Evidence from optic ataxic patients with bilateral lesions to the superior parietal lobes does not support the view that there are separate planning and control mechanisms located in the IPL and SPL respectively. The aberrant reaches of patients with bilateral SPL damage towards extrafoveal targets seem to suggest a deficit in the selection of appropriate motor programmes rather than a deficit restricted to on-line control.

What representational state mediates between perception and action? Bence Nanay says pragmatic representations, which are outputs of perceptual systems. This commits him to the view that optic ataxics face difficulty in performing visually guided arm movements because the relevant perceptual systems output their pragmatic representations incorrectly. Here, I argue that it is not enough to say that pragmatic representations are output incorrectly; we also need to know why they are output that way. Given recent evidence that optic (...) class='Hi'>ataxia impairs peripersonal space representation, I argue that pragmatic representations are output incorrectly because the organizing principle of the vision-for-action system is blocked by optic ataxia. I then show how this means that this principle, not pragmatic representations, is the representational state that mediates between perception and action, i.e. the principle, not pragmatic representations, is the immediate mental antecedent of action. (shrink)

Evidence for a dichotomy between the planning of an action and its on-line control in humans is reviewed. This evidence suggests that planning and control each serve a specialized purpose utilizing distinct visual representations. Evidence from behavioral studies suggests that planning is influenced by a large array of visual and cognitive information, whereas control is influenced solely by the spatial characteristics of the target, including such things as its size, shape, orientation, and so forth. Evidence from brain imaging and neuropsychology (...) suggests that planning and control are subserved by separate visual centers in the posterior parietal lobes, each constituting part of a larger network for planning and control. Planning appears to rely on phylogenetically newer regions in the inferior parietal lobe, along with the frontal lobes and basal ganglia, whereas control appears to rely on older regions in the superior parietal lobe, along with the cerebellum. Key Words: action; apraxia; control; illusions; optic ataxia; PET; planning; reaching;. (shrink)

This book explains the key concepts that surround the issue as well as the nature of the hard problem and the several approaches to it. It gives a comprehensive treatment of the phenomenon, incorporating its main metaphysical and epistemic aspects as well as recent empirical findings, such as the phenomena of blindsight, change blindness, visual-form agnosia and optic ataxia, mirror recognition in other primates, split-brain cases, and visual extinction.

Ataxia‐telangiectasia (A‐T) is a pleiotropic recessive disorder characterized cerebellar ataxia, immunodeficiency, specific developmental defects, profound predisposition to cancer and acute radiosensitivity. Functional inactivation of single gene product, ATM, accounts for this compound phenotype. We suggest that ATM acts as a sensor of reactive oxygen species and/or oxidative damage cellular macromolecules, including DNA. In turn, ATM induces signalling through multiple pathways, thereby coordinating acute phase stress responses with cell cycle checkpoint control and repair of oxidative damage. Absence of ATM (...) is proposed to limit the repair of insidious oxidative damage that can occur under normal physiological conditions, ultimately leading to apoptosis of particularly sensitive cells, such as neurons and thymocytes. (shrink)

Ataxia is a kind of external characteristics when the human body has poor coordination and balance disorder, it often indicates diseases in certain parts of the body. Many internal factors may causing ataxia; currently, observed external characteristics, combined with Doctor’s personal clinical experience play main roles in diagnosing ataxia. In this situation, different kinds of diseases may be confused, leading to the delay in treatment and recovery. Modern high precision medical instruments would provide better accuracy but the (...) economic cost is a non-negligible factor. In this paper, novel non-contact sensing technique is used to detect and distinguish sensory ataxia and cerebellar ataxia. Firstly, Romberg’s test and gait analysis data are collected by the microwave sensing platform; then, after some preprocessing, some machine learning approaches have been applied to train the models. For Romberg’s test, time domain features are considered, the accuracy of all the three algorithms are higher than 96%; for gait detection, Principal Component Analysis is used for dimensionality reduction, and the accuracies of Back Propagation neural Network, Support Vector Machine, and Random Forest are 97.8, 98.9, and 91.1%, respectively. (shrink)

