Individual neurons display characteristic firing patterns determined by the number and kind of ion channels in their membranes. We describe experimental and computational studies that suggest that neurons use activity sensors to regulate the number and kind of ion channels and receptors in their membrane to maintain a stable pattern of activity and to compensate for ongoing processes of degradation, synthesis and insertion of ion channels and receptors. We show that similar neuronal and network outputs can be produced by a (...) number of different combinations of ion channels and synapse strengths. This suggests that individual neurons of the same class may each have found an acceptable solution to a genetically determined pattern of activity, and that networks of neurons in different animals may produce similar output patterns by somewhat variable underlying mechanisms. BioEssays 24:1145–1154, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Theories are processes modelled by thought. When they evolve in time, they are transformed and become new theories. They may cross from one academic discipline to another, then open up to new areas of human knowledge, mixing together the humanities, art, science and even spirituality. The way they are modelled reveals their plasticity and their elasticity is tested in their potential for transfer from one domain to another, while the different contacts they make and mergers they undergo generate a certain (...) hybridity. Plasticity, elasticity and hybridity are the triad which make the transfer of theories possible. (shrink)

Dans le contexte pénitentiaire actuel de la lutte contre la désocialisation, des associations offrent un soutien psychologique et social aux familles des prisonniers. La recherche-action « Regards d’enfants sur l’incarcération » dont rend compte cet article, menée en collaboration avec deux de ces associations, consiste à créer des groupes de soutien pour les enfants qui ont un parent ou un proche en prison. L’objectif de cette recherche-action est d’évaluer les conditions, moyens et outils qui permettraient d’offrir une possibilité d’échange aux (...) enfants pour leur rendre possible de partager leurs expériences et d’exprimer ce qui ne peut être dit à des parents, des proches et à leur environnement social (amis, école, voisins...). Les résultats confirment le besoin manifeste de renforcer les pratiques professionnelles autour des familles, et notamment des enfants, grands absents dans nos dispositifs d’accompagnement français. (shrink)

Remarkably, there have been three decisions by the Court of Appeal and one decision by the Supreme Court (including notably R(G) v Governors of X School) in the space of three years on the same question as to whether the procedural guarantees of Article 6 European Convention on Human Rights (ECHR) can apply to disciplinary proceedings in the workplace. The earlier recent domestic decisions held that Article 6(1) could apply or did apply to workplace disciplinary procedures and could imply or (...) did imply a right to legal representation. More recently, employees have used Article 6 to argue for a right to independent disciplinary panels. In comparison, the more recent domestic decisions have held that Article 6(1) did not apply to workplace disciplinary procedures. This article explores the scope for Article 6(1) to apply to workplace disciplinary procedures by looking at the Strasbourg case law and explores the additional possibility that Article 6 could be engaged in workplace disciplinary procedures based on the alternative civil rights not to be wrongfully dismissed or unfairly dismissed. The benefit of these alternative civil rights would be that they would open up the protection of Article 6 to more employees than just professionals. This article also discusses the apparent conflict between the aims of employees in the cases on Article 6 ECHR and recent broader policy developments in favour of early and informal resolution of employment disputes. It is concluded that these cases reinforce objections to the Coalition Government’s broader ‘rebalancing’ agenda, as dismissal laws require strengthening and not further weakening. (shrink)

This paper studies the effects of social comparison on risk taking behavior. In our theoretical framework, decision makers evaluate the consequences of their choices relative to both their own and their peers’ conditions. We test experimentally whether the position in the social ranking affects risk attitudes. Subjects interact in a simulated workplace environment where they perform a work task, receive possibly different wages, and then undertake a risky decision that may produce an extra gain. We find that social comparison matters (...) for risk attitudes. Subjects are more risk averse in the presence of small social gain than social loss. In addition, risk aversion is decreasing in the size of the social gain. (shrink)

