Morphogenesis is one of the fundamental processes of developing life. Gastrulation, especially, marks a period of major translocations and bustling rearrangements of cells that give rise to the three germ layers. It was also one of the earliest fields in biology where cell movement and behaviour in living specimens were investigated. This article examines scientific attempts to understand gastrulation from the point of view of cells in motion. It argues that the study of morphogenesis in the twentieth century faced a (...) major dilemma, both epistemological and pictorial: representing form and understanding movement are mutually exclusive, as are understanding form and representing movement. The article follows various ways of modelling, imaging, and simulating gastrular processes, from the early twentieth century to present-day systems biology. The first section examines the tactile modelling of shape changes, the second cell cinematography, mainly the pioneering work of the German embryologists Friedrich Kopsch and Ernst Ludwig Gräper in the 1920s but also a series of classic, yet not widely known, studies of the 1960s. The third section deals with the changes that computer simulation and live-cell imaging introduced to the modelling of shape change and the study of cell movement at the turn of the twenty-first century. Although live-cell imaging promises to experiment upon and represent the living body simultaneously, I argue that the new visuals are an obstacle rather than a solution to the puzzle of understanding cell motion. (shrink)

This issue ofScience in Contextis dedicated to the question of whether there was a “cinematographic turn” in the sciences around the beginning of the twentieth century. In 1895, the Lumière brothers presented their projection apparatus to the Parisian public for the first time. In 1897, the Scottish medical doctor John McIntyre filmed the movement of a frog's leg; in Vienna, in 1898, Ludwig Braun made film recordings of the contractions of a living dog's heart (cf. Cartwright 1992); in 1904, (...) Lucien Bull filmed in slow motion a bullet entering a soap bubble. In 1907 and 1908, respectively, Max Seddig and Victor Henri recorded Brownian motion with the help of a cinematograph (Curtis 2005). In 1909, the Swiss Julius Ries was one of the first to film fertilization and cell division in sea urchins (Ries 1909). In that same year in Paris, Louise Chevroton and Frédéric Vlès used a film camera to observe cell division in the same object (Chevroton and Vlès 1909). As early as 1898, the Parisian surgeon Eugène-Louis Doyen began filming several of his operations, among them the spectacular separation of the Siamese twins Doodica and Radica (Bonah and Laukötter 2009). And in England, the scientist and zoologist Francis Martin Duncan produced an array of popular-scientific films for Charles Urban: “The unseen world: A series of microscopic studies” was presented to the public in the Alhambra Theatre in London for the first time in 1903 (see Gaycken in this issue). (shrink)

This paper offers an analysis of the logical form of plural action sentences that shows that collective actions so ascribed are a matter of all members of a group contributing to bringing some event about. It then uses this as the basis for a reductive account of the content of we-intentions according to which what distinguishes we-intentions from I-intentions is that we-intentions are directed about bringing it about that members of a group act in accordance with a shared plan.

(1) Content properties are nonrelational, that is, having a content property does not entail the existence of any contingent object not identical with the thinker or a part of the thinker.2 (2) We have noninferential knowledge of our conscious thoughts, that is, for any of our..

The paper rejects the claim that phenomena such as change and inattentional blindness show that perceptual representations are inaccurate or that a radical overhaul of our traditional picture of perception is required. The paper rejects in particular the sensorimotor theory of perception, which denies that there are any perceptual representations. It further argues that the degree of resolution of perceptual experience relevant to assessing its accuracy is determined by our use of it in standard conditions, and that the integration of (...) behavior with perceptual representation shows that it is by and large as accurate as its degree of resolution requires. (shrink)

Let us call a thought or belief whose content would be expressed by a sentence of subject-predicate form (by the thinker or someone attributing the thought to the thinker) an ‘ascription’. Thus, the thought that Madonna is middle-aged is an ascription of the property of being middle-aged to Madonna. To call a thought of this form an ascription is to emphasize the predicate in the sentence that gives its content. Let us call an ‘x-ascription’ an ascription whose subject is x, (...) that is, an ascription such that the subject of the sentence which would express its content is x. Let us call a ‘self-ascription’ an ascription whose subject is identical with the ascriber. Let us call a ‘reflexive ascription’ a selfascription such that either (i) in the sentence the ascriber would use to attribute correctly the ascription to himself he would use the first person pronoun to refer to himself both as the ascriber and as the subject of the ascription, as in a sentence of the form, I believe that I ö. (shrink)

causal relevance, a three-place relation between event types, and circumstances, and argue for a logical independence condition on properties standing in the causal relevance relation relative to circumstances. In section 3, I apply these results to show that functionally defined states are not causally relevant to the output or state transitions in terms of which they are defined. In section 4, I extend this result to what that output in turn causes and to intervening mechanisms. In section 5, I examine (...) the implications of this result for functional theories of mental states. In section 6, I distinguish between functional descriptions of properties and functional definitions of properties, and argue the former present no obstacle to mental states being causally relevant to behavior, but that this is so because they do not treat mental states as functional states. In section 7, I examine the nature of explanations that appeal to functional states or properties. section 8 identifies some difficulties that arise in thinking about specifically conscious mental states as functional states. section 9 is a brief conclusion. (shrink)

