Early modern humans developed mental capabilities that were immeasurably greater than those of non-human primates. We see this in the rapid innovation in tool making, the development of complex language, and the creation of sophisticated art forms, none of which we find in our closest relatives. While we can readily observe the results of this high-order cognitive capacity, it is difficult to see how it could have developed. We take up the topic of cave art and archeoacoustics, particularly the discovery (...) that cave art is often closely connected to the acoustic properties of the cave chambers in which it is found. Apparently, early modern humans were able to detect the way sound reverberated in these chambers, and they painted artwork on surfaces that were acoustic “hot spots,” i.e., suitable for generating echoes. We argue that cave art is a form of cross-modality information transfer, in which acoustic signals are transformed into symbolic visual representations. This form of information transfer across modalities is an instance of how the symbolic mind of early modern humans was taking shape into concrete, externalized language. We also suggest that the earliest rock art found in Africa may constitute one of the first fossilized proxies for the expression of full-fledged human linguistic behavior. (shrink)

In theLysisSocrates deals with the problem of what is a friend and what is friendship. After giving an introduction and a synopsis of theLysisin section one, I explain, in section two, Socrates’ view that a true friend is “what is akin” or “what is belonging to oneself” which is what is taken from oneself and discovered in another person. When this happens among two persons, they become friends to each other. The content of what is akin is either a good (...) characteristic or ways or form of the soul. Friendship is the desire for what is akin. In section three I show that Socrates remains inaporiawhile he faces several problems. Unless he is able to answer such problems, he will not be truly confident about what is a friend. In section four I deal with and refute Penner’s and Rowe’s view that a true friend means wisdom. In section five I examine the view of friendship which occurs among people who share common deficit. As a conclusion, in section six, I reflect on the significance of my interpretation and the role of theLysisin Plato’s philosophy. (shrink)

The vestibulo-ocular reflex plays an important role in controlling the gaze at a visual target. Although patients with vestibular hypofunction aim to improve their VOR function, some retain dysfunction for a long time. Previous studies have explored the effects of direct current stimulation on vestibular function; however, the effects of random noise stimulation on eye–head coordination have not previously been tested. Therefore, we aimed to clarify the effects of high frequency noisy vestibular stimulation on eye–head coordination related to VOR function. (...) Thirteen healthy young adult participants with no serious disease took part in our study. The current amplitude and density used were 0.4 mA and 0.2 mA/cm2, respectively, with a random noise frequency of 100–640 Hz. The electrodes were located on both mastoid processes. The stimulus duration and fade in/out duration were 600 and 10 s, respectively. Subjects oscillated their head horizontally, gazing at the fixation point, at 1 Hz for 30 repetitions. The coordination of eye–head movements was measured by eye-tracking and a motion capture system. Peak-to-peak angles for eye and head movement and deviation of the visual line from the fixation target revealed no significant differences between HF-nVS and sham. The lag time between the eye and head movement with HF-nVS post-stimulation was significantly shorter than that of the sham. We found that HF-nVS can reduce the lag time between eye and head movement and improve coordination, contributing to a clear retinal image. This technique could be applied as a form of VOR training for patients with vestibular hypofunction. (shrink)

日常においてはいつも素通りされている豊かな経験の世界がある―。“自明”であるがゆえに眼を向けられることのないこの経験の世界を現象学は精査し、われわれにとっての「現実」が成立する構造を明るみに出す。創始 者フッサール以来続く哲学的営為の核心にあるものは何か。そしていまだ汲みつくせないその可能性とは。本書は粘り強い思索の手触りとともに、読者を生と世界を見つけなおす新たな思考へと誘う。.

Many functional glycoproteins are expressed on the lymphocyte cell surface. Some of them carry O-linked oligosaccharides (O-glycans), which are conjugated through serine or threonine residues. During various biological processes, including T-cell activation, a tetrasaccharide on the T-cell surface is dramatically converted to a branched hexasaccharide, called core2 O-glycan. The same structural change in O-glycans is also found on the lymphocytes from patients with immunodeficiency conditions such as Wiskott-Aldrich syndrome and AIDS. Several studies revealing the roles of core2 O-glycans in immune (...) responses show that this is a biologically significant change. In particular, core2 O-glycans expressed on the cell surface reduce cell–cell interactions, thereby regulating immune responses. Furthermore, core2 O-glycan is a key backbone structure in forming selectin ligands. Thus, O-linked oligosaccharides, in particular those containing core2 branches, play vital roles in immune responses and may play dual roles in certain situations. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes. BioEssays 23:46–53, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This article considers Socrates's conception of courage in Plato's Socratic dialogues. Although the Laches, which is the only dialogue devoted in toto to a pursuit of the definition of courage, does not explicitly provide Socrates's definition of courage, I shall point out clues therein which contribute to an understanding of Socrates's conception of courage. The Protagoras is a peculiar dialogue in which Socrates himself offers a definition of courage. Attending to the dramatic structure and personalities of the dialogue, I will (...) point out that Socrates does not commit to the definition and that the hedonism and the definition of courage are used to disclose Protagoras's confusion regarding virtue. Following one of the clues within the Laches I will turn to the Apology and indicate Socrates's conception of courage which is based on his awareness of lack of knowledge of death and his religious conviction that nothing will happen for the good in life or in death. Finally I will show that such conception of Socratic courage satisfies the criteria in the Laches. (shrink)

Pockett has drawn an alternative conclusion from the data of Libet, Alberts, Wright, and Feinstein , and suggested that it takes 80 ms, rather than 500 ms, for the sensation evoked by a stimulus to enter awareness. Here, I suggest that our conscious sensation evolves over time, during the period from 80 to 500 ms after a stimulus, until the sensation is stably localized in space.

This paper investigates the connection between psychological safety at work and physical health outcomes. Employing data from roughly a thousand respondents in Tokyo in 2021 and utilizing machine learning techniques along with traditional statistics, the study reveals that this popular concept in the field of business management and organization behavior, “psychological safety” at work, can enhance physical health of workers under certain conditions. The finding that its effect remains even when mental stress levels are controlled along with basic ascriptive variables, (...) extends the conventional notion around “psychological safety.” The recently developed Causal Forest Double Machine Learning (Causal Forest DML) analysis was used to generate a decision tree, shedding light on the structure of causal inference and indicating the key role of “age” and “personal income” as determinants of the effect of psychological safety on physical health. (shrink)