It Takes Two to Tango: Genotyping and Phenotyping in Genome-Wide Association Studies

Biological Theory 4 (3):294-301 (2009)
  Copy   BIBTEX

Abstract

In this article we examine the “phenotype” concept in light of recent technological advances in Genome-Wide Association Studies . By observing the technology and its presuppositions, we put forward the thesis that at least in this case genotype and phenotype are effectively coidentifled one by means of the other. We suggest that the coidentiflcation of genotype-phenotype couples in expression-based GWAS also indicates a conceptual dependence, which we call “co-deñnition.” We note that viewing these terms as codeflned runs against possible expectations, viz., that genotypes and phenotypes could ultimately be expressed independently from one another. In addition, the co-definition of genotypes and phenotypes in this context emphasizes the correlative character of both genotypes and phenotypes in GWAS

Other Versions

No versions found

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 103,388

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Gene expression and the concept of the phenotype.Ohad Nachtomy, Ayelet Shavit & Zohar Yakhini - 2007 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 38 (1):238-254.
Genotype-Phenotype Maps.Peter F. Stadler & Bärbel M. R. Stadler - 2006 - Biological Theory 1 (3):268-279.
Shallow versus deep genetic causes.Adam C. Smith & Stephen M. Downes - 2023 - Behavioral and Brain Sciences 46:e201.

Analytics

Added to PP
2014-01-24

Downloads
53 (#427,749)

6 months
4 (#864,415)

Historical graph of downloads
How can I increase my downloads?

Author Profiles

Ayelet Shavit
Hebrew University of Jerusalem

Citations of this work

The genotype/phenotype distinction.Richard Lewontin - 2008 - Stanford Encyclopedia of Philosophy.

Add more citations

References found in this work

Philosophy of Experimental Biology.Marcel Weber - 2004 - Cambridge University Press.
Making Sense of Life.Evelyn Fox Keller - 2002 - Cambridge: Harvard University Press.
Sex and Death: An Introduction to Philosophy of Biology.Kim Sterelny & Paul Edmund Griffiths - 1999 - Chicago and London: The University of Chicago Press.
The Return of the Gene.Kim Sterelny & Philip Kitcher - 1988 - Journal of Philosophy 85 (7):339.
Gene.Paul E. Griffiths & Karola Stotz - 2007 - In David L. Hull & Michael Ruse, The Cambridge Companion to the Philosophy of Biology. New York: Cambridge University Press.

View all 12 references / Add more references