Ever since Big Data became a mot du jour across social fields, optical metaphors such as the microscope began to surface in popular discourse to describe and qualify its epistemological impact. While the persistence of optics seems to be at odds with the datafication of vision, this article suggests that the optical metaphor offers an opportunity to reflect about the material consequences of the modes of seeing and knowing that currently shape datafied worlds. Drawing on feminist new materialism, the article (...) investigates the optical metaphor as a material-discursive practice that actively constitutes the world, as metaphors imply modes of thinking, knowing and doing that have material enactions. Expanding visual culture theories, the notion of ‘optical unconscious’ is taken up to discuss the tensions between displacement and persistence of optics within datafied worlds, that is, how optical vision is displaced but also mobilised and repurposed by data-driven knowledge. In dialogue with feminist science and technology studies and speculative ethics, I suggest that the datafication of vision offers a chance to reconceptualize the sense of sight towards a sensorial engagement with Big Data premised on responsibility, care, and an ethics of unknowability. Within this framework, vision may be conceived differently, perhaps not only as enhancement and control, but as generator of new possibilities. Ultimately, the article proposes that the visual theories after which Big Data is being imagined matter not only for our understanding of Big Data's epistemic potential, but also for the possibility of shaping emerging data worlds. (shrink)

_ Source: _Volume 29, Issue 1, pp 86 - 102 The aim of this paper is to give an overview of the place that Hobbes assigns to optics in the context of his classification of sciences and disciplinary boundaries. To do this, I will begin with an account of Hobbes’s conception of philosophy or science, and particularly his distinction between true and hypothetical knowledge. I will also show that in his demarcation between mathematics or geometry and natural philosophy Hobbes was (...) influenced by Galileo’s _Dialogue_. I then analyse the consequences of this distinction for optics, and conclude by clarifying its status among the scientific disciplines. (shrink)

The electron-optical phase shift induced in the electron beam due to the interaction with the electromagnetic field of magnetized nanoparticles of defined shape and arbitrary dimensions is calculated, presented and discussed. Together with the computable knowledge of vector potential and magnetic induction, including the demagnetizing field, and with the extension to more realistic geometries which will be presented in part II, this theoretical framework can be employed for the interpretation of transmission electron microscopy experiments on magnetic particles on the nanometre (...) scale. (shrink)

Seventeenth-century optics naturalizes the eye while estranging the mind from objects. A mere screen, on which rests a blurry array of light stains, the eye no longer furnishes the observer with genuine re-presentations of visible objects. The intellect is thus compelled to decipher flat images of no inherent epistemic value, accidental effects of a purely causal process, as vague, reversed reflections of wholly independent objects. Reflecting on and trespassing the boundaries between natural and artificial, orderly and disorderly, this optical paradox (...) is a Baroque phenomenon; and it is the origin of Descartes’ celebrated doubt---whether we know anything at all. (shrink)

There has been much recent debate about the nature of the omnivoyant image that introduces Nicholas of Cusa’s De visione Dei. In this paper, I argue that Cusa’s concept of contraction and his ‘radical perspectivism’ lead us toward stretching the concept of omnivoyance beyond a simple dichotomy between a phenomenology of the image and a phenomenology of the icon. Instead of putting such emphasis on what is seen by the omnivoyant, we should think an omnivoyant optics starting from the material (...) milieu from which it sees. To this end, I define the concept of omnivoyance through the concept of the elemental. Using both the concept of an element derived from Presocratic Ionian philosophy and recent French and American continental philosophy, I put these discourses into conversation with Cusa in several ways: the way omnivoyance functions as a substratum of contracted seeing rather than as a transcendence, its operation as a pure frontality without objectifiable aspects, and the way in which omnivoyance implies not only a gaze that sees ‘all and each’ but also a plurality of modes of vision. To help us understand this enlarged concept of omnivoyance, I use the example of animal vision, particularly the gaze of the whale. With respect to cetacean vision, I deploy Melville’s metaphysical speculations in Moby Dick as our primary guide. (shrink)

We propose an analogy between optical holography and neural behavior as a hypothesis about the physical mechanisms of neural reuse. Specifically, parameters in optical holography (frequency, amplitude, and phase of the reference beam) may provide useful analogues for understanding the role of different parameters in determining the behavior of neurons (e.g., frequency, amplitude, and phase of spiking behavior).

