Results for 'Embryonic stem cells'

992 found
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  1.  49
    Would the real human embryonic stem cell please stand up?Ben Zhang, Roman Krawetz & Derrick E. Rancourt - 2013 - Bioessays 35 (7):632-638.
    Embryonic stem cells (ESCs) are now classified into two types of pluripotency: “naïve” and “primed” based upon their differing characteristics. Conventional human ESCs have much more in common with mouse epiblast stem cells and are now deemed to be primed. Naïve human ESCs that resemble mouse ESCs have recently been generated from their primed counterpart by cellular reprogramming. Isolation of naïve hESCs from human embryos has proven to be difficult. Is the inability to capture naïve (...)
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  2.  87
    Human Embryonic Stem Cell Research: Ethical Views of Buddhist, Hindu and Catholic Leaders in Malaysia.Mathana Amaris Fiona Sivaraman & Siti Nurani Mohd Noor - 2016 - Science and Engineering Ethics 22 (2):467-485.
    Embryonic Stem Cell Research raises ethical issues. In the process of research, embryos may be destroyed and, to some, such an act entails the ‘killing of human life’. Past studies have sought the views of scientists and the general public on the ethics of ESCR. This study, however, explores multi-faith ethical viewpoints, in particular, those of Buddhists, Hindus and Catholics in Malaysia, on ESCR. Responses were gathered via semi-structured, face-to-face interviews. Three main ethical quandaries emerged from the data: (...)
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  3.  28
    Embryonic stem cells: the disagreement debate and embryonic stem cell research in Israel.F. Simonstein - 2008 - Journal of Medical Ethics 34 (10):732-734.
    While some people claim that the present disagreement over embryonic stem cell research cannot be resolved, others argue that developing transparency and trust are key elements that could resolve the existing disagreements over such research. This paper reveals that transparency is not necessarily a requirement for advancing ES cell research, since in Israel, for instance, there is no transparency, and research nevertheless flourishes. Moreover, trust is not independent of cultural values and religious beliefs. Because of these beliefs, the (...)
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  4. Human embryonic stem cell research: An intercultural perspective.LeRoy Walters - 2004 - Kennedy Institute of Ethics Journal 14 (1):3-38.
    : In 1998, researchers discovered that embryonic stem cells could be derived from early human embryos. This discovery has raised a series of ethical and public-policy questions that are now being confronted by multiple international organizations, nations, cultures, and religious traditions. This essay surveys policies for human embryonic stem cell research in four regions of the world, reports on the recent debate at the United Nations about one type of such research, and reviews the positions (...)
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  5. Human embryonic stem cell research: Why the discarded-created-distinction cannot be based on the potentiality argument.Katrien Devolder - 2005 - Bioethics 19 (2):167-186.
    Discussions about the use and derivation of pluripotent human embryonic stem cells are a stumbling block in developing public policy on stem cell research. On the one hand there is a broad consensus on the benefits of these cells for science and biomedicine; on the other hand there is the controversial issue of killing human embryos. I will focus on the compromise position that accepts research on spare embryos, but not on research embryos ('discarded-created-distinction', from (...)
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  6. Embryonic Stem Cell–Derived Gametes and Genetic Parenthood: A Problematic Relationship.Heidi Mertes & Guido Pennings - 2008 - Cambridge Quarterly of Healthcare Ethics 17 (1):7-14.
    The recent success in generating live offspring from embryonic stem cell –derived gametes in mice sparked visions of growing tailor-made sperm for men faced with infertility. However, although this development will almost certainly lead to new insights into the processes underlying spermatogenesis and thus in the possible causes of male infertility, it is less certain if deriving sperm from ES cells, which are in turn derived from a sterile man, can make someone a genetic parent. As the (...)
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  7.  80
    Embryonic Stem Cell Patents and Human Dignity.David B. Resnik - 2007 - Health Care Analysis 15 (3):211-222.
    This article examines the assertion that human embryonic stem cells patents are immoral because they violate human dignity. After analyzing the concept of human dignity and its role in bioethics debates, this article argues that patents on human embryos or totipotent embryonic stem cells violate human dignity, but that patents on pluripotent or multipotent stem cells do not. Since patents on pluripotent or multipotent stem cells may still threaten human dignity (...)
