The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

When a person decides to do something in the future, she forms an intention and her intention persists. Philosophers have thought about the rational requirement that an agent’s intention persists until its execution. But philosophers have neglected to think about the causal memory mechanisms that could enable this kind of persistence and its role in rational long-term agency. Our aim of this paper is to fill this gap by arguing that memory for intention is a specific kind of memory. We (...) do this by evaluating and rejecting standard declarative accounts of memory for intention and arguing for the plausibility of an alternative model of memory for intention. We argue for the alternative by spelling out a number of computational principles that could enable retaining and retrieving intentions from long-term memory. These principles could explain a number of core features of intentions. (shrink)

This book undertakes an extensive study of the constellation of two eminent thinkers of post-idealism for the first time. The contributions in this volume analyze the relationship between Schopenhauer and Kierkegaard systematically and historically from a number of thematic perspectives: metaphysics and ethics, freedom and original sin, existential philosophy and the theory of suffering, art and aesthetics, religion and science. The book also goes into Kierkegaard s explicit disagreement with Schopenhauer and last but not least discusses the conflicting poles of (...) idealism and modernity. The volume is rounded off by a first complete and annotated German translation of the notes on Schopenhauer, which Kierkegaard wrote in his late journals.". (shrink)

In the United Kingdom (and elsewhere), there are moves to extend formal ethical review of research involving human subjects beyond the traditional oversight by NHS local or multi-centre research ethics committees of medical or clinical research, to also encompass all ‘non-clinical’ research involving human subjects. This paper describes and analyses the development and implementation of a model for ethical review within the university sector. At Cardiff University, a devolved or two-tiered system of ethics review has been created in which a (...) top-level university research ethics committee provides policy advice to and oversight of school-based research ethics committees that engage in formal ethics review of research conducted in their respective schools. We describe the system and reflect on the challenges and benefits of implementing such a coordinated and comprehensive university-wide system of ethics review. (shrink)

På en let tilgængelig og anvendelig måde forsøger bogen Viden, videnskab og virkelighed at forklare studerende på videregående uddannelser, hvad det er de skal vide om videnskaben. Hvad er videnskab? Hvad er de videnskabelige idealer og normer? Hvordan fungerer videnskaben i samfundet i netværk af læreanstalter, virksomheder og andre institutioner? Hvordan vil de studerende selv komme i berøring med videnskaben og hvordan skal de forstå det videnskabelige i det som de laver? -/- Viden, videnskab og virkelighed forsøger at indkredse det (...) særlige ved moderne videnskab og præsenterer derfor også forskellige opfattelser af viden, virkelighed og videnskab inden for filosofi, videnskabsteori og samfundsvidenskab. Men samtidig giver bogen altså konkrete bud på, hvordan man som studerende mestrer refleksion, omsætter viden til praksis og samarbejder på tværs af faggrænser. -/- Bogen henvender sig til alle studerende på videregående uddannelser og til undervisning i videnskabsteori. (shrink)

Ample attention is being paid in the higher education literature to promoting active learning among students. However, critical examination of educational purposes and ends is largely lacki...

The outbreak of the coronavirus disease 2019 has resulted in widespread university lockdown. However, impacts of the university lockdown on the learning and academic development of university students have not been thoroughly investigated. The current study examined college students’ changes of learning outcomes during the COVID-19 lockdown period and clarified what might explain individual differences in students’ learning outcomes after they had learned from home for a whole semester when universities were physically closed due to the COVID-19 pandemic. Data were (...) derived from a longitudinal study examining the development of college students including students’ academic achievement and critical thinking before and after the university lockdown. We observed significant decreases in critical thinking skills and dispositions from pre- to post-lockdown. Both perceived academic achievement and critical thinking exhibited greater variability after the lockdown. In addition, students’ readiness for online learning, especially their self-management skills, consistently predicted post-lockdown learning outcomes after controlling for pre-lockdown outcomes and family socioeconomic status. Those who have assumed more responsibilities at home, or who were more vulnerable to emotional distress during the pandemic, performed less well in post-lockdown learning outcomes. These findings call for better management of student learning and development when major changes are required in higher education practices for responding to the ongoing COVID-19 crisis as well as other potential situations. (shrink)