I argue that the logical difference between classical and quantum mechanics that Stapp (1995) claims shows quantum mechanics is more amenable to an account of consciousness than is classical mechanics is irrelevant to the problem.

Fred Dretske has recently argued, in a highly original book and a series of articles, that action explanations are a very special species of historical explanation, in opposition to the traditional view that action explanations cite causes of actions, which are identical with bodily movements. His account aims to explain how it is possible for there to be a genuine explanatory role for reasons in a world of causes, and, in particular, in a world in which we have available in (...) principle an explanation for any movement of our bodies in neurophysiological terms. While Dretske draws attention to an important, and overlooked, feature of the form of the explananda of action explanations, he draws the wrong conclusion from it. This paper argues argues that his account of the nature of action explanations, and the role of reasons in explaining behavior, cannot be right. This will force us to re©examine the assumptions that suggest that reason explanations and neurophysiological explanations of our movements cannot coexist. (shrink)

Commentary on Charles Siewert's The Significance of Consciousness (Princeton, 1998). I discuss three issues about the relation of phenomenal consciousness, in the sense Siewert isolates, to intentionality. The first is whether, contrary to Siewert, phenomenal consciousness requires higher-order representation. The second is whether intentional features of conscious states are identical with phenomenal features, as Siewert argues, or merely conceptually supervene on them, with special attention to cross modal representations of objects in space. The third is whether phenomenal features are identical (...) with what we can have first person access to, with special attention to features of thoughts that are individuated by reference to the self and the present time. (shrink)

Social externalism is the view that the contents of a person's propositional attitudes are logically determined at least in part by her linguistic community's standards for the use of her words. If social externalism is correct, its importance can hardly be overemphasized. The traditional Cartesian view of psychological states as essentially first personal and non-relational in character, which has shaped much theorizing about the nature of psychological explanation, would be shown to be deeply flawed. I argue in this paper that (...) social externalism faces insuperable difficulties. The first difficulty is that if syntax and semantics are independent, then social externalism is committed to the absurd consequence that many people have beliefs with formally inconsistent contents. I argue none of the possible responses to this objection are plausible. The second difficulty is that if syntax and semantics are independent, then social externalists are committed to a contradiction. After raising and defending these objections, I identify what I think is the underlying flaw in the social externalist position, a failure to pay attention to the structure of communication intentions, and briefly indicate how to neutralize the linguistic evidence social externalists advance in favor of their view. (shrink)

Philosophers constantly see the method of science before their eyes, and are irresistibly tempted to ask and answer questions in the way science does. This tendency is the real source of metaphysics and leads the philosopher into complete darkness.

Suppose that a physical duplicate of me, right down to the arrangements of subatomic particles, comes into existence at the time at which I finish this sentence. Suppose that it comes into existence by chance, or at least by a causal process entirely unconnected with me. It might be so situated that it, too, is seated in front of a computer, and finishes this paragraph and paper, or a corresponding one, just as I do. (i) Would it have the same (...) thoughts I do? (ii) Would it speak my language? (iii) Would my duplicate have any thoughts or (iv) speak any language at all? To fix the interpretation of these questions, I will take ‘thought’ to cover any mental state which has a representational content, where ‘representational content’ is intended to be neutral with respect to psychological mode. By 'psychological mode' I mean what distinguishes kinds of thoughts, such as belief, visual perceptual experience, desire, etc. Representational content, or thought content, as I will also say, determines the conditions under which a thought is true or false, veridical or non-veridical, or, more broadly, is satisfied or fails to be satisfied, independently of relativization to circumstances, possible worlds, or the like. Beliefs, desires, hopes, intentions, and perceptual experiences will all count as thoughts on this usage. The question whether one person has the same (type of) thought as another is the question whether both have a mental state with the same representational content in the same psychological mode. I will not count epistemic verbs, however, as picking out or expressing a (pure) psychological mode. Thus, although knowing that the time is ripe, seeing that there is a goldfinch in the garden, and remembering that my wife’s birthday is next Tuesday are all thoughts, they do not pick out the thoughts by using a verb that expresses a psychological mode. Therefore knowing, seeing or remembering the same things is not a requirement on having the same thoughts.. (shrink)