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  8.  27
    Embryonic Stem Cell Research and Therapy: The Need for a Common European Legal Framework.Carlos M. Romeo&Ndashcasabona - 2002 - Bioethics 16 (6):557-567.
    The possibility of obtaining stem cells from human embryos has given rise to an intensive legal and ethical debate. In this paper, attention is paid to the normative disparity and ambiguity in Europe. An argument for the need for a minimal legal harmonization is made; and a prudent and flexible way to reach this successfully is suggested. Establishing a common legal framework seems to be the only way to guarantee true competitiveness for the European scientific community.
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  9.  69
    Using embryonic stem cells to form a biological pacemaker via tissue engineering technology.Dong-Bo Ou, Hong-Juan Lang, Rui Chen, Xiong-Tao Liu & Qiang-Sun Zheng - 2009 - Bioessays 31 (2):246-252.
    Biological pacemakers can be achieved by various gene‐based and cell‐based approaches. Embryonic stem cells (ESCs)‐derived pacemaker cells might be the most promising way to form biological pacemakers, but there are challenges as to how to control the differentiation of ESCs and to overcome the neoplasia, proarrhythmia, or immunogenicity resulting from the use of ESCs. As a potential approach to solve these difficult problems, tissue‐engineering techniques may provide a precise control on the different cell components of multicellular (...)
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  10. Human embryonic stem cell research and the discarded embryo argument.Mark Moller - 2009 - Theoretical Medicine and Bioethics 30 (2):131-145.
    Many who believe that human embryos have moral status are convinced that their use in human embryonic stem cell (hESC) research can be morally justified as long as they are discarded embryos left over from fertility treatments. This is one reason why this view about discarded embryos has played such a prominent role in the debate over publicly funding hESC research in the United States and other countries. Many believe that this view offers the best chance of a (...)
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  11.  59
    The embryonic stem cell lottery and the cannibalization of human beings.Julian Savulescu - 2002 - Bioethics 16 (6):508–529.
    One objection to embryonic stem (ES) cell research is that it ‘cannibalizes’ human beings, that is, kills some human beings to benefit others. I grant for argument’s sake that the embryo is a person. Nonetheless, killing it may be justified. I show this through the Embryonic Stem Cell Lottery. Whether killing a person is justified depends on: (1) whether innocent people at risk of being killed for ES cell research also stand to benefit from the research (...)
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  12.  50
    Human Embryonic Stem Cell (HESC) Research in Malaysia: Multi-faith Perspectives.Patrick Foong - 2011 - Asian Bioethics Review 3 (3):182-206.
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  13.  81
    Embryonic Stem Cells and Property Rights.A. -K. M. Andersson - 2011 - Journal of Medicine and Philosophy 36 (3):221-242.
    This article contributes to the current debate on human embryonic stem cell researchers’ possible complicity in the destruction of human embryos and the relevance of such complicity for the issue of commodification of human embryos. I will discuss if, and to what extent, researchers who destroy human embryos, and researchers who merely use human embryos destroyed by others, have moral use rights, and/or moral property rights, in these embryos. I argue that the moral status of the human embryo, (...)
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  14.  44
    Nanog Expression in Embryonic Stem Cells - An Ideal Model System to Dissect Enhancer Function.Steven Blinka & Sridhar Rao - 2017 - Bioessays 39 (12):1700086.
    Embryonic stem cells are derived from the preimplantation embryo and can differentiate into virtually any other cell type, which is governed by lineage specific transcriptions factors binding to cis regulatory elements to mediate changes in gene expression. The reliance on transcriptional regulation to maintain pluripotency makes ESCs a valuable model to study the role of distal CREs such as enhancers in modulating gene expression to affect cell fate decisions. This review will highlight recent advance on transcriptional enhancers, (...)
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  15.  31
    Human embryonic stem cells: caught between a ROCK inhibitor and a hard place.Roman J. Krawetz, Xiangyun Li & Derrick E. Rancourt - 2009 - Bioessays 31 (3):336-343.
