Background: Increasing use of genetic technologies in clinical and research settings increases the potential for misattributed paternity to be identified. Yet existing guidance from the President's Commission for the Study of Ethical Problems in Biomedical and Behavioral Research and the Institute of Medicine (among others) offers contradictory advice. Genetic health professionals are thus likely to vary in their practice when misattributed paternity is identified, and empirical investigation into the disclosure of misattributed paternity is scarce. Given the relevance of this ethical (...) dilemma and its significance to users of genetic services, this study aimed to investigate the attitudes of lay people with regard to the disclosure of misattributed paternity. Methods: An online questionnaire was hosted and advertised through Amazon's Mechanical Turk to 200 United States residents aged 18 years or older. Respondents were asked to rate (via a Likert scale) the ethical permissibility of possible actions a clinician may carry out when misattributed paternity is identified. Data analysis consisted of preliminary descriptive analysis, chi-squared analysis, and Wilcoxon signed-rank tests. Results: There was no clear majority support for many of the options surveyed across different contexts, with only six out of ten scenarios displaying some general consensus. Men were more likely to support scenarios where the father is informed of paternity. Importantly, participants' views varied according to whether the desires of the father were previously expressed, suggesting that perceptions of the permissibility of a clinician's action will depend on the interests of all parties affected. Conclusions: This sample of the general public showed attitudes that were, at least to some degree, at variance with some professional guidelines. We give arguments for why at least some of these attitudes might be justified. We argue that case-specific judgments should be made and outline some of the relevant ethical considerations. While general guidelines ought to be considered, context-specific moral judgments cannot be avoided. (shrink)

Hans-Georg Gadamer is one of the leading philosophers in the world today. His philosophical hermeneutics has had a major impact in a wide range of disciplines, including the social sciences, literary criticism, theology and jurisprudence. Truth and Method, his major work, is widely recognised to be one of the great classics of twentieth-century thought. In this book Georgia Warnke provides a clear and systematic exposition of Gadamer's work, as well as a balanced and thoughtful assessment of his views. Warnke (...) gives particular attention to the ways in which Gadamer's work has been taken up and criticised by literary critics, social theorists and philosophers, such as Hirsch, Habermas and Rorty. She thus provides an introduction to Gadamer which demonstrates the relevance of his work to current debates in a variety of disciplines. This book will be invaluable to students and specialists throughout the humanities and social sciences, as well as to anyone who is interested in the most important developments in contemporary thought. (shrink)

This book offers a fresh analysis of the account of Peripatetic ethics in Cicero's On Ends 5, which goes back to the first-century BCE philosopher Antiochus of Ascalon. Georgia Tsouni challenges previous characterisations of Antiochus' philosophical project as 'eclectic' and shows how his reconstruction of the ethics of the 'Old Academy' demonstrates a careful attempt to update the ancient heritage, and predominantly the views of Aristotle and the Peripatos, in the light of contemporary Stoic-led debates. This results in both (...) a hermeneutically complex and a philosophically exciting reading of the old tradition. A case in point is the way Antiochus grounds the 'Old Academic' conception of the happy life in natural appropriation, thus offering a naturalistic version of Aristotelian ethics. (shrink)

This book explores the thought of - and is dedicated to - David Frisby, as one of the leading sociologists of the late twentieth and early twenty-first centuries. Presenting original examinations of his unique social theory and underlining his interdisciplinary approach to the critical interpretation of modern metropolitan society and culture, it emphasises Frisby's legacy in highlighting the role of the social researcher as a collector, reader, observer, detective and archivist of the phenomena and ideas that exemplify the modern metropolis (...) as society. With contributions from sociologists, historians of the city, urban geographers, cultural theorists, architectural historians, architectural theorists and urban designers, The Detective of Modernity constitutes a wide-ranging engagement with Frisby's profound legacy in social and cultural theory. (shrink)

