One of the main challenges in medicine is to guarantee an appropriate drug supply according to the real needs of patients. Closed-loop strategies have been widely used to develop automatic solutions based on feedback variables. However, when the variable of interest cannot be directly measured or there is a lack of knowledge behind the process, it turns into a difficult issue to solve. In this research, a novel algorithm to approach this problem is presented. The main objective of this study (...) is to provide a new general algorithm capable of determining the influence of a certain clinical variable in the decision making process for drug supply and then defining an automatic system able to guide the process considering this information. Thus, this new technique will provide a way to validate a given physiological signal as a feedback variable for drug titration. In addition, the result of the algorithm in terms of fuzzy rules and membership functions will define a fuzzy-based decision system for the drug delivery process. The method proposed is based on a Fuzzy Inference System whose structure is obtained through a decision tree algorithm. A four-step methodology is then developed: data collection, preprocessing, Fuzzy Inference System generation, and the validation of results. To test this methodology, the analgesia control scenario was analysed. Specifically, the viability of the Analgesia Nociception Index as a guiding variable for the analgesic process during surgical interventions was studied. Real data was obtained from fifteen patients undergoing cholecystectomy surgery. (shrink)

El llamado “pacto de postguerra” fue una de las mayores transformaciones institucionales de la historia europea que delimitó los cauces por los que discurrió su política durante varias décadas. En este artículo se ofrece, primero, una descripción de los fundamentos básicos del pacto que ahonda particularmente en el caso británico. En segundo lugar, se aborda el debate socialista británico que generó esta reforma del capitalismo. El desafío del ala derecha del laborismo fue replicado por los miembros del Partido Comunista de (...) Gran Bretaña y de la primera New Left. Se reconstruyen aquí los argumentos del debate prestando especial atención a los disputados conceptos de “democracia”, “propiedad” y “socialismo”. (shrink)

This paper relates Donaldson and Dunfee’s Integrative Social Contracts Theory to the problem of gender discrimination. We make the assumption that multinational managers might seek some guidance from ISCT to resolve ethical issues of gender discrimination in countries indifferent or hostile to gender equaIity. The role of Donaldson and Dunfee’s “hypernorms” seems especially cruciaI, and we find that, under their writings thus far, no “hypernorms” exist to make unethical the most blatant acts of sex discrimination in a host country whose (...) local norms tolerate such discrimination. The genesis of “hypernorms” as “global moral minimums” is recounted, and specific application of ISCT to a familiar ethics case (“A Foreign Assignment”) is provided. (shrink)

Antonia Lolordo presents an original interpretation of John Locke's metaphysics of moral agency, in which to be a moral agent is simply to be free, rational, and a person.

Advancing second-person neuroscience will need strong theories, as well as the new methods detailed by Schilbach et al. I assess computational theories, enactive theories, and cognitive/information processing theories, and argue that information processing approaches have an important role to play in second-person neuroscience. They provide the closest link to brain imaging and can give important insights into social behaviour.

This work focuses on the application of machine learning techniques to assist the clinicians in the administration of analgesic drug during general anaesthesia. Specifically, the main objective is to propose the basis of an intelligent system capable of making decisions to guide the opioid dose changes based on a new nociception monitor, the analgesia nociception index. Clinical data were obtained from 15 patients undergoing cholecystectomy surgery. By means of an off-line study, machine learning techniques were applied to analyse the possible (...) relationship between the analgesic dose changes performed by the physician due to the hemodynamic activity of the patients and the evolution of the ANI. After training different classifiers and testing the results under cross validation, a preliminary relationship between the evolution of ANI and the dosage of remifentanil was found. These results evidence the potential of the ANI as a promising index to guide the infusion of analgesia. (shrink)

Paulo Friere is considered to be one of the most influential educational philosophers of the twentieth century. Within many progressive circles, he would be considered the most important radical educational philosopher of our times, given his contribution to a revolutionary understanding of education and his certainty and faith that education can function as one of the most significant empowering and democratizing forces in the lives of the disenfranchised. In this deeply personal introduction to the man,and his ideas and their contribution (...) to ideas of progressive schooling, Antonia Darder reflects on her personal memories of time spent with Freire and his influence on her own work. (shrink)