Im Zuge einer Änderung des Arzneimittelgesetzes im November 2016 hat der Deutsche Bundestag beschlossen, dass gruppennützige Arzneimittelforschung mit nicht-einwilligungsfähigen Erwachsenen unter bestimmten Bedingungen erlaubt sein soll. Das entsprechende Gesetz wird voraussichtlich im Jahr 2020 in Kraft treten. Das ethische Problem dieser Forschung besteht darin, dass Personen, die nicht in der Lage sind, ihre Einwilligung in die Forschung zu erteilen, nicht vom medizinischen Fortschritt ausgeschlossen werden sollen. Der Gesetzgeber hat versucht, diesen Konflikt zu lösen, indem er die Zulässigkeit der gruppennützigen Forschung (...) mit nicht-einwilligungsfähigen Erwachsenen an die Voraussetzung geknüpft hat, dass Studienteilnehmer ihre Einwilligung zuvor in einer Probandenverfügung erteilen. Der Beitrag hat das Ziel, die neue Regelung zur gruppennützigen Forschung mit nicht-einwilligungsfähigen Erwachsenen aus ethischer Sicht zu bewerten. Die Frage, ob die Gesetzesänderung weitere Forschung ermöglichen wird, hängt wesentlich davon ab, ob man mit Blick auf Studien, die sowohl eigennützige als auch gruppennützige Maßnahmen umfassen, eine Gesamtbetrachtung oder eine Einzelbetrachtung dieser Studien vorzieht. In unserem Beitrag argumentieren wir für eine Einzelbetrachtung. Es wird weiterhin die Auffassung vertreten, dass die im Gesetzgebungsverfahren vorgeschlagene Probandenverfügung die Selbstbestimmung der Patienten fördern kann, wenn sie mit Blick auf die mit der Teilnahme verbundenen Eingriffe ein Mindestmaß an Bestimmtheit erreicht.Zusammenfassend wird die Auffassung vertreten, dass gruppennützige Forschung mit nicht-einwilligungsfähigen Erwachsenen trotz der genannten Bedenken unter bestimmten Bedingungen ethisch zulässig sein kann. In der Gesamtabwägung erscheint dabei die eindeutige Definition und strenge Beachtung der Bedingungen der EU-Verordnung 536/2014 mit Blick auf einen ethisch gerechtfertigten Einbezug von nicht-einwilligungsfähigen Erwachsenen in gruppennützige Forschung als besonders bedeutsam. (shrink)

In Arequipa, Peru’s second largest city, engineers work hard to control water flows and provide different sectors with clean and sufficient water. In 2011, only 10 percent of the totality of water used daily by Arequipa’s then close to 1 million people—in households, tourism, industry, and mining—was treated before it was returned to the river where it continues its flow downstream towards cultivated fields and, finally, into the Pacific Ocean. It takes specialized knowledge and manifold technologies to manage water and (...) sustain life in Arequipa, and engineers are central actors for making water flow. Examining the ecology of water management, this article asks to what extent we can talk of a way of knowing and enacting water that is particular to engineers. Through engineering practices, a technical domain emerges as separate from and superior to political and social domains. This production of categories can be understood as practices of purification. However, a purely technical grip on water is never possible. Unruly elements, like weather, contamination, urban dwellers, and competing interests, interfere and make processes of intervention unstable. Water is never completely cleaned, and, equally, the continuous processes of purification of categories and domains take place while other processes work to blur their boundaries. (shrink)

Although the main responsibility for informed consent of medical procedures rests with doctors, nurses’ roles are also important, especially as patient advocates. Nurses’ preparation for this role in settings with a hierarchical and communal culture has received little attention. We explored the views of hospital managers and nurses regarding the roles of nurses in informed consent and factors influencing these roles. We conducted a qualitative study in a private, multispecialty hospital in Indonesia. Semi-structured interviews were conducted with seven managers. Two (...) rounds of focus group discussions with nurses (n = 27) were conducted. Constant comparative approach was used in the analysis. Nurses can act as manager, witness, information giver, and advocate in the informed consent process. These roles are influenced by nurses’ preparedness, hospital culture and policy, patients’ understanding, family involvement, and cost-related issues. In preparation for these tasks, nurses should acquire communication skills, clinical knowledge, and legal and ethical knowledge. (shrink)