    Since their derivation, human embryonic stem (hES) cells have been used for a variety of applications including developmental biology, pathology, chemical biology, genomics, and proteomics. However, their most important potential application is the generation of cells and tissues, which can be used for cell‐based therapies. One of the main drawbacks of hES cell culture is that they are particularly sensitive to dissociation, which is required for passaging, expansion, cryopreservation, and other applications. Recently, it has been discovered (...)
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  16.  65
    Human Embryonic Stem Cell Research: Its Importance in the Culture Wars.Bishop Thomas - 2013 - Christian Bioethics 19 (1):60-71.
    The debate surrounding human embryonic stem cell research plays a crucial role in the culture wars. Those who embrace post-traditional morality not only see no ethical problem with the destruction of human embryos for research and therapies, but press for their use despite the greater potential for risk from the totipotent cells that are harvested from the destruction of human embryos as opposed to other kinds of stem cells. Indeed, there have been foreseeable negative consequences (...)
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  17.  17
    Cardiomyocytes from human embryonic stem cells: more than heart repair alone.Christine Mummery - 2007 - Bioessays 29 (6):572-579.
    One of the most‐exciting and controversial discoveries of the last decade has been the isolation of embryonic stem cells from human embryos. The capacity of these cells to form all somatic cell types in the human body has captured the imagination of researcher and clinician alike, the perspectives that they represent for cell replacement therapies in multiple chronic disorders being used to justify the use of embryos for this purpose. However, there is a gradual realization that (...)
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  18. Abortion, embryonic stem cell research, and waste.David A. Jensen - 2008 - Theoretical Medicine and Bioethics 29 (1):27-41.
    Can one consistently deny the permissibility of abortion while endorsing the killing of human embryos for the sake of stem cell research? The question is not trivial; for even if one accepts that abortion is prima facie wrong in all cases, there are significant differences with many of the embryos used for stem cell research from those involved in abortion—most prominently, many have been abandoned in vitro, and appear to have no reasonably likely meaningful future. On these grounds (...)
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  19.  71
    Democracy, embryonic stem cell research, and the Roman Catholic church.J. Oakley - 2002 - Journal of Medical Ethics 28 (4):228-228.
    The Roman Catholic Church in Australia has lobbied politicians to prohibit embryonic stem cell research, on the grounds that such research violates the sanctity and inherent dignity of human life. I suggest, however, that reasoned reflection does not uniquely support such conclusions about the morality of stem cell research. A recent parliamentary standing committee report recommended that embryonic stem cell research be allowed to proceed in certain circumstances, and there appears to be widespread support in (...)
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  20. Embryonic Stem Cell Research: A Pragmatic Roman Catholic's Defense.R. Whittington - 2012 - Christian Bioethics 18 (3):235-251.
    The potential benefits of embryonic stem cell research have been clarified by the last ten years of research so that it is necessary to re-examine the foundations for the restrictions imposed on this research. Those who believe that life begins at the moment of fertilization and is imbued with a full complement of human rights have opposed all embryonic research. As one who accepts this premise, I will demonstrate that there are certain limited circumstances in which parents (...)
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  21.  53
    Human embryonic stem cells and respect for life.J. R. Meyer - 2000 - Journal of Medical Ethics 26 (3):166-170.
    The purpose of this essay is to stimulate academic discussion about the ethical justification of using human primordial stem cells for tissue transplantation, cell replacement, and gene therapy. There are intriguing alternatives to using embryos obtained from elective abortions and in vitro fertilisation to reconstitute damaged or dysfunctional human organs. These include the expansion and transplantation of latent adult progenitor cells.
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  22.  82
    Embryonic stem cell research: Ethical challenges for developing world bioethics.Debora Diniz - 2008 - Developing World Bioethics 8 (3).
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  23. The Ethical Dilemma of Embryonic Stem Cell Research.Nabeel Manzar, Bushra Manzar, Nuzhat Hussain, M. Fawwad Ahmed Hussain & Sajjad Raza - 2013 - Science and Engineering Ethics 19 (1):97-106.