PurposeThe purpose of this study was to introduce an orthogonal experimental design to improve the efficiency of building and optimizing models for freezing of gait prediction.MethodsA random forest model was developed to predict FOG by using acceleration signals and angular velocity signals to recognize possible precursor signs of FOG. An OED was introduced to optimize the feature extraction parameters.ResultsThe main effects and interaction among the feature extraction hyperparameters were analyzed. The false-positive rate, hit rate, and mean prediction time were 27%, (...) 68%, and 2.99 s, respectively.ConclusionThe OED was an effective method for analyzing the main effects and interactions among the feature extraction parameters. It was also beneficial for optimizing the feature extraction parameters of the FOG prediction model. (shrink)

Evaluating the price policy of raw milk is of great significance to the sustainable development of an industry supply chain. In this context, our study used the multi-period difference-in-difference method to systematically examine the impact of the policy implementation on product price and profit distribution in the supply chain. The results showed the following: the price of raw milk in the implementation area of the price support policy is 13.54% higher than that of the unimplemented area; the effect of price (...) increase in the western region is higher than that in the eastern region, and the central region ; furthermore, the purchase price guidance policy of raw milk drives price increase or price suppression in the links of the supply chain to promote a balanced distribution of profits among the participants in the chain. These conclusions all have good stability and have reference significance for further improving and adjusting the price support policy of raw milk to realize the sustainable development of the Chinese dairy industry. This will enhance the production confidence of Chinese raw milk producers and improve Chinese consumers’ expectations and consumer psychology regarding domestic dairy products. (shrink)

The present study developed the Chinese Parental Involvement and Support Scale for Preschool Children to measure parental involvement and support for preschool children. In Study 1, we conducted a literature review, open-ended interviews, a theoretical analysis, and expert interviews to create an item bank. In Study 2, 447 parents completed the item bank. Following item and Exploratory Factor Analysis, 30 items were retained. In Study 3, five new items were added to the 30-item version of the CPISSPC. A separate sample (...) of 471 parents completed the 35-item version of the CPISSPC. After Confirmatory Factor Analysis, a final 18-item version of the CPISSPC was created with four factors: psychological support, educational support, play support, and life support. Construct validity and internal reliability were satisfactory. Study 4 evaluated concurrent validity. CPISSPC scores significantly and positively correlated with perceived social support, marital gratification, and children’s self-efficacy. CPISSPC scores significantly and negatively correlated with parents’ levels of burnout and loneliness. The CPISSPC exhibits good psychometric properties and can be used as a tool to measure parental involvement and support for preschool children. (shrink)

Scientonomy is the field that aims to develop a descriptive theory of the actual process of scientific change (Barseghyan, 2015). Scientometrics is the field that aims to employ statistical methods to investigate the quantitative features of scientific research, especially the impact of scientific articles and the significance of scientific citations (Leydesdorff & Milojević, 2013). In this paper, we aim to illustrate how to methodologically integrate scientonomy with scientometrics to investigate both qualitative and quantitative changes of a scientific community. We will (...) use a case study to achieve our aim. The case study is about a scientific community studying a physiological phenomenon called heart-rate variability (HRV). Moreover, we will argue that this methodological integration outperforms cases in which researchers only employ the resources from one of the two fields. (shrink)

The incidental writings of Søren Kierkegaard, published in the twenty-volume Danish edition of the Papirer, provide direct access to the thought of the many-faceted nineteenth-century philosopher who exerted so profound an influence on Protestant theology and modern existentialism. This important material, which Danish scholars regard as the "key to the scriptures" of Kierkegaard’s other work, spans his entire productive life, the last entry of the Papirer being dated only a few days before his death. These writings have been previously inaccessible (...) in English except for a few fragmentary selections; the most significant writings are now being made available in this definitive seven-volume edition under the editorship of two expert scholars and translators. The editors group the selections in Volumes I through IV by theme, with all entries on a given subject under the same heading. Within subject headings, entries are arranged chronologically, making it feasible to trace the evolution of Kierkegaard’s thought on a specific topic. Volumes V and VI are devoted to autobiographical material. Volume VII contains an extensive index with topical crossreferences. (shrink)

