Systemic autoimmune diseases are characterized by the production of antibodies against a broad range of self-antigens. Recent evidence indicates that the majority of these autoantigens are modified in various ways during cell death. This has led to the hypothesis that the primary immune response in the development of autoimmunity is directed to components of the dying cell. In this article, we summarize data on the modification of autoantigens during cell death and the possible consequences of this for autoimmunity. BioEssays 22:627–636, (...) 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Bringing together work composed from 1890 to 1924, the nineteen pieces collected in the posthumously published Last Essays serve as a primer to Conrad's wide interests and to the varieties of his style. This edition, supported by an extensive textual apparatus, brings together various prose pieces, including reminiscences, reviews, essays on the sea and politics, as well as several miscellaneous items, including his 'Congo Diary' and the other notebook he kept in Africa in 1890. The introduction situates these writings in (...) Conrad's career, offers new perspectives on Conrad in the marketplace and as a writer of occasional prose and traces the contemporary reception of the volume. The notes explain literary and historical references, identify real-life places and indicate Conrad's main sources. Early drafts and notes for several essays are published here for the first time, making this authoritative critical edition a major contribution to Conrad studies. (shrink)

Although numbers as Volume 4, this is the second of the Complete Works to appear, following_ The History of King Richard III_. The Latin text is based on the editions of 1516, 1517, and 1518, fully collated and with the variant readings; the parallel English text is a thoroughly revised version of the translation by G. C. Richards. Also included are the letters on the book exchanged by More and his friends, their tributes, and the marginal glosses of the early (...) editions. The text is followed by a commentary on the relation of _Utopia_ to its own age and as it has been interpreted by scholars. The editors' Introduction included an outline of the genesis and composition of _Utopia_, edited by Father Surtz, will also appear in the Yale Paperbound format. Father Surtz is professor of English at Loyola University, and Mr. Hexter is professor of history at Yale University. Previously announced. (shrink)

By the death, last summer, of Jack Robson, the world of utilitarian studies and a wider world of scholarship on both sides of the Atlantic lost one of their most distinguished figures. It would not be appropriate here, even if it were possible now, to attempt a full and measured assessment of his work. Writing only a few months after the news of his death, while the sense of loss is still so sharp for all his many friends, two things (...) are possible. Something can and should be said to acknowledge and celebrate Robson's achievement as a scholar; and to this can be added some personal recollections of one whose human qualities were as outstanding as his scholarship. (shrink)

The full range of Bentham's engagement with Blackstone's view of law is beyond the scope of a single article. Yet it is important to recognize at the outset, even in a more restricted enquiry into the matter, that the engagement, begun when Bentham, not quite sixteen years of age, started to attend Blackstone's Oxford lectures, was indeed a lifelong affair. Whatever Bentham had in mind when, at the age of eighty, in 1828, he began to write a work entitled ‘A (...) familar view of Blackstone: or say Blackstone familiarized’, the manuscripts at least suffice to prove that ‘Our Author’ was still in the forefront of his mind at that octogenarian but still indefatigably active stage of his career. Every aspect of Bentham's multifarious intellectual activity over the intervening decades had been touched in some measure by his response to Blackstone's ideas. It still seems true to say what was said a dozen years ago: It would be an exaggeration to say that Bentham elaborated his own conception of law by way of a constant and conscious dialectic with the views of Blackstone. But it would be an exaggeration for which the evidence would afford some excuse. (shrink)