    To determine the knowledge, attitude, and ethical concerns of medical students and graduates with regard to Embryonic Stem Cell (ESC) research. This questionnaire based descriptive study was conducted at the Civil Hospital Karachi (CHK), Pakistan from February to July 2008. A well structured questionnaire was administered to medical students and graduate doctors, which included their demographic profile as well as questions in line with the study objective. Informed consent was taken and full confidentiality was assured to the participants. (...)
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  24. Ethics and Policy in Embryonic Stem Cell Research.John Ancona Robertson - 1999 - Kennedy Institute of Ethics Journal 9 (2):109-136.
    : Embryonic stem cells, which have the potential to save many lives, must be recovered from aborted fetuses or live embryos. Although tissue from aborted fetuses can be used without moral complicity in the underlying abortion, obtaining stem cells from embryos necessarily kills them, thus raising difficult questions about the use of embryonic human material to save others. This article draws on previous controversies over embryo research and distinctions between intrinsic and symbolic moral status (...)
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  25.  72
    Human embryonic stem cell research debates: a Confucian argument.D. F.-C. Tsai - 2005 - Journal of Medical Ethics 31 (11):635-640.
    Human embryonic stem cell research can bring about major biomedical breakthroughs and thus contribute enormously to human welfare, yet it raises serious moral problems because it involves using human embryos for experiment. The “moral status of the human embryo” remains the core of such debates. Three different positions regarding the moral status of the human embryo can be categorised: the “all” position, the “none” position, and the “gradualist” position.The author proposes that the “gradualist” position is more plausible than (...)
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  26. Monotheistic Religions' Perspectives on Embryonic Stem Cell Research.Mansooreh Saniei & Raymond de Vries - 2008 - Eubios Journal of Asian and International Bioethics 18 (2):45-50.
    The controversy about research on human embryonic stem cells raises many fundamental ethical and religious questions, especially about the sanctity of lifeand the Divine mandate of human dominion over nature. This paper reviews the different perspectives of three monotheistic religions on the use of embryo for stem cell research. Looking at the religious perspectives, it shows us that Islam and Judaism support most forms of stem cell research. Both of them express their beliefs on when (...)
     
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  27.  40
    Embryonic Stem Cell Research and Therapy: The Need for a Common European Legal Framework.Carlos M. Romeo–Casabona - 2002 - Bioethics 16 (6):557-567.
    The possibility of obtaining stem cells from human embryos has given rise to an intensive legal and ethical debate. In this paper, attention is paid to the normative disparity and ambiguity in Europe. An argument for the need for a minimal legal harmonization is made; and a prudent and flexible way to reach this successfully is suggested. Establishing a common legal framework seems to be the only way to guarantee true competitiveness for the European scientific community.
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  28.  40
    The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy.Suzanne Holland, Karen Lebacqz & Laurie Zoloth (eds.) - 2001 - MIT Press.
    Discusses the ethical issues involved in the use of human embryonic stem cells in regenerative medicine.
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  29. Ethical issues in human embryonic stem cell research.Philip J. Nickel - 2007 - In Kristen Renwick Monroe, Ronald Miller & Jerome Tobis, Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues. University of California Press.
    As a moral philosopher, the perspective I will take in this chapter is one of argumentation and informed judgment about two main questions: whether individuals should ever choose to conduct human embryonic stem cell research, and whether the law should permit this type of research. I will also touch upon a secondary question, that of whether the government ought to pay for this type of research. I will discuss some of the main arguments at stake, and explain how (...)
     
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  30.  74
    Will Embryonic Stem Cells Change Health Policy?William M. Sage - 2010 - Journal of Law, Medicine and Ethics 38 (2):342-351.
    Essays on stem cell policy seem to fall into three categories. Some essays in this collection are about logic and principles. Others are about practices and beliefs. The former group draws lines and defends them, a normative project. The latter group attempts to explain the lines that already exist, a descriptive project that may have important normative goals. Still other essays, by scientists, are about growing stem cell lines instead of drawing them.The purpose of this essay is to (...)
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  31. Embryonic stem cell production through therapeutic cloning has fewer ethical problems than stem cell harvest from surplus IVF embryos.J.-E. S. Hansen - 2002 - Journal of Medical Ethics 28 (2):86-88.