Foundations of Christian ethics -- What is Christian ethics? -- Frames of reference -- Christian ethics and moral philosophy -- Christian ethics and the ethics of Christendom -- Christian ethics and the churches -- Christian ethics and the Bible -- Christian ethics and the New Testament -- The covenant, the law, and the prophets -- The covenant -- The law -- The prophets -- Jesus and the Old Testament -- The ethics of Jesus -- What did Jesus teach? -- Eschatology (...) and ethics -- The ethics of compromise -- Ethical perspectives of the early church -- The law and the gospel -- The kingdom and the Christian community -- The gospel and social institutions -- God, sin and Christian character -- God and Christian character -- The Christian virtues -- The nature of sin -- Some illustrations -- Victory over sin -- Duties to self and society -- Duty to self -- Duties in interpersonal relations -- The larger society -- Problems of social decision -- Marriage and the family -- The primacy of the family -- Jesus and the family -- Is monogamy essential? -- Foundations of Christian family life -- Divorce -- The ethics of economic life -- The economic ethics of the New Testament -- The Christian view of property -- The Christian view of work -- What is economic justice? -- Christianity and the race problem -- Biblical foundations -- The causes of race prejudice -- Effects of race prejudice -- Proposals for Christian action -- The Christian conscience and the state -- What is the state? -- Our biblical and theological base -- Love and justice -- Love and coercion -- Liberty, equality, and democracy -- War, peace, and international order -- Basic Christian foundations -- Points of convergence in Christian opinion -- Pacifism and nonpacifism -- Christian ethics and culture -- What is culture? -- Biblical and theological foundations -- Science, art, and education -- Index. (shrink)

_Legitimate Differences_ challenges the usual portrayal of current debates over thorny social issues including abortion, pornography, affirmative action, and surrogate mothering as _moral_ debates. How can it be said that our debates oppose principles of life to those of liberty, principles of liberty to those of equality, principles of equality to those of fairness, and principles of fairness to those of integrity, when we as Americans share all these principles? Debates over such issues are not, Georgia Warnke argues, moral (...) debates over which principles we should adopt. Rather, they are interpretive debates over the meanings of principles we already possess. Warnke traces the structure of these debates with reference to the work of Jane Austen, Hans-Georg Gadamer, Jürgen Habermas, and Bernard Williams. In separate chapters on surrogate mothering, affirmative action, abortion, and pornography she articulates new understandings of the meanings of some of our principles and shows the equal legitimacy of some different interpretations of the meanings of others. Finally, she suggests that the orientation of American public policy ought to be directed less at finding single canonical interpretations of our principles than at accommodating different legitimate understandings of them. The perspective offered by _Legitimate Differences_ should have a significantly beneficial effect on public discussions. (shrink)

À l’occasion du creusement du tunnel RW2 sur le trajet Trapeza-Diakopto de la nouvelle ligne ferroviaire Corinthe-Patras, dans la région de Trapeza Aigialeias, ont été mis au jour des vestiges de bâtiments datant de l’époque archaïque à l’époque hellénistique, qui font partie d’un habitat dépendant de Voura, importante cité située à l’Est d’Aigialeia. Au nombre des trouvailles archéologiques, on compte beaucoup de monnaies de bronze provenant des cités voisines de Sicyone, Corinthe et Athènes, qui constituent l’horizon politique et économique naturel (...) de la cité, ainsi que des pièces émises par d’autres États, notamment les Locriens d’Oponte, le koinon des Épirotes et l’Eubée. En présentant les monnaies trouvées à Trapeza, majoritairement des petites dénominations en bronze, nous entendons souligner leur apport pour une étude de la vie économique de la région et démontrer par ailleurs que les cités, en frappant monnaie, stimulaient de manière significative leur économie. (shrink)

DNA methylation is a repressive epigenetic modification that is essential for development and its disruption is widely implicated in disease. Yet, remarkably, ablation of DNA methylation in transgenic mouse models has limited impact on transcriptional states. Across multiple tissues and developmental contexts, the predominant transcriptional signature upon loss of DNA methylation is the de‐repression of a subset of germline genes, normally expressed in gametogenesis. We recently reported loss of de novo DNA methyltransferase DNMT3B resulted in up‐regulation of germline genes and (...) impaired syncytiotrophoblast formation in the murine placenta. This defect led to embryonic lethality. We hypothesize that de‐repression of germline genes in the Dnmt3b knockout underpins aspects of the placental phenotype by interfering with normal developmental processes. Specifically, we discuss molecular mechanisms by which aberrant expression of the piRNA pathway, meiotic proteins or germline transcriptional regulators may disrupt syncytiotrophoblast development. (shrink)

ABSTRACTIn this conceptual review, we discuss models of emotion and its regulation and identify a spectrum of processes that characterise adaptive adjustment to the affective environment. We descri...