To help retailers gain consumers’ trust, many studies have investigated antecedents of consumer trust. However, distrust, a concept closely related to trust, has attracted only sporadic research attention. As a result, whether factors that increase consumer trust can eliminate consumer distrust is unclear. To deepen understanding of trust and distrust, this study applies the critical incident technique to identify and compare the antecedents of trust and distrust of Chinese consumers. The results show that the antecedents of distrust differ from those (...) of trust, indicating different formulation mechanisms of both. Therefore, on the one hand, retailers should pay attention to increasing consumer trust, and on the other hand, they should develop marketing activities to reduce consumer distrust. (shrink)

Flap EndoNuclease‐1 (FEN‐1) is a multifunctional and structure‐specific nuclease involved in nucleic acid processing pathways. It plays a critical role in maintaining human genome stability through RNA primer removal, long‐patch base excision repair and resolution of dinucleotide and trinucleotide repeat secondary structures. In addition to its flap endonuclease (FEN) and nick exonuclease (EXO) activities, a new gap endonuclease (GEN) activity has been characterized. This activity may be important in apoptotic DNA fragmentation and in resolving stalled DNA replication forks. The multiple (...) functions of FEN‐1 are regulated via several means, including formation of complexes with different protein partners, nuclear localization in response to cell cycle or DNA damage and post‐translational modifications. Its functional deficiency is predicted to cause genetic diseases, including Huntington's disease, myotonic dystrophy and cancers. This review summarizes the knowledge gained through efforts in the past decade to define its structural elements for specific activities and possible pathological consequences of altered functions of this multirole player. BioEssays 27:717–729, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Marx und die "bürgerliche" Nationalökonomie, von G. Aspelin.--Några textkritiska problem i Berkeleyforskningen, av B. Belfrage.--Några kommentarer till C.L. Stevensons teori om etisk oenighet, av L. Befgström.--Viljeteorins premisser, av J. Evers.--Axel Hägerströms analys av värdeupplevelsen, av L. Fröström.--On archetypical performatives, by M. Furberg.--The better something is, the worse its absence, by S. Halldén.--Ett slags representationsteorem för deontisk logik, av B. Hansson.--Om Platons "Euthyphron," av I. Hedenius.--Tolkningssatsernas logik, av G. Hermerén.--Är verkligheten motsägande? Ett dialektiskt argument, av K. Marc-Wogau.--Moral, amoral og indifferens, av (...) H. Ofstad.--Begreppet "property" hos John Locke, av K. Olivecrona.--En skademodell, av U. Persson.--Objektivitet som kunskaps teoretiskt begepp och som värderingsideal, av H. Regnéll.--Satsen "Flickan F är vacker," av E. Ryding.--Lathund för lagläsare, av T. Strömberg. (shrink)

This paper aims to address some methodological issues related to case-based research in the philosophy of contemporary sciences. We focus on the selection processes by which philosophers pick or generate a particular set of papers to conduct their case-based research. We illustrate how to use various quantitative and qualitative methods to improve the epistemic features of the selection processes, and help generate some potential case-based hypotheses for further philosophical investigation.

Background Ethical challenges constitute an inseparable part of daily decision-making processes in all areas of healthcare. Ethical challenges are associated with moral distress that can lead to burnout. Clinical ethics support has proven useful to address and manage such challenges. This paper explores how prehospital emergency personnel manage ethical challenges. The study is part of a larger action research project to develop and test an approach to clinical ethics support that is sensitive to the context of emergency medicine. Methods We (...) explored ethical challenges and management strategies in three focus groups, with 15 participants in total, each attended by emergency medical technicians, paramedics, and prehospital anaesthesiologists. Focus groups were audio-recorded and transcribed verbatim. The approach to data analysis was systematic text condensation approach. Results We stratified the management of ethical challenges into actions before, during, and after incidents. Before incidents, participants stressed the importance of mutual understandings, shared worldviews, and a supportive approach to managing emotions. During an incident, the participants employed moral perception, moral judgments, and moral actions. After an incident, the participants described sharing ethical challenges only to a limited extent as sharing was emotionally challenging, and not actively supported by workplace culture, or organisational procedures. The participants primarily managed ethical challenges informally, often using humour to cope. Conclusion Our analysis supports and clarifies that confidence, trust, and safety in relation to colleagues, management, and the wider organisation are essential for prehospital emergency personnel to share ethical challenges and preventing moral distress turning into burnout. (shrink)

