents a historical overview to show that this understanding of atonement is a plausible interpretation of scripture and tradition. Biblical sacrifices were not intended to propitiate an angry deity but to expiate human sin. New Testament writers who saw Jesus's death on the cross in continuity with these sacrifices were not implying that God was punishing Jesus. Jesus's statements about giving his life as a ransom prophesied the subversion of patron–client power relations rather than predicting a transaction whereby Jesus would pay for sin. Subsequent writers who saw Jesus as gaining victory over the devil saw God and Jesus as united against the powers and Jesus as attaining justice by love. Even Anselm, sometimes blamed for the penal substitutionary view, intended to avoid the idea of the crucifixion as God's punishment of Jesus. In the honor code of the time, either satisfaction or punishment was required. Therefore, Jesus's act of making satisfaction is precisely not punishment. Crysdale sees subsequent conflations of satisfaction and punishment as distorting Anselm's original intent and implying that God requires violent punishment of sin. [End Page 208]Crysdale then takes readers on a tour of changes in scientific, historical, and epistemological consciousness in the modern era to ask how theology might be done today. Drawing on Bernard Lonergan, she describes multiple dimensions of conversion that are all instances of grace when they occur. She then interprets the incarnation as indicating God's offer of friendship with humanity and Jesus's death and resurrection as indicating the transformation of power and oppression. Believing that an abstract atonement over the heads of human beings does not exist, she concludes with further stories of lives transformed by an encounter with God, including Martin Luther King Jr. and Dorothy Day.This book is suitable for educated lay adults, advanced undergraduates, or introductory seminary courses. Protestant audiences may find it typically Catholic, even though Crysdale is an Anglican, because it emphasizes changed lives rather than God's act of justification prior to any change in us. Theologically, it does not deal with every possible objection to its thesis. Those concerned with cultures of impunity, where malevolent lawlessness gets its way, may think that rejecting any sense of punishment of sin in the crucifixion throws the baby out with the bathwater. Recently, Fleming Rutledge (in The Crucifixion), drawing on Karl Barth, has made a point of retaining punishment as one meaning of the atonement even while emphasizing that God's wrath is always in the service of God's love. Transformed Lives does not have the last word on the atonement and would not claim to, since Crysdale wants to invite readers to do theology befitting their changing context. However, readers at many levels will benefit from its accessible treatment of its topic and invitation to reflection that befits a loving, reconciling, evil-opposing God.Virginia W. LandgrafAmerican Theological Library AssociationCopyright © 2018 Society of Christian Ethics... (shrink)

L'A. soutient, contre Germain Grisez, Joseph Boyle, John Finnis et William May, que le contrôle naturel des naissances pratiqué avec une intention mauvaise n'est pas contraception. Il montre que les auteurs identifient de façon incorrecte la fin prochaine de la contraception comme choix qu'il n'y ait pas d'enfant, alors que la fin prochaine véritable est d'empêcher un enfant de venir au monde . Ainsi donc, puisque en NFP un couple ne cherche pas à empêcher la venue au monde d'un enfant, (...) NFP n'implique pas d'action contraceptive. L'A. soutient aussi qu'identifier la fin prochaine comme choix qu'il n'y ait pas d'enfant ne spécifie pas de façon adéquate une classe homogène d'actes objectifs, bien que cela spécifie une classe homogène d'actes moraux. (shrink)

St. Paul writes, “whatever you do, do everything for the glory of God (1 Corinthians 10: 31 NABRE).” This essay employs the work of St. Thomas Aquinas and the recent philosophical work of Daniel Johnson (2020) on this command to investigate a series of questions that the command raises. What is glory? How does one properly act for glory and for the glory of another? How is it possible to do everything for the glory of God? I begin with Aquinas’ (...) account of glory and the pursuit of glory for God’s glory and Aquinas’s answers to some of the above questions that can be drawn from his discussion in De Malo. I defend Aquinas against criticisms from Daniel Johnson and present his own interpretation of the command. I advance the discussion through adding two additional interpretations that do not rely on a controversial assumption Johnson makes. Next, I address the puzzle of how we can intend everything for the glory of God using Aquinas’s three-fold account of intention. Finally, I discuss the relation between charity and the desire for God’s glory and how regular, actual intentions of one’s actions for the glory of God increases charity. (shrink)

Everyone, according to W.A. Mathieu, is musical by nature--it goes right along with being human. And if you don't believe it, this book will convince you. In a series of interrelated short essays, Mathieu takes the reader on a journey through ordinary experiences to open our ears to the rich variety of music that surrounds us but that we are trained to ignore; such as the variety of pitches produced by different objects, like glassware, furniture, drums--anything you can tap; or (...) sounds that hover on the border of music, like laughter, the clinking of glasses in a toast, or the unintentional falsetto produced by yawning. Along the way the author teaches aspects of music theory that nonmusicians might ordinarily shy away from. He reveals the way of music to be a profoundly spiritual path--one that is everyone's birthright. (shrink)