RESUMO A série Black Mirror, transmitida entre 2011 e 2023 pela Netflix, tornou-se um fenômeno de mídia e seus episódios mostraram formas de interação homem-máquina (terminologia também referida como humano-computador). O nome da série se refere ao fato de que, quando uma tela é desligada, ela se torna um espelho negro que reflete a imagem do usuário. Este artigo1 tem como objetivo analisar os efeitos da interação homem-máquina nas organizações produtivas apresentadas em Black Mirror. Esta pesquisa utilizou a análise do (...) discurso, principalmente a partir das contribuições de Mikhail Bakhtin. O método consistiu em três etapas que contaram com a colaboração de estudantes de graduação e pós-graduação em Engenharia de Produção, integrando ensino e pesquisa e desenvolvendo o senso crítico dos pesquisadores-iniciantes. Os resultados indicam que, nas organizações apresentadas na série Black Mirror, há uma transição do conceito de fatores humanos para fatores ciborgues, bem como o uso da interação homem-máquina para promover o controle social. (shrink)

No presente artigo, visando uma Arqueologia da Loucura e buscando ? no encontro dos fundamentos filosóficos com o arcabouço científico e tecnológico – pincelar um olhar para o louco e para a loucura , me debruço sobre duas possibilidades de compreensão do louco cuja consequência última se volta para uma Ética da Alteridade . Ou seja, busco construir um olhar para a diferença inerente ao Homo sapiens sapiens através da leitura de Michel Foucault em Histoire de la folie à l’age (...) classique . Ademais, busco analisar esta Arqueologia da Loucura como uma possibilidade de compreensão prévia das estruturas de biopoder. (shrink)

Die Autorin zeigt, wie Klemens von Alexandria durch die heilsgeschichtliche Interpretation des Zeitbegriffs die antike Dialektik rezipiert, und wie er zur Konkretisierung einer ontotheologischen Dialektik im Sinne seiner christlichen Philosophie gelangt.

Philosophical anthropology, as Helmuth Plessner has explored it, vindicates its relative priority towards ethics, because it can set out the anthropological prerequisites for considering the moral subject as the embodied person. This claim, however, is still an open question. Walter Schulz has argued that the prevalence of science in contemporary life brings ethics to the fore and forces philosophical anthropology to an auxiliary exploration of ‘leading figures of thehuman’. Jürgen Habermas endorses Plessner’s exploration of the issue of the body, in (...) order to oppose biotechnological naturalism. Thus, he enlarges his discourse on ethics through the ethics of the human species by defining the moral agent as the embodied person. Nevertheless, philosophical anthropology is a broader theoretical endeavour that cannot be reduced to ethics. (shrink)

Προσόψεις θεάτρων και Νυμφαία θεατρικής πρόσοψης. Η σχέση μεταξύ τους Το άρθρο αυτο μελετά τις ομοιότητες ανάμεσα στις προσόψεις των θεάτρων και των μνημειακών νυμφαίων. Η συζήτηση αφορά κυρίως στα λεγόμενα νυμφαία με ευθύγραμμη πρόσοψη, τα οποία συγκρίνονται άμεσα με τη scaenae frons ενός ρωμαϊκού θεάτρου. Η έρευνα βασίζεται σε τέσσερις παραμέτρους : α. τη μορφολογία, όπως φαίνεται μέσα από τις ομοιότητες των δύο μνημείων, λ. χ. τη χρήση συγκεκριμένων αρχιτεκτονικών στοιχείων, β. τη λειτουργία και τη χρήση αυτών των δημοσίων (...) μνημείων εντός του αστικού τοπίου – σε σχέση με την κοινωνική, πολιτική και πολιτισμική ζωή των πολιτών, γ. την εικονογραφία, δηλαδή τη μελέτη του γλυπτού διακόσμου, ο οποίος αναπτύσσεται στις μνημειακές προσόψεις και των θεάτρων και των νυμφαίων · και τα δύο αυτά μνημεία φιλοξενούν παρόμοια εικονογραφικά προγράμματα, τα οποία ακολουθούν συγκεκριμένους κανόνες, αποβλέποντας ταυτόχρονα στην προβολή συγκεκριμένων μηνημάτων, δ. τη σχέση με το ιερό στοιχείο, το οποίο ενέχεται τόσο στα θέατρα όσο και στα νυμφαία · ένα μεγάλο μέρος των θεάτρων και των νυμφαίων έχουν κατασκευαστεί εντός ή πλησίον ιερών, ενώ πολλά θέατρα φιλοξενούν νυμφαία στους χώρους τους. (shrink)