I begin by distinguishing between what I will call a pure Fregean theory of reference and a theory of direct reference. A pure Fregean theory of reference holds that all reference to objects is determined by a sense or content. The kind of theory I have in mind is obviously inspired by Frege, but I will not be concerned with whether it is the theory that Frege himself held.1 A theory of direct reference, as I will understand it, denies that (...) all reference to objects is determined by sense or content. We will also distinguish between a theory of reference for thought, and for language. This gives us a fourfold classification of theories. What is puzzling about direct reference theories is not that the semantics of an expression in a public language should assign as its semantic value just a referent, but how such facts could be understood to reflect an underlying feature of thought. There are two interconnected aspects to this.. (shrink)

Objections to Searle's argument for the Connection Principle and its consequences (Searle 1990a) fall roughly into three categories: (1) those that focus on problems with the _argument_ for the Connection Principle; (2) those that focus on problems in understanding the _conclusion_ of this argument; (3) those that focus on whether the conclusion has the _consequences_ Searle claims for it. I think the Connection Principle is both true and important, but I do not think that Searle's argument establishes it. The problem (...) with the argument is that it either begs the question or proves too much. (shrink)

There is a great deal of terminological confusion in discussions of holism. While some well-known authors, such as Davidson and Quine, have used “holism” in various of their writings,2 it is not clear that they have held views attributed to them under that label, views that are said to have wildly counterintuitive results.3 In Davidson’s case, it is not clear that he is describing the same doctrine in each of his uses of “holism” or “holistic.” Critics of holism show a (...) similar license. My aim in this paper, therefore, cannot be to provide and to examine a characterization of content holism that matches every use that has been made of the term. I aim rather to give a precise form to a holistic doctrine at one end of a spectrum of views that ranges from localism or atomism about content to holism about content. This view has the wild consequences often attributed to holism. While it is dubious that anyone has ever seriously held the view I characterize,4 some view like it seems to be what critics often have in mind when arguing against content holism. It is therefore worthwhile to make it precise, to distinguish it from other, related views, and to examine its internal coherence. Thus, in this paper, I will, first, clarify the doctrine, or a doctrine, of content holism, and, second, argue that content holism (so characterized) is not just false (which may be readily granted) but self-contradictory. To begin, we must distinguish between meaning holism and content holism. Let us reserve the term “meaning holism” for doctrines which are about the conditions for the possibility of linguistic expressions having meanings. Meaning holism is therefore a doctrine in the domain of the philosophy of language. “Content holism,” in contrast, we will treat as a doctrine in the philosophy of mind, about the conditions for the possibility of a thought5 having a content. By “a content” we mean, intuitively, what.. (shrink)

Die Entdeckung des Straßburger Empedokles-Papyrus und seine 1999 erfolgte Publikation war für die Erforschung der antiken Philosophie ein einzigartiger Glücksfall. Die neu hinzugekommenen Texte ergänzten die fragmentarische Überlieferung von Empedokles’ naturphilosophischem Lehrgedicht Physika (so der in der Antike gebräuchliche Titel) an entscheidenden Stellen. Allerdings wurde das Potenzial des Papyrus zur Klärung ungelöster Interpretationsprobleme in der auf die Veröffentlichung folgenden Forschungsdiskussion noch nicht ausgeschöpft. In der vorliegenden Arbeit wird auf der Basis einer kontinuierlichen inhaltlichen und sprachlichen Analyse des Textes eine Gesamtrekonstruktion (...) des empedokleischen Theoriegebäudes vorgelegt. Untersucht werden dabei vor allem die zyklische Struktur allen Werdens, die Funktionen von Liebe und Streit, die einzelnen Stadien von Kosmogonie und Zoogonie und das inhaltliche Verhältnis von Physika und einem weiteren Gedicht des Autors, den Katharmoi. Die Ergebnisse werden abschließend auch in einer neuen Übersetzung der durch Einbeziehung des Straßburger Papyrus wiedergewonnenen Teile des Gedichts zusammengeführt. (shrink)

Uit familie-foto's en tekstfragmenten van brieven en aantekeningen samengestelde biografie van de Joods-Oostenrijkse, later in Engeland gevestigde wijsgeer (1889-1951).

Selections from the notebooks of the distinguished philosopher discuss subjects such as music, religion, thinking, science, architecture, and civilization.