Just as bodily actions are things you do with your body, mental actions are things you do with your mind. Both are different from things that merely happen to you. Where does the idea of mental action come from? What are mental actions? And why do they matter in philosophy? These are the three main questions answered in this paper. Section 1 introduces mental action through a brief history of the topic in philosophy. Section 2 explains what it is to (...) be a mental action in terms of intentional action. Section 3 argues that the fact that we can perform mental actions has some striking consequences concerning mental content. Section 4 shows how mental action helps to explain some important facts about self-knowledge and the normativity of thought. The conclusion mentions two further fruitful avenues for philosophical research on mental action. (shrink)

El objetivo de este artículo es proporcionar algunas claves históricas y conceptuales para comprender la historia del socialismo británico libertarian y su relación con la concepción fiduciaria del poder político y del poder económico. Las expresiones de este socialismo no son homogéneas, convivieron con otras ideas rivales llegando en ocasiones a mezclarse con ellas; y fueron formuladas siempre como respuestas concretas ante los problemas que planteaba cada momento histórico. Desde el socialismo republicano de algunos seguidores de Robert Owen hasta los (...) desafíos que planteó la New Left, las teorías fiduciarias encontraron hueco para abrirse paso en los escritos de estos socialistas libertarian. The objective of this paper is to provide some historical and conceptual keys to understand the history of libertarian British socialism, and its relationship with the fiduciary conception of political power and economic power. The expressions of this libertarian socialism are not homogeneous, they coexisted with other rival conceptions, sometimes mixing with them. Those articulations were always formulated as concrete responses to the problems laid out by different historical moments. From the republican socialism of some Robert Owen’s followers to the challenges exposed by the New Left, fiduciary theory found room to break through in the writings of these libertarian socialists. (shrink)

The issue of directed donation of organs from deceased donors for transplantation has recently risen to the fore, given greater significance by the relatively stagnant rate of deceased donor donation in the UK. Although its status and legitimacy is explicitly recognized across the USA, elsewhere a more cautious, if not entirely negative, stance has been taken. In England, Wales and Northern Ireland, the Human Tissue Act 2004, and in Scotland the Human Tissue (Scotland) Act 2006, are both silent in this (...) regard. Although so-called conditional donation, donation to (or perhaps withheld from) a specific class, has been outlawed as a product of guidance issued by the Secretary of State for Health issued in the wake of the controversial incident occurring in the North of England in 1998, its intended application to ‘directed’ donation is less certain. Directed and conditional donations challenge the traditional construct of altruistic donation and impartial (equitable) allocation in a very immediate and striking fashion. They implicitly raise important questions as to whether the body or parts of the body are capable of being owned, and by whom. This paper attempts to explore the notion of donor ownership of body parts and its implications for both directed and conditional donation. (shrink)

You can come to know that you believe that p partly by reflecting on whether p and then judging that p. Call this procedure “the transparency method for belief.” How exactly does the transparency method generate known self-attributions of belief? To answer that question, we cannot interpret the transparency method as involving a transition between the contents p and I believe that p. It is hard to see how some such transition could be warranted. Instead, in this context, one mental (...) action is both a judgment that p and a self-attribution of a belief that p. The notion of embedded mental action is introduced here to explain how this can be so and to provide a full epistemic explanation of the transparency method. That explanation makes sense of first-person authority and immediacy in transparent self-knowledge. In generalized form, it gives sufficient conditions on an attitude’s being known transparently. (shrink)

Aesthetic value empiricism claims that the aesthetic value of an object is grounded in the value of a certain kind of experience of it. The most popular version of value empiricism, and a dominant view in contemporary philosophical aesthetics more generally, is aesthetic hedonism. Hedonism restricts the grounds of aesthetic value to the pleasure enjoyed in the right kind of experience. But hedonism does not enjoy any clear advantage over a more permissive alternative version of value empiricism. This alternative is (...) aesthetic liberalism. On this view, an object’s aesthetic value is fully grounded in any value—not just the hedonic value—of a correct and complete experience of its sensory features. To demonstrate the advantages of liberalism over hedonism, I apply both views to analyze the aesthetic value of the Spring Temple Buddha and Anselm Kiefer’s Seraphim. I detail four advantages of liberalism over hedonism, and I conclude by defending liberalism from two kinds of objection. (shrink)

Infolge der Moderne schwinden absolute Erklärungsprinzipien: Man sucht Orientierung, um seine Lebenswelt und den erfahrungswissenschaftlich aufgeschlossenen Kosmos zu überschauen. Seine sich in diesem Kontext ausbildende, nie ganz bewusst gestaltete Weltanschauung artikuliert der Mensch auch in der Literatur. Antonia Bräutigam analysiert anhand von Jenseitsreisen in Werken von Autoren wie Thomas Mann, Samuel Beckett und C.S. Lewis die durch die Moderne geprägte Weltanschauung und reflektiert diese philosophisch-theologisch. Literatur erweist sich dabei als locus theologicus, als Erkenntnisort für die Theologie, das Motiv der (...) Jenseitsreise als Daseinsmetapher von hoher theologischer Relevanz. (shrink)