The central Platonic concept of the mixture is to be situated in the entire transmission of Methexis: ascending from the level of the participation of the sensible things in the forms to the participation of the forms and finally to the participation of the two Platonic Principles. “Mixture” designates on the one hand the relation between the μέγιστα γένη in the Sophist and on the other hand the one between the Limit and the Unlimited in the Philebus . Thereupon the (...) essence of the Mixture is to be examined and rehabilitated as metaphor, namely as transformation of a sensible image in a philosophical one . Our guiding question will be: W hy can the Mixture be legitimated as a better candidate than the Methexis in the frame of the Sophist? The Mixture is to be regarded as well-founded transformation of Methexis in the context of the equioriginal “greatest kinds” . In our interpretation of the Philebus that restores the disputed unity of this Platonic dialogue, we are about to show how the philosopher Plato “saves” the beautiful phenomena: The fourfold division is to be construed as the place where the beautiful appearances are generated. To them does the philosopher return after his ascent to the σύμφυτον two Platonic Principles. They are no longer degraded as “rolling about in the midregion between being and not-being” , but are rather reevaluated as “procreation” .Der in den späteren platonischen Dialogen zentrale Begriff der Mischung wird zunächst in die ganze Übertragung der Methexis eingeordnet: von der Ebene der Teilhabe des W ahrnehmbaren an der Idee zu der innerideellen Teilhabe aufsteigend und von daher zu der Teilhabe der zwei platonischen Prinzipien. Einerseits wird die Beziehung der μέγιστα γένη untereinander, andererseits diejenige zwischen der Grenze und der U nbegrenztheit im Philebos als Mischung bezeichnet . Daraufhin wird ihr W esen als Metapher behandelt und rehabilitiert, nämlich als Transformation eines sinnlichen Bildes in ein philosophisches . Zur Leitfrage unserer Ausführung wird: W arum kann die im Rahmen des Dialogs Sophistes eingeführte Mischung der größten Gattungen miteinander als ein besserer Kandidat als derjenige der Teilhabe gerechtfertigt werden? Die Mischung wird als eine wohlbegründete Verwandlungsform derTeilhabe in den ideellen Zusammenhängen der gleichursprünglichen größten Gattungen betrachtet . Bei unserer die umstrittene Einheit des Philebos wiederherstellende Interpretation wird aufgezeigt, wie der Philosoph Platon die schönen Phänomene rettet: Die vierfache Einteilung des Ganzen wird als Ort der Genese der schönen Erscheinungen interpretiert. Ihnen wendet sich der Philosoph nach dem Aufstieg zum σύμφυτον der zwei platonischen Prinzipien zu, nicht länger sie als “zwischen dem Sein und dem Nicht-Sein herumschweifend” degradierend , sondern als “Zeugung” würdigend .Pojam miješanja, koji je središnji u kasnijim Platonovim dijalozima, ponajprije se smješta u cjeloviti kontekst transponiranja methexisa: od ravni sudjelovanja osjetilnog u ideji uzlazno k sudjelovanju među idejama te odatle k sudjelovanju dvaju platoničkih principa. S jedne strane se kao miješanje označava međusobni odnos μέγιστα γένη, s druge pak onaj između granice i neograničenosti u Filebu . U tu se svrhu razmatra i rehabilitira bit miješanja kao metafore, naime kao transformacija osjetilne slike u filozofijsku . Glavnim pitanjem našeg izvođenja postaje: zašto se uzajamno miješanje “najviših rodova”, koje se uvodi u okviru dijaloga Sofist, može opravdati kao bolji kandidat od sudjelovanja? Miješanje se razmatra kao dobro utemeljena forma preinake sudjelovanja u odnošenjima jednako izvornih “najviših rodova” . U našoj se interpretaciji, koja nanovo uspostavlja osporavano jedinstvo Fileba, prikazuje kako filozof Platon spašava lijepe fenomene: četvorostruka podjela cjeline interpretira se kao mjesto nastajanja lijepih pojava. Njima se filozof vraća nakon uspona k onom σύμφυτον dvaju platoničkih principa, ne degradirajući ih više kao one koji se “potucaju između bitka i ne-bitka” , već ih cijeni kao “rađanje”. (shrink)

Because citizens of diverse and pluralistic democracies possess different values and interests, deliberative democratic theory founds legitimate decision-making in non-coercive deliberations among free and equal citizens who appeal to public reasons or, in other words, to reasons that can be accepted by ‘all who are possibly affected’. Yet it is not clear that what stymies democratic justification is the failure to offer or accept public reasons. Can we not agree on them while understanding them in different but equally compelling ways? (...) Indeed, might it not be that what stymies justification is our failure to acknowledge this possibility? The first part of this paper explores these questions as they relate both to the original formulations of deliberative theory and to certain revisions. The second part of the paper investigates a hermeneutic alternative that not only acknowledges but also value differences in the ways we can plausibly understand the public reasons to which we agree. (shrink)