    Restrictions on research on therapeutic cloning are questionable as they inhibit the development of a technique which holds promise for succesful application of pluripotent stem cells in clinical treatment of severe diseases. It is argued in this article that the ethical concerns are less problematic using therapeutic cloning compared with using fertilised eggs as the source for stem cells. The moral status of an enucleated egg cell transplanted with a somatic cell nucleus is found to be (...)
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  32.  39
    Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources.Hans-Werner Denker - 2006 - Journal of Medical Ethics 32 (11):665-671.
    The recent discussions about alternative sources of human embryonic stem cells , while stirring new interest in the developmental potential of the various abnormal embryos or constructs proposed as such sources, also raise questions about the potential of the derived embryonic stem cells. The data on the developmental potential of embryonic stem cells that seem relevant for ethical considerations and aspects of patentability are discussed. Particular attention is paid to the meaning (...)
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  33.  46
    Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources.H.-W. Denker - 2006 - Journal of Medical Ethics 32 (11):665-671.
    The recent discussions about alternative sources of human embryonic stem cells , while stirring new interest in the developmental potential of the various abnormal embryos or constructs proposed as such sources, also raise questions about the potential of the derived embryonic stem cells. The data on the developmental potential of embryonic stem cells that seem relevant for ethical considerations and aspects of patentability are discussed. Particular attention is paid to the meaning (...)
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  34.  43
    Moral status of embryonic stem cells: Perspective of an african villager.Godfrey B. Tangwa - 2007 - Bioethics 21 (8):449–457.
    ABSTRACT One of the most important as well as most awesome achievements of modern biotechnology is the possibility of cloning human embryonic stem cells, if not human beings themselves. The possible revolutionary role of such stem cells in curative, preventive and enhancement medicine has been voiced and chorused around the globe. However, the question of the moral status of embryonic stem cells has not been clearly and unequivocally answered. Taking inspiration from the (...)
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  35.  46
    Religion, public reason, and embryonic stem cell research.Cynthia B. Cohen - 2006 - In David E. Guinn, Handbook of bioethics and religion. New York: Oxford University Press.
    This chapter argues that although there are certain limits on how religious bodies and their members should attempt to insert their beliefs into public policy matters, religiously based arguments should, as a matter of principle, be allowed to enter into public debate. This is the case even when many participants in these debates do not accept the premises on which the arguments of religious believers are constructed. The first part of the chapter considers the stances that various religious bodies and (...)
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  36.  28
    Embryonic stem cells and property rights.Anna-Karin M. Andersson - 2011 - Journal of Medicine and Philosophy 36 (3):221-242.
  37.  51
    Towards a global human embryonic stem cell bank.Jason P. Lott & Julian Savulescu - 2007 - American Journal of Bioethics 7 (8):37 – 44.
    An increasingly unbridgeable gap exists between the supply and demand of transplantable organs. Human embryonic stem cell technology could solve the organ shortage problem by restoring diseased or damaged tissue across a range of common conditions. However, such technology faces several largely ignored immunological challenges in delivering cell lines to large populations. We address some of these challenges and argue in favor of encouraging contribution or intentional creation of embryos from which widely immunocompatible stem cell lines could (...)
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  38.  45
    Embryonic stem cell retrieval and a possible ethical bypass.Mary B. Mahowald & Anthony P. Mahowald - 2002 - American Journal of Bioethics 2 (1):42 – 43.
  39.  9
    Embryonic Stem Cells and Totipotency.Nicholas Tonti-Filippini & Peter McCullagh - 2000 - Ethics and Medics 25 (7):1-3.
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  40.  59
    Introduction: Embryonic Stem Cell Research, Abortion, Euthanasia, and the Plurality of Moralities in Bioethics.A. E. Hinkley - 2011 - Journal of Medicine and Philosophy 36 (3):217-220.
  41.  66
    Human embryonic stem cell research: Middle-ground positions and moral compromise.Angeliki Kerasidou - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 57:167-169.