Urban communities in 21st century America are facing severe economic challenges, ones that suggest a mandate to contemplate serious changes in the way America does business. The middle class is diminishing in many parts of the country, with consequences for the economy as a whole. When faced with the loss of its economic base, any business community must make some difficult decisions about its proper role and responsibilities. Decisions to support the community must be balanced alongside and against responsibilities to (...) owners, shareholders and relevant “stakeholders” in a relatively new context. Corporations in urban communities “hollowed out” by white flight or urban sprawl must decide what level of support they can and should provide. This paper examines corporate decisions within the emerging urban prosperity initiatives, using the framework of integrative social contract theory proposed by Donaldson and Dunfee. We suggest that urban prosperity initiatives present a mandate on corporations sufficiently strong as to qualify as an authentic norm. Further, we argue that strict adherence to a corporate bottom line approach or “corporate isolationism” is not congruent with contemporary community standards. (shrink)

Le mouvement ouvrier et étudiant de 68 a fissuré l'assise savante du pouvoir. Jacques Rancière, qui en prend acte, instaure un renversement fondamental : il ne saisit plus l'égalité comme but, mais comme point de départ. C'est d'une déconnexion avec l'ordre hiérarchique qu'elle procède. Sont ainsi mises en avant les capacités des opprimés à inventer des pratiques indociles. Pourtant, depuis une vingtaine d'années, Rancière tend à rétrécir la portée de ce geste : en le déplaçant vers le champ esthétique, il (...) le limite à des "redistributions polémiques du dicible et du visible". Ce livre rompt avec une telle orientation. Il élucide l'égalité dans des luttes impliquant la violence, réintroduit une rationalité du désir et de l'antagonisme. L'aspiration à abolir le rapport capitaliste fait pleinement partie de l'obstination lucide qui anime la confiance égalitaire. Ainsi radicalisée, l'égalité noue l'antagonisme, qui combat un ennemi à détruire, au litige, qui s'inclut dans le monde de l'adversaire par polémique. Elle rencontre les questions que le féminisme pose à l'universel, et s'empare de la défaite comme d'un moment immanent à sa pratique, tirant ses ressources de possibles déjà accomplis, mais aussi des chances manquées d'une lutte."--Page 4 of cover. (shrink)

A systematic reconstruction of Adorno’s philosophy of language in the framework of contemporary linguistic philosophy.

To this day no consensus has been reached concerning the authorship of the 3rd book of Philoponus’ on the Soul. I will begin this article by surveying the discussion of the authorship. In this first section I go into some detail concerning the arguments of scholars who attribute the DAC 3 to Philoponus, and those who do not believe that it is by Philoponus, including those who attribute it to Stephanus of Alexandria. The second section of the paper consists in (...) an analysis and evaluation of the arguments involved in the debate. Finally, I conclude by presenting my own position, including new arguments in favor of the attribution of the DAC 3 to John Philoponus. (shrink)

Background Pediatric critical care physician attitudes about withdrawal of ventricular assist devices (VAD) and extracorporeal membrane oxygenation (ECMO) in cases of medical futility are poorly defined. Our aim was to define current attitudes regarding the withdrawal of these devices. Methods IRB-approved, cross-sectional observational survey conducted among pediatric critical care attending physicians and fellow physicians in the United States between 2016 and 2017. Data was collected anonymously and statistically analyzed. Results A total of 158 physicians responded with 67% being attending physicians. (...) Compared to a VAD, a higher percentage had taken care of a patient on ECMO where the device was turned off because care was believed to be futile (99% vs. 84%), including currently (95% vs. 57%). Nearly all reported that it can be ethically permissible to withdraw support from a patient with a VAD and on ECMO (97% vs. 99%), but varied opinions existed as to who should ultimately make this decision if the patient/their family disagrees. More respondents agreed that a patient/their family should agree to withdrawal of VAD or ECMO support prior to initiation if futility is later determined (60% vs. 58%) and that protocols should be created for VAD and ECMO withdrawal (77% vs. 76%). Conclusion Most pediatric critical care physicians felt that it can be ethically permissible to withdraw VAD and ECMO support. Our study indicates that pediatric VAD and ECMO withdrawal protocols are desired, but further investigation is needed to determine how to best design protocols that would incorporate multiple stakeholders. (shrink)