Der Begriff der Mischung ist von zentraler Bedeutung in der spateren platonischen Philosophie. Um das Wesen der Mischung offenzulegen, fokussiert Georgia Mouroutsou auf den Sophistes und den Philebos. Im ersten Kapitel ordnet sie die 'Mischung' in die ganzheitliche Ubertragung der beruhmten und beruchtigten Teilhabe ein: von der Teilhabe des Wahrnehmbaren an der Idee zu der innerideellen Teilhabe und von da zu der Teilhabe der zwei platonischen Prinzipien. Dabei erhellt die Autorin das Wesen der Mischung als Metapher: als Transformation eines (...) sinnlichen Bildes in ein philosophisches Bild. Als 'Mischung' wird einerseits die Beziehung der grossten Gattungen untereinander, andererseits diejenige zwischen Grenze und Unbegrenztheit bezeichnet. Im zweiten Kapitel wird die Konzeption der Mischung im Sophistes behandelt. Zur Leitfrage wird: Warum ist die Metapher der Mischung im Fall der Verbindung der Idee des Seienden mit der des Anderen gelungener als diejenige der Teilhabe? Mouroutsou bietet eine Analyse von Soph. 246a-259b und eine grundliche Diskussion der entsprechenden Sekundarliteratur. Von einer allgemeinen Ontologie des Seienden als 'Kraft des Tuns und des Leidens' gelangt der Gast aus Elea zu einer speziellen Ontologie des ausgezeichneten ideellen Seienden: Der Dialog kulminiert in der unhintergehbaren Mischung der Ideen des Seienden und des Anderen, die sich als gleichursprunglich erweisen. Die Mischung der grossten Gattungen ereignet sich in 254b-259b nicht auf der Basis vorhandener Elemente, die nachtraglich in Verbindung zueinander gesetzt werden; vielmehr kommen erst in der Dynamik des Vollzugs der Mischung ihre Momente als eigenstandige Elemente zur Erscheinung. Erst das Gefuge der Mischung wird so verantwortlich fur die Entmischung seiner Elemente. Im dritten Kapitel rekonstruiert die Autorin die einheitliche Bewegung von Philebos 15-27. Sie vermeidet Diskrepanzen oder Zusammenhangslosigkeit und verfolgt statt dessen Schritt fur Schritt die Ubertragung der Teilhabe in der dialogischen Bewegung. Der Dialektiker verlasst zunachst das Wahrnehmbare, um den holistischen Anspruchen der Ideendialektik nachzugehen, kehrt dann jedoch zu ihm zuruck. In der vierfachen Einteilung des Ganzen, in der Mouroutsou die Mischung als Ort der Genese der schonen Erscheinungen deutet, zeigt sich Platon als Retter der Phanomene. Nach dem Aufstieg zum Verwachsensein der zwei platonischen Prinzipien degradiert der Philosoph sie nicht langer als 'zwischen Sein und Nicht-Sein herumschweifend', sondern wurdigt sie als 'Zeugung'. Schonheit und Ordnung entstehen durch eine Bezahmung und Bandigung des nie vollig Bezahmbaren, dem sie agonal abgerungen werden: Es geht um die Pragung des Seins auf das von sich aus widerstrebende Werden. Die Momente der Mischung des Sophistes und des Philebos sind verschieden und jeweils anders bedingt. Die vorliegende Deutung versucht nicht, das eine Konzept durch das andere zu erklaren; stattdessen integriert sie beide Momente in eine umfassendere dialektische Bewegung. Der Bezug auf Aristoteles erweist sich bei der Platon-Interpretation erneut als unumganglich, obgleich sich unser Platonsbild seinetwegen oft nur muhevoll rekonstruieren lasst. (shrink)

Jean Grondin’s starting point in his impressive book is what Hans-Georg Gadamer refers to as the universal claim of hermeneutics. Gadamer is better known for the limits his hermeneutics seems to place on universal claims. Against the reliance the Enlightenment placed on the insights of a reason common to humanity, Gadamer stresses the prejudiced and partial character of attempts to understand meaning. And against more contemporary attempts to ground Enlightenment conceptions in universal human competencies, he stresses the historicity and finitude (...) of human knowledge. Our attempts to understand the meaning of texts, conversations, historical events, and social actions and practices are conditioned by the horizon of our language, our own historical experiences, and our assumptions and expectations. Still, Gadamer ends his Truth and Method by stressing not only the linguistic character of understanding but the infinite capacity of all languages to find and express new dimensions of meaning. “Language,” he writes, “forestalls any objection to its jurisdiction. Its universality keeps pace with the universality of reason.”. (shrink)