Significantly, Berkeley, in his Essay Towards a New Theory of Vision, leveled a sustained attack on just this geometrical theory of distance perception. At first glance it may seem, as it did to Berkeley, that Descartes’ geometrical theory is produced by a simple error: namely, by the idea that a physiological optics provides an adequate description of the psychological processes of judging distances. In truth, this is the weakest of Berkeley’s objections to Descartes’ theory. Obviously we do not see the (...) angles and lines of convergence when we focus on a distant object, nor are we aware of having used any geometrical rules in judging distance. And Descartes never claimed this. (shrink)

We have compared two different laser-induced optical light traps for their utility in moving organelles within living animal cells and walled fungal cells. The first trap employed a continuous wave neodymium-yttrium aluminum garnet laser at a wavelength of 1.06 micron. A second trap was constructed using a titanium-sapphire laser tunable from 700 to 1000 nm. With the latter trap we were able to achieve much stronger traps with less laser power and without damage to either mitochondria or spindles. Chromosomes and (...) nuclei were easily displaced, nucleoli were separated and moved far away from interphase nuclei, and Woronin bodies were removed from septa. In comparison, these manipulations were not possible with the Nd-YAG laser-induced trap. The optical force trap induced by the tunable titanium-sapphire laser should find wide application in experimental cell biology because the wavelength can be selected for maximization of force production and minimization of energy absorption which leads to unwanted cell damage. (shrink)

Descartes’ work on optics spanned his entire career and represents a fascinating area of inquiry from both the perspectives of the history of science and his systematic natural philosophy. The first of these entries offers a brief account of Descartes' seminal work in optics, the Dioptrique, often translated as the Optics or, more literally, as the Dioptrics. The second entry overview of Descartes’ understanding of light, his derivations of the two central laws of geometrical optics, and a sampling of the (...) optical phenomena he sought to explain. (shrink)

Minkowski geometry is axiomatized in terms of the asymmetric binary relation of optical connectibility, using ten first-order axioms and the second-order continuity axiom. An axiom system in terms of the symmetric binary optical connection relation is also presented. The present development is much simpler than the corresponding work of Robb, upon which it is modeled.

I argue that quantum optical experiments that purport to refute Bohr’s principle of complementarity fail in their aim. Some of these experiments try to refute complementarity by refuting the so called particle–wave duality relations, which evolved from the Wootters–Zurek reformulation of BPC. I therefore consider it important for my forgoing arguments to first recall the essential tenets of BPC, and to clearly separate BPC from WZPC, which I will argue is a direct contradiction of BPC. This leads to a need (...) to consider the meaning of particle–wave duality relations and to question their fundamental status. I further argue that particle and wave complementary concepts are on a different footing than other pairs of complementary concepts. (shrink)

Neutron matter-wave optics provides the basis for new quantum experiments and a step towards applications of quantum phenomena. Most experiments have been performed with a perfect crystal neutron interferometer where widely separated coherent beams can be manipulated individually. Various geometric phases have been measured and their robustness against fluctuation effects has been proven, which may become a useful property for advanced quantum communication. Quantum contextuality for single particle systems shows that quantum correlations are to some extent more demanding than classical (...) ones. In this case entanglement between external and internal degrees of freedom offers new insights into basic laws of quantum physics. Non-contextuality hidden variable theories can be rejected by arguments based on the Kochen-Specker theorem. (shrink)

_ Source: _Volume 29, Issue 1, pp 39 - 65 Since Euclid, optics has been considered a geometrical science, which Aristotle defines as a “mixed” mathematical science. Hobbes follows this tradition and clearly places optics among physical sciences. However, modern scholars point to a confusion between geometry and physics and do not seem to agree about the way Hobbes mixes both sciences. In this paper, I return to this alleged confusion and intend to emphasize the peculiarity of Hobbes’s geometrical optics. (...) This paper suggests that Hobbes’s conception of geometrical optics, as a mixed mathematical science, greatly differs from Descartes’s one, mainly because they do not share the same “mechanical conception of nature.” I will argue that Hobbes and Descartes also have in common the quest for a different kind of geometry for their optics, different from that of the Ancients. I will show that this departure is not recent since Hobbes’s approach is already evident in 1636, when he judges the demonstrations of his contemporary friends, Claude Mydorge and Walter Warner. Finally the paper broadly suggests what is noteworthy in Hobbes’s optics, that is, the importance of the idea of force in his mechanics, although he was not able to conceptualize it in other terms than “quickness.”. (shrink)

