Abstract
This paper assesses, from a philosophical point of view, the latest cultural neuroscience results that suggest the traditional interpretation of subject of cognition be essentially reconstructed. We must move from a universalistic interpretation of cognitive process to an interpretation taking into explicit account the socio-cultural context of the subject’s activity, as well as often its biological nature. The principle of cultural and cognitive neurobiological determination of knowledge acquisition is proposed. We claim that subject of cognition is fixed in the historical and cultural context and it neurobiologically determined, and thus classical Kantian transcendentalism should be reconsidered in light of recent neuroscience research.