“Readiness cohorts” are an innovation in clinical trial design to tackle the scarcity of time and people in drug studies. This has emerged in response to the challenges of recruiting the “right” research participants at the “right time” in the context of precision medicine. In this paper, we consider how the achievement of “readiness” aligns temporalities, biologies, and market processes of pharmaceutical innovation: how the promise of “willing bodies” in research emerges in relation to intertwined economic and biological time imperatives. (...) Drawing on long-term engagement with the field of Alzheimer’s disease prevention and interviews with researchers from academia and the pharmaceutical industry, we describe the discursive construction and practical arrangement of readiness. This paper contributes to understandings of temporal specificity, or “timing,” within prevention research and casts critical light on the way this specificity—the threshold for “trial readiness”—relates to an opaque and highly speculative drug development pipeline. Extending the study of biomedical potential, as that which holds promise but may not yet exist, we consider how absences operate in adaptive trials. By highlighting these absences, we outline an opportunity for socio-ethical research to intervene in the speculative gaps of drug development. (shrink)

In this paper, we examine the practice and promises of digital phenotyping. We build on work on the ‘data self’ to focus on a medical domain in which the value and nature of knowledge and relations with data have been played out with particular persistence, that of Alzheimer's disease research. Drawing on research with researchers and developers, we consider the intersection of hopes and concerns related to both digital tools and Alzheimer's disease using the metaphor of the ‘data shadow’. We (...) suggest that as a tool for engaging with the nature of the data self, the shadow is usefully able to capture both the dynamic and distorted nature of data representations, and the unease and concern associated with encounters between individuals or groups and data about them. We then consider what the data shadow ‘is’ in relation to ageing data subjects, and the nature of the representation of the individual's cognitive state and dementia risk that is produced by digital tools. Second, we consider what the data shadow ‘does’, through researchers and practitioners’ discussions of digital phenotyping practices in the dementia field as alternately empowering, enabling and threatening. (shrink)

V nastoi︠a︡shchem izdanii raskryvaetsi︠a︡ biografii︠a︡, a takzhe publikuetsi︠a︡ znachitelʹnai︠a︡ chastʹ ėpistoli︠a︡rnogo nasledii︠a︡ poluzabytogo filosofa Adolʹfa Markovicha Lazareva (1872-1944), odnogo iz blizhaĭshikh druzeĭ, edinomyshlennika i uchenika Lʹva Shestova, istolkovateli︠a︡ ego filosofskikh ideĭ. V knigu vkli︠u︡cheny takzhe statʹi A. Lazareva o L. Shestove -- kak opublikovannye, tak i neizvestnye, sokhranivshiesi︠a︡ v ego arkhive. Prinadlezha k t.n. "shestovskomu" krugu -- k chislu tekh, dli︠a︡ kogo byla blizka i nesomnenna, govori︠a︡ ego sobstvennymi slovami, "volnui︠u︡shchai︠a︡ ubeditelʹnostʹ" mysli velikogo filosofa, A. Lazarev okazalsi︠a︡ fakticheski vne issledovatelʹskogo (...) i chitatelʹskogo vnimanii︠a︡. Dannai︠a︡ kniga i︠a︡vli︠a︡etsi︠a︡, po sushchestvu, pervym opytom privlechʹ interes k ego lichnosti i trudam. (shrink)

Originally published in 1920 as part of a series of handbooks for teachers, this book of advice to history teachers is still full of practical information on the use of historical sources and possible classroom exercises designed to engage children with the study of the past. This book will be useful to anyone with an interest in the history of education, historical education in particular.

To this day, the Italian Jewish literary postwar canon is undisputedly ruled by Primo Levi, Giorgio Bassani and Carlo Levi. This study of three major Italian Jewish women writers – Natalia Ginzburg, Clara Sereni and Lia Levi – highlights the presence in Italian literature of a subversive Jewish écriture feminine. These writers’ formal independence and subversive redeployment of narrative and thematic strategies not only consolidated a strong female voice in Italian literature but also produced a specific Italian brand of Jewish (...) literature. The following analysis shows how, through their literary ‘life miniatures’, Ginzburg, Sereni and Levi recentre the domestic everydayness of woman’s personal and historical experience, while, simultaneously, challenging the traditional representations of women’s positions within family and within the public space, as well as interrogating their Jewish identity vis-a-vis their country’s Fascist past. In particular, this article focuses on the way in which all three authors portray themselves as women trying to strike a balance between their Jewish identity and history alive only in the domestic space of their family lives, and their gender identity which is repressed by the patriarchal system both in the house and in the public arena. These women respond by moving ‘out’ of their homes, by exploring the city space – thus turning the ‘urban monster’ into a positive locus for women’s self-determination and political action – and by bonding with other women. Through a demasculinization of the city space, these memoirs re-elaborated notions of family, Judaism, private and historical memory, and they reinvented a poetics for the ‘small virtues’ of woman’s everyday existence while also pioneering a new space in literature that radically changed the direction of patriarchal Italian culture in the second half of the twentieth century. (shrink)

The bear, says Hierocles, is aware that its head is easily injured, and instinctively uses its paws as a protection. The three following lines in the papyrus are badly damaged– καν εί π.ε … δεηθεί Του | βαλανεíον κρημν | πáλιν ύ;β εθεíησιν ε | αυΤήν. This is followed by a description of what the bear does when it is pursued and comes to a precipice. It inflates itself and trusts to the inflation to break its fall. It is hardly (...) possible to restore the damaged lines. Von Arnim thinks that the sense required is: ‘wenn die Bärin, vom Jäger verfolgt, eines Bades bedarf oder auf ihrer Flucht an einen Abgrund kommt,πáλιν ύπ èψίησιν εαψτήν’ But a sensible bear would hardly think of taking a bath when pursued by the hunter. It might take to the water; but the Greek for this would be somewhat different. As I read the passage, there is no reference to the bear as pursued by the hunter till line 34, where I would read πоιεî δè τò τοιóνδε , since the phrase εί δ υν διοκμéνμ in line 38 is resumptive, and implies that the pursuit must have been alluded to before. But before line 35 H. is only describing what the bear does to protect its head in the ordinary routine of its life when it is not harassed by the hunter. It wants a bath, and finds that it cannot reach the water without clambering down an overhanging bank It will not climb down head foremost, but guards its head by sliding backwards down the bank. As the bear would want its bath because it was hot, it is perhaps not too hazardous to conjecture that some phrase such as xs03F0xs2135ν ει π ε<ζομéν πνíγηι δεμθεíν του β. should find its place in line 31. (shrink)