Descartes's Dioptrics is more than a mere technical treatise on optics; it is an essay in the "practical philosophy" that he claimed could render us "masters and possessors of nature." Descartes's practical intent is indicated first by the instrumentalist character of his derivation of the sine law of refraction, which is based on a heuristic and readily mathematizable model that requires no consideration of light's "true nature." Descartes's subsequent discussion of human vision is an extended critique of nature's workmanship that (...) grounds the possibility of improving vision by artificial means. I suggest that this critique is the source of Descartes's doctrine that the purpose of sensory perception is to preserve the mind-body composite, not to provide knowledge of the essential nature of things. Accordingly, the ultimate goal of the Dioptrics is to "master" human vision by raising it from a mere means of self-preservation to an instrument of scientific knowledge. -/- . (shrink)

Recently, βIII spectrins have been recognized as ataxia disease genes, with the identification by Ikeda and co‐workers of pathogenic mutations in the SPTBN2 gene in three large (and mapped) SCA5 families of American and European origin.(1) With their discovery, the large “Lincoln” family has been traced back to the underlying genetic defect for the slowly progressive cerebellar ataxia. In addition, the involvement of this component of the cytoskeleton directs attention towards the possible role of organelle stability during neurodegeneration. (...) The findings suggest that the mechanical properties of neurons and their dynamics may be as important as altered Ca2+ homeostasis, transcriptional dysregulation, and impaired protein degradation in neurodegeneration conditions. BioEssays 28: 785–787, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

This article charts the development of the modern astronomical observational system. I am interested most acutely in the digitization of this system in general, and in the introduction of adaptive optics in particular. I argue that these features have been critical in establishing the modern observatory as a factory for scientific data, rather than as a center of calculation in its own right. Throughout, the theoretical focus is on the nature of technological evolution in the observational system, understood as inextricably (...) bound up with both the system-internal drive to surpass the limits imposed upon the distributed cognition of the researcher and the boundary at which empirical objects resolve themselves into technical objects. In short, this article explores the historically constituted character of expert astronomical perception, arguing that it is impossible to understand without constant reference to its material substrate. (shrink)

This short account summarizes our recent achievements in ultrafast coherent control of isolated molecules in the gas phase, and its ongoing applications to an ensemble of ultracold Rydberg atoms to explore quantum many-body dynamics.

Gluten ataxia is a rare immune-mediated neurological disorder caused by the ingestion of gluten. The diagnosis is not straightforward as antibodies are present in only up to 38% of patients, but often at lower titers. The symptoms of ataxia may be mild at the onset but lead to permanent damage if remain untreated. It is characterized by damage to the cerebellum however, the pathophysiology of the disease is not clearly understood. The present study investigated the neurochemical profile of (...) vermis and right cerebellum and structural changes in various brain regions of patients with gluten ataxia and compared it with healthy controls. Volumetric 3-D T1 and T1-weighted magnetic resonance imaging in the three planes of the whole brain and single-voxel 1H- magnetic resonance spectroscopy of the vermis and right cerebellum were acquired on 3 T human MR scanner. The metabolite concentrations were estimated using LC Model while brain volumes were estimated using the online tool volBrain pipeline and CERES and corrected for partial volumes. The levels of neuro-metabolites were found to be significantly lower in vermis, while N-acetyl aspartate + N-acetyl aspartate glutamate and glycerophosphocholine + phosphocholine was lower in cerebellum regions in the patients with gluten ataxia compared to healthy controls. A significant reduction in the white matter of ; reduction in the volumes of cerebellum lobe and thalamus while lateral ventricles were increased in the patients with gluten ataxia compared to healthy controls. The reduced neuronal metabolites along with structural changes in the brain suggested neuronal degeneration in the patients with gluten ataxia. Our preliminary findings may be useful in understanding the gluten-induced cerebral damage and indicated that MRI and MRS may serve as a non-invasive useful tool in the early diagnosis, thereby enabling better management of these patients. (shrink)

