Isis 116 (1):23-42 (
2025)
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Abstract
In the early to mid-1960s, Ronald Melzack and Patrick Wall at the Massachusetts Institute of Technology developed gate control theory, the most enduring theory of pain of the twentieth century. Challenging the notion of pain as a pure sensation of injury, Melzack and Wall refigured bodily experience as a dynamic state of the entire nervous system, including the higher levels of the brain. Within a decade, their neurophysiological model had become the conceptual foundation for the burgeoning and multidisciplinary field of pain medicine. This essay excavates the conditions of possibility for the invention of gate control theory. It shows how two intellectual cultures emerging across the postwar neuro and psy disciplines—namely, cognitivism and cybernetics—converged in a holistic understanding of patients’ reported experiences. In reframing gate control theory, this story reveals how postwar scientists were able to construct a vision of an integrated, post-Cartesian self.