Abstract

Uchiyama et al. productively discuss how culture can influence genetic heritability and, by modifying environmental conditions, limit the generalizability of genome-wide association studies (GWASs). Here, we supplement their account by highlighting how recent changes in culture and institutions in industrialized, westernized societies – such as increased female workforce participation – may have increased assortative mating. This alters the distribution of genotypes themselves, increasing heritability and phenotypic variance, and may be detectable using the latest methods.