The U.S. National Institute of Allergies and Infectious Diseases and the National Institute of Mental Health have a new research priority: inclusion of terminally ill persons living with HIV in HIV cure-related research. For example, the Last Gift is a clinical research study at the University of California San Diego for PLWHIV who have a terminal illness, with a prognosis of less than 6 months. As end-of-life HIV cure research is relatively new, the scientific community has a timely opportunity to (...) examine the related ethical challenges. Following an extensive review of the EOL and HIV cure research ethics literature, combined with deliberation from various stakeholders and our experience with the Last Gift study to date, we outline considerations to ensure that such research with terminally ill PLWHIV remains ethical, focusing on five topics: 1) protecting autonomy through informed consent, 2) avoiding exploitation and fostering altruism, 3) maintaining a favorable benefits/risks balance, 4) safeguarding against vulnerability through patient-participant centeredness, and 5) ensuring the acceptance of next-of-kin/loved ones and community stakeholders. EOL HIV cure-related research can be performed ethically and effectively by anticipating key issues that may arise. While not unique to the fields of EOL or HIV cure-related research, the considerations highlighted can help us support a new research approach. We must honor the lives of PLWHIV whose involvement in research can provide the knowledge needed to achieve the dream of making HIV infection curable. (shrink)

El misteri del mal no té un tractament específic en Martí Luter, però és a través dels seus múltiples escrits, com són les classes i comentaris bíblics, cartes i sermons, consells i respostes a qüestions que li plantejaren els seus contemporanis, que és possible de refer el seu pensament. Molt característic del seu estil és que, aquí com tots els altres temes que tracta, defuig tot tractament racional i filosòfic, amb la finalitat de posar més clarament al descobert allò (...) que, segons ell, professa una fe cristiana alimentada únicament per la Sagrada Escriptura. (shrink)

The article is an attempt to treat Thomas Mann’s The Magic Mountain as a novel about Germany. According to its author the spiritual condition of Germany personified by Hans Castorp was established during the history through the collision of the elements of Western and Eastern cultures. The first protest against the West was raised by Martin Luter in his critique that led to the internalization of German life. As a consequence, the culture of the nation was dominated by music. (...) This domination mirrored the process in which both elements characteristic for both antagonistic spheres, namely arbitrariness and order, were united as in music counterpoint. Thomas Mann’s idea of humanism, being the continuation of Goethe’s and Nietzsche’s postulates, is a project of their synthesis. (shrink)