To those raised outside of Gitxsan and Witsuwit'en culture, the concept of a child, (or adult) claiming to be, or being attributed as, an ancestor returned as well as the person of this life, sounds like a split personality. In this paper, we examine a single example of this category from among the more than two hundred cases on record for the Gitxsan and Witsuwit'en of northwest British Columbia. The example serves to demonstrate that the Gitxsan and Witsuwit'en do not (...) construe the situation of someone "come back" as a divided self, but as an embedded self, a person with deep roots and double grounding in the territory and the kin group, doubly integrated into the nexus of social life. This contrasts with the poignant cases of people who were fostered or adopted out, sexually abused, and made to feel confused about their heritage. The autobiographical account of the second author is an example of a woman in this category. It demonstrates the response of shutting down emotion, and absenting oneself from the abusive situations by "leaving the body." Our analysis suggests that cultural definition of what is normal varies from Western to Gitxsan and Witsuwit'en culture. It suggests further that the definition of the experience as useful helps recovery of such individuals when they are reunited with their natal culture. (shrink)

In his 1987 novel Foe, J. M. Coetzee re-introduces the figure of Friday, a speechless cannibal, who is Robinson Crusoe’s slave and who allegedly had his tongue severed by slave-traders. Evidently, Friday’s bestialization and his peculiar position within the narrative are inextricably linked to his status as a nonspeaking character. In contrast to Susan, Coetzee’s “failed narrator”, Friday narrates nothing in the novel. Hence, his silence can be seen as a site of resistance to the oppressive power that tries to (...) define him, marking the limit of a language and a literature that seek to place him within western logocentrism. Thus, the enigma of Friday and the enigma that is Friday, are the major axis around which the novel and all relationships within it unfold. Susan’s -and by extension, Coetzee’s own- inability to interpret Friday’s silence does not incapacitate the narrative but quite the contrary: it is only through her productive failure to determine, to identify and to define the figure of Friday that Coetzee is able to restore agency and meaningfulness to Friday’s silence, opening up its void to the possibility of a restitution to come. (shrink)

Recombinant DNA technology has been used to engineer vaccinia virus genetically into a eukaryotic expression vector. An exciting outcome of these gene‐splicing techniques is that after the insertion of one or more genes which encode the information for antigens responsible for conferring immunity toward an infectious disease, vaccinia can be adapted for the development of live recombinant vaccines. This review discusses recombinant vaccinia design and the feasibility of using these vaccines for disease protection.

Locke claims that we have sensitive knowledge of the external world, in virtue of the fact that simple ideas are real, true, and adequate. However, despite his dismissive remarks about Cartesian external-world skepticism, Locke gives us little to go on as to how knowledge of the external world survives the fact of perceptual error, or even how perceptual error is possible. I argue that Locke has an in-principle problem explaining perceptual error.

Antonia LoLordo - Malebranche - Journal of the History of Philosophy 44:1 Journal of the History of Philosophy 44.1 124-125 Andrew Pyle. Malebranche. London: Routledge, 2003. Pp. xiii + 289. Cloth, $80.00. Despite Malebranche's widely recognized importance, no comprehensive overview of his system was available before Pyle's excellent and wide-ranging study. Pyle agrees with scholarly consensus that occasionalism and the vision in God are Malebranche's two most significant doctrines, but his scope extends well beyond those to matters of theology, (...) physics and biology. In the first half of the book, Pyle lays out Malebranche's two key doctrines as responses to tensions within the Cartesian accounts of causation and of ideas. He details how Malebranche's theory of ideas is involved.. (shrink)

Ce texte a déjà paru dans la revue E-rea [En ligne], 13.1 | 2015. Nous remercions Antonia Rigaud et la revue E-rea de nous avoir autorisé à en reproduire le début ici. Représentant une journée dans la vie d'une ville, Manhatta oscille entre un traitement narratif nous invitant à suivre le quotidien de la ville et un traitement beaucoup plus abstrait, cherchant à capter une atmosphère beaucoup plus qu'à produire un document exact. Tourné en 1921, le film est resté (...) dans l'histoire comme le premier film - Cinéma, animation et vidéo – GALERIE – Nouvel article. (shrink)