The optical revolution, that is, the replacement of corpuscular optics by wave optics at the beginning of the nineteenth century, has attracted the attention of philosophers of science for a long time. For a long period the cause of the optical revolution was attributed to “crucial experiments” such as Foucault’s experiment on the velocity of light (Sabra 1954, pp.149-51). Later Frankel argued that social and political factors were necessary for the victory of the wave theory (Frankel 1976, p.142). These accounts, (...) however, were severely criticized by recent theorists of scientific change, especially Lakatos and Laudan. Lakatos calls the opinion that accounted for the optical revolution solely by “crucial experiments” naive “instant rationality” (Lakatos 1978, p.68 & 72n). Laudan also regards the attempt to explain scientific revolution mainly by social and political elements as “jumping to a premature conclusion” (Laudan 1977, p.4). (shrink)

I am troubled by the temper of E. H. Gombrich’s response, “Representation and Misrepresentation” , to my “Ambiguities of Representation and Illusion: An E. H. Gombrich Retrospective” and by his preferring not to sense the profound admiration—indeed, the homage—intended by my essay, both for his contributions to recent theory and for their influence upon its recent developments. But I am more troubled by the confusions his remarks may cause in the interpretation of his own work as well as in the (...) judgment of mine. There are important issues at stake, I feel, especially as regards the relation between scientific and aesthetic inquiry.The very irritated tone of his reaction helps make what I see as my major point: his work has contained a conflict between two Gombrichs—one, the skeptical humanist and, the other, the positive scientist—and with the passing years the second has increasingly sought to obliterate signs of the first, becoming increasingly impatient with any attempt to revive those signs or remind us of their existence. On the other side, since the line of literary criticism with which I associate myself has drawn strength from the first Gombrich, this development in his work and in his attitudes has caused some disappointment. Murray Krieger is University Professor of English at the University of California. He is the author of many works, including The Tragic Vision, The Classic Vision, Theory of Criticism: A Tradition and its System, Poetic Presence and Illusion: Essays in Critical History and Theory, and Arts on the Level. His previous contributions to Critical Inquiry are “Fiction, History, and Empirical Reality” , “Poetic Presence and Illusion: Renaissance Theory and the Duplicity of Metaphor” , and “The Ambiguities of Representation and Illusion: An E. H. Gombrich Retrospective”. (shrink)

Typically developing 3-day-old newborns take significantly more forward steps on a moving treadmill belt than on a static belt. The current experiment examined whether projecting optic flows that specified forward motion onto the moving treadmill surface would further enhance forward stepping. Twenty newborns were supported on a moving treadmill without optic flow, with optic flow matching the treadmill’s direction and speed, with optic flow in the same direction but at a faster speed, and in a control (...) condition with an incoherent optic flow moving at the same speed as in the Congruent condition but in random directions. The results revealed no significant differences in the number or coordination of forward treadmill steps taken in each condition. However, the Faster condition generated significantly fewer leg pumping movements than the Random control condition. When highly aroused, newborns made significantly fewer single steps and significantly more parallel steps and pumping movements. We speculate the null findings may be a function of the high friction material that covered the treadmill surface. (shrink)

Underwater object detection plays an important role in research and practice, as it provides condensed and informative content that represents underwater objects. However, detecting objects from underwater images is challenging because underwater environments significantly degenerate image quality and distort the contrast between the object and background. To address this problem, this paper proposes an optical prior-based underwater object detection approach that takes advantage of optical principles to identify optical collimation over underwater images, providing valuable guidance for extracting object features. Unlike (...) data-driven knowledge, the prior in our method is independent of training samples. The fundamental novelty of our approach lies in the integration of an image prior and the object detection task. This novelty is fundamental to the satisfying performance of our approach in underwater environments, which is demonstrated through comparisons with state-of-the-art object detection methods. (shrink)