Subliminal perception occurs when prime stimuli that participants claim not to be aware of nevertheless influence subsequent processing of a target. This claim, however, critically depends on correct methods to assess prime awareness. Typically, d9 (‘‘d prime’’) tasks administered after a priming task are used to establish that people are unable to discriminate between different primes. Here, we show that such d9 tasks are influenced by the nature of the target, by attentional factors, and by the delay between stimulus presentation (...) and response. Our results suggest that the standard d9 task is not a straightforward measure of prime visibility. We discuss the implications of our findings for subliminal perception research. (shrink)

BackgroundThe public’s attitudes to conscientious objection are likely to influence political decisions about CO and trust towards healthcare systems and providers. Few studies examine the pub...

In the asymptotic safety paradigm, a quantum field theory reaches a regime with quantum scale invariance in the ultraviolet, which is described by an interacting fixed point of the Renormalization Group. Compelling hints for the viability of asymptotic safety in quantum gravity exist, mainly obtained from applications of the functional Renormalization Group. The impact of asymptotically safe quantum fluctuations of gravity at and beyond the Planck scale could at the same time induce an ultraviolet completion for the Standard Model of (...) particle physics with high predictive power. (shrink)

Consolation is needed when a human being suffers (i.e. feels alienated from him-or herself, from other people, from the world or from his or her ultimate source of meaning). The aim of this study was to illuminate the meaning of consolation. Tape-recorded narrative interviews were carried out with 18 professionals from various spheres. The transcribed interviews were interpreted hermeneutically. A model of consolation is outlined in a drawing. It states that the mediator and the receiver of consolation must become ready (...) for consolation before it can take place. To be ready means to be present and available. Availability means expressing suffering and listening respectively, and thereby opening up for communion and consoling dialogue. Communion brings about contact with the sacred dimension that human beings share and thus with goodness, light, joy, beauty and life. Consolation involves a shift of perspective and an experience of meaning in spite of suffering. (shrink)

A new analytical framework for understanding literary videogames, the literary-ludic spectrum, illustrated by close readings of selected works. In this book, Astrid Ensslin examines literary videogames—hybrid digital artifacts that have elements of both games and literature, combining the ludic and the literary. These works can be considered verbal art in the broadest sense (in that language plays a significant part in their aesthetic appeal); they draw on game mechanics; and they are digital-born, dependent on a digital medium (unlike, for (...) example, conventional books read on e-readers). They employ narrative, dramatic, and poetic techniques in order to explore the affordances and limitations of ludic structures and processes, and they are designed to make players reflect on conventional game characteristics. Ensslin approaches these hybrid works as a new form of experimental literary art that requires novel ways of playing and reading. She proposes a systematic method for analyzing literary-ludic (L-L) texts that takes into account the analytic concerns of both literary stylistics and ludology. After establishing the theoretical underpinnings of her proposal, Ensslin introduces the L-L spectrum as an analytical framework for literary games. Based on the phenomenological distinction between deep and hyper attention, the L-L spectrum charts a work's relative emphases on reading and gameplay. Ensslin applies this analytical toolkit to close readings of selected works, moving from the predominantly literary to the primarily ludic, from online hypermedia fiction to Flash fiction to interactive fiction to poetry games to a highly designed literary “auteur” game. Finally, she considers her innovative analytical methodology in the context of contemporary ludology, media studies, and literary discourse analysis. (shrink)

This paper proposes an analytical framework for the analysis of organizational cognition that borrows from distributed and ecological cognition. In so doing, we take a case study featuring a decision on the topic of agreeing on a set point in the agenda of a meeting. It is through the analysis of a few minutes of video-recording used in the case that enables us to demonstrate the power of applying distributed and ecological cognition to organizing processes. Cognitive mechanism, resources, and processes (...) are identified within this combined framework. Mechanisms are described as “socio-material” (CM1)—where “people” and “artifacts” are the related cognitive resources—and as “conceptual” (CM2)—with “group” identity, “topic” understanding, meaning of “procedures,” and perception of “time” as resources. Processes are defined as “coupling,” “de-coupling,” and “un-coupled” depending on the type of relation in place. Finally, the paper presents an agent-based computational simulation to demonstrate the potentials of operationalizing this approach. (shrink)