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  42.  50
    Embryonic stem cell production through therapeutic cloning has fewer ethical problems than stem cell harvest from surplus IVF embryos.J. E. S. Hansen - 2002 - Journal of Medical Ethics 28 (2):86-88.
  43.  30
    Embryonic stem cell funding: California, here I come?Susan Cartier Poland - 2004 - Kennedy Institute of Ethics Journal 14 (4):407-409.
  44.  43
    The Ethics of Embryonic Stem Cell Research.Katrien Devolder - 2015 - Oxford, GB: Oxford University Press.
    Embryonic stem cell research holds great promise for biomedical research, but involves the destruction of human embryos. Katrien Devolder explores the tension between the view that embryos should never be deliberately harmed, and the view that such research must go forward. She provides an in-depth analysis of major attempts to resolve the problem.
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  45.  28
    Bioethics and the Global Moral Economy: The Cultural Politics of Human Embryonic Stem Cell Science.Charlotte Salter & Brian Salter - 2007 - Science, Technology, and Human Values 32 (5):554-581.
    The global development of human embryonic stem cell science and its therapeutic applications are dependent on the nature of its engagement at national and international levels with key cultural values and beliefs concerning the moral status of the early human embryo. This article argues that the political need to reconcile the promise of new health technologies with the cultural costs of scientific advance, dependent in this case on the use of the human embryo, has been met by the (...)
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  46. For love or money? The saga of korean women who provided eggs for embryonic stem cell research.Françoise Baylis - 2009 - Theoretical Medicine and Bioethics 30 (5):385-396.
    In 2004 and 2005, Woo-Suk Hwang achieved international stardom with publications in Science reporting on successful research involving the creation of stem cells from cloned human embryos. The wonder and success all began to unravel, however, when serious ethical concerns were raised about the source of the eggs for this research. When the egg scandal had completely unfolded, it turned out that many of the women who provided eggs for stem cell research had not provided valid consents (...)
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  47. The moral-principle objection to human embryonic stem cell research.Don Marquis - 2007 - Metaphilosophy 38 (2-3):190–206.
    Opponents of human embryonic stem cell (hESC) research claim that such research is incompatible with the moral principle that it is always wrong intentionally to end a human life. In this essay, I discuss how that principle might be revised so that it is subject to as few difficulties as possible. I then argue that even the most defensible version of the principle is compatible with the moral permissibility of hESC research.
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  48.  45
    A qualified endorsement of embryonic stem cell research, based on two widely shared beliefs about the brain-diseased patients such research might benefit.R. DiSilvestro - 2008 - Journal of Medical Ethics 34 (7):563-567.
    Are there persuasive approaches to embryonic stem cell (ESC) research that appeal, not just to those fellow-citizens in one’s own ideological camp, nor just to those undecided citizens in the middle, but to those citizens on the other side of the issue? I believe that there are such arguments and in this short paper I try to develop one of them. In particular, I argue that certain beliefs shared by some proponents and some opponents of ESC research—beliefs about (...)
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  49.  33
    Is Human Embryonic Stem Cell (HESC) Research Still Necessary Today?Patrick Chee-Kuen Foong - 2017 - Asian Bioethics Review 9 (1-2):33-44.
    Given the promise of stem cell therapies, scientists throughout the world are conducting stem cell research using various kinds of stem cells including human embryonic stem cells. However, HESC research is very controversial in some societies as the extraction of stem cells involves the destruction of the human embryo. The ethical concerns of this kind of research have led scientists to search for other methods to derive stem cells that (...)
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  50. Ethical Guidelines for Human Embryonic Stem Cell Research (A Recommended Manuscript).Chinese National Human Genome Center at Shanghai Ethics Committee - 2004 - Kennedy Institute of Ethics Journal 14 (1):47-54.
    In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 14.1 (2004) 47-54 [Access article in PDF] Ethical Guidelines for Human Embryonic Stem Cell Research*(A Recommended Manuscript) Adopted on 16 October 2001Revised on 20 August 2002 Ethics Committee of the Chinese National Human Genome Center at Shanghai, Shanghai 201203 Human embryonic stem cell (ES) research is a great project in the frontier of biomedical science for the twenty-first century. Be- (...)
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