Many great authors claim that reading literature can expand your phenomenal imagination and allow you to imagine experiences you have never had. How is this possible? Your phenomenal imagination is constrained by your phenomenal concepts, which are in turn constrained by the phenomenology of your own actual past experiences. Literature could expand your phenomenal imagination, then, by giving you new phenomenal concepts. This paper explains how this can happen. Literature can direct your attention to previously unnoticed phenomenal properties of your (...) own past experiences, as brought to mind by involuntary memory. This process gives you the opportunity to notice those phenomenal properties for the first time, and so also to form phenomenal concepts of those properties. Forming a new phenomenal concept strictly expands the range of your phenomenal imagination. It gives you the capacity to imagine more than you could have before, including certain specific kinds of experience that you yourself have never enjoyed firsthand. Literature’s capacity to expand your phenomenal imagination in this way is central to its social, moral, and epistemic value. (shrink)

Thomas Aquinas asked the essential philosophical question which continues to resound to the modern day: what constitutes a human being? This volume looks at Aquinas's views on bodily and spiritual identity through a lens of theological concerns, pagan and Arabic authoritative sources, and contemporary polemic with dualist heresy.

There has recently been a resurgence of interest in the early nineteenth century Scottish philosopher Mary Shepherd. This Element is intended to provide an overview of Shepherd's system, including her views on the following wide range of topics: causation, induction, knowledge of the external world, matter, life, animal cognition, the relationship between mind and body, the immortality of the soul, the existence of God, miracles, and the nature of divine creation. The author also provides an overview of relevant secondary literature (...) and argues for their own interpretation of Shepherd's metaphysics. (shrink)

Brazilian educator, Paulo Freire, best known for his work Pedagogy of the Oppressed, challenged education plans that contributed to the marginalization of minorities and the poor. Freire believed that education should be used for liberation by helping learners reflect on their experiences historically, giving immediate reality to issues of racism, sexism, and the exploitation of workers. Known as one of the most influential theoretical innovators of the twentieth century, his views have left a significant mark on progressive thinkers about education (...) and liberation. Reinventing Paulo Freire is an homage to him by protégé Antonia Darder. Here, she explores the legacy of Freire, interviews eight former students who studied him-- now teachers themselves, and reflects on the teaching practice as demonstrated by Freire himself. The interviews take the form of first person narratives; the epilogue consists simply of a letter and a poem. (shrink)

Antonia Darder closely examines Freire's ideas as they are articulated in Pedagogy of the Oppressed, beginning with a historical discussion of his life and a systematic discussion of the central philosophical traditions that informed his revolutionary ideas. Darder explores Freire's fundamental themes and ideas, including issues of humanization, teacher/student relationship, reflection, dialogue, praxis, and his larger emancipatory vision. The book also includes a chapter-by-chapter close reading of the text with sample questions to prompt discussion and engagement with Freire's ideas, (...) as well as a new interview with Freire's widow, Ana Maria Araújo Freire, and a preface by Donaldo Macedo. -- from back cover. (shrink)

El retorno del lenguaje conlleva la desaparición del hombre como figura cardinal del saber moderno. La muerte del hombre anunciada por Foucault está en estrecha relación con la muer-te de Dios anunciada por Nietzsche. El último hombre ha matado a Dios y debe responder ahora de su propia finitud. La obra de Foucault traza una historia crítica del pensamiento. Su escepticismo es una crítica del conocimiento. Foucault dudó de las verdades de cada época y de las verdades intemporales. En este (...) artículo trazo el recorrido del hombre en la obra fou-cauldiana y muestro que el escepticismo en Foucault deviene una herrramienta importante en su crítica del conocimiento. (shrink)

The central idea of the paper is that human thinking consists in a movement through which a person socially interacts with herself. Consequently, thinking does not offer the experience of a private refuge in the intimacy of the individual thinker's self-knowing, but a field where multiple points of view interact by contesting, distancing, approaching, agreeing or disagreeing, one to another. Classical (Isocrates, 1929/1968) and contemporary (Billig, 1987) rhetorical approaches to thinking stress that both “inner” and “social” discourse are addressed to (...) someone else, are determined by the anticipation of this audience, and both are interested in persuading it. In doing so, the discursive, rhetoric, and dialogic aspects of thinking become tied to argumentation. The paper tries to show, following the dialogical notion of discourse of Bakhtin (1986) and Vološinov (1929/1986) that, since every act of thinking consists in the raising of a point of view addressing another one and oriented by a particular interest, every stream of thought involves a rhetorical activity. A distinction between rhetoric and argumentation is proposed. On this basis, the rhetorical nature of thinking is discussed beyond argumentative discourse. Overall, this discussion contributes to a rhetorical approach to dialogism. (shrink)