Dawn, noon, and dusk: this is the course of one day in Nietzschean optics.1 Beginning with daybreak, two paths will lead out of two caves: one will begin with the Platonist prisoner exiting his den of darkness, and the other will follow Zarathustra as he first descends into and then emerges from his cave atop the mountain. As the newly enlightened Platonist slave undertakes an “up-going,” arising up from the depths of his shadowy cave toward the sun, Zarathustra begins a (...) “down-going.” Along the diverging paths of these two different travelers, there will be a pause at the moment when the sun is at the peak of its path along the arc of the sky. This still hour, when the sun is directly overhead, when light is shed on all things and all sides, is not, however, the absolute erasure of shadows. This is the noontide: the time of Nietzsche’s inversion of Platonism. Interpreting this inversion through light and shadows will allow us to approach the different gestures of Nietzschean and Platonist optics. Finally, naturally, the path of this wandering will end with the descent of the sun, when the light goes away and leaves a cloud of darkness upon all things. It is then, while the shadows grow in relation to the sun’s descent, that Nietzsche’s “highest thought,” the thought of eternal recurrence, will occur to Zarathustra. Eternal recurrence, amongst other things, will convey not a clear and distinct truth, but the trust in shadows that embody the movement of nothingness. This twilight hour will then be the conclusion of this short study in Nietzschean optics. Upon reaching the end of this path, a new day will break, and this new day will no longer take the movement of the sun as the beacon of truth, but will, instead, trust in the movement of nothingness as its orienting gesture. (shrink)

Optic neuropathy refers to disease of the optic nerve and can result in loss of visual acuity and/or visual field defects. Combining findings from multiple fMRI modalities can offer valuable information for characterizing and managing optic neuropathies. In this article, we review a subset of resting-state functional magnetic resonance imaging (RS-fMRI) studies of optic neuropathies. We consider glaucoma, acute optic neuritis (ON), discuss traumatic optic neuropathy (TON), and explore consistency between findings from RS and (...) visually driven fMRI studies. Consistent with visually driven studies, glaucoma studies at rest also indicated reduced activation in the visual cortex and dorsal visual stream. RS-fMRI further reported varying levels of functional connectivity in the ventral stream depending on disease severity. ON patients show alterations within the visual cortex in both fMRI techniques. Particularly, higher-than-normal RS activity is observed in the acute phase and decreases as the disease progresses. A similar pattern is observed in the visual cortex of TON-like, open globe injury (OGI), patients. Additionally, visually driven and RS-fMRI studies of ON patients show recovery of brain activity in the visual cortex. RS-fMRI suggests recovery of signals in higher-tier visual areas MT and LOC as well. Finally, RS-fMRI has not yet been applied to TON, although reviewing OGI studies suggests that it is feasible. Future RS-fMRI studies of optic neuropathies could prioritize studying the fine scale RS activity of brain areas that visually driven studies have identified. We suggest that a more systematic longitudinal comparison of optic neuropathies with advanced fMRI would provide improved diagnostic and prognostic information. (shrink)

Socrates, in the Republic , uses the symbol of a divided line to illustrate the distinction between the Visible and Intelligible Worlds, and between the kinds of perception appropriate to each. This paper will present a new hypothesis: that the proportions of the line are derived from optical theory. The construction of the Divided Line is described as follows: Socrates asks his interlocutors to represent the Visible and Intelligible Worlds by a line divided into two unequal segments. The ratio in (...) which the division is to be made is not specified, and it seems that any ratio is acceptable provided that one segment is longer than the other. Socrates then tells them to cut each part again according to the same ratio as the original division. After describing the division of the line thus into four parts, Socrates goes on to explain the philosophical significance of each part. For the purposes of this paper the following brief identification of each segment of the line will suffice. (shrink)

When young Kant meditated upon the distinction between his right and left hands, he could not foresee that the problem of incongruent counterparts would revive in the twentieth century under a new form. In the early days of quantum chemistry, Friedrich Hund developed the so-called Hund paradox that arises from the supposed inability of quantum mechanics to account for the difference between enantiomers. In this paper, the paradox is expressed as a case of quantum measurement, stressing that decoherence does not (...) offer a way out of the problem. The main purpose is to argue for the need to adopt a clear interpretation of quantum mechanics in order to solve the paradox. In particular, I claim that the Modal-Hamiltonian Interpretation, which conceives measurement as a breaking-symmetry process, supplies the tools required to explain the dextro-rotation or levo-rotation properties of optical isomers. (shrink)