This paper presents several applications of the dimensional analysis method to problems investigated in medical sciences. The method is used to analyze various complex processes without using formal laws governing the same. It is particularly suitable for a general analysis of fluid transfer in the human body. This paper mainly serves as an overview of selected applications, mostly those emerging in the recent years, and includes a discussion of the mathematical fundamentals of dimensional analysis together followed by its critical analysis. (...) Containing detailed calculations of two examples, the paper also serves as training material in the area of the computational method of the dimensional analysis algorithm. (shrink)

This research uses an experimental approach to investigate the relationship between market orientation of a company and its level of success in international business. The aim of the study was to develop and use a market orientation scale that is appropriate to the sector. It was discovered that there are four hidden traits that drive market orientation. These include customers, rivals, departmental response, and overall customer satisfaction. According to the results, orientation toward one's customers is more essential than any of (...) the other traits, while orientation toward one's competitors has an inverted U-shaped connection with performance. The performance of the firm was not found to correlate in any way with the responsiveness of its departments. With the help of the comprehensive conceptualization, managers are able to develop specific kinds of orientations that are essential for higher levels of performance. (shrink)

This paper investigates the stabilization and trajectory tracking problem of wheeled mobile robot with a ceiling-mounted camera in complex environment. First, an adaptive visual servoing controller is proposed based on the uncalibrated kinematic model due to the complex operation environment. Then, an adaptive controller is derived to provide a solution of uncertain dynamic control for a wheeled mobile robot subject to parametric uncertainties. Furthermore, the proposed controllers can be applied to a more general situation where the parallelism requirement between the (...) image plane and operation plane is no more needed. The overparameterization of regressor matrices is avoided by exploring the structure of the camera-robot system, and thus, the computational complexity of the controller can be simplified. The Lyapunov method is employed to testify the stability of a closed-loop system. Finally, simulation results are presented to demonstrate the performance of the suggested control. (shrink)

Reinforcement learning relies on the reward prediction error (RPE) signals conveyed by the midbrain dopamine system. Previous studies showed that dopamine plays an important role in both positive and negative reinforcement. However, whether various reinforcement processes will induce distinct learning signals is still unclear. In a probabilistic learning task, we examined RPE signals in different reinforcement types using an electrophysiology index, namely, the feedback-related negativity (FRN). Ninety-four participants were randomly assigned into four groups: base (no money incentive), positive reinforcement (presentation (...) of money rewards), negative reinforcement (removal of money losses), and combined reinforcement (money rewards and removal of money losses) groups. In addition, in order to evaluate the engagement of emotional activity in the different reinforcement processes, Positive and Negative Affect Schedule-Expanded Form (PANAS-X) scales were applied before and after the experiment to detect the emotional changes. The results showed that there was no difference between groups in the dopamine-related learning bias. However, compared to the other three groups, negative reinforcement elicited smaller FRN (the difference-wave measure) during the learning, stronger positive affect and joviality, and less fatigue after the learning, in which the difference between the negative and positive reinforcement groups was smaller. The results indicated that pure avoidance motivation may induce distinct emotional fluctuations, which influence the feedback processing. (shrink)

Many scholars have conducted in-depth research on the evaluation and prediction of scholars’ scientific impact and meanwhile discovered various factors that affect the success of scholars. Among all these relevant factors, scholars’ ages have been universally acknowledged as one of the most important factors for it can shed light on many practical issues, e.g., finding supervisors, discovering rising stars, and research funding or award applications. However, due to the inaccessibility or the privacy issues of acquiring scholars’ personal data, there is (...) little research to explore the true ages of scholars currently. Alternatively, scholars’ publications’ information can be obtained through various digital libraries. Inspired by this fact, we propose a novel scholar’s age prediction method based on their articles’ information. Our method first classifies factors that affect scholars’ ages into intuitive and complex types according to their computational complexity and then apply machine learning algorithms to predict the ages of scholars based on these factors. The experimental results on the real dataset demonstrate that our method can effectively predict the true ages of scholars. Given that there is no completely accurate dataset because of the continuous publication of academic papers, we then apply our method on the incomplete dataset. Nevertheless, our method still has high prediction accuracy in such situations. (shrink)

本书阐述了青年和大学生在人生道路上必然遇到和必须解决的人生目的、人生价值、人生理想、人生态度等人生问题。.