Hoy en día vivimos aún con el estereotipo de las dos culturas, con la idea de una cierta incomunicabilidad entre ciencias y humanidades, en términos más generales: entre la esfera de la ciencia y la de la cultura. Este artículo presenta una visión filosófica de la relación entre cultura y ciencia más allá de la tópica dicotomía, sosteniendo en cambio un enfoque en el que se concibe la ciencia como fenómeno cultural. Un recorrido histórico-sistemático por algunos hitos de la filosofía (...) de la cultura y la filosofía de la ciencia muestra cómo las dos se compenetran entre sí y se influyen mutuamente. Poner el foco en las convergencias entre ambas permite identificar una serie de preocupaciones y retos compartidos que conciernen al campo de la epistemología en su conjunto: afrontar la complejidad de la condición epistémica y la vulnerabilidad cognitiva del ser humano; hacer frente a las posiciones más extremas tanto del relativismo como del fundamentalismo; y desarrollar un concepto de responsabilidad epistémica en los distintos ámbitos de conocimiento para contrarrestar la cultura de desconfianza y la percepción de nuestra época como era de la posverdad. (shrink)

Putting laypeople in an active role as direct expert contributors in the design of service robots becomes more and more prominent in the research fields of human–robot interaction and social robotics. Currently, though, HRI is caught in a dilemma of how to create meaningful service robots for human social environments, combining expectations shaped by popular media with technology readiness. We recapitulate traditional stakeholder involvement, including two cases in which new intelligent robots were conceptualized and realized for close interaction with humans. (...) Thereby, we show how the robot narrative together with aspects of power balancing stakeholders, such as hardware constraints and missing perspectives beyond primary users, and the adaptivity of robots through machine learning that creates unpredictability, pose specific challenges for participatory design processes in HRI. We conclude with thoughts on a way forward for the HRI community in developing a culture of participation that considers humans when conceptualizing, building, and using robots. (shrink)

Francis Bacon's experimental philosophy is discussed, and the way in which it not only shapes scientific methodology but also deeply pervades all philosophical and social learning. Bacon draws us in to participate in an experiment with experience. The central driving force is the idea that learning how to learn is necessary in order to know. To meet this requirement, he considers the relation of form and content of pivotal importance, and therefore the selection of the literary form and the form (...) of data inscription is decisive in the construction of a heuristic tool. His inductive method serves a dual purpose: first, the so-called indicative form aims at securing knowledge by a comprehensible procedure that controls and guides hypothetical thinking. Second, the literary forms "fragment" and "aphorism" embody the subjunctive, and invite intellectual openness and even speculation. In this article, special emphasis is put on Bacon's use and justification of the aphorism. Bacon's pervasive experimentalism meets in some sense today's broad adoption of the experimental mode. His philosophy calls for an ontology that is also at work in recent notions of co-action and co-working, or of affordance. (shrink)

This article addresses a number of phenomena in the field of digital communication - disinformation, infodemics and conspiracy mania - that promote indifference regarding the distinction between truth and lies, fact and fiction, opinion and knowledge. They have thus decisively altered users' patterns of rationality and common sense and contributed to the rise of anti-democratic and anti-scientific positions. To address this complex problem, a systemic approach is provided that considers these phenomena to be factors that disturb the ethical-epistemic equilibrium between (...) uncertainty, trust and responsibility. After identifying a set of dynamics generated by these disruptive factors, three aspects are explored in depth: the polarisation and lack of a deliberative culture, the necessary correction of the social image of scientific practice, and the impact of the post-truth discourse. The article concludes with reflections on redefining the three key concepts of uncertainty, trust and responsibility in light of the demands of the digital sphere. (shrink)